Receptor activado por protease
Os inibidores dos Receptores Ativados por Proteases (PAR) são compostos que têm como alvo e inibem a atividade dos PARs, uma família de receptores acoplados à proteína G que são ativados por clivagem proteolítica. Esses receptores desempenham um papel em vários processos fisiológicos, incluindo coagulação, inflamação e reparo tecidual. Os inibidores de PAR são ferramentas valiosas para estudar os mecanismos desses processos e seu envolvimento em doenças como câncer, distúrbios cardiovasculares e inflamação crônica. Na CymitQuimica, oferecemos inibidores de PAR para apoiar sua pesquisa em transdução de sinal, resposta imunológica e descoberta terapêutica.
Foram encontrados 54 produtos de "Receptor activado por protease"
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TRAP-6 amide TFA
CAS:TRAP-6 amide TFA is a PAR-1 thrombin receptor agonist peptide.Fórmula:C36H58F3N11O10Cor e Forma:SolidPeso molecular:861.922P4pal10 TFA
P4pal10 TFA, the TFA salt form of P4pal10, serves as an antagonist of the protease-activated receptor 4 (PAR4). This compound inhibits platelet aggregation and thrombin generation induced by tissue factor (TF), exhibiting anticoagulant and antithrombotic activities. Additionally, P4pal10 TFA alleviates carrageenan-induced edema and neutrophil infiltration, and ameliorates damage in rat myocardial ischemia/reperfusion (I/R) models.Cor e Forma:Odour SolidTRAP-5 amide
CAS:TRAP-5 amide is a peptide agonist for protease-activated receptor 1 (PAR 1) [1].Fórmula:C30H51N9O6Cor e Forma:SolidPeso molecular:633.78PAR 4 (1-6) (TFA)
PAR 4 (1-6) TFA (GYPGQV TFA), a hexapeptide derived from protease-activated receptor 4 (PAR 4), serves as a specific agonist for PAR 4.Fórmula:C28H41N7O9·xC2HF3O2Cor e Forma:SolidFLLRN
CAS:FLLRN is a biologically active peptide serving as a PAR1-specific antagonist.Fórmula:C31H51N9O7Cor e Forma:SolidPeso molecular:661.79Parstatin(mouse)
CAS:Peptide inhibits endothelial migration/proliferation (IC50 ~20μM), induces cell cycle arrest, triggers apoptosis, and has cardioprotective effects.Fórmula:C189H326N58O57S3Pureza:98%Cor e Forma:SolidPeso molecular:4419.19YFLLRNP
CAS:YFLLRNP is a biologically active peptide functioning as a partial agonist of PAR-1, selectively activating the G12/13 signaling pathway.Fórmula:C45H67N11O10Cor e Forma:SolidPeso molecular:922.08Parstatin(human)
CAS:Cell-permeable PAR1-derived peptide; inhibits endothelial migration, proliferation (IC50 ~3μM), induces apoptosis, and has cardioprotective effects.Fórmula:C191H330N64O53S3Pureza:98%Cor e Forma:SolidPeso molecular:4467.292-Furoyl-LIGRLO-amide
CAS:2-Furoyl-LIGRLO-amide TFA is a peptide that acts as a proteinase-activated receptor-2 (PAR2) agonist, and contains a furoyl group addition at its N-terminal.Fórmula:C36H63N11O8Pureza:98%Cor e Forma:SolidPeso molecular:777.95PAR650097
PAR650097 is a humanized monoclonal antibody targeting PAR2, used in migraine research.Pureza:96.67% (SEC-HPLC) - 98.83% (SEC-HPLC)Cor e Forma:LiquidPeso molecular:144.1 kDatcY-NH2
CAS:Selective PAR4 antagonist peptide. Inhibits endostatin release and platelet aggregation induced by thrombin.Fórmula:C40H49N7O7Pureza:98%Cor e Forma:SolidPeso molecular:739.87PZ-128
CAS:PZ-128, a PAR1 antagonist, is used potentially for the treatment of thrombosis.Fórmula:C55H99N13O9Pureza:98%Cor e Forma:SolidPeso molecular:1086.46FSLLRY-NH2
CAS:PAR2 antagonist; counters taxol effects, PKC in mice; inhibits ERK, collagen in fibroblasts; lessens dermatophyte itch in mice.Fórmula:C39H60N10O8Pureza:98%Cor e Forma:SolidPeso molecular:796.97Protease-Activated Receptor-1, PAR-1 Agonist TFA
PAR-1 Agonist TFA: Selective peptide, mimics thrombin, activates PAR-1 receptor.Cor e Forma:LiquidAY 254
CAS:AY 254: Potent PAR2 agonist, ERK1/2 activation (EC50=2 nM), limits caspase 3/8, aids HT29 cell healing, boosts IL-8.
Fórmula:C30H49N9O6Cor e Forma:SolidPeso molecular:631.779Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2
CAS:Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2 is a biologically active peptide functioning as a selective agonist for Protease Activated Receptor 1 (PAR-1), a subtypeFórmula:C42H63FN12O8Cor e Forma:SolidPeso molecular:883.02PAR-2 (1-6) (human)
CAS:PAR-2 (1-6) (human) (SLIGKV), a peptide ligand, is a PAR-2 agonist [1] .Fórmula:C28H53N7O8Cor e Forma:SolidPeso molecular:615.76SFNGGP-NH2
CAS:SFNGGP-NH2 is a biologically active peptide that interacts with Protease-Activated Receptor 3 (PAR-3), a high-affinity thrombin receptor.Fórmula:C25H36N8O8Cor e Forma:SolidPeso molecular:576.6Protease-Activated Receptor-1, PAR-1 Agonist
CAS:Selective peptide agonist that mimics thrombin to activate PAR-1 receptor, enabling targeted receptor activation.Fórmula:C35H58N10O9Cor e Forma:SolidPeso molecular:762.91Parstatin(human) TFA
Parstatin(human) TFA, a cell-penetrating PAR-1 thrombin receptor agonist peptide, effectively inhibits angiogenesis, as indicated by studies [1] [2].Fórmula:C193H331F3N64O55S3Cor e Forma:SolidPeso molecular:4581.28
