GluR
Inibidores do Receptor de Glutamato são compostos que bloqueiam a atividade dos receptores de glutamato, os principais receptores de neurotransmissores excitatórios no cérebro. Esses receptores desempenham um papel crucial na transmissão sináptica, plasticidade, aprendizado e memória. A desregulação da sinalização do glutamato está associada a vários distúrbios neurológicos, como epilepsia, AVC e doenças neurodegenerativas. Os inibidores dos receptores de glutamato são essenciais para investigar os mecanismos de excitotoxicidade e desenvolver estratégias neuroprotetoras. Na CymitQuimica, oferecemos uma gama de inibidores de receptores de glutamato para apoiar sua pesquisa em função sináptica, neuroproteção e distúrbios cognitivos.
Foram encontrados 255 produtos de "GluR"
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(S)-4CPG
CAS:<p>(S)-4CPG ((S)-4-Carboxyphenylglycine) is a competitive mGlu1 receptor antagonist that attenuates nociceptive hypersensitivity and nociceptive abnormalities associated with sciatic nerve constriction injuries in rats, and may be used in the study of neurological disorders.</p>Fórmula:C9H9NO4Pureza:99.96%Cor e Forma:SolidPeso molecular:195.17CX717
CAS:<p>CX 717 is a positive allosteric modulator of AMPA receptor which has an antidepressant-like effect.</p>Fórmula:C11H11N3O3Pureza:99.81%Cor e Forma:SoildPeso molecular:233.23VU0477886
CAS:<p>VU0477886: Potent mGlu4 PAM, effective in preclinical Parkinson's model HIC.</p>Fórmula:C20H13ClN4O3Pureza:98%Cor e Forma:SolidPeso molecular:392.80IEM 1754 2HBr
CAS:<p>IEM 1754 2HBr (IEM 1754 dihydrobromide) is a selective AMPA/kainate receptor blockers for GluR1 and GluR3 with IC50 of 6 μM.</p>Fórmula:C16H30N2·2HBrPureza:99.71% - 99.72%Cor e Forma:SolidPeso molecular:412.25VU6001966
CAS:<p>VU6001966: potent, selective mGlu2 inhibitor (IC50=78 nM), negative modulator, with good CNS penetration.</p>Fórmula:C17H15FN4O2Pureza:98%Cor e Forma:SolidPeso molecular:326.33BMT-145027
CAS:<p>BMT-145027 is a positive allosteric modulator of mGluR5 without inherent agonist activity (EC50 = 47 nM).</p>Fórmula:C23H14ClF3N4Pureza:99.62%Cor e Forma:SolidPeso molecular:438.83MFZ 10-7 hydrochloride
CAS:MFZ 10-7 hydrochloride is a highly potent and selective negative allosteric modulator of mGluR5 NAMFórmula:C15H10ClFN2Pureza:98%Cor e Forma:SolidPeso molecular:272.71NS 1209
CAS:<p>NS 1209 (SPD 502) is a AMPA receptor antagonist.</p>Fórmula:C24H27N4NaO7SPureza:98%Cor e Forma:SolidPeso molecular:538.55LY392098
CAS:<p>LY392098 (AMPA receptor modulator-3) is an allosteric modulator of AMPA receptor with EC50 of 4.4 μM and can be used in studies about mammalian nervous system.</p>Fórmula:C18H22FNO2SPureza:99.86%Cor e Forma:SolidPeso molecular:335.44VU 0469650
CAS:<p>VU 0469650 is a potent and selective negative allosteric modulator of mGluR1 (IC50 = 99 nM).</p>Fórmula:C22H28N4OPureza:98.03%Cor e Forma:SolidPeso molecular:364.48(1R,2S)-VU0155041
CAS:<p>(1R,2S)-VU0155041 is the cis regioisomer of VU0155041 and a partial agonist of mGluR4.</p>Fórmula:C14H15Cl2NO3Pureza:98.85%Cor e Forma:SolidPeso molecular:316.18Methoxy-PEPy
CAS:<p>Methoxy-PEPy is a potent and selective mGlu5 receptor inhibitor with an IC50 value of 1 nM.</p>Fórmula:C13H10N2OPureza:99.22%Cor e Forma:SolidPeso molecular:210.23LYPLAL1-IN-1
CAS:LYPLAL1-IN-1 is a selective covalent small-molecule inhibitor of Lysophospholipase-like 1 (IC50: 0.006 μM). LYPLAL1-IN-1 also enhances glucose production.Fórmula:C29H29N7O4Pureza:98%Cor e Forma:SolidPeso molecular:539.59(RS)-MCPG disodium salt
CAS:group I/group II metabotropic glutamate receptor antagonistFórmula:C10H11NNaO4Pureza:98%Cor e Forma:SolidPeso molecular:232.193,3'-Difluorobenzaldazine
CAS:<p>allosteric potentiator of mGlu5</p>Fórmula:C14H10F2N2Pureza:98%Cor e Forma:SolidPeso molecular:244.24VU0366248
CAS:<p>VU0366248 is a mGlu5 negative allosteric modulator.</p>Fórmula:C14H7ClF2N2OPureza:98%Cor e Forma:SolidPeso molecular:292.67L-AP4 monohydrate
CAS:<p>L-AP4 (L-APB) is a group III mGluR agonist with EC50s: 0.13μM (mGlu4), 0.29μM (mGlu8), 1.0μM (mGlu6), 249μM (mGlu7).</p>Fórmula:C4H12NO6PCor e Forma:SolidPeso molecular:201.115VU 0360223
CAS:<p>VU 0360223 is a negative allosteric modulator of mGlu5.</p>Fórmula:C15H9FN2SPureza:98%Cor e Forma:SolidPeso molecular:268.31ADX71743
CAS:<p>ADX71743 is a potent and selective negative allosteric modulator of metabotropic glutamate receptor 7.</p>Fórmula:C17H19NO2Cor e Forma:SolidPeso molecular:269.34mGlu4 receptor agonist 1
CAS:<p>Compound 62, an mGlu4 agonist, has a 308 nM EC50 with anxiolytic and antipsychotic effects.</p>Fórmula:C21H15ClN4O2Cor e Forma:SolidPeso molecular:390.82MAP4
CAS:<p>metabotropic glutamate receptor modulator</p>Fórmula:C5H12NO5PPureza:98%Cor e Forma:White SolidPeso molecular:197.13GRN-529
CAS:<p>GRN-529 is a selective negative allosteric modulator of the mGluR5 receptor.</p>Fórmula:C22H15F2N3O2Pureza:98%Cor e Forma:SolidPeso molecular:391.37DFMTI
CAS:<p>DFMTI can completely block the rmGlu1 L757V glutamate response.</p>Fórmula:C20H18F2N4OCor e Forma:SolidPeso molecular:368.38Z-Cyclopentyl-AP4
CAS:Group III mGlu receptor agonistFórmula:C6H12NO5PPureza:98%Cor e Forma:SolidPeso molecular:209.14LY456066
CAS:<p>LY456066 is a mGluR1 receptor-selective, negative allosteric modulator.</p>Fórmula:C19H23N3OSPureza:98%Cor e Forma:SolidPeso molecular:341.47JNJ-40068782
CAS:<p>JNJ-40068782 is a potent, selective and systemically active positive allosteric modulator of the mGlu2 receptor.</p>Fórmula:C21H23N3OPureza:98%Cor e Forma:SolidPeso molecular:333.43TASP0433864
CAS:<p>TASP0433864 enhances mGlu2 activity; EC50: 199 nM (human), 206 nM (rat); not an agonist.</p>Fórmula:C18H23N3O3Pureza:98%Cor e Forma:SolidPeso molecular:329.39(S)-3,5-DHPG
CAS:<p>group I mGlu receptor agonist</p>Fórmula:C8H9NO4Pureza:98%Cor e Forma:SolidPeso molecular:183.16HTL14242
CAS:<p>HTL14242 is a mGlu5 Negative Allosteric Modulator.</p>Fórmula:C16H8ClFN4Cor e Forma:SolidPeso molecular:310.71(RS)-PPG
CAS:<p>(RS)-PPG: Potent, selective III mGluRs agonist; EC50s: hmGluR4a 5.2μM, hmGluR6 4.7μM, hmGluR7b 185μM, hmGluR8a 0.2μM; neuroprotective, anticonvulsive.</p>Fórmula:C8H10NO5PPureza:98%Cor e Forma:SolidPeso molecular:231.14VU0431316
CAS:<p>VU0431316 is a negative mGlu5 allosteric modulator. It has activity in a mouse model of anxiety.</p>Fórmula:C14H9ClN6O2Pureza:98%Cor e Forma:SolidPeso molecular:328.71DCG-IV
CAS:DCG-IV: Class II mGluR agonist; anticonvulsant; neuroprotective; EC50: mGlu2R-0.35μM, mGlu3R-0.09μM; antagonizes Group I/III mGluRs.Fórmula:C7H9NO6Pureza:98%Cor e Forma:SolidPeso molecular:203.15VU0410425
CAS:VU0410425 is a metabotropic glutamate receptor subtype 1 negative allosteric modulator.Fórmula:C19H16ClN3O3Pureza:98%Cor e Forma:SolidPeso molecular:369.8AZ12216052
CAS:<p>AZ12216052 is a GRP8 antagonist with anxiolytic and anti-inflammatory activity and can be used to study obesity and metabolic disorders.</p>Fórmula:C19H22BrNOSPureza:99.29%Cor e Forma:SolidPeso molecular:392.35LY487379 hydrochloride
CAS:Positive allosteric modulator of mGlu2 receptorsFórmula:C21H20ClF3N2O4SPureza:98%Cor e Forma:SolidPeso molecular:488.91VU0361747
CAS:<p>VU0361747 is a positive allosteric modulators (PAM) of metabotropic glutamate receptor subtype 5 (mGlu5).</p>Fórmula:C19H17FN2O2Cor e Forma:SolidPeso molecular:324.35Auglurant
CAS:<p>Auglurant is a novel and selective mGlu5 antagonist (IC50: 11 nM (rat) and an IC50: 14 nM (human)). Auglurant has an acceptable CNS penetration.</p>Fórmula:C16H12FN5O2Cor e Forma:SolidPeso molecular:325.3Desmethyl-YM 298198
CAS:mGlu1-selective antagonistFórmula:C17H21ClN4OSPureza:98%Cor e Forma:SolidPeso molecular:364.89Foliglurax monohydrochloride
CAS:Foliglurax monohydrochloride, an antiparkinsonian, is a selective brain-penetrant mGluR4 PAM with an EC50 of 79 nM.Fórmula:C23H24ClN3O3SCor e Forma:SolidPeso molecular:457.97L-CCG-l
CAS:<p>group II metabotropic glutamate receptor agonist</p>Fórmula:C6H9NO4Pureza:98%Cor e Forma:SolidPeso molecular:159.14(1S,3R)-ACPD
CAS:<p>(1S,3R)-ACPD is a group I and II mGlu receptor agonist.</p>Fórmula:C7H11NO4Pureza:98%Cor e Forma:SolidPeso molecular:173.17VU0404251
CAS:<p>VU0404251 is a positive allosteric modulator of mGlu5.</p>Fórmula:C19H23FN2O2Cor e Forma:SolidPeso molecular:330.4Mavoglurant racemate
CAS:<p>Mavoglurant is a novel, non-competitive mGlu5 receptor antagonist. Mavoglurant (racemate) is the racemate of mavoglurant.</p>Fórmula:C19H23NO3Pureza:98%Cor e Forma:SolidPeso molecular:313.39ACPT-II
CAS:<p>metabotropic receptor antagonist</p>Fórmula:C8H11NO6Pureza:98%Cor e Forma:SolidPeso molecular:217.18DL-AP4 Sodium salt
CAS:Broad spectrum EAA ligandFórmula:C4H10NNaO5PPureza:98%Cor e Forma:SolidPeso molecular:206.09UPF-523
CAS:group I metabotropic glutamate receptors (mGlu1a) antagonistFórmula:C11H11NO4Pureza:98%Cor e Forma:White SolidPeso molecular:221.21JNJ-46356479
CAS:<p>JNJ-46356479: Selective, oral mGlu2 receptor PAM, EC50=78 nM, Emax=256%.</p>Fórmula:C22H22F5N5Cor e Forma:SolidPeso molecular:451.44ACPT-I
CAS:<p>Agonist for group III mGlu receptors</p>Fórmula:C8H11NO6Pureza:98%Cor e Forma:SolidPeso molecular:217.18VU0364289
CAS:<p>VU0364289 is a positive allosteric modulator of mGlu5.</p>Fórmula:C20H21N3O2Cor e Forma:SolidPeso molecular:335.4(S)-4C3HPG
CAS:<p>group I mGlu1a/1a receptor antagonist and mGluR2 agonist</p>Fórmula:C9H9NO5Pureza:98%Cor e Forma:SolidPeso molecular:211.17LSN2814617
CAS:<p>LSN2814617: oral, brain-penetrant mGlu5 PAM, EC50 = 52 nM (human), 42 nM (rat). Promotes wakefulness, useful in schizophrenia study.</p>Fórmula:C18H20FN5OPureza:98%Cor e Forma:SolidPeso molecular:341.38RO4988546
CAS:<p>RO4988546 is a potent negative allosteric modulator of mGlu₂/₃.</p>Fórmula:C21H10F6N4O3SPureza:98%Cor e Forma:SolidPeso molecular:512.38mGluR2 modulator 1
CAS:<p>Potent mGluR2 modulator 1 crosses blood-brain barrier, EC50: 0.03 μM, useful for psychiatric research.</p>Fórmula:C21H20F3N3O3Cor e Forma:SolidPeso molecular:419.4NPEC-caged-LY379268
CAS:<p>NPEC-caged-LY379268 is a type II mGluR agonist [1].</p>Fórmula:C16H16N2O9Cor e Forma:SolidPeso molecular:380.31A 841720
CAS:<p>Potent, selective mGlu1 antagonist A-841720; IC50: 10 nM; 34x selectivity vs mGlu5; analgesic potential.</p>Fórmula:C17H21N5OSCor e Forma:SolidPeso molecular:343.45RO5488608
CAS:<p>RO5488608 is a new type of high-efficiency mGlu2/3 NAM.</p>Fórmula:C23H17F3N2O4SCor e Forma:SolidPeso molecular:474.45Talaglumetad hydrochloride
CAS:<p>Talaglumetad hydrochloride, a prodrug of Eglumegad, targets mGluR2/3 to treat psychiatric disorders.</p>Fórmula:C11H17ClN2O5Cor e Forma:SolidPeso molecular:292.72mGluR2 modulator 2
CAS:<p>mGluR2 modulator 2: potent, selective, oral, EC50 = 0.13 μM, for antipsychotic research.</p>Fórmula:C20H22FN3Cor e Forma:SolidPeso molecular:323.41VU0418506
CAS:<p>VU0418506 is a positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGlu4).</p>Fórmula:C12H8ClFN4Pureza:98%Cor e Forma:SolidPeso molecular:262.67ACDPP hydrochloride
CAS:<p>mGlu5 receptor antagonist</p>Fórmula:C12H13ClN6OPureza:98%Cor e Forma:SolidPeso molecular:292.72Ro 64-5229
CAS:<p>mGlu2 antagonist</p>Fórmula:C17H19Cl2N3OPureza:98%Cor e Forma:SolidPeso molecular:352.26VU6010572
CAS:<p>VU6010572: potent, selective mGlu3 modulator, IC50 245 nM, high CNS penetration.</p>Fórmula:C20H18FNO3Cor e Forma:SolidPeso molecular:339.36VU0463841
CAS:<p>VU0463841 is a mGlu5 negative allosteric modulators.</p>Fórmula:C13H8ClFN4OCor e Forma:SolidPeso molecular:290.68VU 0360172 hydrochloride
CAS:<p>positive allosteric modulator of mGlu5 receptors</p>Fórmula:C18H16ClFN2OPureza:98%Cor e Forma:SolidPeso molecular:330.78mGluR2 modulator 4
CAS:<p>Compound 47 is a potent mGluR2 enhancer with an EC50 of 0.8 μM, potentially useful for antipsychotic research.</p>Fórmula:C18H18BrN3Cor e Forma:SolidPeso molecular:356.26VU0400195
CAS:<p>VU0400195 is a oral effective, positive allosteric modulator of the metabotropic glutamate receptor 4 (mGlu(4)).</p>Fórmula:C21H16ClN3O3Pureza:98%Cor e Forma:SolidPeso molecular:393.82(RS)-4-Carboxy-3-hydroxyphenylglycine
CAS:<p>broad spectrum EAA agonist/antagonist</p>Fórmula:C9H9NO5Pureza:98%Cor e Forma:SolidPeso molecular:211.17Ro4491533
CAS:<p>Ro4491533 is a potent and selective negative allosteric modulator for group II of the metabotropic glutamate receptors (mGluR2/3).</p>Fórmula:C24H20F3N3OCor e Forma:SolidPeso molecular:423.43MMPIP
CAS:<p>allosteric mGlu7-selective receptor antagonist</p>Fórmula:C19H15N3O3Pureza:98%Cor e Forma:SolidPeso molecular:333.34LSP4-2022
CAS:<p>LSP4-2022, a mGlu4 selective agonist, increases behavioral despair in mouse models of antidepressant action.</p>Fórmula:C13H18NO8PPureza:100%Cor e Forma:SolidPeso molecular:347.26VU0424465
CAS:<p>VU0424465 is a mGlu5-selective allosteric agonist.</p>Fórmula:C19H19FN2O2Cor e Forma:SolidPeso molecular:326.36VU0409106
CAS:<p>VU0409106 is a potent, mGlu5-selective inhibitor.</p>Fórmula:C15H11FN4O2SPureza:98%Cor e Forma:SolidPeso molecular:330.34Remeglurant
CAS:<p>Remeglurant is used as a selective antagonist of the mGlu5 receptor.</p>Fórmula:C17H15BrN4OCor e Forma:SolidPeso molecular:371.23IEM 1925 dihydrobromide
CAS:<p>AMPA receptor antagonist</p>Fórmula:C17H30Br2N2Pureza:98%Cor e Forma:SolidPeso molecular:422.24PHCCC(4Me)
CAS:<p>THCCC, a PHCCC analog, is a dual metabotropic glutamate receptor 2/3 negative/positive allosteric modulator.</p>Fórmula:C18H16N2O3Cor e Forma:SolidPeso molecular:308.33MSOP
CAS:MSOP is a selective antagonist of group III metabotropic glutamate receptor (KD of 51 μM for the L-AP4-sensitive presynaptic mGluR).Fórmula:C4H10NO6PPureza:98%Cor e Forma:SolidPeso molecular:199.1CFMMC
CAS:<p>CFMMC is an allosteric mGluR1 antagonist agent.</p>Fórmula:C22H28FNO4Cor e Forma:SolidPeso molecular:389.46YM 230888
CAS:<p>Selective mGlu1 antagonist</p>Fórmula:C19H28N4OSPureza:98%Cor e Forma:SolidPeso molecular:360.52LY2607540
CAS:<p>LY2607540 is a metabotropic glutamate 2 potentiator with potential anxiolytic/antidepressant properties (EC(50) = 23 and 13 nM, respectively).</p>Fórmula:C24H24F3N3O4Pureza:98%Cor e Forma:SolidPeso molecular:475.46(S)-HexylHIBO
CAS:<p>Group I mGlu receptor antagonist</p>Fórmula:C12H20N2O4Pureza:98%Cor e Forma:SolidPeso molecular:256.3LSP1-2111
CAS:<p>LSP1-2111 is a mGlu4 receptor subtype agonist.</p>Fórmula:C12H17N2O9PCor e Forma:SolidPeso molecular:364.25Lu-AF11205
CAS:<p>Lu-AF11205 is a potent positive allosteric modulator (PAM) of mGlu5 receptor.</p>Fórmula:C17H16N2OSPureza:98%Cor e Forma:SolidPeso molecular:296.39(RS)-4-Carboxyphenylglycine
CAS:<p>(RS)-4-Carboxyphenylglycine is a racemic mixture. (S)-4-Carboxyphenylglycine is a selective mGlu1α receptor antagonist.</p>Fórmula:C9H9NO4Pureza:99.04% - >99.99%Cor e Forma:SolidPeso molecular:195.17(R)-4-Carboxyphenylglycine
CAS:<p>(R)-4-Carboxyphenylglycine is a NMDA receptor antagonist.</p>Fórmula:C9H9NO4Pureza:98%Cor e Forma:SolidPeso molecular:195.17VU0652835
CAS:<p>VU0652835 is a negative allosteric modulator of metabotropic glutamate receptor subtype 5 (mGlu5) (IC50: 81 nM).</p>Fórmula:C16H19N3O3SPureza:98%Cor e Forma:SolidPeso molecular:333.41JNJ-55511118
CAS:<p>JNJ-55511118 is a TARP γ8 allosteric modulator with anticonvulsant activity, which can be used in research on chronic operant alcohol self-administration.</p>Fórmula:C14H8ClF3N2O2Cor e Forma:SolidPeso molecular:328.67DCB
CAS:<p>DCB is an mGluR5 allosteric ligand that blocks mGluR modulation, countering DMeOB and DFB effects.</p>Fórmula:C14H10Cl2N2Pureza:99.12% - 99.9%Cor e Forma:SolidPeso molecular:277.15ML337
CAS:ML337 is a negative allosteric modulator of mGlu3 with an IC50 of 593 nM.Fórmula:C21H20FNO3Pureza:99.83%Cor e Forma:SolidPeso molecular:353.39LY382884
CAS:<p>LY382884 is a selective and potent GluR5 kainate receptor antagonist with anxiolytic activity.LY382884 blocks blockade of mossy fibre LTP induction.</p>Fórmula:C18H23NO4Pureza:98.32% - 98.71%Cor e Forma:SolidPeso molecular:317.38TC-N 22A
CAS:<p>TC-N 22A is a strong, selective, oral active mGlu4 forward allosteric regulator (PAM) that can cross the blood-brain barrier.</p>Fórmula:C14H13N5SPureza:99.95%Cor e Forma:SolidPeso molecular:283.35CPPHA
CAS:<p>CPPHA, a positive allosteric modulator of glutamate receptors mGluR5 and mGluR1, is commonly used in development for central nervous system diseases.</p>Fórmula:C22H15ClN2O4Pureza:98.07%Cor e Forma:SolidPeso molecular:406.82ML289
CAS:<p>ML289 is a potent CNS-penetrant mGlu3 modulator with IC50 of 0.66 μM, >15-fold selectivity over mGlu2, and inactive against mGlu5.</p>Fórmula:C22H23NO3Pureza:99.54%Cor e Forma:SolidPeso molecular:349.42Foliglurax
CAS:<p>Foliglurax is a highly selective brain-penetrant metabotropic glutamate receptor 4 positive allosteric modulator (mGluR4 PAM) (EC50: 79 nM).</p>Fórmula:C23H23N3O3SPureza:98%Cor e Forma:SolidPeso molecular:421.51VU6001376
CAS:<p>VU6001376 is an effective and selective positive allosteric modulator of the metabotropic glutamate receptor 4 (EC50: 50.1 nM).</p>Fórmula:C18H14F2N6OSPureza:98%Cor e Forma:SolidPeso molecular:400.41Ro 67-4853
CAS:<p>Ro 67-4853 is a positive allosteric modulator of mGluR1, selectively enhancing the response to the agonist (S)-3,5-dihydroxy-phenylglycine (DHPG).</p>Fórmula:C19H19NO4Pureza:98.57%Cor e Forma:SolidPeso molecular:325.36VU0155041 sodium
CAS:VU0155041 sodium is a positive allosteric modulator of mGluR4 that promotes extinction in male rats.Fórmula:C14H14Cl2NNaO3Pureza:98%Cor e Forma:SolidPeso molecular:338.16HexylHIBO
CAS:<p>HexylHIBO is a type I mGluR antagonist that inhibits mGlu1a and mGlu5a, with Kb values of 140 and 110 μM, respectively.HexylHIBO decreases sEPSC in rats.</p>Fórmula:C12H20N2O4Pureza:99.55%Cor e Forma:SolidPeso molecular:256.3(S)-MCPG
CAS:<p>(S)-MCPG is the active isomer of (RS)-MCPG, non-selective group I/group II metabotropic glutamate receptor antagonist.</p>Fórmula:C10H11NO4Pureza:98.72%Cor e Forma:SolidPeso molecular:209.20DMeOB
CAS:<p>DMeOB (3,3'-Dimethoxybenzaldazine) is a negative regulator with mGluR5 agonist activity and is used in the study of neurological disorders.</p>Fórmula:C16H16N2O2Pureza:98.34%Cor e Forma:SolidPeso molecular:268.31A-794282
CAS:<p>A-794282 is a selective antagonist of mGluR1.</p>Fórmula:C19H18N4OSPureza:99.87%Cor e Forma:SolidPeso molecular:350.44
