Proteassoma
Os inibidores de proteassoma são compostos que inibem o proteassoma, um grande complexo proteico responsável pela degradação de proteínas indesejadas ou danificadas dentro da célula. A inibição do proteassoma leva ao acúmulo de proteínas, o que pode induzir a parada do ciclo celular e a apoptose, especialmente em células de rápida divisão, como as células cancerosas. Os inibidores de proteassoma são cruciais na pesquisa e terapia do câncer, especialmente no tratamento do mieloma múltiplo e outras malignidades hematológicas. Na CymitQuimica, oferecemos inibidores de proteassoma para apoiar sua pesquisa em oncologia, biologia celular e desenvolvimento de fármacos.
Foram encontrados 91 produtos para "Proteassoma".
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Epoxomicin
CAS:Epoxomicin, a selective proteasome inhibitor, chiefly blocks CH-L activity, mildly affecting T-L and PGPH at lower rates.Fórmula:C28H50N4O7Pureza:98.65% - 98.86%Cor e Forma:SolidPeso molecular:554.72Ref: TM-T6830
1mg118,00€5mg295,00€1mL*10mM (DMSO)355,00€10mg475,00€25mg773,00€50mg1.071,00€100mg1.423,00€500mg2.862,00€Carfilzomib
CAS:Carfilzomib (PR-171) is a proteasome inhibitor that irreversibly binds to the chymotrypsin of the 20S proteasome.Fórmula:C40H57N5O7Pureza:99.6% - 99.84%Cor e Forma:White SolidPeso molecular:719.91Ixazomib citrate
CAS:Ixazomib citrate (MLN9708), a prodrug of Ixazomib (MMLN-2238), is an oral 2nd-gen proteasome inhibitor with anti-cancer potential (IC50: 3.4 nM).Fórmula:C20H23BCl2N2O9Pureza:98.37% - >99.99%Cor e Forma:White SolidPeso molecular:517.12Tomatine
CAS:Tomatine (lycopersicin) is an antiproliferatve agent of breast adenocarcinoma cells.Fórmula:C50H83NO21Pureza:98.42% - 99.93%Cor e Forma:SolidPeso molecular:1034.19MG-101
CAS:MG-101 (Calpain inhibitor I) is a cell-permeable and potent inhibitor of cysteine proteases including calpains and lysosomal cathepsins.Fórmula:C20H37N3O4Pureza:97.02% - 98%Cor e Forma:SolidPeso molecular:383.53Bortezomib-pinanediol
CAS:Bortezomib-pinanediol is a proteasome inhibitor. is a prodrug of Bortezomib.Fórmula:C29H39BN4O4Pureza:97.5%Cor e Forma:SolidPeso molecular:518.46DD1
CAS:DD1 (HUN85111) is a proteasome inhibitor that induces human myeloid tumor-selective apoptosis.Fórmula:C16H14N2O3Pureza:99.57%Cor e Forma:SolidPeso molecular:282.29Calpeptin
CAS:Calpeptin is a potent, cell-permeable calpain inhibitor.Fórmula:C20H30N2O4Pureza:97.06% - 98.33%Cor e Forma:SolidPeso molecular:362.46PI-1840
CAS:PI-1840 is a reversible and selective chymotrypsin-like (CT-L) inhibitor, with little proteasome proteolytic effects on trypsin-like (T-L) and PGPH-L.Fórmula:C22H26N4O3Pureza:98.82%Cor e Forma:SolidPeso molecular:394.47Tripterin
CAS:Tripterin (Celastrol) is an proteasome inhibitor for the chymotrypsin-like activity of a purified 20S proteasome with antioxidant and anti-inflammatory effects.Fórmula:C29H38O4Pureza:98.56% - 99.8%Cor e Forma:Orange SolidPeso molecular:450.61Vepdegestrant
CAS:Vepdegestrant(ARV-471 ) is a orally active Cereblon -based estrogen receptor (ER) PROTAC degrader. ARV-471 is developed for the research of breast cancer.Fórmula:C45H49N5O4Pureza:97.15% - >99.99%Cor e Forma:SolidPeso molecular:723.9Proteasome inhibitor IX
CAS:Proteasome inhibitor IX (PS-IX) is an inhibitor of chymotrypsin-like activity of the 20S proteasome (IC50 ~1 μM).Fórmula:C20H21B2NO5Pureza:99.77%Cor e Forma:SolidPeso molecular:377.01Alloxan monohydrate
CAS:Alloxan Monohydrate is a glucose analog used to induce diabetes by destroying beta-cells.Fórmula:C4H4N2O5Pureza:99.01% - 99.42%Cor e Forma:SolidPeso molecular:160.09VR23
CAS:VR23: Potent proteasome inhibitor; IC50: 1 nM trypsin, 50-100 nM chymotrypsin, 3 μM caspase-like.Fórmula:C19H16ClN5O6SPureza:98.99% - 99.22%Cor e Forma:White SolidPeso molecular:477.88Brensocatib
CAS:Brensocatib (AZD7986) is a Dipeptidyl peptidase 1 (DPP1) inhibitor (pIC50s: 6.85, 7.7, 7.6, 7.8, and 7.8 in human, rat, mouse, rabbit, and dog, respectively).Fórmula:C23H24N4O4Pureza:97.55% - 98.69%Cor e Forma:SolidPeso molecular:420.464'-Hydroxychalcone
CAS:4'-Hydroxychalcone (2-Benzal-4-Hydroxyacetophenone) is a chalcone metabolite with hepatoprotective activityFórmula:C15H12O2Pureza:99.86% - 99.87%Cor e Forma:SolidPeso molecular:224.25TCH-165
CAS:TCH-165 boosts 20S proteasome levels, enhancing IDP breakdown.Fórmula:C39H37N3O3Pureza:98.2% - 99.97%Cor e Forma:White SolidPeso molecular:595.73ONX-0914
CAS:ONX-0914 (PR-957) is an effective and specific immunoproteasome inhibitor, which has minimal cross-reactivity for the constitutive proteasome.Fórmula:C31H40N4O7Pureza:98.24% - 99.31%Cor e Forma:SolidPeso molecular:580.6718α-Glycyrrhetinic acid
CAS:18α-Glycyrrhetinic acid (Enoxolone) is a pentacyclic triterpenoid derivative of the beta-amyrin type obtained from the hydrolysis of glycyrrhizic acid.Fórmula:C30H46O4Pureza:98.54% - 99.68%Cor e Forma:SolidPeso molecular:470.68Bortezomib
CAS:Bortezomib (LDP 341) is a 20S proteasome inhibitor (Ki=0.6 nM) that is reversible and selective.Fórmula:C19H25BN4O4Pureza:97.79% - >99.99%Cor e Forma:White SolidPeso molecular:384.24Ref: TM-T2399
5mg50,00€1mL*10mM (DMSO)50,00€10mg60,00€25mg75,00€50mg92,00€100mg137,00€200mg213,00€500mg353,00€PSI
CAS:PSI is a proteasome inhibitor.Fórmula:C32H50N4O8Pureza:97% - 98.33%Cor e Forma:SolidPeso molecular:618.76KZR-504
CAS:KZR-504 is a selective inhibitor of immunoproteasome low molecular mass polypeptide 2 (LMP2) (IC50s: 51 nM, 4.274 μM for LMP2 and LMP7, respectively).Fórmula:C21H23N3O6Cor e Forma:SolidPeso molecular:413.42Diprotin B
CAS:Diprotin B is a dipeptidyl peptidase IV inhibitor.Fórmula:C16H29N3O4Pureza:98%Cor e Forma:SolidPeso molecular:327.42Z-LLF-CHO
CAS:Z-LLF-CHO (Z-Leu-Leu-Phe-CHO) effectively inhibits the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex with a Ki value of 460 nM.Fórmula:C29H39N3O5Pureza:98%Cor e Forma:SolidPeso molecular:509.64BC-23
CAS:BC-23 (NSC 45382) is a proteasome inhibitor with antitumor and antimicrobial activity for the study of leukemia and small cell lung cancer.Fórmula:C21H14ClN3O4SPureza:99.99%Cor e Forma:SolidPeso molecular:439.87Proteasome-IN-1
CAS:Proteasome-IN-1 is an inhibitor of proteasome.Fórmula:C42H35N5O3Pureza:98%Cor e Forma:SolidPeso molecular:657.7620S Proteasome activator 1
CAS:20S Proteasome activator 1: IC50—0.3 μM (trypsin), 0.7 μM (chymotrypsin), 1.8 μM (caspase); reduces alpha-synuclein A53T, aids neurodegenerative studies.Fórmula:C27H19ClF2N2OSPureza:99.82%Cor e Forma:SolidPeso molecular:492.97Arimoclomol
CAS:Arimoclomol (BRX-220 free base) is a co-inducer of heat shock proteins (HSP) and can be used in studies about the treatment of amyotrophic lateral sclerosis (Fórmula:C14H20ClN3O3Pureza:99.15%Cor e Forma:SolidPeso molecular:313.78LU-002i
CAS:LU-002i is a selective inhibitor targeting the human proteasome subunits β2c and β2i, demonstrating an inhibitory concentration (IC50) of 220 nM for β2i [1].Fórmula:C35H52N4O7Pureza:98%Cor e Forma:SolidPeso molecular:640.81Proteasome-IN-5
CAS:Proteasome-IN-5, also known as compound 5, acts as a proteasome inhibitor [1].Fórmula:C20H30BN5O7Pureza:98%Cor e Forma:SolidPeso molecular:463.29Proteasome β2c/i-IN-1
CAS:Proteasome β2c/i-IN-1 (compound 37) serves as a selective inhibitor targeting the β2c and β2i subunits of the human proteasome [1].Fórmula:C32H48N4O7Pureza:98%Cor e Forma:SolidPeso molecular:600.75DPP-4-IN-15
CAS:DPP-4-IN-15 (Compound 22) is a non-competitive inhibitor of dipeptidyl peptidase-4 (DPP-4) with an IC50 value of 8.24 μM.Fórmula:C17H14F3N3O2SCor e Forma:SolidPeso molecular:381.372Gemigliptin tartrate hydrate
CAS:Gemigliptin (LC15-0444) tartrate hydrate is a selective, reversible, and competitive inhibitor of dipeptidyl peptidase 4 (DPP-4), with an IC50 value of 10.3 nM for human recombinant DPP-4. It exhibits strong anti-glycation properties and is used in research on advanced glycation end product-related diabetic complications.Fórmula:C22H27F8N5O9Cor e Forma:SolidPeso molecular:657.47(2S,4R)-Teneligliptin
CAS:(2S,4R)-Teneligliptin is a selective inhibitor of dipeptidyl peptidase IV (DPP-4). It increases the concentration of active glucagon-like peptide-1 (GLP-1) in plasma, which in turn stimulates insulin secretion when blood glucose levels are elevated, thereby exhibiting hypoglycemic effects. (2S,4R)-Teneligliptin is a promising candidate for research in type 2 diabetes.Fórmula:C22H30N6OSCor e Forma:SolidPeso molecular:426.578PB01
CAS:PB01 is a DPP-4 inhibitor with an IC50 of 15.66 nM. It effectively suppresses high glucose-induced ROS generation and mitochondrial superoxide production while significantly reducing the cellular expression of DPP-4. Additionally, PB01 notably lowers blood glucose levels in diabetic mice. It demonstrates excellent safety, exhibiting almost no cytotoxicity at a concentration of 100 μM. PB01 holds promise for research in the diabetes field.Fórmula:C18H21N5O3Cor e Forma:SolidPeso molecular:355.391ZINC09518833
CAS:ZINC09518833 is an α-ketoamide non-peptide proteasome inhibitor with an IC50 value of 12.4 μM. It can bind with both the active and inactive sites of the proteasome. ZINC09518833 shows promise for use in research related to multiple myeloma (MM).Fórmula:C24H25N3O5Cor e Forma:SolidPeso molecular:435.47Immunoproteasome activator 1
CAS:Immunoproteasome Activator 1 (compound A) is a selective immunoproteasome activator that enhances the presentation of individual MHC-I binding peptides by over 100 times. It binds to the proteasomal structural subunit PSMA1 and facilitates the association of the proteasome activators PA28α/β (PSME1/PSME2) with the immunoproteasome.Fórmula:C24H23N3O3Cor e Forma:SolidPeso molecular:401.46TCL1
CAS:TCL1 acts as a selective non-covalent inhibitor targeting the Pru domain of the Rpn-13 subunit within the 19S regulatory particle (19S RP) of the proteasome, with an IC50 value around 26 μM. It disrupts the recognition and transport of ubiquitinated proteins by Rpn-13, thus inhibiting proteasomal degradation and affecting intracellular protein metabolism balance. TCL1 holds potential for research in hematologic malignancies.Fórmula:C19H14BrClN4O2SCor e Forma:SolidPeso molecular:477.762RBx-0597
CAS:RBx-0597 is a selective DPP-IV inhibitor with IC50 values of 32 nM, 31 nM, and 39 nM for human, mouse, and rat plasma DPP-IV, respectively. It is utilized in research focused on type 2 diabetes.Fórmula:C19H20F2N4O2Cor e Forma:SolidPeso molecular:374.384BI-1942
CAS:BI-1942 is a chymase inhibitor with an IC50 value of 0.4 nM against human chymase. It is applicable for research in ophthalmic diseases.Fórmula:C24H26N4O4Cor e Forma:SolidPeso molecular:434.488ZINC000003015356
CAS:ZINC000003015356 acts as a DPP4 inhibitor [1].Fórmula:C25H25N3O5Peso molecular:447.48
