Células - tronco e Derivados
Os inibidores de células-tronco são compostos que visam especificamente as vias de sinalização e proteínas envolvidas na manutenção, diferenciação e proliferação de células-tronco. Esses inibidores são cruciais para compreender a biologia das células-tronco e para desenvolver estratégias para manipular células-tronco para fins terapêuticos, como medicina regenerativa e tratamento do câncer. Ao controlar o destino das células-tronco, esses inibidores podem ajudar a orientar a diferenciação das células-tronco em tipos celulares específicos ou prevenir o crescimento celular indesejado. Na CymitQuimica, oferecemos uma seleção de inibidores de células-tronco de alta qualidade para apoiar sua pesquisa em biologia de células-tronco, biologia do desenvolvimento e medicina regenerativa.
Subcategorias de "Células - tronco e Derivados"
- Gama-secretase(63 produtos)
- Hedgehog/Smoothened(49 produtos)
- Via Hippo(7 produtos)
- JAK(243 produtos)
- Porcupine(9 produtos)
- ROCK(61 produtos)
- STAT(100 produtos)
- Células - tronco(185 produtos)
- TGF-beta/Smad(60 produtos)
- Wnt/beta-catenina(61 produtos)
Exibir 2 mais subcategorias
Foram encontrados 470 produtos de "Células - tronco e Derivados"
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RBPJ Inhibitor-1
CAS:RBPJ Inhibitor-1 (RIN1), a compound that impedes the functional interaction between RBPJ and SHARP, effectively inhibits NOTCH-dependent tumor cellFórmula:C17H14FN3O2Pureza:99.79%Cor e Forma:SoildPeso molecular:311.31Ref: TM-T35566
1mg38,00€2mg50,00€5mg84,00€1mL*10mM (DMSO)93,00€10mg130,00€25mg215,00€50mg371,00€100mg537,00€WDR5 ligand 2
CAS:WDR5ligand 2 is a ligand for WDR5 and can be utilized in the synthesis of PROTAC WDR5degrader 1.Fórmula:C29H31F3N4O4Cor e Forma:SolidPeso molecular:556.576NVP-BSK805 2HCl (1092499-93-8(free base))
NVP-BSK805 2HCl (1092499-93-8(free base)) (BSK 805)(IC50=0.5 nM), a specific and effective ATP-competitive JAK2 inhibitor, is more than 20-fold specificity overFórmula:C27H28F2N6O·2HClPureza:99.13%Cor e Forma:SolidPeso molecular:563.47Ref: TM-T6294
1mg35,00€5mg99,00€10mg137,00€1mL*10mM (DMSO)215,00€25mg245,00€50mg346,00€100mg495,00€200mg677,00€Prafnosbart
CAS:Prafnosbart (DS-6016A) is a humanized IgG1-kappa monoclonal antibody targeting ACVR1 (activin A receptor type 1, ACVRLK2, ALK2, ACVR1A, SKR1), utilized inCor e Forma:LiquidSJ1008030 TFA
SJ1008030 (compound 8) TFA is a selective JAK2-degrading PROTAC that inhibits the growth of MHH-CALL-4 leukemia cells with an IC50 of 5.4 nM, indicating itsFórmula:C44H44F3N13O9SPureza:98%Cor e Forma:SolidPeso molecular:987.96OICR41114
OICR41114 (PROTAC4) is a PROTAC degrader targeting WDR5. It effectively degrades endogenous WDR5 with an EC50 of 40 nM and a Dmax of 49%. The degradation of HiBiT-tagged WDR5 by OICR41114 occurs in a proteasome-dependent manner. This compound is composed of a target protein ligand, Dimethyl-F-OICR-9429-COOH, an E3 ligase ligand, OICR-8268-acrylic acid, and a PROTAC linker, Amino-PEG9-amine. Notably, the conjugate of the E3 ligase ligand and the linker is OICR-8268-acrylic acid-amino-PEG9-amine.Fórmula:C70H83Cl2F6N9O15Cor e Forma:SolidPeso molecular:1475.36Disitertide acetate
Disitertide acetate: a TGF-β1 and PI3K blocker, promotes apoptosis; inhibits receptor interaction.Fórmula:C70H113N17O24S2Pureza:95.11%Cor e Forma:SoildPeso molecular:1640.88Rovalpituzumab MMAE
Rovalpituzumab-MMAE (Anti-DLL3 Reference Antibody), produced in CHO cells, consists of a huIgG1 heavy chain and a hukappa light chain. The molecular weight of this antibody is predicted to be 145.02 kDa.Cor e Forma:LiquidPeso molecular:145 kDaP17 Peptide
CAS:P17 Peptide, a human TGF-β1 inhibitory peptide, effectively blocks the activity of woodchuck TGF-β1.Fórmula:C95H139N27O21Cor e Forma:SolidPeso molecular:1995.29JAK-IN-15
CAS:JAK-IN-15 is a JAK inhibitor. WO2016119700A1 (Compound 15).Fórmula:C22H23FN4O3SCor e Forma:SolidPeso molecular:442.51FDA-Approved Kinase Inhibitor Library
A unique collection of 263 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.
Cor e Forma:LiquidEpigenetics Compound Library
Well-chosen 953 compounds related to epigenetic regulation for research in epigenetics, high throughput screening (HTS) and high content screening (HCS) for newCor e Forma:Odour SolidRef: TM-L1200
1mgA consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultar250μL*10mM (DMSO)A consultarTubastatin
CAS:Tubastatin inhibits TGF-β1-induced S6K phosphorylation, HIF-1α expression and VEG F expression.Fórmula:C21H22N2O2Pureza:98.23%Cor e Forma:SolidPeso molecular:334.41TEAD-IN-16
TEAD-IN-16 (compound BC-011) is a potent inhibitor of TEAD, with an IC50 of 72.43 μM. This compound plays a significant role in cancer research.Fórmula:C16H14F3NO3Peso molecular:325.09258JAK2-IN-10
CAS:JAK2-IN-10 (compound 5) is a potent inhibitor of JAK2v617f, with an IC50 value of ≤10 nM.Fórmula:C33H33D3FN9O2Cor e Forma:SolidPeso molecular:612.71Plant 14-3-3-IN-1
Plant 14-3-3-IN-1 (Compound 2) is an inhibitor of the Arabidopsis thaliana 14-3-3 protein, with an IC50 of 1.21 μM. It exhibits varying inhibitory activity against different 14-3-3 isoforms and promotes the closure of leaf stomata.Fórmula:C22H19NO7SPeso molecular:441.08822Deuruxolitinib
CAS:Deuruxolitinib functions as an inhibitor of JAK1/2.Fórmula:C17H18N6Cor e Forma:SolidPeso molecular:314.41S-Ruxolitinib
CAS:S-Ruxolitinib can be used in related research in the field of life sciences. Its product number is T3066 and CAS number is 1160597-27-2.
Fórmula:C17H18N6Pureza:98%Cor e Forma:SolidPeso molecular:306.37SAHM1
CAS:Notch pathway inhibitor - stabilized hydrocarbon-stapled alpha helical peptide. Targets the protein-protein interface and prevents Notch complex assembly.Fórmula:C94H162N36O23SPureza:98%Cor e Forma:SolidPeso molecular:2196.58Super-TDU (1-31) (TFA)
Super-TDU (1-31) TFA, a peptide, inhibits YAP-TEAD; it has strong anti-tumor effects in gastric cancer models.Fórmula:C141H218N40O48·C2HF3O2Cor e Forma:SolidPeso molecular:3355.5Povorcitinib phosphate
CAS:Povorcitinib phosphate is a selective JAK1 inhibitor and can be used in studies about the treatment of cutaneous lupus erythematosus and Lichen planus.Fórmula:C23H25F5N7O5PPureza:99.57%Cor e Forma:SolidPeso molecular:605.45Ref: TM-T39113L
1mg46,00€5mg96,00€1mL*10mM (DMSO)128,00€10mg145,00€25mg236,00€50mg339,00€100mg460,00€200mg622,00€PSEN1-IN-2
PSEN1-IN-2 (Compound 13K) is a potent inhibitor of both PSEN1-APH1A and PSEN1-APH1B complexes, exhibiting IC50 values of 6.9 nM and 2.4 nM, respectively.Fórmula:C20H18ClFN2O3SCor e Forma:SolidPeso molecular:420.88PSEN1-IN-1
PSEN1-IN-1 (Compound (+)-13b) functions as an inhibitor of PSEN1, displaying potent inhibition of the PSEN1-APH1A and PSEN1-APH1B complexes with respective IC50Fórmula:C20H19ClF3NO3SCor e Forma:SolidPeso molecular:445.88MR24
CAS:MR24 is a derivative of G-5555 and acts as an inhibitor of mammalian STE20-like (MST) kinases. It selectively targets MST3 and MST4, with EC50 values of 57 nM and 583 nM, respectively.Fórmula:C26H29ClN6O3Peso molecular:509.00MSC-5046
MSC-5046 is a selective inhibitor of TEAD1.Fórmula:C24H18F3N5O3Cor e Forma:SolidPeso molecular:481.43HAT-SIL-TG-1&AT
HAT-SIL-TG-1&AT: a hypoxia-activated JAK inhibitor that curbs HEL cell growth & STAT3/5 phosphorylation in tumors.Fórmula:C60H69N17O11SCor e Forma:SolidPeso molecular:1236.36SPL-707
CAS:SPL-707 is an effective and selective signal peptide peptidase-like 2a inhibitor (IC50: 80 nM).Fórmula:C27H28FN5O4Pureza:98%Cor e Forma:SolidPeso molecular:505.54YAP-IN-1
YAP-IN-1 (Compound (+)-1) is an autophagy inhibitor specifically targeting YAP1. It binds to the Hippo pathway transcription factor YAP1 with a Kd of 9.13 μM, promoting its degradation through the chaperone-mediated autophagy (CMA) pathway. This process inhibits the Rab7-mediated fusion of autophagosomes with lysosomes and decreases autophagy levels without affecting lysosomal function. YAP-IN-1 shows potential for cancer research, including in hepatocellular carcinoma and breast cancer.Cor e Forma:Odour SolidTYK2 activator-1
TYK2activator-1 (16b) is a TYK2 activator with an EC50 value of 1.78 μM. It inhibits JAK2 and JAK3 with IC50 values of 6.8 μM and 6.3 μM, respectively.Fórmula:C23H21FN4O2Cor e Forma:SolidPeso molecular:404.16485JAK3-IN-15
JAK3-IN-15 (compound 22) is a JAK3 inhibitor that reduces the secretion of p-JAK3 induced by LPS. It is utilized in research for rheumatoid arthritis.Cor e Forma:Odour SolidFRM-024
CAS:FRM-024 is a powerful gamma secretase modulator with the ability to penetrate the central nervous system (CNS), designed specifically for the treatment ofFórmula:C22H22ClN5O2Cor e Forma:SolidPeso molecular:423.9TEAD-IN-19
TEAD-IN-19 (Compound 1l) is a transcriptional inhibitor of TEAD, showing inhibition rates of 38.5%, 36.2%, 57.8%, and 71.3% for TEAD1, TEAD2, TEAD3, and TEAD4, respectively, at 10 μM. It exhibits strong antiproliferative and antimigratory effects on prostate cancer cell lines and significantly reduces the expression of TEAD-regulated downstream genes. TEAD-IN-19 holds potential for research in the field of cancer therapeutics.Cor e Forma:Odour SolidWnt/β-catenin agonist 3
CAS:Wnt/β-catenin agonist 3 is a Wnt/beta-catenin agonist.
Fórmula:C16H15ClN4O2Pureza:99.52%Cor e Forma:SolidPeso molecular:330.77SJ10542
CAS:SJ10542: potent JAK2/3-targeting PG-PROTAC; DC50s: JAK2 - 14 nM, JAK3 - 11 nM, JAK2-fusion ALL - 24 nM; CRBN recruiter.Fórmula:C41H46N12O5SCor e Forma:SolidPeso molecular:818.95TYD-68
TYD-68 is a potent and selective CRBN-recruiting TYK2 PROTAC degrader, with a DC50 value of 0.42 nM. This compound effectively inhibits IL-12 and IFN-α-induced phosphorylation of STAT4 and STAT1, thereby blocking TYK2-dependent signaling pathways. TYD-68 is applicable in psoriasis research.Cor e Forma:Odour SolidLH168
LH168 is a potent and selective probe for WDR5, with a SPR Kd value of 13 nM.Fórmula:C29H31F3N6O2SCor e Forma:SolidPeso molecular:584.665β-Cholanic acid
CAS:5β-Cholanic acid (5beta-Cholanic acid) is a potent γ-secretase modulator used in Alzheimer's disease research.
Fórmula:C24H40O2Pureza:98.91% - 99.89%Cor e Forma:SoildPeso molecular:360.57Wnt/Hedgehog/Notch Compound Library
A unique collection of 237 Wnt/Hedgehog/Notch signaling targeted compounds for high throughput and high content screening;
Cor e Forma:Odour SolidNotch 1 TFA
Notch 1 TFA encodes a member of the NOTCH family of proteins.Fórmula:C64H98N15F3O25S3Pureza:98%Cor e Forma:SolidPeso molecular:1614.81STX-0119
CAS:STX-0119 is a selective, orally active STAT3 dimerization inhibitor. STX-0119 inhibits STAT3 transcription with an IC50 of 74 μM.
Fórmula:C22H14N4O3Pureza:99.61%Cor e Forma:SolidPeso molecular:382.37γ-Secretase modulator 10
CAS:γ-Secretase modulator 10 is a novel γ-secretase modulator.Fórmula:C25H23F3N4O2Cor e Forma:SolidPeso molecular:468.48SJ1008030
CAS:SJ1008030, a JAK2 PROTAC, degrades JAK2; EC50: 5.4 nM, IC50: 32.09 nM in MHH-CALL-4 cells for leukemia research.
Fórmula:C42H43N13O7SCor e Forma:SolidPeso molecular:873.94WAY-297174
CAS:WAY-297174 is a human protein kinase CK2 inhibitor with IC50 of > 33 μM.
Fórmula:C11H12N2O2S2Pureza:99.53%Cor e Forma:SoildPeso molecular:268.36AS2553627
CAS:AS2553627 is a JAK inhibitor. AS2553627 prevents chronic rejection in rat cardiac allografts.Fórmula:C18H19N5OCor e Forma:SolidPeso molecular:321.38MR44397
MR44397 is a ligand for WD40 repeat (WDR) 5 and is applicable in cancer research.Fórmula:C23H26N4O2SCor e Forma:SolidPeso molecular:422.54Adenosine receptor modulator 1
Adenosine receptor modulator 1 acts as an inducer of collagen VII (C7). It enhances the expression of COL7A1 mRNA in donor-derived keratinocytes and, in synergy with Gentamicin, increases the overall levels of C7.Fórmula:C25H28N6O3Cor e Forma:SolidPeso molecular:460.53SJ1008030 formic
SJ1008030 (compound 8) formic is a selective JAK2 degrader within the PROTAC class, demonstrating efficacy in inhibiting MHH-CALL-4 leukemia cell growth with anFórmula:C43H45N13O9SPureza:98%Cor e Forma:SolidPeso molecular:919.96SJ988497
CAS:SJ988497: PROTAC JAK2 degrader, inhibits CRLF2r cell growth, degrades GSPT1, combines Ruxolitinib, linker, Pomalidomide; researched for ALL.Fórmula:C36H36N10O5Cor e Forma:SolidPeso molecular:688.74Axltide
CAS:Axltide mimics mouse Insulin receptor substrate 1, amino acids 979-989 with sequence KKSRGDYMTMQIG.Fórmula:C63H107N19O20S2Pureza:98%Cor e Forma:SolidPeso molecular:1514.77TGFβRI-IN-7
TGFβRI-IN-7 (compound 16W) is a potent inhibitor of TGFβRI. It effectively inhibits the phosphorylation of SMAD2/3 and reduces the viability of H22 cells, with IC50 values of 12 nM and 65 nM, respectively. In an H22 cell xenograft model, TGFβRI-IN-7 exhibits antitumor efficacy with a TGI of 79.6%.Fórmula:C27H32N6O2Cor e Forma:SolidPeso molecular:472.582
