c-Fms
Os inibidores de c-Fms têm como alvo o Receptor do Fator Estimulador de Colônias-1 (c-Fms), uma tirosina quinase envolvida na regulação de macrófagos e outras células imunológicas. A sinalização de c-Fms desempenha um papel na proliferação, diferenciação e sobrevivência dessas células. A desregulação do c-Fms está associada a doenças como câncer, condições inflamatórias e osteoporose. Na CymitQuimica, oferecemos inibidores de c-Fms para apoiar sua pesquisa em imunologia, oncologia e doenças inflamatórias.
Foram encontrados 105 produtos de "c-Fms"
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c-Fms-IN-2
CAS:c-Fms-IN-2 is an inhibitor of c-FMS kinase (IC50 = 24 nM).Fórmula:C19H21N3O3Pureza:99.56%Cor e Forma:SolidPeso molecular:339.39Ref: TM-T10775
1mg92,00€5mg241,00€10mg355,00€25mg532,00€50mg750,00€100mg1.009,00€1mL*10mM (DMSO)180,00€ABD-295
CAS:ABD-295, a biphenylsulfide derivative, inhibits osteoclasts and prevents bone loss in vitro and in vivo.Fórmula:C17H19F2NO3SPureza:98%Cor e Forma:SolidPeso molecular:355.4c-Fms-IN-6
CAS:c-Fms-IN-6 is a potent inhibitor of c-FMS (IC50 ≤10 nM for unphosphorylated c-FMS) and also weakly inhibits unphosphorylated c-KIT and PDGFR (IC50: > 1 μM).Fórmula:C22H25N7O2Pureza:98%Cor e Forma:SolidPeso molecular:419.48IACS-9439
CAS:IACS-9439 is a potent, selective, and orally active inhibitor of CSF1R, exhibiting a K(i) of 1 nM.Fórmula:C23H26ClN7O3SPureza:98%Cor e Forma:SolidPeso molecular:516.02c-Fms-IN-1
CAS:c-Fms-IN-1 is an inhibitor of c-FMS kinase (IC50 = 0.8 nM).Fórmula:C22H27N5O2Pureza:99.94%Cor e Forma:SolidPeso molecular:393.48Chiauranib
CAS:Chiauranib, a potent anticancer agent, inhibits angiogenesis kinases (VEGFR1-3, PDGFRα, c-Kit), Aurora B, and CSF1R with IC50 values of 1-9 nM.
Fórmula:C27H21N3O3Pureza:99.22%Cor e Forma:SolidPeso molecular:435.47c-Fms-IN-3
CAS:c-Fms-IN-3 is a novel inhibitor of the c-FMS and can be used in studies about antirheumatic and anti-inflammatory diseases.Fórmula:C23H30N6OPureza:99.87%Cor e Forma:SolidPeso molecular:406.52Ref: TM-T10649
1mg52,00€5mg105,00€10mg161,00€25mg264,00€50mg358,00€100mg522,00€1mL*10mM (DMSO)110,00€c-Fms-IN-13
CAS:c-Fms-IN-13 (compound 14) is a potent FMS kinase inhibitor (IC50= 17 nM). c-Fms-IN-13 is an anti-inflammatory agent.Fórmula:C22H26N4O2Pureza:99.93% - 99.97%Cor e Forma:SolidPeso molecular:378.47Pimicotinib
CAS:Pimicotinib (ABSK021) is a potent CSF1R inhibitor with antitumor activity and can be used to study advanced solid tumors.Fórmula:C22H24N6O3Pureza:99.8%Cor e Forma:SolidPeso molecular:420.46Ref: TM-T79157
1mg52,00€5mg111,00€10mg170,00€25mg329,00€50mg528,00€100mg843,00€1mL*10mM (DMSO)156,00€CSF1R-IN-3
CAS:CSF1R-IN-3 is an orally effective CSF-1R inhibitor with an IC50 value of 2.1 nM.Fórmula:C30H38N8O4Pureza:98.4%Cor e Forma:SolidPeso molecular:574.67Ref: TM-T64066
1mg101,00€5mg245,00€10mg358,00€25mg665,00€50mg973,00€100mg1.395,00€1mL*10mM (DMSO)309,00€Ataquimast
CAS:Ataquimast is used in curing advanced receptor-positive breast cancer.Fórmula:C11H14ClN3OPureza:99.92%Cor e Forma:SolidPeso molecular:239.7Ref: TM-T30190
1mg64,00€5mg129,00€10mg188,00€25mg299,00€50mg427,00€100mg575,00€200mg750,00€1mL*10mM (DMSO)116,00€JTE-952
CAS:JTE-952: oral, selective Type II CSF-1R inhibitor, IC50 = 13 nM for CSF1R, 261 nM for TrkA, effective in mouse arthritis model.Fórmula:C30H34N2O6Pureza:98%Cor e Forma:SolidPeso molecular:518.6c-Fms-IN-14
CAS:c-Fms-IN-14 (Example 76) is a potent inhibitor of the c-Fms kinase with an IC50 of 4 nM, utilized in cancer and autoimmune disease research [1].Fórmula:C26H24N6OPureza:98%Cor e Forma:SolidPeso molecular:436.51Axl/Mer/CSF1R-IN-2
CAS:Axl/Mer/CSF1R-IN-2 (Comp 4) serves as an inhibitor for Axl, Mer, and CSF1R [1].Fórmula:C24H22F3N5O5Cor e Forma:SolidPeso molecular:517.46CSF1R-IN-5
CAS:CSF1R-IN-5: Potent CSF1R inhibitor, may alter TAM/glioma inflammatory exchanges, potential cancer research tool. (WO2021197276A1, Compound 11)Fórmula:C22H19N7O3Cor e Forma:SolidPeso molecular:429.43Axl/Mer/CSF1R-IN-1
CAS:Axl/Mer-IN-1 is a compound that functions as an inhibitor for Axl/Mer receptor tyrosine kinase (Axl/Mer RTK) and CSF1R, exhibiting dissociation constants (Kds)Fórmula:C25H24F3N5O5Cor e Forma:SolidPeso molecular:531.48Adrixetinib
CAS:Adrixetinib is an inhibitor of protein tyrosine kinase with antineoplastic activity .Fórmula:C25H24F3N5O5Cor e Forma:SolidPeso molecular:531.48ARRY-382
CAS:ARRY-382 is a highly selective oral inhibitor of CSF-1R with an IC50 of 9 nM.
Fórmula:C32H36N8O2Pureza:99.76%Cor e Forma:SolidPeso molecular:564.68Enrupatinib
CAS:Enrupatinib is an inhibitor of the colony stimulating factor 1 receptor (CSF1R), exhibiting antitumor activity.Fórmula:C27H26N6O3Cor e Forma:SolidPeso molecular:482.53c-Fms-IN-15
CAS:c-Fms-IN-15 (compound 8g) is a potent inhibitor of FMS kinase, with an IC50 of 563 nM.Fórmula:C29H28F3N7O2Peso molecular:563.57
