FLT
Os inibidores de FLT (Fms-like tyrosine kinase) são compostos que têm como alvo os receptores FLT, que estão envolvidos na regulação da angiogênese através da via do VEGF (fator de crescimento endotelial vascular). Os receptores FLT desempenham um papel crucial no desenvolvimento de novos vasos sanguíneos em tumores. Inibir os receptores FLT pode reduzir efetivamente a angiogênese e o crescimento tumoral, tornando esses inibidores importantes na terapia contra o câncer. Na CymitQuimica, oferecemos uma seleção de inibidores de FLT de alta qualidade para apoiar sua pesquisa em oncologia, biologia vascular e angiogênese.
Foram encontrados 86 produtos para "FLT".
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INE963
CAS:INE963: Potent against Pf 3D7 (EC50=6nM), clears parasites in <24h; effective on P. falciparum/vivax isolates (EC50=0.01-7nM).Fórmula:C19H26N6O2SPureza:99.08% - 99.45%Cor e Forma:SolidPeso molecular:402.51FLT3-IN-2
CAS:FLT3-IN-2 is an FLT3 inhibitor (IC50<1 μM).Fórmula:C21H16ClF3N4Pureza:97.57% - 98.53%Cor e Forma:SolidPeso molecular:416.83Fostamatinib Disodium
CAS:Fostamatinib Disodium (R788 Disodium) is an orally available Syk kinase inhibitor with potential anti-inflammatory and immunomodulating activities.Fórmula:C23H24FN6O9P·2NaPureza:96.13% - 99.09%Cor e Forma:White SolidPeso molecular:624.42Ref: TM-T2605
1mg44,00€2mg52,00€5mg84,00€1mL*10mM (DMSO)110,00€10mg117,00€25mg210,00€50mg354,00€100mg530,00€500mg1.153,00€TAK-659 hydrochloride
CAS:TAK-659 hydrochloride (TAK-659) is a potent and selective inhibitor of spleen tyrosine kinase (SYK) with an IC50 value of 3.2 nM.Fórmula:C17H22ClFN6OPureza:99.28% - 99.82%Cor e Forma:SolidPeso molecular:380.85TCS 359
CAS:TCS 359 (FLT3 Inhibitor) is a potent FLT3 inhibitor with IC50 of 42 nM.Fórmula:C18H20N2O4SPureza:99.31%Cor e Forma:SolidPeso molecular:360.427Adezkibart
CAS:Adezkibart is a human-derived monoclonal antibody immunosuppressant that targets the human FMS-like tyrosine kinase 3 ligand (FLT3LG). It was discovered in the Chinese hamster ovary cell line CHO-K1. Adezkibart binds to FLT3LG, blocking the associated signaling pathways to suppress immune responses, thereby exerting an immunosuppressive effect. It holds potential for research in immune-related diseases.Emirodatamab
CAS:Emirodatamab (AMG-427) is an anti-FLT3/CD3 bispecific T-cell engager with an extended half-life. It can induce high cytotoxicity in primary AML progenitor cells and enhance FLT-3 expression. Combining Emirodatamab with anti-PD-1 antibodies increases T-cell dependent cytotoxicity (TDCC). This compound is under investigation for use in relapsed or refractory AML.Cor e Forma:LiquidFLT3-IN-15
CAS:FLT3-IN-15 is an orally active and potent FLT3 inhibitor, capable of acting on FLT3 (IC50: 0.87 nM) and FLT3/D835Y (IC50: 0.32 nM).Fórmula:C22H23ClFN5O2Cor e Forma:SolidPeso molecular:443.91FLT3/ITD-IN-2
CAS:FLT3/ITD-IN-2: Powerful FLT3/ITD, FLT3D835Y, and FLT3 inhibitor; hinders AML cell growth. IC50s: 0.3-1.0 nM.Fórmula:C23H26F3N7O2Cor e Forma:SolidPeso molecular:489.49FLT3-IN-6
CAS:FLT3-IN-6 is a potent and selective inhibitor of FLT3-ITD (FLT3 mutation) with an IC50 of 1.336 nM.Fórmula:C23H25N5O3Cor e Forma:SolidPeso molecular:419.48AAE871
CAS:AAE871 is a type I FLT3 inhibitor.Fórmula:C24H34N8O2SCor e Forma:SolidPeso molecular:498.64LBW242
CAS:LBW242: oral 3-mer Smac mimetic, IAP inhibitor, targets multiple myeloma, enhances TRAIL/chemo death in ovarian cancer, active on mutant FLT3 cells.Fórmula:C27H42N4O2Pureza:98%Cor e Forma:SolidPeso molecular:454.65FLT3/ITD-IN-3
CAS:FLT3/ITD-IN-3 (Compound 19) is a potent FLT3-ITD inhibitor with IC50 values: FLT3D835Y (0.3 nM), FLT3 (0.4 nM), inhibits AML cell proliferation.Fórmula:C22H26ClN7O2Cor e Forma:SolidPeso molecular:455.94KRN383
CAS:KRN383 inhibits ITD cell growth at ≤2.9 nM, erases ITD tumors in mice at 80 mg/kg dose, and may suit various treatment plans.Fórmula:C17H17N3O4Cor e Forma:SolidPeso molecular:327.33FLT3-IN-12
CAS:FLT3-IN-12: potent, selective oral FLT3 inhibitor; FLT3-WT IC50: 1.48 nM, FLT3-D835Y: 2.87 nM; >1000x selective over c-KIT; anti-AML, IC50: 0.75 nM MV4-11.Fórmula:C21H23F3N6OCor e Forma:SolidPeso molecular:432.44PDGFRα/FLT3-ITD-IN-2
CAS:PDGFRα/FLT3-ITD-IN-2 is a potent inhibitor of PDGFRα (IC50>20 μM) and FLT3 (IC50: 0.004 μM).Fórmula:C28H41N9OCor e Forma:SolidPeso molecular:519.68FLT3-IN-18
CAS:FLT3-IN-18: potent, selective FLT3 inhibitor, IC50 0.003 μM, induces apoptosis, G1 arrest, blocks FLT3/STAT5, potential in AML research.Fórmula:C26H36N8OCor e Forma:SolidPeso molecular:476.62FLT3/D835Y-IN-1
CAS:FLT3/D835Y-IN-1, an oral FLT3 inhibitor (IC50: FLT3 - 0.26 nM, D835Y - 0.18 nM), shows anticancer potential in AML research.Fórmula:C22H21N5O3Cor e Forma:SolidPeso molecular:403.43AGL 2043
CAS:AGL 2043 is a potent, reversible, ATP-competitive inhibitor of type III receptor tyrosine kinases.Fórmula:C15H12N4SCor e Forma:SolidPeso molecular:280.35MDK5466
CAS:MDK5466 is an Flt3 inhibitor that acts by preventing glutamate-induced cell death.Fórmula:C21H23N3OSPureza:98%Cor e Forma:SolidPeso molecular:365.49
