FLT
Os inibidores de FLT (Fms-like tyrosine kinase) são compostos que têm como alvo os receptores FLT, que estão envolvidos na regulação da angiogênese através da via do VEGF (fator de crescimento endotelial vascular). Os receptores FLT desempenham um papel crucial no desenvolvimento de novos vasos sanguíneos em tumores. Inibir os receptores FLT pode reduzir efetivamente a angiogênese e o crescimento tumoral, tornando esses inibidores importantes na terapia contra o câncer. Na CymitQuimica, oferecemos uma seleção de inibidores de FLT de alta qualidade para apoiar sua pesquisa em oncologia, biologia vascular e angiogênese.
Foram encontrados 86 produtos para "FLT".
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PDGFRα/FLT3-ITD-IN-1
CAS:PDGFRα/FLT3-ITD-IN-1 are potent inhibitors of PDGFRα/FLT3, and their IC50 values are greater than 0.036 and 0.003 μM, respectively.Fórmula:C27H39N9OCor e Forma:SolidPeso molecular:505.66BSc5371
CAS:BSc5371: Irreversible FLT3 inhibitor; Kds 0.83-5.8 nM for various FLT3 mutants including wild type.Fórmula:C24H31N5O4SPureza:98%Cor e Forma:SolidPeso molecular:485.6PDGFRα/FLT3-ITD-IN-3
CAS:PDGFRα/FLT3-ITD-IN-3 (Compound 18d) is a potent inhibitor of PDGFRα (IC50: 0.153 μM), FLT3 (IC50: 0.004 μM) and PDGFRα/FLT3-ITD-IN-3 has the potential to beFórmula:C26H39N9Cor e Forma:SolidPeso molecular:477.65FLT3-IN-11
CAS:FLT3-IN-11, an oral FLT3 kinase inhibitor: potent, selective, IC50 - wild-type 7.22 nM, FLT3-D835Y 4.95 nM, anti-AML IC50 3.2 nM for MV4-11.Fórmula:C20H25F3N6OCor e Forma:SolidPeso molecular:422.45HP1328
CAS:HP1328: potent FLT3/ITD inhibitor, reduces leukemia, extends survival in mice, belongs to benzoimidazole family.Fórmula:C23H23N3O3Cor e Forma:SolidPeso molecular:389.45TG-46
CAS:TG-46 (TG46) inhibits JAK2, FLT3, RET, JAK3 and can be used to study glaucoma.Fórmula:C26H34N6O3SPureza:98.82% - 99.86%Cor e Forma:SolidPeso molecular:510.65FLT3-IN-4
CAS:FLT3-IN-4 (FLT3 inhibitor 9u) is a potent and orally effective Fms-like tyrosine receptor kinase 3 (FLT3; IC50=7 nM) inhibitor ,for treating acute myelogenousFórmula:C23H25N7O2Pureza:99.9%Cor e Forma:SolidPeso molecular:431.49GTP-14564
CAS:GTP-14564 is a novel tyrosine kinase inhibitor that also inhibits wt-FLT3 and ITD-FLT3.Fórmula:C15H10N2OPureza:99.81%Cor e Forma:SolidPeso molecular:234.2527UNC4203
CAS:UNC4203 inhibits MERTK (1.2 nM), AXL (140 nM), TYRO3 (42 nM), FLT3 (90 nM); potent, selective, oral.Fórmula:C30H44N6OCor e Forma:SolidPeso molecular:504.71HPK1-IN-2 dihydrochloride
CAS:HPK1-IN-2 dihydrochloride, a potent and orally active inhibitor of hematopoietic progenitor kinase-1 (HPK1) with an IC 50 of less than 0.05 µM, demonstrates significant antitumor activity. It additionally exhibits inhibition of Lck kinase activity, with an IC 50 ranging from 0.05 to less than 0.5 µM, and Flt3 kinase activity, with an IC 50 of less than 0.05 µM [1].Fórmula:C19H22Cl2N6OSCor e Forma:SolidPeso molecular:453.39OTS447
CAS:OTS447 is a potent FLT3 inhibitor (IC50: 21 nM) with potential anticancer activity for cancer research .Fórmula:C27H32ClN3O2Pureza:98.25%Cor e Forma:Green SolidPeso molecular:466.02TAK-659
CAS:TAK-659 is a spleen tyrosine kinase (SYK) inhibitor.Fórmula:C17H21FN6OPureza:98%Cor e Forma:SolidPeso molecular:344.39FLT3/ITD-IN-5
CAS:FLT3/ITD-IN-5 (Example 6) is an orally active inhibitor of both FLT3 and FLT3-ITD, exhibiting IC50 values of 0.088 nM and 0.348 nM, respectively. This compound is utilized in cancer research.Fórmula:C23H25N7O2Cor e Forma:SolidPeso molecular:431.49FLT3/ITD-IN-1
FLT3/ITD-IN-1 inhibits FLT3-ITD with IC50s: 38.2 nM (FLT3) and 144.1 nM (ITD), and fights acute myeloid leukemia.Fórmula:C19H22N6O2Cor e Forma:SolidPeso molecular:366.42D-65476
CAS:D-65476 is a type III receptor tyrosine kinase (Flt3) inhibitor. It inhibits the proliferation of TEL-Flt3 transfected BA/F3 cells in the absence of IL-3, with an IC50 of 0.2 μM, and is useful for researching Flt3-driven leukemia.Fórmula:C21H18N2O3Cor e Forma:SolidPeso molecular:346.38FLT3-IN-38
CAS:FLT3-IN-38 (Flt-3 Inhibitor II) is a compound that acts as an FLT3 inhibitor. It also exhibits off-target effects by inhibiting the serine/threonine kinase haspin, a mitotic signaling coordinator. FLT3-IN-38 has potential applications in cancer research.Fórmula:C17H12N2O3Peso molecular:292.29BDT001
CAS:BDT001 (Example 1) is a selective antagonist of the FLT3 receptor, which can be utilized in research related to painful conditions, cancer, and autoimmune diseases.Fórmula:C18H19ClN2O4SPeso molecular:394.87Lomonitinib
CAS:Lomonitinib is a potent and selective pan-FLT3/IRAK4 inhibitor with antitumor properties. It shows promise for research in myeloid leukemia.Fórmula:C27H24N4O2Cor e Forma:SolidPeso molecular:436.505Multi-kinase inhibitor 4
CAS:Multi-kinase inhibitor 4 (compound 14) serves as an orally effective inhibitor targeting FLT1, KDR, FLT3, FLT4, PDGFRα, and PDGFRβ, exhibiting IC50 values of 1.97 nM, 1.04 nM, 0.33 nM, 1.44 nM, 0.18 nM, and 0.89 nM respectively. This compound plays a crucial role in cancer research.Fórmula:C25H24N6O2Cor e Forma:SolidPeso molecular:440.50
