c-Fms
Os inibidores de c-Fms têm como alvo o Receptor do Fator Estimulador de Colônias-1 (c-Fms), uma tirosina quinase envolvida na regulação de macrófagos e outras células imunológicas. A sinalização de c-Fms desempenha um papel na proliferação, diferenciação e sobrevivência dessas células. A desregulação do c-Fms está associada a doenças como câncer, condições inflamatórias e osteoporose. Na CymitQuimica, oferecemos inibidores de c-Fms para apoiar sua pesquisa em imunologia, oncologia e doenças inflamatórias.
Foram encontrados 108 produtos de "c-Fms"
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CSF1R-IN-12
CAS:<p>CSF1R-IN-12 is an effective CSF1R inhibitor. CSF1R-IN-12 has research potential in cancer diseases.</p>Fórmula:C21H17F3N4OCor e Forma:SolidPeso molecular:398.38CSF1R-IN-7
CAS:<p>CSF1R-IN-7 is a highly selective CSF-1R inhibitor with good brain penetration for treatment of diseases associated with microglia-mediated neuroinflammation.</p>Fórmula:C22H22N6O3Pureza:99.41% - 99.93%Cor e Forma:SolidPeso molecular:418.45CSF1R-IN-9
CAS:<p>CSF1R-IN-9 (Compound 46) is a CSF-1R inhibitor (IC50: 0.028 μM).</p>Fórmula:C26H26N4O2Cor e Forma:SolidPeso molecular:426.51CSF1R-IN-6
CAS:<p>CSF1R-IN-6, a compound, effectively inhibits macrophage CSF1R essential for survival and differentiation.</p>Fórmula:C20H18N8O3Cor e Forma:SolidPeso molecular:418.41c-Fms-IN-2
CAS:<p>c-Fms-IN-2 is an inhibitor of c-FMS kinase (IC50 = 24 nM).</p>Fórmula:C19H21N3O3Pureza:99.56%Cor e Forma:SolidPeso molecular:339.39ABD-295
CAS:<p>ABD-295, a biphenylsulfide derivative, inhibits osteoclasts and prevents bone loss in vitro and in vivo.</p>Fórmula:C17H19F2NO3SPureza:98%Cor e Forma:SolidPeso molecular:355.4c-Fms-IN-6
CAS:<p>c-Fms-IN-6 is a potent inhibitor of c-FMS (IC50 ≤10 nM for unphosphorylated c-FMS) and also weakly inhibits unphosphorylated c-KIT and PDGFR (IC50: > 1 μM).</p>Fórmula:C22H25N7O2Pureza:98%Cor e Forma:SolidPeso molecular:419.48IACS-9439
CAS:<p>IACS-9439 is a potent, selective, and orally active inhibitor of CSF1R, exhibiting a K(i) of 1 nM.</p>Fórmula:C23H26ClN7O3SPureza:98%Cor e Forma:SolidPeso molecular:516.02c-Fms-IN-1
CAS:<p>c-Fms-IN-1 is an inhibitor of c-FMS kinase (IC50 = 0.8 nM).</p>Fórmula:C22H27N5O2Pureza:99.94%Cor e Forma:SolidPeso molecular:393.48Chiauranib
CAS:<p>Chiauranib, a potent anticancer agent, inhibits angiogenesis kinases (VEGFR1-3, PDGFRα, c-Kit), Aurora B, and CSF1R with IC50 values of 1-9 nM.</p>Fórmula:C27H21N3O3Pureza:99.22%Cor e Forma:SolidPeso molecular:435.47c-Fms-IN-3
CAS:<p>c-Fms-IN-3 is a novel inhibitor of the c-FMS and can be used in studies about antirheumatic and anti-inflammatory diseases.</p>Fórmula:C23H30N6OPureza:99.87%Cor e Forma:SolidPeso molecular:406.52c-Fms-IN-13
CAS:<p>c-Fms-IN-13 (compound 14) is a potent FMS kinase inhibitor (IC50= 17 nM). c-Fms-IN-13 is an anti-inflammatory agent.</p>Fórmula:C22H26N4O2Pureza:99.93% - 99.97%Cor e Forma:SolidPeso molecular:378.47Pimicotinib
CAS:<p>Pimicotinib (ABSK021) is a potent CSF1R inhibitor with antitumor activity and can be used to study advanced solid tumors.</p>Fórmula:C22H24N6O3Pureza:99.8%Cor e Forma:SolidPeso molecular:420.46CSF1R-IN-3
CAS:<p>CSF1R-IN-3 is an orally effective CSF-1R inhibitor with an IC50 value of 2.1 nM.</p>Fórmula:C30H38N8O4Pureza:97.31%Cor e Forma:SolidPeso molecular:574.67c-Fms-IN-14
CAS:<p>c-Fms-IN-14 (Example 76) is a potent inhibitor of the c-Fms kinase with an IC50 of 4 nM, utilized in cancer and autoimmune disease research [1].</p>Fórmula:C26H24N6OPureza:98%Cor e Forma:SolidPeso molecular:436.51Axl/Mer/CSF1R-IN-2
CAS:<p>Axl/Mer/CSF1R-IN-2 (Comp 4) serves as an inhibitor for Axl, Mer, and CSF1R [1].</p>Fórmula:C24H22F3N5O5Cor e Forma:SolidPeso molecular:517.46Axl/Mer/CSF1R-IN-1
CAS:<p>Axl/Mer-IN-1 is a compound that functions as an inhibitor for Axl/Mer receptor tyrosine kinase (Axl/Mer RTK) and CSF1R, exhibiting dissociation constants (Kds)</p>Fórmula:C25H24F3N5O5Cor e Forma:SolidPeso molecular:531.48Ataquimast
CAS:<p>Ataquimast is used in curing advanced receptor-positive breast cancer.</p>Fórmula:C11H14ClN3OPureza:99.92%Cor e Forma:SolidPeso molecular:239.7JTE-952
CAS:<p>JTE-952: oral, selective Type II CSF-1R inhibitor, IC50 = 13 nM for CSF1R, 261 nM for TrkA, effective in mouse arthritis model.</p>Fórmula:C30H34N2O6Pureza:98%Cor e Forma:SolidPeso molecular:518.6CSF1R-IN-5
CAS:<p>CSF1R-IN-5: Potent CSF1R inhibitor, may alter TAM/glioma inflammatory exchanges, potential cancer research tool. (WO2021197276A1, Compound 11)</p>Fórmula:C22H19N7O3Cor e Forma:SolidPeso molecular:429.43
