Autofagia
Os inibidores da autofagia têm como alvo o processo celular de autofagia, que envolve a degradação e reciclagem de componentes celulares através dos lisossomas. A autofagia é um mecanismo crítico para a manutenção da homeostase celular, mas sua desregulação está implicada em várias doenças, incluindo câncer, neurodegeneração e infecções. Os inibidores da autofagia podem bloquear este processo, tornando-os ferramentas valiosas para estudar o papel da autofagia nas doenças e desenvolver estratégias terapêuticas. Na CymitQuimica, oferecemos inibidores da autofagia para apoiar sua pesquisa em biologia celular, oncologia e doenças neurodegenerativas.
Foram encontrados 1483 produtos de "Autofagia"
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NAcM-OPT HCl(2089293-61-6 free base)
CAS:NAcM-OPT HCL: Oral DCN1 inhibitor targeting N-Acetyl-UBE2M & DCN1, IC50=79 nM.Fórmula:C23H30Cl3N3OPureza:99.43%Cor e Forma:SolidPeso molecular:470.86AZD-8055
CAS:<p>AZD8055 is an ATP-competitive mTOR inhibitor (IC50: 0.8 nM in MDA-MB-468 cells). It is ~1,000-fold selective for mTOR over all PI3K isoforms.</p>Fórmula:C25H31N5O4Pureza:98% - 99.69%Cor e Forma:SolidPeso molecular:465.54ARRY-797
CAS:<p>ARRY-797 (ARRY-371797) is a potent and selective p38α inhibitor and inhibits LPS-Induced IL-6.</p>Fórmula:C22H26F2N4O2Pureza:98.97% - 99.81%Cor e Forma:SolidPeso molecular:416.46Sulfosuccinimidyl oleate sodium
CAS:Sulfosuccinimidyl oleate sodium is a long-chain fatty acid that inhibits fatty acid transport into cells.Cost-effective and quality-assured.Fórmula:C22H36NNaO7SPureza:96.53%Cor e Forma:SolidPeso molecular:481.58Lamotrigine hydrate
CAS:Lamotrigine hydrate: oral anticonvulsant, blocks Na+ channels, stabilizes neurons, inhibits glutamate, treats epilepsy, focal seizure.Fórmula:C9H9Cl2N5OCor e Forma:SolidPeso molecular:274.11Entrectinib
CAS:Entrectinib (RXDX-101) is an orally Trk, ROS1, and ALK inhibitor. Entrectinib exhibits antitumor activity. Cost-effective and quality-assured.Fórmula:C31H34F2N6O2Pureza:98.03% - 99.61%Cor e Forma:SolidPeso molecular:560.64Quercetin
CAS:Quercetin (Sophoretin) is a natural flavonoid and is an agonist of SIRT1.Fórmula:C15H10O7Pureza:96.29% - 98.05%Cor e Forma:Sensitive To Exposure To Air And Light Insoluble In Water Alcoholic Solutions Taste Very Bitter (Ntp 1992)Peso molecular:302.24Dronedarone
CAS:Dronedarone (SR 33589) is an amiodarone analogue which has an effective and promising treatment for Atrial fibrillation.Fórmula:C31H44N2O5SPureza:98.85% - 99.99%Cor e Forma:SolidPeso molecular:556.76PF-04457845
CAS:PF-04457845 is a greatly and effctive FAAH inhibitor, and for hFAAH(IC50=7.2±0.63 nM) and rFAAH(IC50=7.4±0.62 nM).Fórmula:C23H20F3N5O2Pureza:>99.99%Cor e Forma:SolidPeso molecular:455.43MRT68921
CAS:MRT68921 is a potent and dual autophagy kinase ULK1/2 inhibitor with IC50 of 2.9 nM and 1.1 nM, respectively.Fórmula:C25H34N6OPureza:99.23%Cor e Forma:SolidPeso molecular:434.58KU-55933
CAS:<p>KU-55933 (ATM Kinase Inhibitor) is an ATM inhibitor that is selective and ATP-competitive. KU-55933 has antitumor effects. Cost-effective and quality-assured.</p>Fórmula:C21H17NO3S2Pureza:97.21% - >99.99%Cor e Forma:SolidPeso molecular:395.49CGI-1746
CAS:CGI1746 is a potent and highly selective small-molecule Btk inhibitor with IC50 of 1.9 nM.Fórmula:C34H37N5O4Pureza:97.69% - 97.88%Cor e Forma:SolidPeso molecular:579.69Tolvaptan
CAS:<p>Tolvaptan (OPC-41061) is an orally bioavailable, selective, arginine vasopressin receptor 2 (V2, AVPR2) antagonist that can be used to treat hyponatremia.</p>Fórmula:C26H25ClN2O3Pureza:99.78% - >99.99%Cor e Forma:SolidPeso molecular:448.94Telaglenastat hydrochloride
CAS:Telaglenastat (CB-839) HCl: First-in-class, oral GLS1 inhibitor, targets KGA/GAC, IC50 23-28 nM, triggers autophagy, anticancer.Fórmula:C26H25ClF3N7O3SCor e Forma:SolidPeso molecular:608.04SBE13
CAS:SBE13 is a selective and potent inhibitor of Plk1 (IC50: 200 pM). SBE13 has a weak effect on Plk2 or Plk3 with IC50 values of >66 μM and 875 nM respectively.Fórmula:C24H27ClN2O4Cor e Forma:SolidPeso molecular:442.94Biochanin A
CAS:Biochanin A: an isoflavone from red clover with anticancer properties and inhibits FAAH.Fórmula:C16H12O5Pureza:97.1% - 98.97%Cor e Forma:SolidPeso molecular:284.26Nur77 modulator 1
CAS:Nur77 modulator 1: binds at 3.58 μM, boosts expression, alters location, triggers ER stress/autophagy, induces apoptosis, and fights hepatoma.Fórmula:C28H25N5O2SPureza:99.62%Cor e Forma:SolidPeso molecular:495.6KM11060
CAS:KM11060 is a novel corrector of the F508del-CFTR trafficking defect, Correcting F508del-CFTR trafficking, increasing the amount of functional CFTR at the plasmaFórmula:C19H17Cl2N3O2SPureza:98.86%Cor e Forma:SolidPeso molecular:422.33Pirarubicin HCl
CAS:Pirarubicin HCl, a less cardiotoxic doxorubicin analogue, hinders DNA replication and repairs by intercalating into DNA and inhibiting topoisomerase II.Fórmula:C32H38ClNO12Cor e Forma:SolidPeso molecular:664.1Fasudil hydrochloride
CAS:Fasudil hydrochloride (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.Fórmula:C14H18ClN3O2SPureza:99.54% - ≥95%Cor e Forma:White SolidPeso molecular:327.83
