IGF-1R

Os inibidores de IGF-1R são compostos que especificamente alvo e inibem o Receptor do Fator de Crescimento Semelhante à Insulina 1 (IGF-1R), uma tirosina quinase receptora envolvida no crescimento celular, desenvolvimento e sobrevivência. A sinalização de IGF-1R desempenha um papel significativo na progressão do câncer, tornando esses inibidores valiosos na pesquisa oncológica. Na CymitQuimica, oferecemos inibidores de IGF-1R para apoiar sua pesquisa em biologia do câncer, endocrinologia e desenvolvimento de terapias direcionadas.

Foram encontrados 119 produtos para "IGF-1R".

Filtrar por

Percentagem de pureza

100

produtos por página.

+ Info
Ganitumab
CAS:
- 905703-97-1
Ganitumab (AMG 479) is a potent monoclonal antibody targeting IGF1R with 0.22 nM affinity; used in cancer research.
Pureza:100% (SEC-HPLC) - > 95%
Cor e Forma:Transparent Liquid
Peso molecular:145.70 kDa (Predicted)
Ref: TM-T76810
+ Info
ALK inhibitor 1
CAS:
- 761436-81-1
ALK inhibitor 1 is a selective ALK kinase inhibitor.
Fórmula:C₂₃H₂₈BrN₇O₃S
Pureza:98.27%
Cor e Forma:White Solid
Peso molecular:562.483
Ref: TM-T10285
+ Info
GIP (3-42), human
CAS:
- 1802086-25-4
Human GIP (3-42) is a peptide antagonist of GIP receptors, affecting insulin regulation and diabetes research.
Fórmula:C₂₁₄H₃₂₄N₅₈O₆₃S
Pureza:95.73%
Cor e Forma:Solid
Peso molecular:4749.35
Ref: TM-T37589
+ Info
Robatumumab
CAS:
- 934235-44-6
Robatumumab (Sch 717454) is a fully humanized anti-IGF-1R monoclonal antibody with antitumor activity and antiproliferative activity.
Pureza:96.9% (SDS-PAGE); 98.1% (SEC-HPLC) - 96.9% (SDS-PAGE); 98.1% (SEC-HPLC)
Cor e Forma:Transparent Liquid
Peso molecular:145.56 kDa (Predicted)
Ref: TM-T76759
+ Info
NBI-31772
CAS:
- 374620-70-9
NBI-31772 (NBI 31772) is the potent inhibitor of insulin-like growth factor-1 binding protein (IGFBP, Ki = 47 nM).
Fórmula:C₁₇H₁₁NO₇
Pureza:99.37% - 99.79%
Cor e Forma:Yellow Solid
Peso molecular:341.27
Ref: TM-T8906
+ Info
MSDC-0602K
CAS:
- 1314533-27-1
MSDC-0602K, a Ps-TZD, targets PPARγ (IC50: 18.25 μM) and MPC, may help study fatty liver, lipid imbalance, inflammation, and insulin issues.
Fórmula:C₁₉H₁₆KNO₅S
Pureza:99.42%
Cor e Forma:White Solid
Peso molecular:409.5
Ref: TM-T38715
+ Info
Teprotumumab
CAS:
- 1036734-93-6
Teprotumumab: human antibody, inhibits IGF-1R, used for thyroid eye diseases.
Pureza:/ - 95.2% (SDS-PAGE); 99.6% (SEC-HPLC)
Cor e Forma:Transparent Liquid
Peso molecular:145.62 kDa (Predicted)
Ref: TM-T76727
+ Info
GIP (human) acetate
GIP (human) acetate boosts insulin, limits gastric acid, affects lipid metabolism, and obesity development.
Pureza:98.65%
Cor e Forma:Solid
Ref: TM-TP2018L
+ Info
AZ7550 hydrochloride
CAS:
- 2309762-40-9
AZ7550 hydrochloride (AZ7550 hydrochloride ), an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
Fórmula:C₂₇H₃₂ClN₇O₂
Pureza:99.65%
Cor e Forma:Solid
Peso molecular:522.042
Ref: TM-T13564L
+ Info
HNMPA
CAS:
- 132541-52-7
HNMPA blocks insulin receptor kinase, halting autophosphorylation; no impact on cAMP protein kinase or PKC.
Fórmula:C₁₁H₁₁O₄P
Pureza:99.18%
Cor e Forma:Solid
Peso molecular:238.18
Ref: TM-T21761
+ Info
Acetyl Gastric Inhibitory Peptide (human)
CAS:
- 299898-33-2
Acetyl Gastric Inhibitory Peptide: improved insulinotropic, antihyperglycemic, for diabetes/obesity research.
Fórmula:C₂₂₈H₃₄₀N₆₀O₆₇S
Cor e Forma:Solid
Peso molecular:5025.6
Ref: TM-T76310
+ Info
Gastric Inhibitory Peptide (1-42) (porcine) TFA
Gastric Inhibitory Peptide (1-42) (porcine) TFA is a glucose-dependent insulinotropic polypeptide released by intestinal K-cells.
Fórmula:C₂₂₅H₃₄₂N₆₀O₆₆S·XCF₃COOH
Cor e Forma:White Solid
Peso molecular:4975.55
Ref: TM-T83694
+ Info
IGF-I (24-41)
CAS:
- 135861-49-3
IGF-I (24-41) is a fragment of IGF-I, affecting GH activities with anabolic, antioxidant, anti-inflammatory, and cytoprotective properties.
Fórmula:C₈₈H₁₃₃N₂₇O₂₈
Pureza:98%
Cor e Forma:Solid
Peso molecular:2017.16
Ref: TM-TP1124
+ Info
WAY-270250
CAS:
- 852367-46-5
WAY-270250 is an IGF-1R/SRC inhibitor.
Fórmula:C₁₈H₁₆N₂O₂
Pureza:99.97%
Cor e Forma:Green Solid
Peso molecular:292.33
Ref: TM-T77624
+ Info
GIP, human
CAS:
- 100040-31-1
Insulinotropic hormone from K-cells, binds GIP receptors, boosts insulin, affects lipids, and has antiapoptotic properties.
Fórmula:C₂₂₆H₃₃₈N₆₀O₆₆S
Pureza:98%
Cor e Forma:Solid
Peso molecular:4983.6
Ref: TM-TP2018
+ Info
Insulin peglispro
CAS:
- 1200440-65-8
Insulin peglispro (BIL) is a basal insulin with a stable, extended activity and may offer improved blood sugar control.
Fórmula:C₃₇₀H₅₆₆N₁₀₄O₁₁₀S₄
Cor e Forma:Solid
Peso molecular:8359.32
Ref: TM-T76540
+ Info
(Pro3) GIP, human
CAS:
- 299898-52-5
(Pro3) GIP, human: stable hGIPR full agonist, high affinity (Ki/Kd=0.90nM), for obesity-related diabetes research.
Fórmula:C₂₂₆H₃₃₈N₆₀O₆₄S
Cor e Forma:Solid
Peso molecular:4951.53
Ref: TM-T76313
+ Info
IGF-1R inhibitor-2
CAS:
- 1116236-15-7
IGF-1R inhibitor-2 blocks the insulin-like growth factor-1 receptor, potentially reversing tumor cell transformation and increasing apoptosis susceptibility.
Fórmula:C₂₄H₂₄FN₇O₂
Cor e Forma:Solid
Peso molecular:461.501
Ref: TM-T38502
+ Info
cis-NVP-ADW742
CAS:
- 475489-15-7
NVP-ADW742 is an IGF-1R inhibitor with IC₅₀ of 0.17 μM, >16-fold more potent against IGF-1R than InsR; little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl and c-Kit.
Fórmula:C₂₈H₃₁N₅O
Cor e Forma:Solid
Peso molecular:453.59
Ref: TM-T2107
+ Info
[D-Ala2]-GIP (human)
CAS:
- 444073-04-5
[D-Ala2]-GIP (human), GIP agonist (EC₅₀=630 pM), improves glucose/cognition, anti-neurotoxicity, for diabetes and Parkinson's.
Fórmula:C₂₂₆H₃₃₈N₆₀O₆₆S
Pureza:98%
Cor e Forma:Solid
Peso molecular:4983.58
Ref: TM-TP2019