CaMK
Os inibidores da Proteína Quinase Dependente de Cálcio/Calmodulina (CaMK) são compostos especializados que inibem a atividade da CaMK, uma quinase crucial envolvida em uma variedade de processos celulares, particularmente no sistema nervoso. A CaMK é essencial para traduzir sinais de cálcio em várias respostas celulares, incluindo a plasticidade sináptica, a formação de memória e a expressão gênica. A desregulação da atividade da CaMK está associada a vários distúrbios neurológicos, tornando esses inibidores ferramentas valiosas para o estudo da sinalização sináptica, do aprendizado e da memória. Na CymitQuimica, oferecemos inibidores de CaMK de alta qualidade para apoiar sua pesquisa em plasticidade sináptica, função cognitiva e neurofarmacologia.
Foram encontrados 69 produtos de "CaMK"
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A-3 hydrochloride
CAS:<p>A-3 hydrochloride: potent, reversible kinase antagonist; permeable; inhibits PKC, CKI, PKA, CKII, MLCK; Ki: 4.3-80 μM.</p>Fórmula:C12H14Cl2N2O2SPureza:99.32%Cor e Forma:SolidPeso molecular:321.22Y-33075 dihydrochloride
CAS:<p>Y-33075 dihydrochloride is a selective inhibitor of ROCK(IC50 of 3.6 nM).</p>Fórmula:C16H18Cl2N4OPureza:98.88% - 99.89%Cor e Forma:SolidPeso molecular:353.25Trifluoperazine dihydrochloride
CAS:Trifluoperazine dihydrochloride (SKF5019) is a potent dopamine D2 receptor inhibitor used as an antipsychotic and an antiemetic.Fórmula:C21H26Cl2F3N3SPureza:99.57% - 99.96%Cor e Forma:Cream Fine PowderPeso molecular:480.43Elziverine
CAS:<p>Elziverine: oral calmodulin antagonist, inhibits Ca-induced acanthocyte formation, potential for neurological and cognitive disorder treatment.</p>Fórmula:C32H37N3O5Pureza:99.79%Cor e Forma:SolidPeso molecular:543.65Nifedipine
CAS:<p>Nifedipine (Procardia) is a dihydropyridine calcium channel blocking agent.</p>Fórmula:C17H18N2O6Pureza:99.39% - 99.49%Cor e Forma:Yellow Crystals Physical Description Odorless Yellow Crystals Or Powder Tasteless (Ntp 1992)Peso molecular:346.33Dibucaine
CAS:<p>Dibucaine (Cinchocaine), a local anesthetic of the amide type, is now usually used for surface anesthesia.</p>Fórmula:C20H29N3O2Pureza:99.698% - 99.88%Cor e Forma:Colorless Or Almost Colorless Powder SolidPeso molecular:343.46TAT-CN21 (scrambled)
<p>TAT-CN21(scrambled) is a control peptide lacking specific targeting activity and serves as a negative control for TatCN21. TatCN21 is an effective and selective inhibitory peptide for calcium/calmodulin-dependent protein kinase II (CaMKII).</p>Cor e Forma:Odour SolidFasciculic acid A
CAS:<p>Fasciculic acid A is a calmodulin antagonist isolated from mushroom Naematoloma fasciculare.</p>Fórmula:C36H60O8Cor e Forma:SolidPeso molecular:620.868Fasciculic acid B
CAS:<p>Fasciculic acid B: ester of fasciculol B, 3-hydroxy-methylglutaric acid; a calmodulin antagonist from Naematoloma fasciculare.</p>Fórmula:C36H60O9Pureza:98%Cor e Forma:SolidPeso molecular:636.86Calmodulin-Dependent Protein Kinase II 290-309 acetate
<p>Calmodulin-Dependent Protein Kinase II 290-309 acetate is an effective antagonist of Ca2+/calmodulin-dependent protein kinase II (IC50 = 52 nM).</p>Fórmula:C105H189N31O26SPureza:96.7%Cor e Forma:SolidPeso molecular:2333.88Encecalinol
CAS:<p>Encecalinol, a compound isolated from the aerial parts of Ageratina grandifolia, acts as a potent inhibitor of calmodulin [1].</p>Fórmula:C14H18O3Cor e Forma:SolidPeso molecular:234.29Beauverolide Ja
CAS:<p>Beauverolide Ja: cyclotetradepsipeptide, CaM inhibitor; Kd 0.078 μM, Ki 0.39 μM; from Isaria fumosorosea.</p>Fórmula:C35H46N4O5Cor e Forma:SolidPeso molecular:602.76CALP2
CAS:<p>CALP2 is a CaM antagonist blocking EF-hand/Ca2+ site; inhibits CaM phosphodiesterase, raises Ca2+, and activates alveolar macrophages.</p>Fórmula:C68H104N14O13SPureza:98%Cor e Forma:SolidPeso molecular:1357.72CALP2 TFA
<p>CALP2 TFA, a CaM antagonist with 7.9 µM Kd, blocks CaM-dependent enzymes, boosts Ca2+ levels, and activates macrophages.</p>Fórmula:C70H105F3N14O15SCor e Forma:SolidPeso molecular:1471.72Acremonidin A
CAS:<p>Acremonidin A, from Purpureocillium lilacinum, is a strong CaM inhibitor binding to hCaM M124C-mBBr with a Kd of 19.40 nM.</p>Fórmula:C33H26O12Cor e Forma:SolidPeso molecular:614.55Cloxacepride
CAS:<p>cloxacepride is a CaM antagonist that is used to treat asthma disease.</p>Fórmula:C22H27Cl2N3O4Pureza:99.62%Cor e Forma:SolidPeso molecular:468.37Calmodulin-Dependent Protein Kinase II (281-309)
CAS:<p>Calmodulin-Dependent Protein Kinase II (281-309) is a synthetic peptide that can be phosphorylated at Thr286 by PKC and inhibits CaM kinase II (IC50 = 80 nM).</p>Fórmula:C146H254N46O39S3Pureza:98%Cor e Forma:SolidPeso molecular:3374.06Fasciculic acid C
CAS:<p>Fasciculic acid C is a calmodulin antagonist isolated from mushroom Naematoloma fasciculare.</p>Fórmula:C38H63NO11Pureza:98%Cor e Forma:SolidPeso molecular:709.91RA306
<p>RA306 is an orally active CAMK2 inhibitor that effectively disrupts the PEAK1/CAMK2 signaling pathway. It demonstrates anti-tumor activity by inhibiting proliferation, migration, and invasion of breast cancer cells. Additionally, RA306 shows potential in cardiac disease research, as it improves dilated cardiomyopathy in mice.</p>Cor e Forma:Odour SolidTAT-CN21
<p>TatCN21, with an IC 50 of 77 nM, serves as a potent and selective inhibitor peptide of the calcium/calmodulin-dependent protein kinase II (CaMKII), a ubiquitously-expressed multifunctional serine/threonine protein kinase. It is particularly useful in research pertaining to ischemia and neurodegenerative diseases.</p>Fórmula:C169H303N69O43Cor e Forma:SolidPeso molecular:3989.65
