CaMK
Os inibidores da Proteína Quinase Dependente de Cálcio/Calmodulina (CaMK) são compostos especializados que inibem a atividade da CaMK, uma quinase crucial envolvida em uma variedade de processos celulares, particularmente no sistema nervoso. A CaMK é essencial para traduzir sinais de cálcio em várias respostas celulares, incluindo a plasticidade sináptica, a formação de memória e a expressão gênica. A desregulação da atividade da CaMK está associada a vários distúrbios neurológicos, tornando esses inibidores ferramentas valiosas para o estudo da sinalização sináptica, do aprendizado e da memória. Na CymitQuimica, oferecemos inibidores de CaMK de alta qualidade para apoiar sua pesquisa em plasticidade sináptica, função cognitiva e neurofarmacologia.
Foram encontrados 68 produtos para "CaMK".
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Elziverine
CAS:Elziverine: oral calmodulin antagonist, inhibits Ca-induced acanthocyte formation, potential for neurological and cognitive disorder treatment.Fórmula:C32H37N3O5Pureza:99.79%Cor e Forma:SolidPeso molecular:543.6533A-3 hydrochloride
CAS:A-3 hydrochloride: potent, reversible kinase antagonist; permeable; inhibits PKC, CKI, PKA, CKII, MLCK; Ki: 4.3-80 μM.Fórmula:C12H14Cl2N2O2SPureza:99.32%Cor e Forma:SolidPeso molecular:321.22Trifluoperazine dihydrochloride
CAS:Trifluoperazine dihydrochloride (SKF5019) is a potent dopamine D2 receptor inhibitor used as an antipsychotic and an antiemetic.Fórmula:C21H26Cl2F3N3SPureza:99.57% - 99.96%Cor e Forma:SolidPeso molecular:480.417Y-33075 dihydrochloride
CAS:Y-33075 dihydrochloride is a selective inhibitor of ROCK(IC50 of 3.6 nM).Fórmula:C16H18Cl2N4OPureza:98.88% - 99.89%Cor e Forma:SolidPeso molecular:353.246MLCK Peptide
CAS:MLCK Peptide, a high-affinity (pM), fully reversible CaM-binding peptide, is derived from smooth muscle myosin light-chain kinase [1].Fórmula:C91H156N36O20Cor e Forma:SolidPeso molecular:2074.44Fasciculic acid C
CAS:Fasciculic acid C is a calmodulin antagonist isolated from mushroom Naematoloma fasciculare.Fórmula:C38H63NO11Pureza:98%Cor e Forma:SolidPeso molecular:709.91AC3-I, myristoylated
Myristoylated AC3-I is a biologically active peptide and a myristoylated variant of the Autocamtide-3-Derived Inhibitory Peptide (AC3-I).Fórmula:C78H137N21O20Pureza:98%Cor e Forma:SolidPeso molecular:1689.05TAT-CN21 (scrambled)
TAT-CN21(scrambled) is a control peptide lacking specific targeting activity and serves as a negative control for TatCN21. TatCN21 is an effective and selective inhibitory peptide for calcium/calmodulin-dependent protein kinase II (CaMKII).Cor e Forma:Odour SolidRA306
RA306 is an orally active CAMK2 inhibitor that effectively disrupts the PEAK1/CAMK2 signaling pathway. It demonstrates anti-tumor activity by inhibiting proliferation, migration, and invasion of breast cancer cells. Additionally, RA306 shows potential in cardiac disease research, as it improves dilated cardiomyopathy in mice.Cor e Forma:Odour SolidTAT-CN21
TAT-CN21 is a cell-permeable CaMKII inhibitory peptide used to study neuronal excitotoxicity and ischemic injury by blocking CaMKII activity.Fórmula:C169H303N69O43Cor e Forma:White SolidPeso molecular:3989.65Fluphenazine-N-2-chloroethane (hydrochloride)
CAS:Fluphenazine-N-2-chloroethane hydrochloride is a fluphenazine derivative used as a calmodulin probe.Fórmula:C22H27Cl3F3N3SCor e Forma:SolidPeso molecular:528.89CALP2 TFA
CALP2 TFA, a CaM antagonist with 7.9 µM Kd, blocks CaM-dependent enzymes, boosts Ca2+ levels, and activates macrophages.Fórmula:C70H105F3N14O15SCor e Forma:SolidPeso molecular:1471.72Cloxacepride
CAS:cloxacepride is a CaM antagonist that is used to treat asthma disease.Fórmula:C22H27Cl2N3O4Pureza:99.76%Cor e Forma:SolidPeso molecular:468.373CALP2
CAS:CALP2 is a CaM antagonist blocking EF-hand/Ca2+ site; inhibits CaM phosphodiesterase, raises Ca2+, and activates alveolar macrophages.Fórmula:C68H104N14O13SPureza:98%Cor e Forma:SolidPeso molecular:1357.72Beauverolide Ja
CAS:Beauverolide Ja: cyclotetradepsipeptide, CaM inhibitor; Kd 0.078 μM, Ki 0.39 μM; from Isaria fumosorosea.Fórmula:C35H46N4O5Cor e Forma:SolidPeso molecular:602.76CaMKIIδ-IN-1 hydrochloride
CaMKIIδ-IN-1 (Compound 15e) hydrochloride is a pyrimidine-based inhibitor of CaMKIIδ with an IC50 value of 12 nM.Calmodulin Binding Peptide 1
CAS:Calmodulin Binding Peptide 1, a high-affinity MLCK-derived inhibitor, blocks IP3-induced Ca2+ release.Fórmula:C231H373N69O70S2Pureza:98%Cor e Forma:SolidPeso molecular:5301.1Calmodulin-Dependent Protein Kinase II 290-309 acetate
Calmodulin-Dependent Protein Kinase II 290-309 acetate is an effective antagonist of Ca2+/calmodulin-dependent protein kinase II (IC50 = 52 nM).Fórmula:C105H189N31O26SPureza:96.7%Cor e Forma:SolidPeso molecular:2333.88Calmodulin-Dependent Protein Kinase II (281-309)
CAS:Calmodulin-Dependent Protein Kinase II (281-309) is a synthetic peptide that can be phosphorylated at Thr286 by PKC and inhibits CaM kinase II (IC50 = 80 nM).Fórmula:C146H254N46O39S3Pureza:98%Cor e Forma:SolidPeso molecular:3374.06Calmodulin Kinase IINtide, Myristoylated
Myristoylated Calmodulin Kinase IINtide (Myr-CaMKIINtide) serves as a selective and noncompetitive inhibitor of CaMKII [1].Fórmula:C156H275N47O43Pureza:98%Cor e Forma:SolidPeso molecular:3497.14
