Autofagia
Os inibidores da autofagia têm como alvo o processo celular de autofagia, que envolve a degradação e reciclagem de componentes celulares através dos lisossomas. A autofagia é um mecanismo crítico para a manutenção da homeostase celular, mas sua desregulação está implicada em várias doenças, incluindo câncer, neurodegeneração e infecções. Os inibidores da autofagia podem bloquear este processo, tornando-os ferramentas valiosas para estudar o papel da autofagia nas doenças e desenvolver estratégias terapêuticas. Na CymitQuimica, oferecemos inibidores da autofagia para apoiar sua pesquisa em biologia celular, oncologia e doenças neurodegenerativas.
Foram encontrados 1428 produtos de "Autofagia"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
(Rac)-BL-918
CAS:<p>(Rac)-BL-918 is the racemic form of BL-918. BL-918 is an effective activator of UNC-51-like kinase 1 (ULK1) (EC₅₀ = 24.14 nM), Parkinson's disease.</p>Fórmula:C23H15F8N3OSPureza:98%Cor e Forma:SolidPeso molecular:533.44MPM-1
<p>MPM-1, a marine mimic, induces rapid necrotic-like death in cancer cells, disrupts autophagy, and causes lysosomal swelling.</p>Fórmula:C34H44F6N4O7Cor e Forma:SolidPeso molecular:734.73SB-332235
CAS:<p>SB-332235 is an effective specific CXCR2 antagonist. And it is effectively inhibited CS-induced neutrophilia in a dose-dependent manner.</p>Fórmula:C13H10Cl3N3O4SCor e Forma:SolidPeso molecular:410.66Autophagy-IN-C1
CAS:<p>Autophagy-IN-C1 is a cinchona alkaloid derivative containing urea.</p>Fórmula:C29H28F6N4O2Cor e Forma:SolidPeso molecular:578.55IZCZ-3
CAS:<p>IZCZ-3,antitumor activity. is a potent c-MYC transcription inhibitor.</p>Fórmula:C46H49N7OPureza:98%Cor e Forma:SolidPeso molecular:715.93ICT5040
CAS:<p>ICT5040 is a CXCR4 antagonist.</p>Fórmula:C10H8F3N3OSCor e Forma:SolidPeso molecular:275.25FAAH-IN-1
CAS:<p>FAAH-IN-1 is a fatty acid amide hydrolase (FAAH) inhibitor, with IC50s of 145 nM and 650 nM for rat and human FAAH, respectively.</p>Fórmula:C20H19ClN4OSPureza:98%Cor e Forma:SolidPeso molecular:398.91Norswertianin
CAS:<p>Norswertianin, a xanthone, induces GBM cell differentiation and autophagy via oxidative stress and Akt/mTOR.</p>Fórmula:C13H8O6Cor e Forma:SolidPeso molecular:260.2Quinacrine analog 34
CAS:<p>Quinacrine: anti-protozoal, autophagy inhibitor (toxic at 2.5 μM). Analog 34 less toxic (LD50 = 27 μM), raises LC3-II protein, deacidifies lysosomes.</p>Fórmula:C20H27ClN4Cor e Forma:SolidPeso molecular:358.91VUF11211
CAS:<p>VUF11211 is an effective antagonist of CXCR3 that acts by extending from the minor pocket into the major pocket of the transmembrane domains.</p>Fórmula:C26H35Cl2N5OPureza:98%Cor e Forma:SolidPeso molecular:504.49CXCR4 antagonist 9
CAS:<p>CXCR4 antagonist 9, with IC50s of 15 nM & 1.3 nM against CXCR4 & Ca²⁺ rise by CXCL12 respectively.</p>Fórmula:C21H27FN6Cor e Forma:SolidPeso molecular:382.48SMYD3-IN-2
<p>SMYD3-IN-2, a cancer research chemical, inhibits SMYD3 (IC50 0.81 μM) and BGC823 (IC50 0.75 μM), inducing fatal autophagy in gastric cancer.</p>Fórmula:C26H21BrN2O4Cor e Forma:SolidPeso molecular:505.36AUTEN-67
CAS:<p>AUTEN-67 inhibits MTMR14, boosts autophagy, has antiaging/neuroprotective properties, and combats Huntington's disease onset/severity.</p>Fórmula:C23H14N4O6SCor e Forma:SolidPeso molecular:474.45CXCR4 modulator-2
CAS:<p>CXCR4 modulator-2 (Z7R) has high potency (IC50: 1.25 nM), stable in mouse serum (t1/2=77.1 min), and anti-inflammatory in mice.</p>Fórmula:C21H32N8O2Cor e Forma:SolidPeso molecular:428.53Antiproliferative agent-5
CAS:<p>Compound 4o inhibits gastric cancer growth, blocks G2/M cell cycle, induces ROS, and triggers autophagy. Used in anti-cancer studies.</p>Fórmula:C28H21BrN8OSCor e Forma:SolidPeso molecular:597.49NSC 33994
CAS:<p>NSC 33994 is a selective inhibitor of JAK2 (IC50 = 60 nM). It also shows no effect on Src and TYK2 tyrosine kinase activity at a concentration of 25 μM.</p>Fórmula:C28H42N2O2Pureza:98%Cor e Forma:SolidPeso molecular:438.65SR 3677 dihydrochloride
CAS:<p>Potent and selective Rho-kinase inhibitor (IC50 values are 3 and 56 nM for ROCK-II and ROCK-I respectively).</p>Fórmula:C22H26Cl2N4O4Cor e Forma:SolidPeso molecular:481.37CXCR4 antagonist 8
CAS:<p>CXCR4 antagonist 8 (Compound 3) blocks CXCR4, IC50 of 57 nM; stops CXCL12-induced Ca2+ increase, IC50 of 0.24 nM; hinders cell migration.</p>Fórmula:C21H26N6Cor e Forma:SolidPeso molecular:362.47Lamotrigine isethionate
CAS:<p>Water-soluble salt of lamotrigine . Displays anticonvulsant effects and inhibits glutamate release, possibly through inhibition of Na+, K+ and Ca2+ currents.</p>Fórmula:C11H13Cl2N5O4SCor e Forma:SolidPeso molecular:382.22PF-06371900
CAS:<p>PF-06371900 is a potent and highly selective inhibitor of leucine-rich repeat kinase 2 (LRRK2).</p>Fórmula:C17H16N6O2SCor e Forma:SolidPeso molecular:368.41
