COX
Os inibidores da ciclooxigenase (COX) são compostos que bloqueiam a atividade das enzimas COX, envolvidas na produção de prostaglandinas, mediadores chave da inflamação e dor. Em neurociências, os inibidores de COX são estudados por seu potencial em reduzir a neuroinflamação, que está implicada em várias doenças neurodegenerativas, como a doença de Alzheimer, Parkinson e esclerose múltipla. Ao inibir a COX, esses compostos podem ajudar a mitigar os processos inflamatórios no cérebro e proteger contra danos neuronais. Na CymitQuimica, oferecemos uma variedade de inibidores de COX para apoiar sua pesquisa em neuroinflamação, gestão da dor e doenças neurodegenerativas.
Foram encontrados 562 produtos de "COX"
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(-)-Epicatechin
CAS:<p>(-)-Epicatechin (Epicatechin) is an inhibitor of cyclooxygenase-1 (COX-1), inhibiting the IL-1β-induced expression of iNOS by blocking the nuclear localization</p>Fórmula:C15H14O6Pureza:98.55% - 98.80%Cor e Forma:SolidPeso molecular:290.27Licofelone
CAS:<p>Licofelone (ML-3000) is a dual COX/LOX inhibitor potentially for the treatment of osteoarthritis.</p>Fórmula:C23H22ClNO2Pureza:99.25%Cor e Forma:Yellowish SolidPeso molecular:379.88SC-236
CAS:<p>SC-236 (Sc 236) is an orally active and selective inhibitor of COX-2 (IC50 of 0.005 μM and 17.8 μM for COX-2 and COX-1, respectively).</p>Fórmula:C16H11ClF3N3O2SPureza:99.74%Cor e Forma:SolidPeso molecular:401.79Chebulagic acid
CAS:<p>Chebulagic acid, isolated from the Terminalia chebula Retz, is a COX-LOX dual inhibitor.</p>Fórmula:C41H30O27Pureza:97.82% - 99.8%Cor e Forma:SolidPeso molecular:954.66(-)-Epicatechin gallate
CAS:<p>(-)-Epicatechin gallate, a catechin isomer and strong antioxidant, affects membrane proteins and alters gA channel function in bilayers.</p>Fórmula:C22H18O10Pureza:99.16% - 99.93%Cor e Forma:SolidPeso molecular:442.37Flurbiprofen Axetil
CAS:<p>Flurbiprofen Axetil (Lipfen) is an anti-inflammatory used as an analgesic.</p>Fórmula:C19H19FO4Pureza:97.58% - 98%Cor e Forma:SolidPeso molecular:330.35Phenidone
CAS:<p>Phenidone inhibits COX/LOX, reducing rat autoimmune paralysis and lowering blood pressure in hypertensive rats.</p>Fórmula:C9H10N2OPureza:97.24%Cor e Forma:White Solid Solid CrystallinePeso molecular:162.19Ataquimas
CAS:<p>Ataquimast inhibits IL-5 secretion along with that of TNF-a, IL-4 and GM-CSF from human cells.</p>Fórmula:C11H13N3OPureza:99.96%Cor e Forma:SolidPeso molecular:203.24Neochlorogenic acid
CAS:<p>Neochlorogenic acid (trans-5-O-Caffeoylquinic acid) is an antioxidant compound used in the treatment of oxidative stress and related afflictions.</p>Fórmula:C16H18O9Pureza:99.12% - 99.54%Cor e Forma:White PowderPeso molecular:354.31Ibuprofen Lysine
CAS:<p>Ibuprofen Lysine (Neoprofen) is a non-steroidal anti-inflammatory drug.</p>Fórmula:C19H32N2O4Pureza:99.26%Cor e Forma:CoaPeso molecular:352.473-TERT-BUTYL-4-HYDROXYANISOLE
CAS:<p>3-tert-Butyl-p-hydroxyanisole is an antioxidant which is produced via water chlorination.</p>Fórmula:C11H16O2Pureza:99.65%Cor e Forma:White Solid WaxyPeso molecular:180.24Diclofenac Epolamine
CAS:<p>Diclofenac Epolamine (DHEP) is a non-steroidal anti-inflammatory agent (NSAID) with analgesic and antipyretic actions.</p>Fórmula:C20H24Cl2N2O3Pureza:99.56%Cor e Forma:SolidPeso molecular:411.32SC-560
CAS:<p>SC-560 is a member of the diaryl heterocycle class of cyclooxygenase (COX) inhibitors.</p>Fórmula:C17H12ClF3N2OPureza:99.97%Cor e Forma:SolidPeso molecular:352.74Prim-O-glucosylcimifugin
CAS:<p>Prim-O-glucosylcimifugin (Cimifugin 7-glucoside) can inhibit the proliferation of SMC stimulated by TNF-alpha, increase the proportion of G0/G1 phase.</p>Fórmula:C22H28O11Pureza:98.57% - 99.92%Cor e Forma:SolidPeso molecular:468.45RHC 80267
CAS:<p>RHC 80267 (U-57908) is a selective inhibitor of DAGL (IC50 : 4 μM in canine platelets)</p>Fórmula:C20H34N4O4Pureza:99.54%Cor e Forma:White SolidPeso molecular:394.51ETHYL CAFFEATE
CAS:<p>Ethyl Caffeate (ETHYL 3,4-DIHYDROXYCINNAMATE) suppressed the differentiation of naive CD4+ T cells into Th1 in vitro.</p>Fórmula:C11H12O4Pureza:97.79%Cor e Forma:SolidPeso molecular:208.21Ufenamate
CAS:<p>Ufenamate (Flufenamic acid butyl ester) is an anthranilic acid-based anti-inflammatory drug developed for skin diseases</p>Fórmula:C18H18F3NO2Pureza:99.89%Cor e Forma:SolidPeso molecular:337.34Veratric acid
CAS:<p>Veratric acid (3,4-Dimethoxybenzoic acid) is a simple benzoic acid derived from plants and fruits with anti-oxidant, anti-inflammation and blood pressure-</p>Fórmula:C9H10O4Pureza:99.44%Cor e Forma:SolidPeso molecular:182.17Indomethacin farnesil
CAS:<p>Indomethacin farnesil (Infree) is a prodrug of indomethacin. It acts as a nonsteroidal anti-inflammatory drug (NSAID) and disease-modifying anti-rheumatic drug.</p>Fórmula:C34H40ClNO4Pureza:97.29%Cor e Forma:SolidPeso molecular:562.14N-trans-Feruloyltyramine
CAS:<p>NTF is hepatoprotective, antioxidant, inhibits COX, prevents platelet aggregation, and reduces melanin by downregulating tyrosinase.</p>Fórmula:C18H19NO4Pureza:99.56% - >99.99%Cor e Forma:SolidPeso molecular:313.35Phenethyl ferulate
CAS:<p>Phenethyl ferulate is a chemopreventive against colon cancer, enhancing apoptosis in tumors and inhibiting COX/5-LOX (IC50: 4.35/5.75 μM).</p>Fórmula:C18H18O4Pureza:99.88% - 99.91%Cor e Forma:SolidPeso molecular:298.33(S)-Flurbiprofen
CAS:<p>Esflurbiprofen is an inhibitor of COX-1 and COX-2.</p>Fórmula:C15H13FO2Pureza:99.99%Cor e Forma:White To Yellowish Crystalline PowderPeso molecular:244.26Dehydrodiisoeugenol
CAS:<p>Dehydrodiisoeugenol suppresses COX-2 expression and NF-κB activity, reducing inflammation in LPS-stimulated murine macrophages.</p>Fórmula:C20H22O4Pureza:99.97%Cor e Forma:SolidPeso molecular:326.39Ketorolac
CAS:<p>Ketorolac (Acuvail) is an NSAID that blocks prostaglandin synthesis, related to heterocyclic acetic acids.</p>Fórmula:C15H13NO3Pureza:99.68%Cor e Forma:White Crystalline Or White PowderPeso molecular:255.27Xanthohumol
CAS:<p>Xanthohumol, also known as 2', 4, 4'-trihydroxy-6'-methoxy-3'-prenylchalcone or desmethylxanthohumol, is a member of the class of compounds known as 3-</p>Fórmula:C21H22O5Pureza:98.19% - 99.67%Cor e Forma:Orange PowderPeso molecular:354.4Loxoprofen sodium (dihydrate)
CAS:<p>Loxoprofen sodium dihydrate: Non-steroidal anti-inflammatory with analgesic, antipyretic, antitumor effects; COX-1/COX-2 inhibitor. IC50: 6.5/13.5 μM.</p>Fórmula:C15H21NaO5Cor e Forma:SolidPeso molecular:304.318Tenidap
CAS:<p>Tenidap (CP-66248) is a selective COX-1 and SLC26A3 inhibitor with anti-inflammatory, analgesic, and anti-rheumatic activities.</p>Fórmula:C14H9ClN2O3SPureza:98.56% - 99.42%Cor e Forma:SolidPeso molecular:320.75NF-κB/MAPK-IN-1
CAS:<p>NF-κB/MAPK-IN-1 is an NF-κB and MAPK pathway inhibitor. NF-κB/MAPK-IN-1 is used to prevent rheumatoid arthritis (RA).</p>Fórmula:C27H27NO7Pureza:97.03%Cor e Forma:SolidPeso molecular:477.51Bromfenac sodium hydrate
CAS:<p>Bromfenac sodium hydrate (Bromfenac monosodium salt sesquihydrate) is the sodium salt form of bromfenac, a NSAID with analgesic and anti-inflammatory effects.</p>Fórmula:C15H12BrNO3H2O·NaPureza:91.85% - 99.65%Cor e Forma:SolidPeso molecular:383.17Oxyphenbutazone
CAS:<p>Oxyphenbutazone: Non-selective COX inhibitor, anti-inflammatory, kills dormant Mycobacterium tuberculosis.</p>Fórmula:C19H20N2O3Pureza:99.41% - 99.88%Cor e Forma:White To Yellowish White Crystalline Powder SolidPeso molecular:324.37Meloxicam
CAS:<p>Meloxicam (Metacam) is a Nonsteroidal Anti-inflammatory Drug.</p>Fórmula:C14H13N3O4S2Pureza:97.09% - 99.60%Cor e Forma:Light Yellow SolidPeso molecular:351.40Fenoprofen
CAS:<p>Fenoprofen (LILLY-5385) is a non-steroidal anti-inflammatory compound and a modifier enhancer of the melanocortin receptor, increasing ERK1/2 activation.</p>Fórmula:C15H14O3Pureza:98.4%Cor e Forma:SolidPeso molecular:242.27(S)-(+)-Ibuprofen
CAS:<p>(S)-(+)-Ibuprofen (Dexibuprofen) , is a non-steroidal anti-inflammatory drug (NSAID), inhibiting cyclooxygenase (COX).</p>Fórmula:C13H18O2Pureza:99.51% - 99.86%Cor e Forma:Colourless Crystalline SolidPeso molecular:206.28Paradol
CAS:<p>Paradol, a spicy compound in ginger, offers anti-cancer, anti-inflammatory, antioxidant, and neuroprotective benefits.</p>Fórmula:C17H26O3Pureza:98.4% - 98.98%Cor e Forma:SolidPeso molecular:278.39Fontolizumab
CAS:<p>Fontolizumab (HuZAF) is a humanised IgG1 monoclonal anti-IFN-gamma (IFN-γ) antibody for the study of Crohn's disease.</p>Pureza:95%Cor e Forma:LiquidPeso molecular:150 (kDa)Aspirin DL-lysine
CAS:<p>Aspirin DL-lysine: a water-soluble, injectable NSAID that may also hinder cancer growth.</p>Fórmula:C15H22N2O6Cor e Forma:Crystalline SolidPeso molecular:326.35Cadonilimab
CAS:<p>Cadonilimab (AK104) is a tetravalent PD-1/CTLA-4 bispecific humanised antibody that activates T cells by enhancing IL-2 and IFN-γ secretion.</p>Pureza:95% - 95%Cor e Forma:LiquidImidazole Salicylate
CAS:<p>Imidazole Salicylate, a non-steroidal anti-inflammatory drug, has limited inhibitory effects on prostaglandin synthesis.</p>Fórmula:C10H10N2O3Pureza:98%Cor e Forma:SolidPeso molecular:206.2Indometacin Farnesil
CAS:Fórmula:C34H40ClNO4Pureza:>98.0%(HPLC)Cor e Forma:Light yellow to Yellow to Orange clear liquidPeso molecular:562.15Ketorolac-d5
CAS:<p>Ketorolac-d5 is a deuterated compound of ketorolac for isotope tracing. Ketorolac is a non-steroidal anti-inflammatory agent and inhibitor of COX-1 and COX-2.</p>Fórmula:C15H8D5NO3Pureza:98.99%Cor e Forma:SolidPeso molecular:260.3Nepafenac-d5
CAS:<p>Nepafenac D5 is the deuterium labeled Nepafenac, which is a selective inhibitor of COX-2 .</p>Fórmula:C15H14N2O2Pureza:98%Cor e Forma:SolidPeso molecular:259.31AHR-10037
CAS:<p>AHR-10037, a NSAID, offers pain relief, fever reduction, safety, and low stomach risk, acting as a prodrug for COX inhibitors.</p>Fórmula:C15H13ClN2O2Pureza:98%Cor e Forma:SolidPeso molecular:288.73Amfenac
CAS:<p>Amfenac promotes apoptosis in ARPE-19 cell culture.</p>Fórmula:C15H13NO3Cor e Forma:SolidPeso molecular:255.27Pelubiprofen
CAS:<p>Pelubiprofen is a non-steroidal anti-inflammatory agent and a COX-2 inhibitor, which effectively reduces PGE(2) production by inhibiting COX activity.</p>Fórmula:C16H18O3Pureza:99.69%Cor e Forma:SolidPeso molecular:258.31COX-2-IN-2
CAS:<p>COX-2-IN-2 selectively inhibits COX2 (IC50: 0.24 μM); COX-2-IN-1 offers anti-inflammatory and pain relief.</p>Fórmula:C17H12FN3O2SPureza:97.62%Cor e Forma:SolidPeso molecular:341.36COX-2-IN-26
CAS:<p>COX-2-IN-26: Oral, selective COX-2 inhibitor, low IC50s; anti-inflammatory with GI safety.</p>Fórmula:C23H21N7OS3Cor e Forma:SolidPeso molecular:507.65Loxoprofenol-SRS tromethamine
CAS:<p>Loxoprofenol-SRS tromethamine (HR1405-01), a metabolite of Loxoprofen, is a safe IV NSAID with strong anti-inflammatory and pain relief properties.</p>Fórmula:C19H31NO6Cor e Forma:SolidPeso molecular:369.45COX-2-IN-24
CAS:<p>COX-2-IN-24 is an orally active COX-2 inhibitor (IC50: 0.17 μM) with anti-inflammatory and hypo-ulcerogenic effects.</p>Fórmula:C24H24BrN5O3S2Cor e Forma:SolidPeso molecular:574.51COX-2-IN-18
CAS:<p>COX-2-IN-18 is a potent COX-2 inhibitor similar to Celecoxib, showing promise in cancer research. IC50=0.775μM.</p>Fórmula:C18H19N3O3S2Cor e Forma:SolidPeso molecular:389.49COX-2-IN-14
CAS:<p>COX-2-IN-14 (2a) is a potent, selective COX-2 inhibitor with high affinity and notable anti-inflammatory effects in mice.</p>Fórmula:C18H18N4O6Cor e Forma:SolidPeso molecular:386.364SC57666
CAS:<p>SC57666 is a highly selective COX2 inhibitor (IC50 at 26 nM) that shows no activity against COX1.</p>Fórmula:C18H17FO2SPureza:98.83%Cor e Forma:SolidPeso molecular:316.39FR-188582
CAS:<p>FR-188582 is a highly selective cyclooxygenase (COX)-2 inhibitor (IC50: 17 nM).</p>Fórmula:C16H13ClN2O2SPureza:98%Cor e Forma:SolidPeso molecular:332.8Anti-inflammatory agent 56
CAS:<p>Anti-inflammatory agent 56 (Compound 9), a selective COX-2 inhibitor with an IC50 of 0.54 μM, exhibits anti-oxidant and anti-inflammatory properties by</p>Fórmula:C21H15F3N4O4SPureza:98%Cor e Forma:SolidPeso molecular:476.43COX/5-LO-IN-1
CAS:<p>COX/5-LO-IN-1 is a cyclooxygenase and 5-lipoxygenase (5-LO) inhibitor, and used for inflammatory and allergic disease states.</p>Fórmula:C16H15FN2O2SPureza:98%Cor e Forma:SolidPeso molecular:318.37MK-0703
CAS:<p>MK-0703 is a selective cyclooxygenase-2 inhibitor.</p>Fórmula:C17H22O5SPureza:98%Cor e Forma:SolidPeso molecular:338.42COX-2/15-LOX-IN-1
CAS:<p>COX-2/15-LOX-IN-1 is a dual inhibitor for COX-2/15-LOX with anti-inflammatory properties (IC50: COX-1 10.65μM, COX-2 0.075μM, 15-LOX 2.98μM).</p>Fórmula:C21H21N7S3Cor e Forma:SolidPeso molecular:467.63COX-2-IN-17
CAS:<p>COX-2-IN-17 is a potent, blood-brain barrier permeable COX-2 (cyclooxygenase-2) inhibitor (IC50: 0.02 μM) with anti-inflammatory and analgesic activity.</p>Fórmula:C20H23ClN6O2Cor e Forma:SolidPeso molecular:414.89COX-2-IN-23
CAS:<p>COX-2-IN-23 selectively inhibits COX-2 (IC50=0.28μM), weakly affects COX-1 (IC50=20.14μM), and has anti-inflammatory and low ulcerogenic properties.</p>Fórmula:C24H25N5O3S2Cor e Forma:SolidPeso molecular:495.62COX-1/2-IN-3
CAS:<p>COX-1/2-IN-3 (Compound 7a) is a dual inhibitor of COX-1 and COX-2. COX-1/2-IN-3 has anti-inflammatory activity with low toxicity [1].</p>Fórmula:C14H8N2O8Cor e Forma:SolidPeso molecular:332.22COX-1/2-IN-1
CAS:<p>"COX-1/2-IN-2: Strong dual inhibitor of COX-1 (IC50 = 13.9 μM) and COX-2 (IC50 = 6.4 μM)."</p>Fórmula:C15H10BrClN2OCor e Forma:SolidPeso molecular:349.61K-80001
CAS:<p>K-80001 is a selective RXRα ligand and a COX-1/2 inhibitor, exhibiting IC50 values of 82.9μM for RXRα, 3.4μM for COX-1, and 1.2μM for COX-2, respectively [1].</p>Fórmula:C20H17FO2Cor e Forma:SolidPeso molecular:308.35Anti-inflammatory agent 8
CAS:<p>Anti-inflammatory agent 8 targets COX-2 over COX-1, IC50 of 0.09 nM, orally bioavailable.</p>Fórmula:C18H15N5OS2Cor e Forma:SolidPeso molecular:381.47Apricoxib
CAS:<p>Apricoxib: oral NSAID with antiangiogenic, antineoplastic properties; inhibits COX-2, may reduce tumor growth and angiogenesis.</p>Fórmula:C19H20N2O3SCor e Forma:SolidPeso molecular:356.44COX-2/sEH-IN-1
CAS:<p>COX-2/sEH-IN-1, oral dual inhibitor: COX-2 (IC50=1.24 μM), sEH (IC50=0.40 μM); boosts anti-inflammatory action, cuts heart risk.</p>Fórmula:C23H18F3N5O3SCor e Forma:SolidPeso molecular:501.48Naproxen glucuronide
CAS:<p>Naproxen glucuronide: NSAID, propionic class, eases pain, fever, inflammation. Nonselective COX blocker.</p>Fórmula:C20H22O9Cor e Forma:SolidPeso molecular:406.38AL-8417
CAS:<p>AL-8417 is an enzyme inhibitor with antioxidant, anti-inflammatory, and cytostatic properties; prevents vitrectomy-induced lens alterations.</p>Fórmula:C29H34O5Pureza:98%Cor e Forma:SolidPeso molecular:462.58PD 127443
CAS:<p>PD 127443 is a Leukotriene B4 antagonist, it is also a dual inhibitor of cyclooxygenase and 5-lipoxygenase.</p>Fórmula:C20H28N2OCor e Forma:SolidPeso molecular:312.45COX-2-IN-32
CAS:<p>COX-2-IN-32 (Compound 2f) is a dual inhibitor of iNOS and COX-2, known to downregulate NF-κB expression.</p>Fórmula:C25H24O6Pureza:98%Cor e Forma:SolidPeso molecular:420.45Thiazolinobutazone
CAS:<p>Thiazolinobutazone is the 2-amino-2-thiazoline salt of phenylbutazone.</p>Fórmula:C22H26N4O2SCor e Forma:SolidPeso molecular:410.53ASP-6537
CAS:<p>ASP-6537 is a selective and reversible inhibitor of cyclooxygenase-1.</p>Fórmula:C17H17N3O3Pureza:98%Cor e Forma:SolidPeso molecular:311.34COX/5-LOX-IN-1
CAS:<p>Compound 6b is a potent dual inhibitor of COX/5-LOX with IC50s: 1.07μM (COX-1), 0.55μM (COX-2), 0.28μM (5-LOX) for inflammation research.</p>Fórmula:C18H30O3Cor e Forma:SolidPeso molecular:294.43Pifoxime
CAS:<p>Pifoxime: a NSAID with COX-1/2 inhibition, used in anti-inflammatory treatment and neuropsychiatric studies.</p>Fórmula:C15H20N2O3Cor e Forma:SolidPeso molecular:276.33COX-2-IN-16
CAS:<p>COX-2-IN-16: potent, selective oral COX-2 blocker, IC50=102 μM, reduces NO, anti-inflammatory.</p>Fórmula:C19H12BrN3O2Cor e Forma:SolidPeso molecular:394.22COX-2/5-LOX-IN-3
CAS:<p>COX-2/5-LOX-IN-3 inhibits COX-2/5-LOX with IC50s: COX-1 45.73μM, COX-2 5.45μM, 5-LOX 4.33μM; promising for inflammation research.</p>Fórmula:C17H16ClN3O2SCor e Forma:SolidPeso molecular:361.85ATB-337
CAS:<p>S-Diclofenac, an NSAID with H2S-releasing moiety, protects gastric mucosa while inhibiting prostaglandins.</p>Fórmula:C23H15Cl2NO2S3Cor e Forma:SolidPeso molecular:504.47Flosulide
CAS:<p>Flosulide is an effective selective COX-2 inhibitor for the treatment of inflammatory diseases.</p>Fórmula:C16H13F2NO4SPureza:98%Cor e Forma:SolidPeso molecular:353.34AHR-6293
CAS:<p>AHR-6293 is used to distinguishing the effect of anti-platelet aggregating drug properties and the effect of anti-inflammatory properties.</p>Fórmula:C15H12ClNO3Cor e Forma:SolidPeso molecular:289.71NCX 466
CAS:<p>cyclooxygenase (COX)-inhibiting nitric oxide (NO) donor</p>Fórmula:C20H24N2O9Pureza:98%Cor e Forma:SolidPeso molecular:436.41Etoricoxib HCl
CAS:<p>Etoricoxib HCl is a synthetic NSAID that inhibits COX-2, blocking prostaglandin production.</p>Fórmula:C18H16Cl2N2O2SCor e Forma:SolidPeso molecular:395.30Lobeglitazone Sulfate
CAS:<p>Lobeglitazone Sulfate (CKD-501) is an anti-inflammatory thiazolidinedione that prevents NLRP3 inflammasome activation and is used in T2DM research.</p>Fórmula:C24H26N4O9S2Pureza:98.69%Cor e Forma:SolidPeso molecular:578.61LY 25648
CAS:<p>LY 25648 is an antagonist of leukotriene B4.</p>Fórmula:C19H27NO2SCor e Forma:SolidPeso molecular:333.49ZXX2-77
CAS:<p>ZXX2-77 is a cyclooxygenase-1 inhibitor.</p>Fórmula:C13H13ClN2O2SPureza:98%Cor e Forma:SolidPeso molecular:296.77LY 150310
CAS:<p>LY 150310, a histamine H1-receptor antagonist, can alter prostanoid concentrations in vitro and in vivo.</p>Fórmula:C13H14N2Cor e Forma:SolidPeso molecular:198.26PC407-ws
CAS:<p>PC407-ws is a water-soluble novel COX-2 inhibitor.</p>Fórmula:C24H18F3N3Na2O5SPureza:98%Cor e Forma:SolidPeso molecular:563.46Isonixin
CAS:<p>Isonixin is used for the treatment of inflammation and pain associated with musculoskeletal and joint disorders.</p>Fórmula:C14H14N2O2Pureza:98%Cor e Forma:SolidPeso molecular:242.27Prostaglandin G/H synthase 1 inhibitor
CAS:<p>Prostaglandin G/H synthase 1 inhibitor (CP 74006) is a selective D5D inhibitor with an IC(50) value of 20 nM.</p>Fórmula:C13H11ClN2OPureza:99.76%Cor e Forma:SolidPeso molecular:246.69Tenosal
CAS:<p>Tenosal obtained by esterifying salicylic acid with 2-thiophene-carboxylic acid, and with analgesic and antipyretic properties, anti-inflammatory.</p>Fórmula:C12H8O4SPureza:98%Cor e Forma:SolidPeso molecular:248.25LY 178002
CAS:<p>LY 178002 inhibits 5-LPO (IC50: 0.6 μM), PLA2, and LTB4 production; weak on cyclooxygenase.</p>Fórmula:C18H25NO2SPureza:98%Cor e Forma:SolidPeso molecular:319.46L 748780
CAS:<p>L 748780 is a selective inducible COX-2 inhibitor.</p>Fórmula:C19H14Cl3NO4Pureza:98%Cor e Forma:SolidPeso molecular:426.68Eicosatetraynoic acid
CAS:<p>ETYA activates PPARα/γ at 10μM, inhibits cyclooxygenase (ID50=8μM) and lipoxygenase (ID50=4μM).</p>Fórmula:C20H24O2Pureza:98%Cor e Forma:SolidPeso molecular:296.4COX-2-IN-20
CAS:<p>COX-2-IN-20 (Compound 5d) is a selective and orally active inhibitor of COX-2 (IC 50 = 17.9 nM) with anti-inflammatory activity [1].</p>Fórmula:C11H9ClFN3O2Cor e Forma:SolidPeso molecular:269.66Feprazone
CAS:<p>Feprazone (DA-2370) possesses anti-inflammatory and antiadipogenic properties. Feprazone can be used in studies about the treatment of joint and muscular pain.</p>Fórmula:C20H20N2O2Pureza:99.6% - 99.89%Cor e Forma:SolidPeso molecular:320.39Tilmacoxib
CAS:<p>Tilmacoxib is a highly selective, time-dependent, and irreversible inhibitor of human COX-2 ( IC50: 85 nM in an enzyme assay).</p>Fórmula:C16H19FN2O3SPureza:98%Cor e Forma:SolidPeso molecular:338.4COX-2-IN-1
CAS:<p>COX-2-IN-1 is a potent and selective COX-2 inhibitor (IC50: 3.9 μM).</p>Fórmula:C18H14ClF3N4O2SPureza:>99.99%Cor e Forma:SolidPeso molecular:442.84Carpro-AM1
CAS:<p>Carpro-AM1, dual FAAH/COX inhibitor, IC50: 94 nM.</p>Fórmula:C21H18ClN3OCor e Forma:SolidPeso molecular:363.84Enflicoxib
CAS:<p>Enflicoxib is an effective treatment for canine osteoarthritis pain and inflammation, with faster onset than mavacoxib, improving veterinary outcomes.</p>Fórmula:C16H12F5N3O2SPureza:99.88%Cor e Forma:SolidPeso molecular:405.34Insulin levels modulator
CAS:<p>Insulin level regulators can be used to treat diabetes.</p>Fórmula:C21H23N7OSPureza:98%Cor e Forma:SolidPeso molecular:421.52SC58451
CAS:<p>SC58451 is a novel potent, orally active and selective COX-2 inhibitor.SC58451 showed anti-inflammatory activity in a rat model of arthritis.</p>Fórmula:C20H19FO2SPureza:>99.99%Cor e Forma:SolidPeso molecular:342.43COX-2-IN-21
CAS:<p>COX-2-IN-21 (Compound 5c) is an orally active, selective COX-2 inhibitor (IC50: 0.039 μM). COX-2-IN-21 has good anti-inflammatory potential.</p>Fórmula:C21H22N6O4Cor e Forma:SolidPeso molecular:422.44APHS
CAS:<p>APHS is a cyclooxygenase-2 (COX-2) inhibitor with anti-inflammatory action. It also more potent than aspirin in the inhibition of COX-1.</p>Fórmula:C15H18O2SCor e Forma:SolidPeso molecular:262.37Safrole oxide
CAS:<p>Safrole oxide inhibits neuronal growth, induces apoptosis, elevates COX-2, IL-8, ROS, promoting endothelial-to-neuron-like cell transdifferentiation.</p>Fórmula:C10H10O3Pureza:100%Cor e Forma:SolidPeso molecular:178.18(-)-Ibuprofenamide
CAS:<p>(-)-Ibuprofenamide is an amide prodrug of Ibuprofen with anti-inflammatory activity.</p>Fórmula:C13H19NOPureza:98%Cor e Forma:SolidPeso molecular:205.3Piroxicam cinnamate
CAS:<p>Cinnoxicam is a COX inhibitor used for bone/joint inflammation, rheumatic issues, and varicocele-related oligospermia.</p>Fórmula:C24H19N3O5SCor e Forma:SolidPeso molecular:461.49GW-406381
CAS:<p>GW-406381 is a highly selective COX-2 inhibitor peripherally and centrally, reducing spontaneous ectopic discharges following chronic compressive injury.</p>Fórmula:C21H19N3O3SPureza:99.54%Cor e Forma:SolidPeso molecular:393.46COX-2/5-LOX-IN-2
CAS:<p>COX-2/5-LOX-IN-2, a benzothiophen derivative, inhibits COX-1, COX-2, 5-LOX with IC50s of 5.40, 0.01, 1.78 μM. More effective than Celecoxib, Indomethacin.</p>Fórmula:C18H13N3O4S2Cor e Forma:SolidPeso molecular:399.44COX-2-IN-19
CAS:<p>COX-2-IN-19, a potent COX-2 inhibitor, IC50 of 1.76 μM, has strong anti-inflammatory effects in vivo.</p>Fórmula:C18H18N4O2SCor e Forma:SolidPeso molecular:354.43Timegadine
CAS:<p>Timegadine is a competitive inhibitor of COX and lipo-oxygenase, with IC50s ranging from 5 nM (washed rabbit platelets) to 20 μM (rat brain) for COX and 100 μM</p>Fórmula:C20H23N5SPureza:98%Cor e Forma:SolidPeso molecular:365.5ADU-S100
CAS:<p>ADU-S100 (MIW815) is a STING agonist that significantly induces the production of IFN-β,TNF-α,IL-6,and MCP-1,induces TBK1 and IRF3 phosphorylation,antitumour.</p>Fórmula:C20H24N10O10P2S2Pureza:99.83%Cor e Forma:SolidPeso molecular:690.54COX-2/5-LOX-IN-1
CAS:<p>COX-2/5-LOX-IN-1, a benzothiophen-2-yl pyrazole, inhibits COX-2 & 5-LOX with IC50: COX-1 (12.13μM), COX-2 (0.4μM), 5-LOX (4.96μM). Better than Celecoxib.</p>Fórmula:C14H10ClN3O4S2Cor e Forma:SolidPeso molecular:383.83Heterophdoid A
CAS:<p>Heterophdoid A is an anti-inflammatory agent that inhibits NO production in BV-2 cells (IC50: 5.93 μM).</p>Fórmula:C26H42O10Cor e Forma:SolidPeso molecular:514.61Naproxcinod
CAS:<p>Naproxcinod is a derivative of naproxen, analgesic and anti-inflammatory, a COX-inhibitory nitric oxide donor (CINOD), osteoarthritis and inflammatory.</p>Fórmula:C18H21NO6Cor e Forma:SolidPeso molecular:347.36Nitroflurbiprofen
CAS:<p>Nitroflurbiprofen (Nitroxybutyl flurbiprofen) is a NO-releasing COX inhibitor and modulates the increased intrahepatic vascular tone in portal hypertensive</p>Fórmula:C19H20FNO5Pureza:99.88%Cor e Forma:SolidPeso molecular:361.36COX-2-IN-28
CAS:<p>COX-2-IN-28 is a potent and selective COX-2 inhibitor capable of acting on COX-2 (IC50: 0.054 μM), 15-LOX (IC50: 2.14 μM) and COX-1 (IC50: 13.21 μM).</p>Fórmula:C30H27N7S3Cor e Forma:SolidPeso molecular:581.78COX-2-IN-11
CAS:<p>COX-2-IN-11 (compound 7b2) is a potent and selective COX-2 inhibitor. COX-2-IN-11 has the potential in inflammation disease research[1].</p>Fórmula:C12H12OS3Cor e Forma:SolidPeso molecular:268.42Naproxen etemesil
CAS:<p>Naproxen, a COX-1/2 inhibitor, has IC50s of 8.72/5.15 μM. Its prodrug, naproxen etemesil, is lipophilic and converts to active form upon absorption.</p>Fórmula:C17H20O5SPureza:98%Cor e Forma:SolidPeso molecular:336.4Apyramide
CAS:<p>Apyramide, an NSAID and prodrug of indomethacin, inhibits COX1/COX2 and permeates the blood-brain barrier.</p>Fórmula:C27H23ClN2O5Pureza:99.93%Cor e Forma:SolidPeso molecular:490.93ABT-963
CAS:<p>ABT-963: COX-2 inhibitor for osteoarthritis/pain with high selectivity, potency, and gastric safety.</p>Fórmula:C22H22F2N2O5SPureza:98% - 99.85%Cor e Forma:SolidPeso molecular:464.48ER-34122
CAS:<p>ER-34122, a novel orally available dual 5-lipoxygenase/cyclooxygenase inhibitor with potent anti-inflammatory activity.</p>Fórmula:C27H26ClN3O5Pureza:>99.99%Cor e Forma:SolidPeso molecular:507.96Eltenac
CAS:<p>Eltenac, a cyclooxygenase (COX) inhibitor, is used potentially for the treatment of pain.</p>Fórmula:C12H9Cl2NO2SPureza:98.53%Cor e Forma:SolidPeso molecular:302.18Sudoxicam
CAS:<p>Sudoxicam (4-Hydroxy-2-methyl-N-2-thiazolyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide) is a reversible antagonist of COX with anti-inflammatory, anti-edema</p>Fórmula:C13H11N3O4S2Pureza:99.93%Cor e Forma:SolidPeso molecular:337.37LM-1685
CAS:<p>LM-1685是一种有效且具有选择性的人单核细胞和全血中COX-2抑制剂，IC50分别为0.65 µM 和IC50 = 4.3 μM，是治疗炎症的潜在化合物。</p>Fórmula:C18H16ClNO4SPureza:98.16%Cor e Forma:SolidPeso molecular:377.84SC-75416
CAS:<p>SC-75416, a cyclooxygenase-2 (COX-2) inhibitor, is used potentially for the treatment of postoperative inflammation.</p>Fórmula:C15H14ClF3O3Pureza:98.67% - 98.67%Cor e Forma:SolidPeso molecular:334.72BN-82451 2HCl
CAS:<p>BN-82451, a cyclooxygenase inhibitor, is used potentially for the treatment of Huntington’s disease.</p>Fórmula:C18H28Cl2N2OSPureza:99.84% - >99.99%Cor e Forma:SolidPeso molecular:391.4Indazole-Cl
CAS:<p>Indazole-Cl is a selective ERß agonist and a selective estrogen receptor modifier (SERM).</p>Fórmula:C13H9ClN2O2Pureza:99.02% - 99.86%Cor e Forma:SolidPeso molecular:260.68Biofor 389
CAS:<p>Biofor 389 (BF389) has anti-inflammatory activity and can be used to study arthritis.</p>Fórmula:C20H29NO3Pureza:98.84% - 99.97%Cor e Forma:SolidPeso molecular:331.45L 651896
CAS:<p>L 651896 is an inhibitor of 5-lipoxygenase.</p>Fórmula:C18H18O3Pureza:96.06% - 99.85%Cor e Forma:SolidPeso molecular:282.33Prostaglandin E2 Ethanolamide
CAS:<p>Prostaglandin E2 Ethanolamide (PGE 2 -EA), an analog of PGE2, is enzymatically synthesized through COX-2 oxygenation of endocannabinoids. It has the potential to modulate the production of the proinflammatory cytokine TNF-α in human blood and monocytic cells [1] [2].</p>Fórmula:C22H37NO5Cor e Forma:SolidPeso molecular:395.54Benoxaprofen
CAS:<p>Benoxaprofen (NSC-299582) is a non-steroidal anti-inflammatory drug.</p>Fórmula:C16H12ClNO3Pureza:98.87%Cor e Forma:SolidPeso molecular:301.72BW 755C
CAS:<p>BW 755C is a dual inhibitor of 5-lipoxygenase (5-LO) and cyclooxygenase (COX) pathways.</p>Fórmula:C10H10F3N3Pureza:96.52%Cor e Forma:SolidPeso molecular:229.2Antioxidant agent-15
CAS:<p>Antioxidant agent-15 (Compound 4) demonstrates potent antioxidant inhibition activity, exhibiting an IC50 value of 15.44 nM.</p>Fórmula:C19H14O2Pureza:98%Cor e Forma:SolidPeso molecular:274.31Thioflosulide
CAS:<p>Thioflosulide (L-745337) is a selective and potent COX2 inhibitor (IC50: 2.3 nM) with anti-inflammatory activity for the study of gastric ulcers.</p>Fórmula:C16H13F2NO3S2Pureza:>99.99%Cor e Forma:SolidPeso molecular:369.41Thromboxane B3
CAS:<p>Thromboxane B3 (TXB3), the stable hydrolysis product of TXA3, is synthesized from eicosapentaenoic acid (EPA) through the action of COX and thromboxane synthase enzymes. This compound is biosynthesized in several tissues, including seminal vesicles, lungs, polymorphonuclear leukocytes (PMNL), and ocular tissues.</p>Fórmula:C20H32O6Cor e Forma:SolidPeso molecular:368.5Amtolmetin guacil
CAS:<p>Amtolmetin guacil (ST-679) 抑制前列腺素合成和环氧合酶。 Amtolmetin guacil 具有与托美汀类似的 NSAID 特性，具有额外的镇痛、解热和胃保护特性。</p>Fórmula:C24H24N2O5Pureza:99.85%Cor e Forma:White Needle-Shaped CrystalPeso molecular:420.46(-)-Bornyl ferulate
CAS:<p>(-)-Bornyl ferulate is a dual inhibitor of 5-lipoxygenase and cyclooxygenase (COX), exhibiting half-maximal inhibitory concentrations (IC50s) of 10.4 μM for 5-</p>Fórmula:C20H26O4Pureza:98%Cor e Forma:SolidPeso molecular:330.42Cimicoxib
CAS:<p>Cimicoxib (UR8880) is a potent and selective inhibitor of COX-2 with anti-inflammatory and analgesic activity.</p>Fórmula:C16H13ClFN3O3SPureza:98.22%Cor e Forma:SolidPeso molecular:381.81COX-2-IN-10
<p>COX-2-IN-10 is a potent COX-2 inhibitor, reducing IL-6, TNF-α, IL-1β, PGE2 (IC50=2.54 μM), and iNOS expression.</p>Fórmula:C31H32FN5O2SCor e Forma:SolidPeso molecular:557.68COX-2-IN-12
<p>COX-2-IN-12: Potent, selective COX-2 inhibitor, IC50=19.98μM, safe anti-inflammatory with low acute toxicity.</p>Fórmula:C17H19NO3Cor e Forma:SolidPeso molecular:285.34COX-2-IN-13
<p>COX-2-IN-13 is a potent, selective COX-2 inhibitor with 0.98 μM IC50; shows strong anti-inflammatory properties and low acute toxicity.</p>Fórmula:C19H18N2O5SCor e Forma:SolidPeso molecular:386.42COX-2-IN-8
<p>COX-2-IN-8 (Compound 6a) is a potent, selective, orally active COX-2 inhibitor (IC50: 6.585 μM) with a higher COX-2 selectivity than Celecoxib.</p>Fórmula:C19H19N3O4S2Cor e Forma:SolidPeso molecular:417.5Anti-inflammatory agent 9
<p>Benzimidazothiazole-derived Compound 28 from tilomisole targets COX-2, has potent anti-inflammatory effects & is orally bioavailable.</p>Fórmula:C18H15N5O2SCor e Forma:SolidPeso molecular:365.41Soquelitinib
CAS:<p>Soquelitinib (CPI-818) is a selective ITK inhibitor， inhibits tumor growth,T-cell, up-regulatCXCR3, IFNγ, TNFα, and CD107a expression in normal CD8 cells.</p>Fórmula:C25H30N4O4S2Pureza:99.54%Cor e Forma:SolidPeso molecular:514.66NLRP3-IN-69
CAS:<p>NLRP3-IN-69 (Compound 23) inhibits the activation of NF-κBp65 and the formation of the NLRP3 inflammasome. It suppresses the overexpression of IL-1β, iNOS, and COX-2 induced by LPS, and inhibits the production of NO (IC50=5.66 μM), thereby demonstrating anti-inflammatory activity.</p>Fórmula:C25H24O7Cor e Forma:SolidPeso molecular:436.454Anti-inflammatory agent 10
<p>Tilomisole-derived benzimidazole-thiazole, orally active, favors COX-2 inhibition over COX-1.</p>Fórmula:C17H13BrN4O3S2Cor e Forma:SolidPeso molecular:465.34STAT1/3-IN-1
CAS:<p>STAT1/3-IN-1 (Compound 6k) is an inhibitor of STAT1/3 phosphorylation. It prevents the phosphorylation and nuclear translocation of STAT1/3. Additionally, STAT1/3-IN-1 inhibits the inflammatory enzymes iNOS and COX-2. This compound exhibits anti-inflammatory properties by reducing pro-inflammatory cytokines, such as IL-1β, IL-6, and TNF-α, without significant cytotoxicity.</p>Fórmula:C28H25ClN6O5Cor e Forma:SolidPeso molecular:560.988XO/COX/LOX-IN-1
<p>XO/COX/LOX-IN-1 targets XO/COX/LOX, used in research of inflammation, cancer, and metabolic disorders.</p>Fórmula:C24H20N4O2SCor e Forma:SolidPeso molecular:428.51COX-2-IN-6
CAS:<p>COX-2-IN-6: Potent, selective COX-2 inhibitor; oral; IC50 0.84μM, Ki 69nM; blocks PGE2 synthesis; prevents colorectal cancer.</p>Fórmula:C20H27NO6SPureza:99.29% - 99.69%Cor e Forma:SoildPeso molecular:409.5COX-1/2-IN-2
<p>COX-1/2-IN-2, a potent dual inhibitor, has IC50s: COX-1 at 9.7μM & COX-2 at 4.6μM.</p>Fórmula:C15H10ClIN2OCor e Forma:SolidPeso molecular:396.61COX-2-IN-29
<p>COX-2-IN-29 is a selective inhibitor of orally active COX-2 (IC50: 0.005 μM).</p>Fórmula:C22H23FN2O6S2Cor e Forma:SolidPeso molecular:494.56(R)-Ketoprofen
CAS:<p>(R)-Ketoprofen is a non-steroidal anti-inflammatory drug (NSAID) that exhibits oral activity and analgesic properties. Unlike its counterpart, (R)-Ketoprofen does not significantly enhance the increase of inflammatory cytokines (such as Tumor Necrosis Factor (TNF) and Interleukin-1 (IL-1)) induced by LPS. However, it can inhibit the anti-inflammatory activity of (S)-Ketoprofen.</p>Fórmula:C16H14O3Cor e Forma:SolidPeso molecular:254.28Ambuic acid
CAS:<p>Ambuic acid: cyclohexanone with antifungal, quorum-inhibiting, antibacterial properties, blocks cyclic peptides; reduces MRSA abscesses in mice.</p>Fórmula:C19H26O6Cor e Forma:SolidPeso molecular:350.41COX-2-IN-7
<p>COX-2-IN-7: potent, orally active COX-2 inhibitor with higher selectivity than Celecoxib, IC50 6.585 uM, anti-inflammatory, low ulcer risk.</p>Fórmula:C15H13N3O2S2Cor e Forma:SolidPeso molecular:331.41Sabialimon P
CAS:<p>Sabialimon P (compound 16), with an IC50 of 18.12 μM, functions as a NO release inhibitor and exhibits anti-inflammatory properties. It effectively diminishes the secretion of TNF-α, iNOS, IL-6, and NF-κB, and suppresses the expression of COX-2 and NF-κB/p65 in LPS-induced RAW264.7 cells.</p>Fórmula:C31H50O4Cor e Forma:SolidPeso molecular:486.73Neral
CAS:<p>Neral, a monoterpenoid compound, exhibits anti-inflammatory and anticancer activities. It inhibits TNF-α and IL-6, along with inflammatory mediators such as pro-IL-1β, iNOS, COX-2, and NLRP-3.</p>Fórmula:C10H16OCor e Forma:SolidPeso molecular:152.23COX-2-IN-51
CAS:<p>COX-2-IN-51 (E25) is a potent COX-2 inhibitor with an IC50 of 70.7 nM. It significantly suppresses LPS-induced release of NO and PGE2, the expression of COX-2 and iNOS, and the activation of the NF-κB pathway. Displaying anti-inflammatory and analgesic effects in various mouse models through NF-κB pathway inhibition, COX-2-IN-51 has lower gastrointestinal side effects compared to Indomethacin.</p>Fórmula:C23H18F4O3SCor e Forma:SolidPeso molecular:450.446COX-2/15-LOX-IN-5
CAS:<p>COX-2/15-LOX-IN-5 (Compound 4f) functions as a dual inhibitor of COX-2 and 15-LOX, demonstrating both anti-inflammatory and antioxidant properties [1]. This compound effectively reduces NF-κB activation in RAW 264.7 macrophages that is induced by lipopolysaccharide.</p>Fórmula:C25H21N3O3SCor e Forma:SolidPeso molecular:443.52COX-2/NO-IN-1
<p>COX-2/NO-IN-1: oral iNOS & NO blocker (IC50=3.52μM), COX-2 supressor, anti-inflammatory, protects kidneys.</p>Fórmula:C15H15NO3Cor e Forma:SolidPeso molecular:257.28COX-2-IN-47
CAS:<p>COX-2-IN-47 (compound 6c) is a selective inhibitor of COX-2, exhibiting an IC50 of 0.03 μM. This compound also displays antiedema activity.</p>Fórmula:C18H18N2O4Cor e Forma:SolidPeso molecular:326.35COX-2/PI3K-IN-2
<p>COX-2/PI3K-IN-2 (5f): anti-inflammatory & anti-cancer, selectively inhibits COX-2 (Ki=3.02nM), potently blocks PI3K (IC50=2.78nM).</p>Fórmula:C16H17N5O2Cor e Forma:SolidPeso molecular:311.34COX-2/PI3K-IN-1
<p>COX-2/PI3K-IN-1 (compound 5d) is a potent inhibitor of PI3K (IC50: 1.14 nM). COX-2/PI3K-IN-1 is a selective inhibitor of COX-2 (Ki: 3.24 nM).</p>Fórmula:C19H14ClN5S2Cor e Forma:SolidPeso molecular:411.93COX-2-IN-9
<p>COX-2-IN-9: potent oral COX-2 blocker, selective over Celecoxib, IC50 10.17 μM, less ulcers, strong anti-inflammatory.</p>Fórmula:C25H23N5O4S2Cor e Forma:SolidPeso molecular:521.61Racemic Naproxen
CAS:<p>Racemic Naproxen is a biochemical substance.</p>Fórmula:C14H14O3Pureza:98%Cor e Forma:Crystals From Acetone-Hexane White SolidPeso molecular:230.26Alminoprofen
CAS:<p>Alminoprofen: NSAID; reduces anaphylactic bronchoconstriction at 30 mg/kg intraduodenally.</p>Fórmula:C13H17NO2Cor e Forma:SolidPeso molecular:219.28
