Autofagia
Os inibidores da autofagia têm como alvo o processo celular de autofagia, que envolve a degradação e reciclagem de componentes celulares através dos lisossomas. A autofagia é um mecanismo crítico para a manutenção da homeostase celular, mas sua desregulação está implicada em várias doenças, incluindo câncer, neurodegeneração e infecções. Os inibidores da autofagia podem bloquear este processo, tornando-os ferramentas valiosas para estudar o papel da autofagia nas doenças e desenvolver estratégias terapêuticas. Na CymitQuimica, oferecemos inibidores da autofagia para apoiar sua pesquisa em biologia celular, oncologia e doenças neurodegenerativas.
Foram encontrados 1424 produtos de "Autofagia"
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sbp-7455
CAS:<p>SBP-7455 potently inhibited ULK1/2 enzymatic activity in vitro and in cells, reduced the viability of TNBC cells and had oral bioavailability in mice.</p>Fórmula:C16H17F3N4O2Pureza:97.90% - 99.842%Cor e Forma:SolidPeso molecular:354.33Kaempferol
CAS:<p>Kaempferol (Robigenin) is a natural flavonoid and an inverse agonist of ERRα and ERRγ.</p>Fórmula:C15H10O6Pureza:98% - 99.41%Cor e Forma:Yellow Needles From Alcohol And Water SolidPeso molecular:286.24Amsacrine hydrochloride
CAS:<p>Amsacrine hydrochloride (acridinyl anisidide hydrochloride) is topoisomerase II inhibitor , is used in the treatment of acute myelogenous leukemia.</p>Fórmula:C21H20ClN3O3SPureza:99.05% - 99.92%Cor e Forma:SolidPeso molecular:429.92Typhaneoside
CAS:<p>Typhaneoside (Aervitrin) is a flavonoid glycoside plant extract with potential ability to treat primary dysmenorrhea through the Shaofu Zhuyu decoction.</p>Fórmula:C34H42O20Pureza:98.92% - 99.95%Cor e Forma:SolidPeso molecular:770.69DPN
CAS:<p>DPN (Diarylpropionitrile) is an selective agonist of estrogen receptor β (ERβ) .</p>Fórmula:C15H13NO2Pureza:99.01%Cor e Forma:Off-White SolidPeso molecular:239.27Pantoprazole
CAS:<p>Pantoprazole (BY1023) is a proton pump inhibitor used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux</p>Fórmula:C16H15F2N3O4SPureza:99.28% - 99.63%Cor e Forma:Almost White SolidPeso molecular:383.37AS-605240
CAS:<p>AS-605240 is an effective and specific inhibitor of PI3Kγ (IC50/Ki: 87.8 nM).</p>Fórmula:C12H7N3O2SPureza:97% - 99.91%Cor e Forma:SolidPeso molecular:257.27Nutlin-3a
CAS:<p>Nutlin-3a is the active enantiomer of Nutlin-3, an MDM2 antagonist that inhibits MDM2-p53 interaction. Nutlin-3a has antitumor activity. Cost-effective and quality-assured.</p>Fórmula:C30H30Cl2N4O4Pureza:95.62% - 99.71%Cor e Forma:SolidPeso molecular:581.49FIPI
CAS:<p>FIPI, a halopemide derivative, strongly blocks PLD1 and PLD2 (IC50s: 25 nM, 20 nM) and hinders PLD-mediated cell activity.</p>Fórmula:C23H24FN5O2Pureza:97.21% - 98.68%Cor e Forma:SolidPeso molecular:421.47Sirtinol
CAS:<p>Sirtinol is a selective SIRT1/2 inhibitor (IC50: 131/38 μM).</p>Fórmula:C26H22N2O2Pureza:97.12% - 99.96%Cor e Forma:SolidPeso molecular:394.47Quercitrin
CAS:<p>Quercitrin (3-rhamnosyl quercetin) is a plant-derived flavonoid compound, displays antioxidant and anti-inflammatory activities.</p>Fórmula:C21H20O11Pureza:98.89% - 99.66%Cor e Forma:Yellow Crystals From Dil Methanol Or Ethanol SolidPeso molecular:448.38Embelin
CAS:<p>Embelin (Embelic acid), isolated from the Japanese Ardisia herb, is an inhibitor of the X-linked inhibitor of apoptosis (IC50: 4.1 uM).</p>Fórmula:C17H26O4Pureza:97.07% - 99.88%Cor e Forma:SolidPeso molecular:294.39GNE-9605
CAS:<p>GNE-9605 is a highly effective, specifical, and brain-penetrant LRRK2 inhibitor (IC50: 19 nM).</p>Fórmula:C17H20ClF4N7OPureza:98.55% - 98.75%Cor e Forma:SolidPeso molecular:449.83PX-478
CAS:<p>PX-478 is a HIF-1α inhibitor with selectivity, oral activity, and blood-brain barrier permeability.</p>Fórmula:C13H20Cl4N2O3Pureza:97% - 99.79%Cor e Forma:SolidPeso molecular:394.12Rotenone
CAS:<p>Rotenone, a plant-derived insecticide, inhibits mitochondrial electron transport, found in Leguminosae.</p>Fórmula:C23H22O6Pureza:89.58% - 99.88%Cor e Forma:Less To Brownish Crystals Or A White To Brownish-White Crystalline Powder Has Neither Odor Nor Taste (Ntp 1992)Peso molecular:394.42Quisinostat dihydrochloride
CAS:<p>Quisinostat dihydrochloride (JNJ26854165(Quisinostat) 2HCl) 是一种有口服活性，高效的 pan-HDAC 抑制剂，具有广泛的抗肿瘤活性。它对 HDAC1、HDAC2、HDAC4、HDAC10和HDAC11 的IC50值分别为 0.11 nM、0.33 nM、0.64 nM、0.46 nM 和 0.37 nM。</p>Fórmula:C21H28Cl2N6O2Pureza:97.13%Cor e Forma:SolidPeso molecular:467.39Mdivi-1
CAS:<p>Mdivi-1 (Mitochondrial division inhibitor 1) is a mitochondrial division inhibitor that inhibits DRP1 and Dynamin I (IC50=1-10 μM).</p>Fórmula:C15H10Cl2N2O2SPureza:96.57% - 99.23%Cor e Forma:SolidPeso molecular:353.22SMER28
CAS:<p>SMER28 triggers autophagy in cells without mTOR, blocking amyloid beta buildup.</p>Fórmula:C11H10BrN3Pureza:99.94% - >99.99%Cor e Forma:SolidPeso molecular:264.12Rasagiline Mesylate
CAS:<p>Rasagiline Mesylate (AGN1135) is a novel MAO-B inhibitor, which can treat idiopathic Parkinson's disease.</p>Fórmula:C13H17NO3SPureza:99.33%Cor e Forma:White PowderPeso molecular:267.34LC3-mHTT-IN-AN1
CAS:<p>LC3-mHTT-IN-AN1 is a mHTT-LC3 linker compound that interacts with both mutant huntingtin protein (mHTT) and LC3B.</p>Fórmula:C15H9Br2NO3Pureza:97.26%Cor e Forma:SolidPeso molecular:411.04Alisertib
CAS:<p>Alisertib (MLN 8237) is a specific Aurora A inhibitor (IC50: 1.2 nM). The selectivity of Alisertib(MLN 8237) is >200-fold higher for Aurora A than Aurora B.</p>Fórmula:C27H20ClFN4O4Pureza:98.31% - >99.99%Cor e Forma:SolidPeso molecular:518.92Afatinib
CAS:<p>Afatinib (BIBW 2992) is an irreversible and orally EGFR family inhibitor that inhibits EGFR and HER2. Afatinib has antitumor activity. Cost effective and quality assured.</p>Fórmula:C24H25ClFN5O3Pureza:98.56% - 99.9%Cor e Forma:Off-White SolidPeso molecular:485.94Tubastatin A
CAS:<p>Tubastatin A: Selective HDAC6 inhibitor, IC50 of 15 nM, 1000x less effective on other isozymes except HDAC8.</p>Fórmula:C20H21N3O2Pureza:97.22% - 99.51%Cor e Forma:SolidPeso molecular:335.4Mycro 3
CAS:<p>Mycro 3 is potent and selective for c-Myc in whole cell assays.</p>Fórmula:C24H17ClF2N6O4Pureza:99.51% - 99.61%Cor e Forma:SolidPeso molecular:526.88Neferine
CAS:<p>Neferine: anti-tumor, enhances DOX efficacy, prevents diabetic vasculopathy; mediates via CYP3A4, GSH depletion, blocks ROS/Akt/NF-κB.</p>Fórmula:C38H44N2O6Pureza:98.81% - 99.65%Cor e Forma:SolidPeso molecular:624.773-Bromopyruvic acid
CAS:<p>3-Bromopyruvic acid (Hexokinase II Inhibitor II, 3-BP) is a hexokinase II inhibitor with Ki of 2.4 mM for glycolysis/hexokinase inhibition.</p>Fórmula:C3H3BrO3Pureza:95% - 99.644%Cor e Forma:White To Pale Yellow Crystalline PowderPeso molecular:166.96MK-2206 dihydrochloride
CAS:<p>MK-2206 dihydrochloride (MK-2206 2HCl) is a variant Akt inhibitor that inhibits Akt1, Akt2, and Akt3 (IC50=8/12/65 nM) with orally active, highly potent and</p>Fórmula:C25H23Cl2N5OPureza:99.228% - 99.94%Cor e Forma:SolidPeso molecular:480.39Diosgenin glucoside
CAS:<p>Diosgenin glucoside (Trillin) and other synthetic glycosides with similar activities may be of use in the management of hypercholesterolemia and atherosclerosis</p>Fórmula:C33H52O8Pureza:97.17% - 99.44%Cor e Forma:SolidPeso molecular:576.76Fangchinoline
CAS:<p>Fangchinoline (Tetrandrine B) is extracted from Stephania tetrandra S. Moore.</p>Fórmula:C37H40N2O6Pureza:99.86% - >99.99%Cor e Forma:SolidPeso molecular:608.72Schisandrol B
CAS:<p>Schisandrol B fights neuroinflammation, liver/renal damage, and reduces cell growth via multiple signaling pathways.</p>Fórmula:C23H28O7Pureza:99.14% - 99.95%Cor e Forma:SolidPeso molecular:416.46AZD 6482
CAS:<p>AZD 6482 (KIN-193) is a potent and selective inhibitor of p110β and PI3Kβ with IC50 values of 0.69nM and 10nM.Cost-effective and quality-assured.</p>Fórmula:C22H24N4O4Pureza:99.79% - 99.95%Cor e Forma:SolidPeso molecular:408.45Brefeldin A
CAS:<p>Brefeldin A (Cyanein) belongs to the class of macrolide antibiotics and is an ATPase inhibitor (IC50=0.2 μM).</p>Fórmula:C16H24O4Pureza:96.45% - 99.89%Cor e Forma:White SolidPeso molecular:280.36Dioscin
CAS:<p>Dioscin (Collettiside III) is a saponin with antitumor activities.</p>Fórmula:C45H72O16Pureza:99.85% - 99.87%Cor e Forma:SolidPeso molecular:869.04GLPG1837
CAS:<p>GLPG1837 (ABBV-974) is an effective CFTR potentiator, with EC50s of 3 nM and 339 nM for F508del and G551D CFTR, respectively.</p>Fórmula:C16H20N4O3SPureza:99.64% - 99.91%Cor e Forma:SolidPeso molecular:348.42ABT-737
CAS:<p>ABT-737 is a BH3 mimetic and an inhibitor of Bcl-2, Bcl-xL, and Bcl-w. ABT-737 exhibits antitumor activity and anti-aging activity. Cost-effective and quality-assured.</p>Fórmula:C42H45ClN6O5S2Pureza:98.15% - >99.99%Cor e Forma:SolidPeso molecular:813.43Neflamapimod
CAS:<p>Neflamapimod (VX-745) , a specific and effective inhibitor of p38α(IC50=10 nM), is 22-fold greater specificity against p38β and no inhibition activity to p38γ.</p>Fórmula:C19H9Cl2F2N3OSPureza:97.88% - 99.75%Cor e Forma:SolidPeso molecular:436.26Turofexorate Isopropyl
CAS:<p>Turofexorate Isopropyl (XL335) is a potent, selective, and orally bioavailable FXR agonist with EC50 of 4 nM</p>Fórmula:C25H24F2N2O3Pureza:98.55% - 99.73%Cor e Forma:SolidPeso molecular:438.47Calcimycin
CAS:<p>Calcimycin (A-23187) is a polyether antibiotic that transports Ca²⁺, uncouples phosphorylation, and inhibits ATPase in mitochondria.</p>Fórmula:C29H37N3O6Pureza:98%Cor e Forma:SolidPeso molecular:523.62Vandetanib
CAS:<p>Vandetanib (ZD6474) is a potent inhibitor of VEGFR2 (IC50: 40 nM). It also inhibits VEGFR3 and EGFR.</p>Fórmula:C22H24BrFN4O2Pureza:99.7% - >99.99%Cor e Forma:White SolidPeso molecular:475.35SGI-1776
CAS:<p>SGI-1776 (Pim-Kinase Inhibitor IX) has been used in trials studying the treatment of Prostate Cancer, Non-Hodgkins Lymphoma, and Relapsed/Refractory Leukemias.</p>Fórmula:C20H22F3N5OPureza:99.3% - >99.99%Cor e Forma:SolidPeso molecular:405.42Carbamazepine
CAS:<p>Carbamazepine: a tricyclic with anticonvulsant and analgesic effects, treats trigeminal neuralgia.</p>Fórmula:C15H12N2OPureza:99.78% - 99.79%Cor e Forma:SolidPeso molecular:236.27Milciclib
CAS:<p>Milciclib (PHA-848125) is a potent CDK2 inhibitor with a 45 nM IC50, selective over CDK1/2/4/5/7. In Phase 2 trials.</p>Fórmula:C25H32N8OPureza:99.28%Cor e Forma:SolidPeso molecular:460.57STF-62247
CAS:<p>STF-62247 is TGN inhibitor with IC50 of 0.625 μM and 16 μM in RCC4 and RCC4/VHL cells, respectively.</p>Fórmula:C15H13N3SPureza:99.6% - 99.67%Cor e Forma:SolidPeso molecular:267.35Fenretinide
CAS:<p>Fenretinide (4-HPR) is an orally-active synthetic retinoid derivative with potential antineoplastic and chemopreventive activities.</p>Fórmula:C26H33NO2Pureza:98% - 99.68%Cor e Forma:Yellow PowderPeso molecular:391.55Isoalantolactone
CAS:<p>Isoalantolactone (Isohelenin), isolated from Inula spp., can inhibit the growth of several types of Y cells.</p>Fórmula:C15H20O2Pureza:99.75% - 99.94%Cor e Forma:SolidPeso molecular:232.32CD437
CAS:<p>CD437 (AHPN) is a specifc Retinoic Acid Receptor γ (RARγ) agonist.</p>Fórmula:C27H26O3Pureza:98.92% - 99.63%Cor e Forma:SolidPeso molecular:398.49Zoledronic acid monohydrate
CAS:<p>Zoledronic acid monohydrate (CGP 42446) is a synthetic imidazole bisphosphonate analog with anti-bone-resorption activity.</p>Fórmula:C5H12N2O8P2Pureza:99.91%Cor e Forma:White To Off-White PowderPeso molecular:290.1Betulinic acid
CAS:<p>Betulinic acid, a lupane-type triterpene from white birch bark, has antiretroviral, antimalarial, anti-inflammatory, and anticancer properties.</p>Fórmula:C30H48O3Pureza:99.12% - 99.7%Cor e Forma:White Crystalline PowderPeso molecular:456.7ISOGINKGETIN
CAS:<p>ISOGINKGETIN (4',4'''-Dimethylamentoflavone), a compound derived from the leaves of Ginkgo biloba, to up-regulate adiponectin secretion.</p>Fórmula:C32H22O10Pureza:98% - 99.72%Cor e Forma:SolidPeso molecular:566.51FERULIC ACID METHYL ESTER
CAS:<p>FERULIC ACID METHYL ESTER (Methyl ferulate) is a hydroxycinnamic acid that is abundant in plants. FERULIC ACID METHYL ESTER has antioxidant activities.</p>Fórmula:C11H12O4Pureza:99.66% - 99.95%Cor e Forma:SolidPeso molecular:208.21Wogonoside
CAS:<p>Wogonoside (Wogonin 7-O-glucuronide) acts as a positive allosteric modulator of the benzodiazepine site of the GABAA receptor.</p>Fórmula:C22H20O11Pureza:98.24% - >99.99%Cor e Forma:SolidPeso molecular:460.39Oroxin B
CAS:<p>Oroxin B (Hypocretin-2) has antioxidant activity.</p>Fórmula:C27H30O15Pureza:98.22% - 99.81%Cor e Forma:SolidPeso molecular:594.52Topotecan
CAS:<p>Topotecan (NSC-609669) is a Topoisomerase I inhibitor,and is an antineoplastic agent used to treat ovarian cancer that works by inhibiting DNA topoisomerases.</p>Fórmula:C23H23N3O5Pureza:96.14% - 98.23%Cor e Forma:Light Yellow Needle Crystal Or Crystalline PowderPeso molecular:421.45Obatoclax Mesylate
CAS:<p>Obatoclax Mesylate (GX15-070) is a Bcl-2 antagonist (Ki: 0.22 μM) and can induce apoptosis with up-regulation of Bim, induced cytochrome c release, and</p>Fórmula:C20H19N3O·CH4O3SPureza:99.58% - 99.88%Cor e Forma:SolidPeso molecular:413.49LRRK2-IN-1
CAS:<p>LRRK2-IN-1 is an effective and selective LRRK2 inhibitor.</p>Fórmula:C31H38N8O3Pureza:98% - 98.82%Cor e Forma:SolidPeso molecular:570.69Cabazitaxel
<p>Cabazitaxel (XRP6258) is a taxane used for castration-resistant metastatic prostate cancer post-docetaxel failure.</p>Fórmula:C45H57NO14Pureza:98% - 99.93%Cor e Forma:SolidPeso molecular:835.93Daphnetin
CAS:<p>Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM),</p>Fórmula:C9H6O4Pureza:97.47% - 99.8%Cor e Forma:SolidPeso molecular:178.14H-89 dihydrochloride
CAS:<p>H-89 dihydrochloride (5-Isoquinolinesulfonamide) is a potent inhibitor of protein kinase A (PKA; IC50: 0.14 μM, Ki: 48 nM).</p>Fórmula:C20H20BrN3O2S·2HClPureza:98.22% - >99.99%Cor e Forma:SolidPeso molecular:519.28PD98059
CAS:<p>PD98059 is an MEK inhibitor that inhibits MEK1 and MEK2 (IC50=2/50 μM) and is non-ATP-competitive.</p>Fórmula:C16H13NO3Pureza:98.63% - >99.99%Cor e Forma:Yellow SolidPeso molecular:267.28ML327
CAS:<p>ML327 is a MYC blocker. ML327 can also de-repress E-cadherin transcription and reverse Epithelial-to-Mesenchymal Transition (EMT).</p>Fórmula:C19H18N4O4Pureza:98.47%Cor e Forma:SolidPeso molecular:366.37Chloroquine
CAS:<p>Chloroquine: antimalarial, anti-inflammatory, autophagy/TLRs inhibitor, treats arthritis, effective against COVID-19 in vitro. EC50: 1.13 μM.</p>Fórmula:C18H26ClN3Pureza:99.5% - 99.98%Cor e Forma:White To Slightly Yellow Crystalline Powder SolidPeso molecular:319.87Samotolisib
CAS:<p>Samotolisib (LY3023414) inhibits PI3K, DNA-PK, mTOR; tested for solid tumors including breast and colon cancer.</p>Fórmula:C23H26N4O3Pureza:98.41% - 99.69%Cor e Forma:SolidPeso molecular:406.48Sitagliptin phosphate
CAS:<p>Sitagliptin phosphate (MK-0431 phosphate) is a dipeptidyl peptidase-4 (DPP4) inhibitor.</p>Fórmula:C16H18F6N5O5PPureza:99.72% - 99.91%Cor e Forma:White SolidPeso molecular:505.31A-484954
CAS:<p>A-484954 (A 484954) is a highly specific eukaryotic elongation factor-2 (eEF2, IC50: 280 nM) inhibitor.</p>Fórmula:C13H15N5O3Pureza:97.47% - 99.86%Cor e Forma:SolidPeso molecular:289.29KN-92 phosphate
CAS:<p>KN-92 phosphate (KN92-H3PO4) is an inactive derivative of KN-93.</p>Fórmula:C24H28ClN2O7PSPureza:99.86%Cor e Forma:SolidPeso molecular:554.98Autophinib
CAS:<p>Autophinib is a potent autophagy inhibitor with a novel chemotype with IC50 values of 90 and 40 nM for autophagy in starvation induced autophagy assay and</p>Fórmula:C14H11ClN6O3Pureza:99.25% - 99.41%Cor e Forma:SolidPeso molecular:346.73Salvigenin
CAS:<p>Salvigenin is a potent hMAO-A inhibitor, has neuroprotective, antitumor and immunomodulatory effects.</p>Fórmula:C18H16O6Pureza:99.17% - 99.78%Cor e Forma:SolidPeso molecular:328.32Wortmannin
CAS:<p>Wortmannin (SL-2052) is a PI3K inhibitor (IC50=3 nM) that is covalent and irreversible.</p>Fórmula:C23H24O8Pureza:95.84% - 99.76%Cor e Forma:White SolidPeso molecular:428.43Leonurine
CAS:<p>Leonurine (SCM-198) is an alkaloid that has been found in H. leonuri and with anti-oxidative and anti-inflammatory.</p>Fórmula:C14H21N3O5Pureza:98.55%Cor e Forma:White Crystalline PowderPeso molecular:311.33GW786034B
CAS:<p>Pazopanib HCl (Votrient) inhibits VEGFR1-3, PDGFR, FGFR, c-Kit, c-Fms with IC50 range 10-146 nM in cell-free assays.</p>Fórmula:C21H23N7O2S·HClPureza:99.87%Cor e Forma:SolidPeso molecular:473.98PF-04691502
CAS:<p>PF-04691502 is a potent and selective inhibitor of PI3K and mTOR kinases with antitumor activity.</p>Fórmula:C22H27N5O4Pureza:96.27% - ≥95%Cor e Forma:SolidPeso molecular:425.48Losmapimod
CAS:<p>Losmapimod (GSK-AHAB) (GW856553X; SB856553; GSK-AHAB) is a specific, potent, and orally active p38 MAPK inhibitor (pKi: 8.1/7.6 for p38α/β).</p>Fórmula:C22H26FN3O2Pureza:98.35% - 99.89%Cor e Forma:SolidPeso molecular:383.46DC661
CAS:<p>DC661 is a palmitoyl-protein thioesterase 1 (PPT1) inhibitor that acts as an anti-lysosomal agent by inhibiting autophagy, demonstrating anti-cancer activity.</p>Fórmula:C31H39Cl2N5Pureza:99.07%Cor e Forma:SolidPeso molecular:552.58Linifanib
CAS:<p>Linifanib (AL-39324) (ABT-869) is a novel, potent ATP-competitive VEGFR/PDGFR inhibitor for KDR (IC50: 4 nM), CSF-1R (IC50: 3 nM), Flt-1/3 (IC50: 3/4 nM) and</p>Fórmula:C21H18FN5OPureza:98% - 98.24%Cor e Forma:SolidPeso molecular:375.4Indophagolin
CAS:<p>Indophagolin: autophagy inhibitor, IC50 140 nM; blocks P2X4, P2X1, P2X3 receptors, IC50s 2.71, 2.40, 3.49 μM.</p>Fórmula:C19H15BrClF3N2O3SPureza:99.76%Cor e Forma:SolidPeso molecular:523.75Saracatinib
CAS:<p>Saracatinib (AZD0530) (AZD0530) is an effective Src inhibitor (IC50: 2.7 nM), and effective to Lck, Fyn, Lyn, Blk, Fgr and c-Yes.</p>Fórmula:C27H32ClN5O5Pureza:98% - 99.63%Cor e Forma:SolidPeso molecular:542.03Pamapimod
CAS:<p>Pamapimod (R1503) (R-1503, Ro4402257) is a novel, selective inhibitor of p38 mitogen-activated protein kinase.</p>Fórmula:C19H20F2N4O4Pureza:99.52% - 99.99%Cor e Forma:SolidPeso molecular:406.38Crizotinib hydrochloride
CAS:<p>Crizotinib hydrochloride (PF-02341066 hydrochloride) is a novel inhibitor of anaplastic lymphoma kinase and c-Met(IC50s of 20 and 8 nM)</p>Fórmula:C21H23Cl3FN5OPureza:98.73% - 98.87%Cor e Forma:SolidPeso molecular:486.8Danusertib
CAS:<p>Danusertib (PHA-739358) is a small-molecule 3-aminopyrazole derivative with potential antineoplastic activity.</p>Fórmula:C26H30N6O3Pureza:97.88% - 98.79%Cor e Forma:White PowderPeso molecular:474.553-Methyladenine
CAS:<p>3-Methyladenine (3-MA) is a PI3K inhibitor that selectively inhibits class IB PI3Kγ (IC50=60 μM) and class III VPS34 (IC50=25 μM).</p>Fórmula:C6H7N5Pureza:98.02% - 99.65%Cor e Forma:SolidPeso molecular:149.15WYC-209
CAS:<p>WYC-209 inhibits proliferation of malignant murine melanoma tumor-repopulating cells (TRCs, IC50: 0.19 uM). It targets the retinoic acid receptor (RAR).</p>Fórmula:C20H20N2O3SPureza:99.77%Cor e Forma:SolidPeso molecular:368.45Salirasib
CAS:<p>Salirasib: Competitive PPMTase inhibitor, blocks Ras methylation, potential cancer treatment, Ki=2.6 μM.</p>Fórmula:C22H30O2SPureza:99.45%Cor e Forma:SolidPeso molecular:358.54Afatinib Dimaleate
CAS:<p>Afatinib Dimaleate (BIBW 2992MA2) is an orally bioavailable anilino-quinazoline derivative and inhibitor of the EGFR family, with antineoplastic activity.</p>Fórmula:C32H33ClFN5O11Pureza:98.11% - 99.87%Cor e Forma:SolidPeso molecular:718.08PFK-015
CAS:<p>PFK-015 (PFK15) is an effective inhibitor of PFKFB3 (IC50: 110 nM) and inhibits PFKFB3 activity in Y cells (IC50: 20 nM).</p>Fórmula:C17H12N2OPureza:99.7% - 99.85%Cor e Forma:SolidPeso molecular:260.29TA-02
CAS:<p>TA-02 is a p38 MAPK inhibitor with IC50 of 20 nM.TA-02 especially inhibits TGFBR-2.</p>Fórmula:C20H13F2N3Pureza:99.35% - 99.79%Cor e Forma:SolidPeso molecular:333.33Sepantronium bromide
CAS:<p>Sepantronium bromide (YM155) is a small-molecule proapoptotic agent with potential antineoplastic activity.</p>Fórmula:C20H19BrN4O3Pureza:99.68% - 99.85%Cor e Forma:SolidPeso molecular:443.26LY294002
CAS:<p>LY294002 (SF 1101) is a broad-spectrum inhibitor of PI3K, inhibiting PI3Kα, PI3Kδ, and PI3Kβ (IC50=0.5/0.57/0.97 μM).</p>Fórmula:C19H17NO3Pureza:98% - 99.96%Cor e Forma:Pale Yellow SolidPeso molecular:307.34Pogostone
CAS:<p>Pogostone: anti-bacterial/fungal, blocks T-cells, modulates cytokines, protects against gastric ulcers, boosts antioxidants/PGE2/NP-SH.</p>Fórmula:C12H16O4Pureza:98.46% - 99.03%Cor e Forma:SolidPeso molecular:224.25PFI-1
CAS:<p>PFI-1 (PF-6405761), a specific BET (bromodomain-containing protein) inhibitor for BRD4, is with the IC50 of 0.22 μM in a cell-free assay.</p>Fórmula:C16H17N3O4SPureza:98.74% - 99.19%Cor e Forma:SolidPeso molecular:347.393'-Hydroxypterostilbene
CAS:<p>3'-Hydroxypterostilbene suppresses colon cancer cell growth (COLO 205, HCT-116, HT-29) by triggering apoptosis and autophagy, affecting key pathways.</p>Fórmula:C16H16O4Pureza:98.25% - 99.19%Cor e Forma:SolidPeso molecular:272.3BIIB021
CAS:<p>BIIB021 (CNF2024) is an orally-available, fully synthetic inhibitor of HSP90(Ki=1.7 nM, EC50=38 nM).</p>Fórmula:C14H15ClN6OPureza:98% - 99.82%Cor e Forma:SolidPeso molecular:318.76Andrographolide
CAS:<p>Andrographolide (Andrographis)(Andrographis), an irreversible antagonist of NF-κB, has anti-inflammatory and anti-platelet aggregation activities and potential</p>Fórmula:C20H30O5Pureza:99.39% - 99.97%Cor e Forma:PowderPeso molecular:350.45Sapanisertib
CAS:<p>Sapanisertib (INK 128) is an oral raptor-mTOR and rictor-mTOR inhibitor with potential cancer-fighting properties.</p>Fórmula:C15H15N7OPureza:99.19% - >99.99%Cor e Forma:SolidPeso molecular:309.33BIX-01294 trihydrochloride
CAS:<p>BIX-01294 trihydrochloride is an inhibitor of G9a histone methyltransferase.In a cell-free assay, the IC50=2.7 μM for G9a histone methyltransferase.</p>Fórmula:C28H38N6O2·3HClPureza:99.41% - 99.95%Cor e Forma:SolidPeso molecular:600.02yangonin
CAS:<p>Yangonin (Y100550) is a novel CB1 receptor ligand with affinity for human recombinant CB1 receptors.</p>Fórmula:C15H14O4Pureza:98.82% - 99.55%Cor e Forma:Pale Yellow PowderPeso molecular:258.27Torkinib
CAS:<p>Torkinib (PP 242) (PP 242) is a selective and ATP-competitive mTOR inhibitor (IC50: 8 nM). It also inhibits mTORC1/2 (IC50s: 30/58 nM).</p>Fórmula:C16H16N6OPureza:99.11%Cor e Forma:SolidPeso molecular:308.34CCT007093
CAS:<p>CCT007093 is an effective PPM1D (WIP1) inhibitor (IC50: 8.4 μM).</p>Fórmula:C15H12OS2Pureza:98% - 99.88%Cor e Forma:SolidPeso molecular:272.39Resatorvid
CAS:<p>Resatorvid (TAK-242) inhibits TLR4, with IC50s for IL-6, TNF-R, NO at 1.3, 1.9, 1.8 nM respectively.</p>Fórmula:C15H17ClFNO4SPureza:99.31% - >99.99%Cor e Forma:SolidPeso molecular:361.82Fulvestrant
CAS:<p>Fulvestrant (ZM 182780) is an estrogen receptor (ER) antagonist (IC50=9.4 nM) and an agonist of GPR30.</p>Fórmula:C32H47F5O3SPureza:99.1% - >99.99%Cor e Forma:White PowderPeso molecular:606.77Flavopiridol hydrochloride
CAS:<p>Flavopiridol hydrochloride (MDL 107826A), an inhibitor of cyclin-dependent kinase, is a synthetic N-methylpiperidinyl chlorophenyl flavone compound.</p>Fórmula:C21H21Cl2NO5Pureza:98.87% - 99.88%Cor e Forma:SolidPeso molecular:438.3Orthanilamide
CAS:<p>Orthanilamide (Orthanilamide) is a molecule containing the sulfonamide functional group attached to an aniline.</p>Fórmula:C6H8N2O2SPureza:99.72% - 99.96%Cor e Forma:White To Pale Cream Crystalline Powder Or CrystalsPeso molecular:172.2AGN 193109
CAS:<p>AGN 193109, a retinoid analog, is a potent and specific antagonist of RARs (Kds: 2 nM, 2 nM, and 3 nM for RARα, RARβ, and RARγ).</p>Fórmula:C28H24O2Pureza:99.87% - 99.89%Cor e Forma:SolidPeso molecular:392.49MPP+ iodide
CAS:<p>MPP+ iodide, a neurotoxin byproduct, mimics Parkinson's by killing substantia nigra neurons and affecting neuron transporters, inducing cell death.</p>Fórmula:C12H12INPureza:99.49% - 99.96%Cor e Forma:SolidPeso molecular:297.13Telaglenastat
CAS:<p>Telaglenastat (CB 839) (IC50 of 24 nM), an effective, specific, and oral inhibitor, which is bioavailable glutaminase, for recombinant human GAC.</p>Fórmula:C26H24F3N7O3SPureza:97.57% - 99.89%Cor e Forma:SolidPeso molecular:571.57GSK2578215A
CAS:<p>GSK2578215A is a potent and selective LRRK2 kinase inhibitor.</p>Fórmula:C24H18FN3O2Pureza:99.57% - 99.94%Cor e Forma:SolidPeso molecular:399.42Imatinib
CAS:<p>Imatinib (STI571) is a multi-targeted receptor tyrosine kinase inhibitor that selectively inhibits the kinase activities of BCR/ABL, v-Abl, PDGFR, and c-kit</p>Fórmula:C29H31N7OPureza:99.42% - 99.94%Cor e Forma:Off White PowderPeso molecular:493.6Sinomenine
CAS:<p>Sinomenine (Kukoline) is a pure alkaloid isolated from the Sinomenium acutum, is utilized in the treatment of rheumatism and arthritis.</p>Fórmula:C19H23NO4Pureza:99.02% - 99.73%Cor e Forma:White PowderPeso molecular:329.39Demethoxycurcumin
CAS:<p>Demethoxycurcumin: antioxidant, anti-inflammatory, anti-proliferative, anti-acanthamoebic, enhances chemo for resistant cancers, inhibits cancer pathways.</p>Fórmula:C20H18O5Pureza:94.54% - 99.86%Cor e Forma:SolidPeso molecular:338.35Ginkgolide K
CAS:<p>Ginkgolide K induces protective autophagy through the AMPK/mTOR/ULK1 signalling pathway. It possesses neuroprotective activity.</p>Fórmula:C20H22O9Pureza:99.44% - 99.72%Cor e Forma:SolidPeso molecular:406.38Aloperine
CAS:<p>Aloperine exhibits anti-inflammatory, antibacterial, antiviral, and anti-tumor properties.</p>Fórmula:C15H24N2Pureza:98% - 99.88%Cor e Forma:Yellow Crystalline PowderPeso molecular:232.36Arglabin
CAS:<p>Arglabin ((+)-Arglabin) is a natural product isolated from Artemisia glabella, is a NLRP3 inflammasome inhibitor, has anti-atherogenic and anticancer effects.</p>Fórmula:C15H18O3Pureza:98.97% - 99.62%Cor e Forma:SolidPeso molecular:246.3Bilobalide
CAS:<p>Bilobalide ((-)-Bilobalide), a bioactive from Gingko Biloba, is active on hypoxia-induced alterations.</p>Fórmula:C15H18O8Pureza:98.81% - 99.92%Cor e Forma:White SolidPeso molecular:326.3Clematichinenoside AR
CAS:<p>Clematichinenoside AR is anti-inflammatory, immunosuppressive, and combats arthritis via PI3K/Akt and TNF-α pathways.</p>Fórmula:C82H134O43Pureza:99.04% - 99.69%Cor e Forma:SolidPeso molecular:1807.92Apocynin
CAS:<p>Apocynin (NSC 2146) is a specific NADPH-oxidase inhibitor (IC50: 10 μM).</p>Fórmula:C9H10O3Pureza:99.71% - 99.98%Cor e Forma:Yellowish To Brown PowderPeso molecular:166.17HA15
CAS:<p>HA15 targets BiP/GRP78/HSPA5, showing anti-cancer effects on all tested melanoma cells, resistant or patient-derived.</p>Fórmula:C23H22N4O3S2Pureza:99.77% - 99.86%Cor e Forma:SolidPeso molecular:466.58Dimethyl fumarate
CAS:<p>Dimethyl fumarate (DMF) is an orally Nrf2 activator. Dimethyl fumarate has antimicrobial and anti-inflammatory activities. Cost-effective and quality-assured.</p>Fórmula:C6H8O4Pureza:90.51% - >99.99%Cor e Forma:White To Off-White Powder White Crystalline PowderPeso molecular:144.13ISRIB (trans-isomer)
CAS:<p>ISRIB (trans-isomer) is a potent inhibitor of PERK that rescues protein translation and prevents SG formation in the presence of P-eIF2α. Cost effective and quality assured.</p>Fórmula:C22H24Cl2N2O4Pureza:97.86% - 99.27%Cor e Forma:SolidPeso molecular:451.34Salubrinal
CAS:<p>Salubrinal, a phosphatases (PP1) inhibitor(IC50=1.7 μM), exhibits function on the eukaryotic translation initiation factor 2 subunit (eIF2α).</p>Fórmula:C21H17Cl3N4OSPureza:97.25% - >99.99%Cor e Forma:SolidPeso molecular:479.81Binimetinib
CAS:<p>Binimetinib (ARRY-162) is a MEK1/2 inhibitor (IC50=12 nM) with selective and oral activity. Binimetinib has antitumor activity. Cost-effective and quality-assured.</p>Fórmula:C17H15BrF2N4O3Pureza:98.03% - >99.99%Cor e Forma:SolidPeso molecular:441.23Reparixin
CAS:<p>Reparixin inhibits CXCR1 (IC50=1 nM) strongly, CXCR2 weakly (IC50=100 nM), and it's a CXCL8 receptor blocker.</p>Fórmula:C14H21NO3SPureza:98% - 99.89%Cor e Forma:SolidPeso molecular:283.39Daurisoline
CAS:<p>Daurisoline ((R,R)-Daurisoline) is a hERG inhibitor. Daurisoline is also an autophagy blocker.</p>Fórmula:C37H42N2O6Pureza:98% - 99.96%Cor e Forma:Light Yellow PowderPeso molecular:610.74Bigelovin
CAS:<p>Bigelovin: RXRα agonist, inhibits mTOR via ROS, induces apoptosis/autophagy, anti-tumor sesquiterpene from Inula sp.</p>Fórmula:C17H20O5Pureza:99.61% - 99.72%Cor e Forma:SolidPeso molecular:304.34Britannin
CAS:<p>Britannin, a sesquiterpene lactone, inhibits proliferation and induces apoptosis through the mitochondrial signaling pathway in human breast cancer cells.</p>Fórmula:C19H26O7Pureza:98% - 99.98%Cor e Forma:SolidPeso molecular:366.41Verteporfin
CAS:<p>Verteporfin (BPD-MA) is a YAP inhibitor that inhibits YAP-TEAD interactions.</p>Fórmula:C41H42N4O8Pureza:95.37% - 99.82%Cor e Forma:Dark Green To Black SolidPeso molecular:718.79Ralimetinib dimesylate
CAS:<p>Ralimetinib dimesylate (LY2228820 dimesylate) is a orally available, p38 MAPK inhibitor with potential anti-inflammatory and antineoplastic activities.</p>Fórmula:C24H29FN6·2CH4O3SPureza:98% - 99.38%Cor e Forma:SolidPeso molecular:612.74Hydroxyprogesterone caproate
CAS:<p>Hydroxyprogesterone caproate (Delalutin) is a synthetic progestin that activates progesterone receptors and inhibits ovulation.</p>Fórmula:C27H40O4Pureza:99.70%Cor e Forma:White Or Almost White Crystalline PowerPeso molecular:428.60Tizoxanide
CAS:<p>Tizoxanide (Desacetyl-nitazoxanide) is a metabolite of lamivudine.</p>Fórmula:C10H7N3O4SPureza:98.89% - 99.28%Cor e Forma:SolidPeso molecular:265.25Bardoxolone Methyl
CAS:<p>Bardoxolone Methyl (TP-155) is a synthetic triterpenoid that acts as an activator of the Nrf2 pathway and an inhibitor of the NF-κB pathway with potential anti-</p>Fórmula:C32H43NO4Pureza:97.81% - 99.09%Cor e Forma:SolidPeso molecular:505.69BMS-582949 hydrochloride
CAS:<p>The BMS-582949 hydrochloride (BMS-582949 HCl) is a highly specific p38α MAPK inhibitor (IC50: 13 nM).</p>Fórmula:C22H27ClN6O2Pureza:97.57% - 98.75%Cor e Forma:SolidPeso molecular:442.95Tazarotene
CAS:<p>Tazarotene (Zorac), a synthetic topical retinoid, treats psoriasis by normalizing keratinocytes and reducing growth.</p>Fórmula:C21H21NO2SPureza:97.01% - 99.14%Cor e Forma:White SolidPeso molecular:351.46Deguelin
CAS:<p>Deguelin ((-)-Deguelin) is a PI3K/AKT Inhibitor, which is a natural product isolated from plants in the Mundulea sericea family.</p>Fórmula:C23H22O6Pureza:96.39% - 99.29%Cor e Forma:SolidPeso molecular:394.42BIA 10-2474
CAS:<p>BIA 10-2474 is a long-acting reversible inhibitor of FAAH that increases levels of the neurotransmitter anandamide in the nervous system.</p>Fórmula:C16H20N4O2Pureza:99.27%Cor e Forma:SolidPeso molecular:300.36Pirarubicin
CAS:<p>Pirarubicin (Theprubicin), an anthracycline antibiotic, inhibits DNA/RNA synthesis and is used as an antineoplastic.</p>Fórmula:C32H37NO12Pureza:97.80% - 99.15%Cor e Forma:Red Crystalline PowderPeso molecular:627.64kaempferide
CAS:<p>kaempferide (4'-Methylkaempferol) is an O-methylated flavonol present in Kaempferia kaempferi with antiviral activity.</p>Fórmula:C16H12O6Pureza:98.31% - 99.66%Cor e Forma:SolidPeso molecular:300.26SR12813
CAS:<p>SR12813 (GW 485801) is a pregnane X receptor (PXR) agonist.</p>Fórmula:C24H42O7P2Pureza:99.43%Cor e Forma:SolidPeso molecular:504.53Meloxicam
CAS:<p>Meloxicam (Metacam) is a Nonsteroidal Anti-inflammatory Drug.</p>Fórmula:C14H13N3O4S2Pureza:97.09% - 99.60%Cor e Forma:Light Yellow SolidPeso molecular:351.40740 Y-P
CAS:<p>740 Y-P (740YPDGFR) is a PI3K activator with cell permeability,binds GST fusion proteins containing the N-and C-terminal SH2 domains of p85. Low-Cost!</p>Fórmula:C141H222N43O39PS3Pureza:98.3% - 99.87%Cor e Forma:SolidPeso molecular:3270.7Fluvastatin
CAS:<p>Fluvastatin (XU-62320) is an HMG-CoA reductase inhibitor used to lower plasma cholesterol levels and prevent cardiovascular disease.</p>Fórmula:C24H26FNO4Pureza:98.94%Cor e Forma:SolidPeso molecular:411.47ML 145
CAS:<p>ML 145 is a selective antagonist of GPR35/CXCR8 (IC50/EC50 of 20.1 nM)</p>Fórmula:C24H22N2O5S2Pureza:97.74%Cor e Forma:SolidPeso molecular:482.57SB 203580 hydrochloride
CAS:<p>SB 203580 hydrochloride (Adezmapimod hydrochloride) is a p38 MAPK inhibitor that induces mitochondrial autophagy and cytosolic autophagy.</p>Fórmula:C21H17ClFN3OSPureza:97.79%Cor e Forma:SolidPeso molecular:413.9mTOR inhibitor-8
CAS:<p>mTOR inhibitor-8 is an mTOR inhibitor and autophagy inducer with antiviral and antitumor activity for the study of non-small cell lung cancer.</p>Fórmula:C24H19ClN4OSPureza:98.11%Cor e Forma:SolidPeso molecular:446.95Ketanserin tartrate
CAS:<p>Ketanserin tartrate (KJK-945 tartrate) is a 5-HT2A receptor and α1-adrenergic receptor antagonist for the study of systemic sclerosis.</p>Fórmula:C26H28FN3O9Pureza:99.68%Cor e Forma:SolidPeso molecular:545.51Ezetimibe ketone
CAS:<p>Ezetimibe ketone (EZM-K) exhibits antioxidant activity and alleviates H2O2-induced NRK-52E cell apoptosis by upregulating Nrf2 and HO-1 levels.</p>Fórmula:C24H19F2NO3Pureza:99.32%Cor e Forma:White Crystalline SolidPeso molecular:407.41Doxorubicin
CAS:<p>Doxorubicin (Adriamycin) is a Topoisomerase II (Top2) inhibitor with antineoplastic activity.</p>Fórmula:C27H29NO11Pureza:99.31%Cor e Forma:Red Crystalline Solid SolidPeso molecular:543.52Chenodeoxycholic Acid sodium salt
CAS:<p>Chenodeoxycholic Acid sodium salt (CDCA sodium salt) is a bile acid in humans that activates the nuclear receptor FXR, rescues axonal degeneration of induced pluripotent stem cell-derived neurons in patients with spastic paraplegia type 5 and cerebral xanthomatosis, and can be used to study pancreatic necrosis.</p>Fórmula:C24H39NaO4Pureza:99.68% - 99.72%Cor e Forma:SolidPeso molecular:414.55H-89
CAS:<p>H-89 is a PKA inhibitor, a candidate cardioprotectant, induces spatial learning impairment in rats, and can be used to study myocardial infarction.</p>Fórmula:C20H20BrN3O2SPureza:98.06%Cor e Forma:Off-White PowderPeso molecular:446.36Sitagliptin phosphate monohydrate
CAS:<p>Sitagliptin phosphate monohydrate (MK-0431 phosphate monohydrate) is a potent inhibitor of DPP-IV with IC50 of 19 nM in Caco-2 cell extracts.</p>Fórmula:C16H15F6N5O·H3PO4·H2OPureza:99.85% - 99.98%Cor e Forma:White Or Almost White Crystalline PowderPeso molecular:523.33Latrepirdine dihydrochloride
CAS:<p>Latrepirdine dihydrochloride (Dimebolin dihydrochloride) is an orally active, and neuroactive antagonist of multiple drug targets.</p>Fórmula:C21H25N3·2HClPureza:98.45%Cor e Forma:SolidPeso molecular:392.37Rosuvastatin-d6 Sodium Salt
CAS:<p>Rosuvastatin-d6 Sodium Salt is a deuterated compound of Rosuvastatin Sodium Salt. Rosuvastatin Sodium Salt has a CAS number of 1007871-86-4.</p>Fórmula:C22H21D6FN3NaO6SCor e Forma:SolidPeso molecular:509.56Irinotecan-d10 Hydrochloride
CAS:<p>Irinotecan-d10 Hydrochloride is a deuterated compound of Irinotecan Hydrochloride. Irinotecan Hydrochloride has a CAS number of 100286-90-6. Irinotecan Hydrochloride is the hydrochloride salt of a semisynthetic derivative of camptothecin. Irinotecan, a prodrug, is converted to a biologically active metabolite 7-ethyl-10-hydroxy-camptothecin (SN-38) by a carboxylesterase-converting enzyme. One thousand-fold more potent than its parent compound irinotecan, SN-38 inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks that inhibit DNA replication and trigger apoptotic cell death. Because ongoing DNA synthesis is necessary for irinotecan to exert its cytotoxic effects, it is classified as an S-phase-specific agent.</p>Fórmula:C33H29D10ClN4O6Cor e Forma:SolidPeso molecular:633.20Tigecycline-d9
CAS:<p>Tigecycline-d9 is a deuterated compound of Tigecycline. Tigecycline has a CAS number of 220620-09-7. Tigecycline is a broad-spectrum glycylcycline antibiotic derived from tetracycline. Tigecycline binds to the 30S ribosomal subunit, thereby interfering with the binding of aminoacyl-tRNA to the mRNA-ribosome complex.</p>Fórmula:C29H30D9N5O8Cor e Forma:SolidPeso molecular:594.70Lovastatin-d3
CAS:<p>Lovastatin-d3 is a deuterated compound of Lovastatin. Lovastatin has a CAS number of 75330-75-5. Lovastatin is an HMG-CoA Reductase Inhibitor, used for lowering cholesterol.</p>Fórmula:C24H33D3O5Cor e Forma:SolidPeso molecular:407.56VX-702
CAS:<p>VX-702: selective p38α MAPK inhibitor, potent anti-cytokine for rheumatoid arthritis.</p>Fórmula:C19H12F4N4O2Pureza:99% - >99.99%Cor e Forma:SolidPeso molecular:404.32MK-5108
CAS:<p>MK-5108 (VX-689) is a highly potent and specific Aurora-A kinase inhibitor with an IC50 value of 0.064 nM.</p>Fórmula:C22H21ClFN3O3SPureza:99.22%Cor e Forma:SolidPeso molecular:461.94Bexarotene
CAS:<p>Bexarotene (LGD1069) is a retinoid analogue that is used to treat the skin manifestations of cutaneous T cell lymphoma (CTCL).</p>Fórmula:C24H28O2Pureza:99% - 99.65%Cor e Forma:White SolidPeso molecular:348.48Alisol A
CAS:<p>Alisol A: induces autophagy, anti-cancer, inhibits HepG2, MDA-MB-231, MCF-7 cells.</p>Fórmula:C30H50O5Pureza:99.77% - 99.94%Cor e Forma:SolidPeso molecular:490.71Dehydrocorydaline nitrate
CAS:<p>DHC curbs antibody and cell-mediated allergies, inhibits mitochondrial potential in macrophages, and has antinociceptive, anti-inflammatory effects.</p>Fórmula:C22H24N2O7Pureza:99.79% - 99.92%Cor e Forma:SolidPeso molecular:428.44Atorvastatin
CAS:<p>Orally active atorvastatin inhibits HMG-CoA reductase, lowers lipids, hinders SV-SMC cell growth, and can up thrombotic risk with clopidogrel.</p>Fórmula:C33H35FN2O5Pureza:99.37% - 99.69%Cor e Forma:SolidPeso molecular:558.64BGT226 maleate
CAS:<p>BGT226 maleate (NVP-BGT226) is a class I PI3K/mTOR inhibitor for PI3Kα/β/γ (IC50: 4/63/38 nM) .</p>Fórmula:C28H25F3N6O2·C4H4O4Pureza:97.75% - 98.78%Cor e Forma:SolidPeso molecular:650.6Brivanib (alaninate)
CAS:<p>Brivanib Alaninate (BMS-582664) is an alaninate salt of a vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with potential antineoplastic effect.</p>Fórmula:C22H24FN5O4Pureza:99.46% - 99.66%Cor e Forma:SolidPeso molecular:441.46Rac-Efavirenz
CAS:<p>Rac-Efavirenz is a non stereospecific structure of Efavirenz.</p>Fórmula:C14H9ClF3NO2Cor e Forma:SolidPeso molecular:315.67Chloroquine dihydrochloride
CAS:<p>Chloroquine: treats malaria, amebiasis, rheumatoid arthritis, lupus; works by inhibiting parasites in red blood cells.</p>Fórmula:C18H27Cl2N3Cor e Forma:SolidPeso molecular:356.33Metyrapone Tartrate
CAS:<p>Metyrapone Tartrate: a test inhibitor for diagnosing Cushing's; blocks steroid 11-beta-hydroxylase.</p>Fórmula:C22H26N2O13Cor e Forma:SolidPeso molecular:526.45Euchrysine 3RX
CAS:<p>Euchrysine 3RX is an agent of bioactive chemicals.</p>Fórmula:C20H26BrCl2N3OPureza:98%Cor e Forma:Brown PowderPeso molecular:475.25Pravastatin
CAS:<p>Pravastatin reduces lipoproteins by blocking HMG-CoA reductase and VLDL synthesis.</p>Fórmula:C23H36O7Pureza:98%Cor e Forma:White PowderPeso molecular:424.53Resveratrol analog 2
CAS:<p>Resveratrol analog 2 mimics Resveratrol, a natural antioxidant with anti-inflammatory, cardioprotective, and anticancer benefits.</p>Fórmula:C16H13FO3Pureza:98%Cor e Forma:SolidPeso molecular:272.27YT-8-8
CAS:<p>YT-8-8 is a ligand for the p62-ZZ domain and can activate p62-dependent selective autophagy. This compound is also applicable in AUTOTAC design.</p>Fórmula:C18H23FN2O2Cor e Forma:SolidPeso molecular:318.39Erlotinib mesylate
CAS:<p>Erlotinib: reversible inhibitor binding to ATP site of epidermal growth factor receptor.</p>Fórmula:C23H27N3O7SPureza:98%Cor e Forma:SolidPeso molecular:489.54Esmolol hydrochloride
CAS:<p>Esmolol is a cardioselective beta-blocker used in parenteral forms in the treatment of arrhythmias and severe hypertension.</p>Fórmula:C16H25NO4·HClPureza:98.72% - 99.48%Cor e Forma:White SolidPeso molecular:331.15TAMRA alkyne, 6-isomer
CAS:<p>TAMRA alkyne, 6-isomer: a xanthene dye linker with orange emission, used for DNA/RNA labeling, reacts via Click Chemistry.</p>Fórmula:C28H25N3O4Cor e Forma:SolidPeso molecular:467.52Gavilimomab
CAS:<p>Gavilimomab(ABX-CBL) is a murine-derived IgM monoclonal antibody against CD147 antigen used in immunosuppressive treatments for glucocorticoid-resistant GVHD).</p>Pureza:95%Cor e Forma:LiquidPBA-1105
CAS:<p>PBA-1105, an autophagy-targeting chimeric molecule (AUTOTAC), facilitates the self-oligomerization of p62. Additionally, PBA-1105 enhances the autophagic flux of Ub-conjugated aggregates.</p>Fórmula:C39H48N2O6Cor e Forma:SolidPeso molecular:640.81Seriniquinone
CAS:<p>Seriniquinone is a selective agent of anticancer that acts by inducing cell death via autophagocytosis and targeting the cancer-protective protein dermcidin.</p>Fórmula:C20H8O4SPureza:98%Cor e Forma:SolidPeso molecular:344.34Paroxetine hydrochloride hemihydrate
CAS:<p>Paroxetine hydrochloride hemihydrate (Paxil) is an effective and selective serotonin reuptake inhibitor (SSRI).</p>Fórmula:C38H44Cl2F2N2O7Pureza:99.949%Cor e Forma:SolidPeso molecular:749.67SU11274
CAS:<p>SU11274 (Met Kinase Inhibitor)(IC50=10 nM) is a specific Met inhibitor. It shows no significant effects on PGDFRβ, EGFR or Tie2.</p>Fórmula:C28H30ClN5O4SPureza:98.62% - 99.53%Cor e Forma:Orange PowderPeso molecular:568.09Metofenazate
CAS:<p>Metofenazate is an selective inhibitor of calmodulin .</p>Fórmula:C31H36ClN3O5SPureza:98%Cor e Forma:SolidPeso molecular:598.15CXCR3 Antagonist 6c
CAS:<p>CXCR3 antagonist 6c blocks CXCR3 and inhibits Ca2+ movement and T-cell migration (IC50: 0.06 µM & 100 nM) with selectivity over 14 other GPCRs.</p>Fórmula:C30H32Cl3N5O3Cor e Forma:SolidPeso molecular:616.97Momelotinib Mesylate
CAS:<p>Momelotinib Mesylate is an ATP-competitive JAK1/JAK2 inhibitor (IC50: 11 nM/18 nM). It has 10-fold selectivity versus JAK3.</p>Fórmula:C24H26N6O5SPureza:98%Cor e Forma:SolidPeso molecular:510.57MF-095
CAS:<p>MF-095 is a control probe for MF-094, which is a potent inhibitor of ubiquitin specific protease 30.</p>Fórmula:C27H31N3O4SCor e Forma:SolidPeso molecular:493.62(3S,5R)-Rosuvastatin
CAS:<p>(3S,5R)-Rosuvastatin is the (3R,5R)-enantiomer of Rosuvastatin. Rosuvastatin is a competitive HMG-CoA reductase inhibitor (IC50: 11 nM).</p>Fórmula:C22H28FN3O6SPureza:98%Cor e Forma:SolidPeso molecular:481.54p38 MAPK-IN-2
CAS:<p>p38 MAPK-IN-2 is an inhibitor of p38 kinase.</p>Fórmula:C20H19ClFN5O2Pureza:98%Cor e Forma:SolidPeso molecular:415.85HF50731
CAS:<p>HF50731 is a CXCR4 antagonist with high binding affinity (IC50: 19.8 nM) and inhibits calcium mobilization, cell migration, and HIV-1 (IC50: 1.5 nM).</p>Fórmula:C26H46N4Cor e Forma:SolidPeso molecular:414.67ATG7-IN-2
CAS:<p>ATG7-IN-2 inhibits ATG7 protein with 0.089 μM IC50 and suppresses autophagy marker LC3B.</p>Fórmula:C11H16N6O7SCor e Forma:SolidPeso molecular:376.35GLPG2451
CAS:<p>GLPG2451 potentiates F508del CFTR at low temp (EC50: 11.1 nM), aiding cystic fibrosis treatment.</p>Fórmula:C16H16F3N3O5SCor e Forma:SolidPeso molecular:419.38SMER18
CAS:<p>SMER18, a small molecule enhancer of rapamycin, acts as an mTOR-independent inducer of autophagy and can be used to study neurodegenerative diseases.</p>Fórmula:C16H14ClNO2Pureza:97.27%Cor e Forma:SolidPeso molecular:287.74Omeprazole Sodium
CAS:<p>Omeprazole Sodium is a proton pump inhibitor(PPI) and suppresses gastric acid secretion.</p>Fórmula:C17H18N3NaO3SPureza:99.84%Cor e Forma:Clear In WaterPeso molecular:367.4Ivacaftor hydrate
CAS:<p>Ivacaftor hydrate is an orally bioavailable CFTR potentiator. It also is used for cystic fibrosis treatment.</p>Fórmula:C24H30N2O4Pureza:98%Cor e Forma:SolidPeso molecular:410.514CXCR4 antagonist 5
CAS:<p>CXCR4 antagonist with IC50 of 8.8 nM, inhibits CXCL12-induced calcium increase and chemotaxis, with good safety and minimal CYP, hERG impact.</p>Fórmula:C21H30N6Cor e Forma:SolidPeso molecular:366.5Poloppin
CAS:<p>Poloppin modulates polo-like kinases, targets mutant KRAS, and enhances Crizotinib's effects against KRAS-mutant cancers.</p>Fórmula:C20H15BrF3NO2Pureza:98%Cor e Forma:SolidPeso molecular:438.24PF-06455943
CAS:<p>PF-06455943: LRRK2 inhibitor, IC50=3nM, PET radioligand, used for ADME/neuro PK & Parkinson's research.</p>Fórmula:C17H14FN5OCor e Forma:SolidPeso molecular:323.32Ivacaftor benzenesulfonate
CAS:<p>Ivacaftor benzenesulfonate used for cystic fibrosis treatment. is an orally bioavailable CFTR potentiator.</p>Fórmula:C30H34N2O6SPureza:98%Cor e Forma:SolidPeso molecular:550.67eIF4A3-IN-2
CAS:<p>eIF4A3-IN-2 is a highly selective and noncompetitive eukaryotic initiation factor 4A-3 inhibitor with an IC50 of 110 nM.</p>Fórmula:C25H19Br2ClN4O2Pureza:98%Cor e Forma:SolidPeso molecular:602.71Ralimetinib
CAS:<p>Ralimetinib blocks MK2 phosphorylation at Thr334 without affecting p38α MAPK or JNK. It is an ATP-competitive inhibitor of p38 MAPK α/β (IC50 5.3/3.2 nM).</p>Fórmula:C24H29FN6Pureza:99.16% - 99.21%Cor e Forma:SolidPeso molecular:420.53PF-06371900
CAS:<p>PF-06371900 is a potent and highly selective inhibitor of leucine-rich repeat kinase 2 (LRRK2).</p>Fórmula:C17H16N6O2SCor e Forma:SolidPeso molecular:368.41Lamotrigine isethionate
CAS:<p>Water-soluble salt of lamotrigine . Displays anticonvulsant effects and inhibits glutamate release, possibly through inhibition of Na+, K+ and Ca2+ currents.</p>Fórmula:C11H13Cl2N5O4SCor e Forma:SolidPeso molecular:382.22SR 3677 dihydrochloride
CAS:<p>Potent and selective Rho-kinase inhibitor (IC50 values are 3 and 56 nM for ROCK-II and ROCK-I respectively).</p>Fórmula:C22H26Cl2N4O4Cor e Forma:SolidPeso molecular:481.37NSC 33994
CAS:<p>NSC 33994 is a selective inhibitor of JAK2 (IC50 = 60 nM). It also shows no effect on Src and TYK2 tyrosine kinase activity at a concentration of 25 μM.</p>Fórmula:C28H42N2O2Pureza:98%Cor e Forma:SolidPeso molecular:438.65CXCR4 modulator-2
CAS:<p>CXCR4 modulator-2 (Z7R) has high potency (IC50: 1.25 nM), stable in mouse serum (t1/2=77.1 min), and anti-inflammatory in mice.</p>Fórmula:C21H32N8O2Cor e Forma:SolidPeso molecular:428.53SMYD3-IN-2
<p>SMYD3-IN-2, a cancer research chemical, inhibits SMYD3 (IC50 0.81 μM) and BGC823 (IC50 0.75 μM), inducing fatal autophagy in gastric cancer.</p>Fórmula:C26H21BrN2O4Cor e Forma:SolidPeso molecular:505.36Quinacrine analog 34
CAS:<p>Quinacrine: anti-protozoal, autophagy inhibitor (toxic at 2.5 μM). Analog 34 less toxic (LD50 = 27 μM), raises LC3-II protein, deacidifies lysosomes.</p>Fórmula:C20H27ClN4Cor e Forma:SolidPeso molecular:358.91
