c-Fms
Os inibidores de c-Fms têm como alvo o Receptor do Fator Estimulador de Colônias-1 (c-Fms), uma tirosina quinase envolvida na regulação de macrófagos e outras células imunológicas. A sinalização de c-Fms desempenha um papel na proliferação, diferenciação e sobrevivência dessas células. A desregulação do c-Fms está associada a doenças como câncer, condições inflamatórias e osteoporose. Na CymitQuimica, oferecemos inibidores de c-Fms para apoiar sua pesquisa em imunologia, oncologia e doenças inflamatórias.
Foram encontrados 105 produtos de "c-Fms"
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Trabikibart
CAS:Trabikibart (CSL311) is a human βc-specific antibody inhibiting IL-3, GM-CSF and IL-5, regulating eosinophil survival in chronic inflammatory disease research.Pureza:95% - 95.6% (SDS-PAGE); 99.3% (SEC-HPLC)Cor e Forma:LiquidPeso molecular:144.64 kDaNamilumab
CAS:Namilumab (AMG203) is a humanised IgG1 monoclonal antibody that neutralises GM-CSF. rheumatoid arthritis and active axial spondyloarthritis.Pureza:95%Cor e Forma:LiquidCSF1R-IN-19
CAS:CSF1R-IN-19 is a robust inhibitor of CSF1R that influences the exchange of inflammatory factors between TAMs and glioma cells. It holds potential for cancer research [1].Fórmula:C20H27N7OCor e Forma:SolidPeso molecular:381.47Sotuletinib dihydrochloride
CAS:Sotuletinib (BLZ945) dihydrochloride is an orally administered, blood-brain barrier-permeable inhibitor specifically targeting CSF1-R with an IC50 of 1 nM.Fórmula:C20H24Cl2N4O3SPureza:98%Cor e Forma:SolidPeso molecular:471.4c-Fms-IN-9
CAS:c-Fms-IN-9 inhibits c-FMS/uFMS and uKIT with IC50 <0.01μM and 0.1-1μM, from patent WO2014145023A1.Fórmula:C21H23N7O2Pureza:98%Cor e Forma:SolidPeso molecular:405.45Leustroducsin A
CAS:Leustroducsin A is an inducer of colony-stimulating factors (CSFs) extracted from Streptomyces platensis SANK 60191.Fórmula:C32H52NO10PCor e Forma:SolidPeso molecular:641.73c-Fms-IN-7
CAS:c-Fms-IN-7 is a cFMS inhibitor (IC50: 18.5 nM).Fórmula:C26H24N6OSPureza:98%Cor e Forma:SolidPeso molecular:468.57c-Fms-IN-8
CAS:c-Fms-IN-8 is a colony-stimulating factor-1 receptor (CSF-1R, c-FMS) Type II inhibitor (IC50: 9.1 nM). It is compound 4a in the reference.Fórmula:C27H30N2O5Pureza:98%Cor e Forma:SolidPeso molecular:462.54JNJ-28312141
CAS:JNJ-28312141: oral CSF1R/FLT3 inhibitor, potential for treating acute myeloid leukemia, tumors, and bone events.Fórmula:C26H32N6O2Pureza:98%Cor e Forma:SolidPeso molecular:460.57CSF1R-IN-4
CAS:CSF1R-IN-4, a potent CSF-1R inhibitor, may impact TAM/glioma cell communication, with cancer research potential. (WO2021197276A1, compound 104)Fórmula:C23H20N6O3Cor e Forma:SolidPeso molecular:428.44c-Fms-IN-10
CAS:c-Fms-IN-10 is a thieno[3,2-d]pyrimidine derivative, an FMS kinase inhibitor with IC50 of 2 nM, exhibiting anti-tumor properties.Fórmula:C22H19N7OSPureza:98%Cor e Forma:SolidPeso molecular:429.5CSF1R-IN-13
CAS:CSF1R-IN-13: potent cancer research CSF1R inhibitor impacting cell growth regulation.Fórmula:C21H20N4O3Cor e Forma:SolidPeso molecular:376.41CSF1R-IN-8
CAS:CSF1R-IN-8 (Compound 22) is a CSF-1R inhibitor (IC50: 0.012 μM).Fórmula:C24H22N4O4Cor e Forma:SolidPeso molecular:430.46CSF1R-IN-10
CAS:CSF1R-IN-10 (Compound 48) is a CSF-1R inhibitor (IC50: 0.005 μM).Fórmula:C25H22N4O3Cor e Forma:SolidPeso molecular:426.47Leustroducsin C
CAS:Leustroducsin C is an inducer of colony-stimulating factors CSF extracted from Streptomyces platensis SANK 60191.Fórmula:C34H56NO10PCor e Forma:SolidPeso molecular:669.78CSF1R-IN-14
CAS:CSF1R-IN-14, an isoindolinone derivative, powerfully inhibits CSF1R, with potential in cancer research. See WO2019134662A1, compound 1.Fórmula:C23H22F3N5OCor e Forma:SolidPeso molecular:441.45CSF1R-IN-12
CAS:CSF1R-IN-12 is an effective CSF1R inhibitor. CSF1R-IN-12 has research potential in cancer diseases.Fórmula:C21H17F3N4OCor e Forma:SolidPeso molecular:398.38CSF1R-IN-7
CAS:CSF1R-IN-7 is a highly selective CSF-1R inhibitor with good brain penetration for treatment of diseases associated with microglia-mediated neuroinflammation.Fórmula:C22H22N6O3Pureza:99.41% - 99.93%Cor e Forma:SolidPeso molecular:418.45CSF1R-IN-9
CAS:CSF1R-IN-9 (Compound 46) is a CSF-1R inhibitor (IC50: 0.028 μM).Fórmula:C26H26N4O2Cor e Forma:SolidPeso molecular:426.51CSF1R-IN-6
CAS:CSF1R-IN-6, a compound, effectively inhibits macrophage CSF1R essential for survival and differentiation.
Fórmula:C20H18N8O3Cor e Forma:SolidPeso molecular:418.41
