Ubiquitinação
Os inibidores de ubiquitinação são compostos que interferem no processo de ubiquitinação, onde as proteínas são marcadas com moléculas de ubiquitina para degradação pelo proteassoma. Esses inibidores são críticos para o estudo da renovação de proteínas, transdução de sinais e regulação de vários processos celulares. A ubiquitinação desempenha um papel fundamental em muitas doenças, incluindo câncer, distúrbios neurodegenerativos e disfunções do sistema imunológico. Ao modular a ubiquitinação, esses inibidores podem fornecer insights sobre os mecanismos das doenças e abrir novas vias para intervenções terapêuticas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de ubiquitinação de alta qualidade para apoiar sua pesquisa em biologia celular, proteômica e descoberta de medicamentos.
Subcategorias de "Ubiquitinação"
Foram encontrados 65 produtos para "Ubiquitinação".
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CB-5083
CAS:CB-5083 is a potent, selective, and orally bioavailable p97 AAA ATPase inhibitor ( IC50=11 nM).Fórmula:C24H23N5O2Pureza:95.95% - 99.92%Cor e Forma:SolidPeso molecular:413.47Ref: TM-T6796
1mg43,00€2mg56,00€1mL*10mM (DMSO)92,00€5mg93,00€10mg130,00€25mg281,00€50mg444,00€100mg650,00€500mg1.369,00€NMS-873
CAS:NMS-873 is a potent, selective allosteric VCP/p97 inhibitor.Fórmula:C27H28N4O3S2Pureza:99.05% - 99.85%Cor e Forma:SolidPeso molecular:520.67ML240
CAS:ML240 is a selective, ATP-competitive p97 inhibitor.Fórmula:C23H20N6OPureza:99.73% - >99.99%Cor e Forma:White SolidPeso molecular:396.44Ref: TM-T3535
1mg35,00€2mg50,00€5mg77,00€1mL*10mM (DMSO)84,00€10mg105,00€25mg178,00€50mg295,00€100mg477,00€200mg677,00€ML241 hydrochloride
CAS:ML241 is a potent and selective inhibitors of p97 ATPase.ML241 inhibits degradation of a p97-dependent but not a p97-independent proteasome substrate in a dual-Fórmula:C23H25ClN4OPureza:99.91% - 99.97%Cor e Forma:SolidPeso molecular:408.92MID-1
CAS:MID-1 is an inhibitor of MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) interaction.Fórmula:C12H11N3O4SPureza:99.39%Cor e Forma:SolidPeso molecular:293.3Ref: TM-T8773
1mg52,00€5mg92,00€1mL*10mM (DMSO)103,00€10mg138,00€25mg245,00€50mg363,00€100mg515,00€200mg700,00€WSB1 Degrader 1
CAS:WSB1 Degrader 1 is a potent, orally active degrader of WD repeat and SOCS box-containing 1, exhibiting anti-cancer metastatic effects.Fórmula:C21H22N2O2Pureza:98.57%Cor e Forma:SolidPeso molecular:334.41PR-619
CAS:PR-619 (2,6-Diamino-3,5-dithiocyanopyridine) is a DUB inhibitor. PR-619 induces endoplasmic reticulum stress and activates autophagy. Cost-effective and quality-assured.Fórmula:C7H5N5S2Pureza:97.25% - >99.99%Cor e Forma:White SolidPeso molecular:223.28Skp2 Inhibitor C1
CAS:Skp2 Inhibitor C1 (SKPin C1)(SKPin C1) is a specific small molecule inhibitor of Skp2-mediated p27 degradation.Fórmula:C18H13BrN2O4S2Pureza:97.36%Cor e Forma:SolidPeso molecular:465.34Ref: TM-T4253
2mg34,00€5mg52,00€1mL*10mM (DMSO)54,00€10mg85,00€25mg164,00€50mg264,00€100mg386,00€200mg537,00€BC-1382
CAS:BC-1382 is a potent ubiquitin E3 ligase HECTD2 inhibitor that specificly disrupts the HECTD2/PIAS1 interaction(IC50 of 5 nM).Fórmula:C23H29N3O5SPureza:99.15% - 99.94%Cor e Forma:SolidPeso molecular:459.56Ref: TM-T8564
1mg81,00€5mg170,00€1mL*10mM (DMSO)240,00€10mg250,00€25mg505,00€50mg730,00€100mg1.018,00€200mg1.369,00€ML241
CAS:ML241 is a potent and selective inhibitors of p97 ATPase.Fórmula:C23H24N4OPureza:98%Cor e Forma:SolidPeso molecular:372.46COH000
CAS:COH000 is a covalent and irreversible inhibitor of small ubiquitin-like modifier (SUMO)-activating enzyme and inhibited SUMOylation (IC50: ~ 0.2 μM in vitro).Fórmula:C25H25NO5Pureza:99.23%Cor e Forma:SolidPeso molecular:419.47Ref: TM-T5199
1mg170,00€5mg371,00€1mL*10mM (DMSO)409,00€10mg537,00€25mg964,00€50mg1.333,00€100mg1.882,00€LANOSTEROL
CAS:Lanosterol (3β-Hydroxy-8,24-lanostadiene) is a tetracyclic triterpenoid which is the compound from which all steroids are derived.Fórmula:C30H50OPureza:97.99% - 99.67%Cor e Forma:SolidPeso molecular:426.72GS143
CAS:GS143 inhibits IκBα ubiquitination (IC50=5.2μM), suppresses NF-κB, and has anti-asthma properties without hindering proteasomes.Fórmula:C28H19FN2O4Pureza:97.67%Cor e Forma:SolidPeso molecular:466.46Ref: TM-T25465
2mg35,00€5mg55,00€1mL*10mM (DMSO)57,00€10mg87,00€25mg161,00€50mg245,00€100mg358,00€200mg520,00€Subasumstat
CAS:Subasumstat (TAK-981) is a selective the SUMOylation enzymatic cascade inhibitor, has potential immune-activating and antineoplastic activities.Fórmula:C25H28ClN5O5S2Pureza:97.02% - 98.22%Cor e Forma:Yellow SolidPeso molecular:578.1DKM 2-93
CAS:DKM 2-93 is a relatively selective inhibitor of UBA5(IC50 : 430 μM).Fórmula:C11H14ClNO3Pureza:98.37% - 99.39%Cor e Forma:White SolidPeso molecular:243.69TCID
CAS:TCID (UCH-L3 Inhibitor)(IC50=0.6 μM) is a DUB inhibitor of ubiquitin C-terminal hydrolase L3. It has the 125-fold selectivity to L1.Fórmula:C9H2Cl4O2Pureza:98.87% - 99.34%Cor e Forma:SolidPeso molecular:283.92BI8626
CAS:BI8626 is a ubiquitin ligase inhibitor with protective effects against spontaneous dry syndrome in NOD/ShiLtj mice and inhibits the proliferation of CD4 T cellsFórmula:C25H28N8Pureza:98.66%Cor e Forma:Yellow ViscousPeso molecular:440.54Ref: TM-T14569
1mg87,00€5mg178,00€1mL*10mM (DMSO)203,00€10mg260,00€25mg462,00€50mg655,00€100mg887,00€200mg1.198,00€FX12
CAS:FX12 acts as a selective inhibitor and degrader of the RNF5 E3 ubiquitin ligase. It directly binds to RNF5, inhibiting its E3 activity in vitro and facilitates the proteasomal degradation of RNF5 in cells through ERAD.Fórmula:C10H8O4SCor e Forma:SolidPeso molecular:224.23Smurf1-IN-1
CAS:Smurf1-IN-1, a selective E3 ubiquitin protein ligase 1 (SMURF1) inhibitor, exhibits oral activity with an IC50 of 92 nM and demonstrates considerable efficacyFórmula:C24H29ClN6O2Pureza:98%Cor e Forma:SolidPeso molecular:468.98DT204
CAS:DT204 is an SCFSkp2 inhibitor that reduces the binding of Skp2 to Cullin-1 and Commd1. It can be used to study multiple myeloma.Fórmula:C19H13BrClNO5SPureza:99.17%Cor e Forma:SolidPeso molecular:482.73
