IGF-1R
Os inibidores de IGF-1R são compostos que especificamente alvo e inibem o Receptor do Fator de Crescimento Semelhante à Insulina 1 (IGF-1R), uma tirosina quinase receptora envolvida no crescimento celular, desenvolvimento e sobrevivência. A sinalização de IGF-1R desempenha um papel significativo na progressão do câncer, tornando esses inibidores valiosos na pesquisa oncológica. Na CymitQuimica, oferecemos inibidores de IGF-1R para apoiar sua pesquisa em biologia do câncer, endocrinologia e desenvolvimento de terapias direcionadas.
Foram encontrados 106 produtos para "IGF-1R".
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Gastric Inhibitory Peptide (1-42) (porcine) TFA
Gastric Inhibitory Peptide (1-42) (porcine) TFA is a glucose-dependent insulinotropic polypeptide released by intestinal K-cells.Fórmula:C225H342N60O66S·XCF3COOHCor e Forma:White SolidPeso molecular:4975.55IGF-I (24-41)
CAS:IGF-I (24-41) is a fragment of IGF-I, affecting GH activities with anabolic, antioxidant, anti-inflammatory, and cytoprotective properties.Fórmula:C88H133N27O28Pureza:98%Cor e Forma:SolidPeso molecular:2017.16Xenin 8 acetate
Xenin 8 acetate is a biologically active fragment of Xenin in the neurotensin/xenopsin family.Fórmula:C53H83N15O11Pureza:99.98%Cor e Forma:SolidPeso molecular:1106.32Proinsulin C-Peptide (55-89), human
CAS:Proinsulin, insulin's precursor, has A and B chains linked by a 31 amino acid C-peptide. Enzymes cleave it, yielding insulin and C-peptide.Fórmula:C153H259N49O52Pureza:98%Cor e Forma:SolidPeso molecular:3616.99GIP (3-42), human acetate
GIP (3-42), human acetate is an antagonist of a glucose-dependent insulinotropic polypeptide (GIP) receptor and regulates insulin secretion and GIP metabolismPureza:98%Cor e Forma:Solidcis-NVP-ADW742
CAS:NVP-ADW742 is an IGF-1R inhibitor with IC50 of 0.17 μM, >16-fold more potent against IGF-1R than InsR; little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl and c-Kit.Fórmula:C28H31N5OCor e Forma:SolidPeso molecular:453.59INSR agonist 1
INSR agonist 1, an insulin receptor (INSR) agonist, effectively elevates INSR pY1355/1361 levels and exhibits synergistic effects with insulin.Fórmula:C36H47BrN4O6Cor e Forma:SolidPeso molecular:711.69LAGIPRA peptide
LAGIPRA peptide is a long-acting agonist of GIP1R. It improves insulin sensitivity by enhancing glucose handling and reduces circulating branched-chain amino acids (BCAA) and keto acids. LAGIPRA peptide holds potential for research in type 2 diabetes.LDD39
LDD39, a PROTAC targeting the degradation of RET protein, effectively and persistently degrades total RET (tRET) protein in vivo and inhibits phosphorylated RET (pRET) signaling.Fórmula:C55H59F2N11O6Cor e Forma:SolidPeso molecular:1008.12Xenin-8
CAS:neurotensin-like peptide that modulate pancreatic insulin and glucagon secretion/effectsFórmula:C51H79N15O9Pureza:98%Cor e Forma:SolidPeso molecular:1046.27TAK-778
CAS:TAK-778, a derivative of ipriflavone, demonstrates the ability to stimulate bone growth in both in vitro and in vivo models.Fórmula:C24H28NO7PSPureza:98%Cor e Forma:SolidPeso molecular:505.52TLK19781
CAS:TLK19781 is an insulin receptor modulator.Fórmula:C33H24Cl2N4O13S4Pureza:98%Cor e Forma:SolidPeso molecular:883.73HNMPA-(AM)3
CAS:HNMPA-(AM)3 抑制 ERK 磷酸化的激活以及促促胸腺激素 (PTTH) 刺激蜕皮类固醇产生。 此外，HNMPA-(AM)3 对蜕皮类固醇产生 (IC50=14.2 μM) 和胰岛素受体活性 (IC50=14.2 μM 和 200 μM，在蚊子和哺乳动物中分别) 具有抑制作用。Fórmula:C20H23O10PPureza:97.22%Cor e Forma:Transparent LiquidPeso molecular:454.36IGF1R/CD221 Protein, Mouse, Recombinant (His)
IGF1R/CD221 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.Pureza:> 95% as determined by Bis-Tris PAGE > 90% as determined by HPLC - > 95% as determined by Bis-Tris PAGE > 90% as determined by HPLCCor e Forma:Lyophilized PowderPeso molecular:80.72+23.0 kDa (predicted); 110-140 kDa and 50-65 kDa, corresponding to the α subunit and β subunit respectively (reducing condition, due to glycosylation)IGF1R/CD221 Protein, Human, Recombinant (His & Avi)
The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosisCor e Forma:Lyophilized PowderPeso molecular:105.8 kDa (alpha subunit) and 23 kDa (beta subunit) (predicted). Due to glycosylation, the protein migrates to 110-120 kDa(alpha subunit) and 52-55 kDa(beta subunit) based on Tris-Bis PAGE result.IMP2-IN-1
CAS:IMP2-IN-1 effectively inhibits IMP2 (IC50: 81.3-127.5 μM), reduces IMP2 in SW480 cells, and hinders Huh7 cell activity.Fórmula:C21H14F3NO4Cor e Forma:SolidPeso molecular:401.34IGF1R/CD221 Protein, Human, Recombinant (aa 31-932, His & Avi), Biotinylated
The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosisCor e Forma:Lyophilized PowderPeso molecular:105.8 kDa (alpha subunit) and 23 kDa (beta subunit) (predicted). Due to glycosylation, the protein migrates to 110-120 kDa (alpha subunit) and 52-55 kDa (beta subunit) based on Tris-Bis PAGE result.Ref: TM-TMPK-00456
5µg94,00€10µg138,00€20µg220,00€50µg434,00€100µg732,00€200µg1.324,00€500µg2.925,00€Ceritinib dihydrochloride
CAS:Ceritinib dihydrochloride (LDK378 dihydrochloride) is a selective, orally bioavailable, ATP-competitive inhibitor of ALK tyrosine kinase with antitumour effect.Fórmula:C28H38Cl3N5O3SPureza:99.85% - 99.99%Cor e Forma:Yellow SolidPeso molecular:631.06AZ7550
CAS:AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).Fórmula:C27H31N7O2Pureza:97.07% - 99.75%Cor e Forma:SolidPeso molecular:485.58NVP-TAE 226
CAS:NVP-TAE 226: Potent FAK inhibitor, IC50=5.5nM, stronger vs Pyk2, IC50=3.5nM, weaker against IGF-1R, InsR, c-Met, ALK.Fórmula:C23H25ClN6O3Pureza:98.07% - 98.78%Cor e Forma:SolidPeso molecular:468.94Ref: TM-T1918
1mg46,00€2mg59,00€5mg96,00€1mL*10mM (DMSO)96,00€10mg155,00€25mg250,00€50mg358,00€100mg537,00€
