GluR
Inibidores do Receptor de Glutamato são compostos que bloqueiam a atividade dos receptores de glutamato, os principais receptores de neurotransmissores excitatórios no cérebro. Esses receptores desempenham um papel crucial na transmissão sináptica, plasticidade, aprendizado e memória. A desregulação da sinalização do glutamato está associada a vários distúrbios neurológicos, como epilepsia, AVC e doenças neurodegenerativas. Os inibidores dos receptores de glutamato são essenciais para investigar os mecanismos de excitotoxicidade e desenvolver estratégias neuroprotetoras. Na CymitQuimica, oferecemos uma gama de inibidores de receptores de glutamato para apoiar sua pesquisa em função sináptica, neuroproteção e distúrbios cognitivos.
Foram encontrados 265 produtos de "GluR"
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LY487379
CAS:LY487379: human mGluR2 PAM, boosts glutamate binding, aids cognitive flexibility, may treat schizophrenia. EC50: 1.7 μM (mGlu2), >10 μM (mGlu3).Fórmula:C21H19F3N2O4SCor e Forma:SolidPeso molecular:452.45EGLU
CAS:EGLU, an antidepressant and potent mGluR-2 antagonist, binds with a 66 μM Kd to (lS,3S)-ACPD sites.Fórmula:C7H13NO4Pureza:99.98%Cor e Forma:SolidPeso molecular:175.18γ-DGG
CAS:gamma-DGG is a competitive blocker of AMPA receptor.Fórmula:C7H12N2O5Pureza:98%Cor e Forma:SolidPeso molecular:204.18AMN082
CAS:AMN082 is an mGluR7 agonist with antidepressant effects. Neuroprotective effect of AMN082 on neuronal apoptosis in rats with traumatic brain injury.Fórmula:C28H30Cl2N2Pureza:97.13% - 98.63%Cor e Forma:SolidPeso molecular:465.46GYKI 53655 hydrochloride
CAS:GYKI 53655 hydrochloride (LY300168 hydrochloride) is an antagonist of AMPA and is used in the study of neurological disorders.Fórmula:C19H21ClN4O3Pureza:98.02%Cor e Forma:SolidPeso molecular:388.85LY341495
CAS:LY341495 is a potent metabotropic glutamate receptor antagonist and can be used to study neurological disorders.Fórmula:C20H19NO5Pureza:98.53% - 99.37%Cor e Forma:SolidPeso molecular:353.37VU0364770 hydrochloride
CAS:VU0364770 hydrochloride: potent, selective mGlu4 PAM; EC50=290 nM (rat), 1.1 μM (human).Fórmula:C12H10Cl2N2OPureza:98%Cor e Forma:SolidPeso molecular:269.13VU0422288
CAS:VU0422288 (ML396) is a type III mGlu receptor (mGlus) orthosteric modulator with inhibitory effects on mGluR4.VU0422288 can be used to study Rett syndrome.Fórmula:C17H11Cl2N3O2Pureza:99.77%Cor e Forma:SolidPeso molecular:360.19Ro 01-6128
CAS:Positive allosteric modulator of mGlu1 receptorsFórmula:C17H17NO3Pureza:98%Cor e Forma:SolidPeso molecular:283.32JNJ-46778212
CAS:JNJ-46778212 (VU 0409551) is a selective and potent mGlu5 allosteric modulator (EC50: 260 nM) for the study of neurodissection.Fórmula:C20H17FN2O3Pureza:99.24%Cor e Forma:SolidPeso molecular:352.36CFMTI
CAS:CFMTI: potent mGluR1 allosteric antagonist, 2000x selectivity over mGluR5, IC50: 2.6 nM.Fórmula:C19H16FN5OPureza:97.23%Cor e Forma:SolidPeso molecular:349.36Ref: TM-T3482
1mg57,00€2mg82,00€5mg120,00€1mL*10mM (DMSO)133,00€10mg170,00€25mg304,00€50mg432,00€100mg602,00€(S)-ATPO
CAS:(S)-ATPO is Competitive antagonist at GluR1-4 (AMPA-preferring) receptors.
Fórmula:C11H19N2O7PPureza:98.37% - 99.41%Cor e Forma:SolidPeso molecular:322.25MTEP
CAS:MTEP: potent, selective mGluR5 antagonist; IC50=5 nM, Ki=16 nM; may have antidepressant/anxiolytic effects; useful in Parkinson's research.Fórmula:C11H8N2SCor e Forma:SolidPeso molecular:200.26Ro0711401
CAS:Ro0711401 is an agonist of mGlu1 receptor.Fórmula:C18H11F3N2O3Pureza:97.57%Cor e Forma:SolidPeso molecular:360.29DNQX
CAS:DNQX (FG 9041) is a competitive, non-NMDA glutamate receptor antagonist (IC50s = 0.5 and 0.1 μM for AMPA and kainate receptors, respectively)
Fórmula:C8H4N4O6Pureza:97.27% - 99.1%Cor e Forma:Off-White Powder With A Yellow TingePeso molecular:252.14VU0155041
CAS:VU0155041 is an effective and positive allosteric modulator/allosteric agonist at mGlu4 receptors (EC50: 798/693 nM, at human/rat).Fórmula:C14H15Cl2NO3Pureza:99.52% - 99.56%Cor e Forma:SolidPeso molecular:316.18Ref: TM-T3565
2mg38,00€5mg55,00€1mL*10mM (DMSO)60,00€10mg80,00€25mg138,00€50mg178,00€100mg285,00€200mg413,00€VU0361737
CAS:VU0361737 (ML-128) is a mGlu4 PAM; EC50 is 240 nM (human) and 110 nM (rat), weak at mGlu5/8, inactive at mGlu1/2/3/6/7, CNS-penetrant.Fórmula:C13H11ClN2O2Pureza:99.60% - 99.85%Cor e Forma:SolidPeso molecular:262.69ADX88178
CAS:ADX88178 is a potent positive allosteric modulator for metabotropic glutamate receptor 4 (mGluR4) with EC50 of 4 nM for human mGluR4.Fórmula:C12H12N6SPureza:99.55%Cor e Forma:SolidPeso molecular:272.33JNJ-40411813
CAS:JNJ-40411813 (ADX-71149) (ADX-71149) is a new positive allosteric modulator of the metabotropic glutamate 2 receptor (mGlu2R, EC50: 147 nM).
Fórmula:C20H25ClN2OPureza:99.74%Cor e Forma:SolidPeso molecular:344.88CX614
CAS:CX614 is a positive allosteric modulator of the AMPA receptor concerning AMPA.Fórmula:C13H13NO4Pureza:97.37%Cor e Forma:SolidPeso molecular:247.25Ref: TM-T19698
5mg52,00€1mL*10mM (DMSO)55,00€10mg78,00€25mg119,00€50mg172,00€100mg259,00€200mg388,00€
