Ubiquitinação
Os inibidores de ubiquitinação são compostos que interferem no processo de ubiquitinação, onde as proteínas são marcadas com moléculas de ubiquitina para degradação pelo proteassoma. Esses inibidores são críticos para o estudo da renovação de proteínas, transdução de sinais e regulação de vários processos celulares. A ubiquitinação desempenha um papel fundamental em muitas doenças, incluindo câncer, distúrbios neurodegenerativos e disfunções do sistema imunológico. Ao modular a ubiquitinação, esses inibidores podem fornecer insights sobre os mecanismos das doenças e abrir novas vias para intervenções terapêuticas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de ubiquitinação de alta qualidade para apoiar sua pesquisa em biologia celular, proteômica e descoberta de medicamentos.
Subcategorias de "Ubiquitinação"
Foram encontrados 106 produtos de "Ubiquitinação"
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Skp2 inhibitor 3
<p>Skp2 inhibitor 3 (E35), a potent antitumor agent, acts as a robust inhibitor of S-phase kinase-associated protein 2 (SKP2) with an IC50 of 4.86 μM for Skp2-Cks1 binding. It significantly suppresses colony formation and migration, while inducing cell cycle arrest in the S-phase.</p>Cor e Forma:Odour SolidUP158
CAS:<p>UP158 enhances ATPase activity and stimulates valosin-containing protein (VCP), with an EC50 of 2.57 μM.</p>Fórmula:C17H17ClN4O2Cor e Forma:SolidPeso molecular:344.8E3 ligase Ligand 41
CAS:<p>E3 Ligase Ligand 41 (Compound SI-13) serves as a ligand for the E3 ubiquitin ligase DCAF16. It is designed to connect with SLF through a linker, enabling the formation of KB03-SLF.</p>Fórmula:C13H12ClF3N2O4Cor e Forma:SolidPeso molecular:352.69RNF5 agonist 1
CAS:<p>RNF5 agonist 1 (analog-1), a structural analog of the RNF5 inhibitor inh-02, is a potent RNF5 agonist. In CFBE41o- cells expressing F508del-CFTR, RNF5 agonist 1 enhances the ubiquitination of ATG4B.</p>Fórmula:C22H18N4SCor e Forma:SolidPeso molecular:370.47STD1T
CAS:<p>STD1T is a USP2a inhibitor with anticancer activity that reduces levels of the cell cycle protein D1 protein in HCT116 colon cancer cells.</p>Fórmula:C19H19N3O4S2Pureza:98.77%Cor e Forma:SolidPeso molecular:417.5MSC1094308
CAS:<p>MSC1094308 is a reversible, non-ATP-competitive inhibitor targeting type II AAA ATPase (VCP/p97) and type I AAA ATPase (VPS4B) and affects protein degradation.</p>Fórmula:C29H29F3N2Cor e Forma:SolidPeso molecular:462.55USP8-IN-1
CAS:<p>USP8-IN-1 is an inhibitor of USP8 with an IC 50 of 1.9 μM. USP8-IN-1 inhibits H1975 cell growth with a GI 50 of 82.04 μM [1].</p>Fórmula:C18H21N5O3SPureza:99.07%Cor e Forma:SoildPeso molecular:387.46ML241 hydrochloride
CAS:<p>ML241 is a potent and selective inhibitors of p97 ATPase.ML241 inhibits degradation of a p97-dependent but not a p97-independent proteasome substrate in a dual-</p>Fórmula:C23H25ClN4OPureza:99.91% - 99.96%Cor e Forma:SolidPeso molecular:408.92DUB-IN-3
CAS:<p>DUB-IN-3 is a potent deubiquitinase (USP) enzyme inhibitor and the IC50 for USP8 is 0.56 μM.</p>Fórmula:C16H9N5OPureza:99.34%Cor e Forma:SolidPeso molecular:287.28USP25/28 inhibitor AZ1
CAS:<p>USP25/28 inhibitor AZ1 is a selective, orally active and non-competitive dual ubiquitin-specific protease USP25/28 inhibitor.Cost-effective and quality-assured.</p>Fórmula:C17H16BrF4NO2Pureza:99.79% - 99.79%Cor e Forma:SolidPeso molecular:422.21XL177A
CAS:<p>XL177A is a selective irreversible USP7 inhibitor(IC50 : 0.34 nM). XL177A elicits cancer cell killing through a p53-dependent mechanism.</p>Fórmula:C48H57ClN8O5Pureza:98.75%Cor e Forma:SolidPeso molecular:861.47ML240
CAS:<p>ML240 is a selective, ATP-competitive p97 inhibitor.</p>Fórmula:C23H20N6OPureza:99.73% - >99.99%Cor e Forma:SolidPeso molecular:396.44NSC632839
CAS:<p>NSC-632839 (Ubiquitin Isopeptidase Inhibitor II) is a nonselective isopeptidase inhibitor, which inhibits USP2 (EC50: 45±4 μM), USP7 (EC50: 37±1 μM), and SENP2</p>Fórmula:C21H22ClNOPureza:99.74% - 99.88%Cor e Forma:SolidPeso molecular:339.86Skp2 Inhibitor C1
CAS:<p>Skp2 Inhibitor C1 (SKPin C1)(SKPin C1) is a specific small molecule inhibitor of Skp2-mediated p27 degradation.</p>Fórmula:C18H13BrN2O4S2Pureza:97.36%Cor e Forma:SolidPeso molecular:465.34GNE-6640
CAS:<p>GNE-6640: non-covalent USP7 inhibitor; IC50s: 0.75 µM (full), 0.43 µM (catalytic), 20.3 µM (USP43), 0.23 µM (Ub-MDM2).</p>Fórmula:C20H18N4OPureza:98.64%Cor e Forma:SolidPeso molecular:330.38USP7/USP47 inhibitor
CAS:<p>USP7/USP47 inhibitor (USP7/47 inhibitor-1) is a selective ubiquitin-specific protease 7/47 (USP7/USP47) inhibitor, with EC50s of 0.42 μM and 1.0 μM,</p>Fórmula:C18H11Cl2N3O3S3Pureza:98.5% - 98.71%Cor e Forma:SolidPeso molecular:484.4SJB2-043
CAS:SJB2-043 is an inhibitor of USP1-UAF1 ( IC50 : 544 nM).Fórmula:C17H9NO3Pureza:98.44%Cor e Forma:SolidPeso molecular:275.26NMS-873
CAS:<p>NMS-873 is a potent, selective allosteric VCP/p97 inhibitor.</p>Fórmula:C27H28N4O3S2Pureza:99.05% - 99.85%Cor e Forma:SolidPeso molecular:520.67USP7-IN-8
CAS:Benzamide, 4-[6-amino-4-ethyl-5-(4-hydroxyphenyl)-3-pyridinyl]-N-methyl- is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM.Fórmula:C21H21N3O2Pureza:99.31%Cor e Forma:SolidPeso molecular:347.41DUB-IN-2
CAS:<p>Dub-in-2, with an IC50 value of 0.28 for USP8, is an effective deubiquitinase inhibitor.</p>Fórmula:C15H9N5OPureza:98.96%Cor e Forma:SolidPeso molecular:275.26
