IGF-1R
Os inibidores de IGF-1R são compostos que especificamente alvo e inibem o Receptor do Fator de Crescimento Semelhante à Insulina 1 (IGF-1R), uma tirosina quinase receptora envolvida no crescimento celular, desenvolvimento e sobrevivência. A sinalização de IGF-1R desempenha um papel significativo na progressão do câncer, tornando esses inibidores valiosos na pesquisa oncológica. Na CymitQuimica, oferecemos inibidores de IGF-1R para apoiar sua pesquisa em biologia do câncer, endocrinologia e desenvolvimento de terapias direcionadas.
Foram encontrados 87 produtos de "IGF-1R"
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NBI-31772 hydrate
<p>NBI-31772 hydrate blocks IGF and IGFBPs binding, freeing IGF-I with Ki 1-24 nM; it has anxiolytic and antidepressant effects.</p>Fórmula:C17H13NO8Cor e Forma:SolidPeso molecular:372.82Linsitinib
CAS:<p>OSI-906 (Linsitinib) is an oral inhibitor of IGF-1R with anti-cancer properties, potentially halting tumor growth and inducing cell death.</p>Fórmula:C26H23N5OPureza:99.71% - ≥95%Cor e Forma:SolidPeso molecular:421.49AZD-3463
CAS:<p>AZD-3463 (ALK/IGF1R inhibitor) , an orally bioavailable ALK inhibitor (Ki: 0.75 nM), can inhibit IGF1R with equivalent potency.</p>Fórmula:C24H25ClN6OPureza:99.13%Cor e Forma:SolidPeso molecular:448.95BRD7552
CAS:<p>BRD7552 is an inducer of transcription factor PDX1, which increases insulin expression. BRD7552 increases PDX1 expression in mouse αTC cells but not βTC cells.</p>Fórmula:C33H33N3O15Pureza:>99.99% - ≥98%Cor e Forma:SolidPeso molecular:711.63Sari 59-801
CAS:Sari 59-801 is a novel, orally effective hypoglycemic compound that appears to act largely by stimulation of insulin release.Fórmula:C18H23N3O2Pureza:99.92%Cor e Forma:SolidPeso molecular:313.39PQ401 hydrochloride (196868-63-0(free base))
<p>PQ401 inhibits autophosphorylation of IGF-1R domain with IC50 of <1 μM.</p>Fórmula:C18H17Cl2N3O2Pureza:99.86%Cor e Forma:SolidPeso molecular:378.25AG1024
CAS:<p>AG1024 (Tyrphostin) suppresses IGF-1R autophosphorylation(IC50=7 μM), and is less potent for IR(IC50=57 μM).</p>Fórmula:C14H13BrN2OPureza:98% - 99.37%Cor e Forma:SolidPeso molecular:305.17Indirubin Derivative E804
CAS:<p>Indirubin Derivative E804 is a potent insulin-like growth factor type 1 receptor (IGF1R) inhibitor with potential antitumor activity.</p>Fórmula:C20H19N3O4Pureza:98.54%Cor e Forma:SolidPeso molecular:365.38GSK1904529A
CAS:<p>GSK1904529A (GSK 4529) is a specific inhibitor of IGF-1R (IC50=27 nM) and IR(IC50=25 nM) .</p>Fórmula:C44H47F2N9O5SPureza:98.2% - 99.38%Cor e Forma:SolidPeso molecular:851.96Anti-IGFBP2 Antibody (M14)
<p>Anti-IGFBP2 Antibody (M14) is a human monoclonal antibody inhibitor that binds with high affinity to IGFBP2 and prevents its interaction with IGF1. Additionally, Anti-IGFBP2 Antibody (M14) can inhibit the recruitment of human endothelial cells, thereby obstructing tumor progression in human metastatic cancers.</p>Cor e Forma:Odour LiquidFigitumumab
CAS:<p>Figitumumab is a potent anti-IGF1R mAb (IC50=1.8 nM) showing promise in advanced lung squamous cell carcinoma.</p>Pureza:95%Cor e Forma:LiquidDusigitumab
CAS:<p>Dusigitumab (MEDI573) is a fully humanised monoclonal antibody targeting IGF1/IGF2, inhibiting IGF1/IGF2-induced IGF-1R phosphorylation.</p>Pureza:95% - 95%Cor e Forma:LiquidVeligrotug
CAS:<p>Veligrotug is an IV anti-IGF-1R antibody for thyroid eye disease, reducing diplopia and orbital inflammation, supporting autoimmune ophthalmopathy research.</p>Pureza:95% - 95%Cor e Forma:LiquidS961
CAS:<p>S961: High-affinity IR antagonist; IC50: HIR-A 0.048 nM, HIR-B 0.027 nM, HIGF-IR 630 nM.</p>Fórmula:C211H297N55O71S2Pureza:98%Cor e Forma:SolidPeso molecular:4804.13BMS-754807
CAS:<p>BMS-754807 is an oral IGF-1R/InsR inhibitor with potential anti-cancer properties.</p>Fórmula:C23H24FN9OPureza:99.69% - 99.94%Cor e Forma:SolidPeso molecular:461.49AZ12253801
CAS:<p>AZ12253801 is a type 1 insulin-like growth factor receptor (IGF-1R) inhibitor.</p>Fórmula:C21H22N8OPureza:98%Cor e Forma:SolidPeso molecular:402.45BM-131246
CAS:<p>BM-131246 is an orally available and antidiabetic active thiazolidinedione derivative for the study of diabetes.</p>Fórmula:C22H20N2O4SPureza:>99.99%Cor e Forma:SolidPeso molecular:408.47D-(+)-Sorbose
CAS:<p>D-(+)-Sorbose, an enantiomer inhibiting disaccharidase, lowers glucose and insulin post-meal in rats, possibly preventing diabetes.</p>Fórmula:C6H12O6Cor e Forma:SolidPeso molecular:180.16KU14R
CAS:<p>KU14R is a new I(3)-R antagonist, which selectively blocks the insulin secretory response to imidazolines.</p>Fórmula:C13H14N2OPureza:98%Cor e Forma:White SolidPeso molecular:214.26NT219
CAS:<p>NT219 is a dual inhibitor of insulin receptor substrate 1/2 (IRS1/2) and STAT3 that enhances the aggregation of misfolded prion proteins NT219 Effects.</p>Fórmula:C16H14BrNO5SPureza:98.06% - 99.72%Cor e Forma:SolidPeso molecular:412.26
