Ubiquitinação
Os inibidores de ubiquitinação são compostos que interferem no processo de ubiquitinação, onde as proteínas são marcadas com moléculas de ubiquitina para degradação pelo proteassoma. Esses inibidores são críticos para o estudo da renovação de proteínas, transdução de sinais e regulação de vários processos celulares. A ubiquitinação desempenha um papel fundamental em muitas doenças, incluindo câncer, distúrbios neurodegenerativos e disfunções do sistema imunológico. Ao modular a ubiquitinação, esses inibidores podem fornecer insights sobre os mecanismos das doenças e abrir novas vias para intervenções terapêuticas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de ubiquitinação de alta qualidade para apoiar sua pesquisa em biologia celular, proteômica e descoberta de medicamentos.
Subcategorias de "Ubiquitinação"
Foram encontrados 69 produtos para "Ubiquitinação".
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FX12
CAS:FX12 acts as a selective inhibitor and degrader of the RNF5 E3 ubiquitin ligase. It directly binds to RNF5, inhibiting its E3 activity in vitro and facilitates the proteasomal degradation of RNF5 in cells through ERAD.Fórmula:C10H8O4SCor e Forma:SolidPeso molecular:224.23Smurf1-IN-1
CAS:Smurf1-IN-1, a selective E3 ubiquitin protein ligase 1 (SMURF1) inhibitor, exhibits oral activity with an IC50 of 92 nM and demonstrates considerable efficacyFórmula:C24H29ClN6O2Pureza:98%Cor e Forma:SolidPeso molecular:468.98DT204
CAS:DT204 is an SCFSkp2 inhibitor that reduces the binding of Skp2 to Cullin-1 and Commd1. It can be used to study multiple myeloma.Fórmula:C19H13BrClNO5SPureza:99.17%Cor e Forma:SolidPeso molecular:482.73CB-5339
CAS:p97-IN-1 is a potent inhibitor of p97 with an IC 50 <30 nM [1].Fórmula:C24H24N6OPureza:97.66%Cor e Forma:SolidPeso molecular:412.49Ubiquitination-IN-1
CAS:Ubiquitination-IN-1 is an inhibitor of ubiquitination and Cksl-Skp2 protein-protein interaction (IC50: 0.17 μM).Fórmula:C21H14F3N3O2SPureza:98.39% - 99.88%Cor e Forma:SolidPeso molecular:429.42Ref: TM-T13244
5mg66,00€1mL*10mM (DMSO)73,00€10mg90,00€25mg165,00€50mg264,00€100mg395,00€500mg888,00€UPCDC30766
CAS:UPCDC30766, a potent allosteric inhibitor of p97, exhibits an IC50 of 12 nM and is applicable for colon cancer research [1].Fórmula:C30H32F2N6O3SPureza:98%Cor e Forma:SolidPeso molecular:594.68Cbl-b-IN-8
CAS:Cbl-b-IN-8 (Compound 293) is an inhibitor of both casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting half maximal inhibitory concentrations (IC50s) of 5Fórmula:C35H44F3N7O3Pureza:98%Cor e Forma:SolidPeso molecular:667.76DI-591
CAS:DI-591 selectively inhibits DCN1-UBC12 interaction and cullin 3 neddylation.Fórmula:C31H47N5O4SCor e Forma:White SolidPeso molecular:585.80Cbl-b-IN-13
CAS:Cbl-b-IN-13 (Example 520) is a potent Cbl-b inhibitor exhibiting an IC50 of less than 100 nM and is capable of activating T-cells [1].Fórmula:C29H30F3N5O2Pureza:98%Cor e Forma:SolidPeso molecular:537.58Cbl-b-IN-6
CAS:Cbl-b-IN-6 (Compound 246) is an inhibitor of both casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting inhibitory half-maximal inhibitory concentrations (Fórmula:C30H32F5N5OPureza:98%Cor e Forma:SolidPeso molecular:573.6Cbl-b-IN-10
CAS:Cbl-b-IN-10 (Compound 463) is a potent inhibitor of both casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting half-maximal inhibitory concentrations (Fórmula:C31H37F3N6OPureza:98%Cor e Forma:SolidPeso molecular:566.66PYZD-4409
CAS:PYZD-4409 is a selective UBA1 inhibitor with an IC50 of 20 μM.Fórmula:C14H7ClFN3O5Pureza:99.71%Cor e Forma:SolidPeso molecular:351.67Cbl-b-IN-9
CAS:Cbl-b-IN-9 (Compound 300) is an inhibitor targeting casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting potent inhibitory activity with half-maximalFórmula:C30H33F3N6O2Pureza:98%Cor e Forma:SolidPeso molecular:566.62CC0651
CAS:CC0651 is a highly selective allosteric inhibitor of human Cdc34 ubiquitin-conjugating enzyme (UCE), inhibiting p27 Kip1 ubiquitination (IC50=1.72 μM).Fórmula:C20H21Cl2NO6Pureza:99.03%Cor e Forma:White SolidPeso molecular:442.29Cbl-b-IN-12
CAS:Cbl-b-IN-12 (Example 10) is an inhibitor of casitas B-lineage lymphoma-b (CBL-B), demonstrating a half-maximal inhibitory concentration (IC50) of less than 100Fórmula:C28H29F3N6O2Pureza:98%Cor e Forma:SolidPeso molecular:538.56Cbl-b-IN-7
CAS:Cbl-b-IN-7 (Compound 248) is an inhibitor of casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting inhibitory half-maximal inhibitory concentrations (IC50sFórmula:C29H31F4N5O2Pureza:98%Cor e Forma:SolidPeso molecular:557.58Skp2 inhibitor 2
CAS:Skp2 inhibitor 2 (14f) impedes the F-box protein S-phase kinase-associated protein 2 (Skp2), demonstrating an IC50 of 10.2 μM against Skp2-Cks1.Fórmula:C27H32N4OPureza:98%Cor e Forma:SolidPeso molecular:428.57Cbl-b-IN-11
CAS:Cbl-b-IN-11 (Compound 466) is an inhibitor of both casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting half-maximal inhibitory concentrations (IC50s) ofFórmula:C31H35F5N6OPureza:98%Cor e Forma:SolidPeso molecular:602.64UC-764864
CAS:UC-764864, a UBE2N inhibitor, impedes the enzymatic activity of UBE2N and exhibits cytotoxic effects through the disruption of UBE2N-dependent signaling inFórmula:C19H18N2OSPureza:99.3%Cor e Forma:SolidPeso molecular:322.42SPOP-IN-2
CAS:SPOP-IN-2 (Compound E1) is a potent inhibitor of speckle-type POZ protein (SPOP), with an IC50 of 0.58 μM. It disrupts the interaction between SPOP and substrates and selectively inhibits the proliferation of clear cell renal cell carcinoma (ccRCC).Fórmula:C15H13ClN2O5SCor e Forma:SolidPeso molecular:368.79
