DUB
Os inibidores de DUB (desubiquitinases) são compostos que têm como alvo as enzimas que removem moléculas de ubiquitina das proteínas, regulando assim a estabilidade, localização e atividade das proteínas dentro da célula. As desubiquitinases desempenham papéis essenciais em vários processos celulares, incluindo a regulação do ciclo celular, a reparação do DNA e as respostas imunológicas. A desregulação da atividade das DUB está associada ao câncer, distúrbios neurodegenerativos e infecções virais. Inibidores de DUB podem modular esses processos, oferecendo abordagens terapêuticas potenciais para essas condições. Na CymitQuimica, oferecemos inibidores de DUB para apoiar sua pesquisa em homeostase proteica, câncer e neurobiologia.
Foram encontrados 110 produtos para "DUB".
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POSH-IN-1
CAS:POSH-IN-1 (Compound 108) is an inhibitor of the POSH polypeptide （e3 ligase) and has antiviral, anticancer, and neurodegenerative disease potential.Fórmula:C14H8FNO3SPureza:99.29%Cor e Forma:SolidPeso molecular:289.28VCPIP1-IN-2
CAS:VCPIP1-IN-1 (Compound 076) is an inhibitor of VCPIP1.Fórmula:C14H13ClFN3O2Cor e Forma:SolidPeso molecular:309.72USP28-IN-4
CAS:USP28-IN-4 is a USP28 inhibitor with anticancer activity that dose-dependently down-regulates cellular levels of c-Myc via the ubiquitin-proteasome system.Fórmula:C22H18Cl2N2O3SPureza:98.39%Cor e Forma:Yellow SolidPeso molecular:461.36I-138
CAS:I-138 is an orally active and reversible inhibitor of USP1-UAF1.I-138 induces mono-ubiquitination of FANCD2 and PCNA and inhibits USP1 auto-cleavage in cells.Fórmula:C26H23F3N6OPureza:99.66%Cor e Forma:SolidPeso molecular:492.5HBX28258
CAS:HBX28258, a human USP7 inhibitor, binds covalently and selectively deactivates USP7 in colon cancer and kidney cells.Fórmula:C26H30ClN3OPureza:98%Cor e Forma:SolidPeso molecular:435.99USP7-IN-4
CAS:USP7-IN-4 is a non-competitive, potent and selective inhibitor of USP7, up-regulates p53 and p21, down-regulates MDM2,anti-proliferativity RS4;11 (leukemia) .Fórmula:C29H34N6O3Pureza:98.27% - 99.09%Cor e Forma:SolidPeso molecular:514.62BAP1-IN-1
CAS:BAP1-IN-1 is an inhibitor of the catalytic activity of BRCA1-associated protein 1 (BAP1), which is related to cancer and can be used to study cancer.Fórmula:C18H16N2O2Pureza:99.13%Cor e Forma:SolidPeso molecular:292.3318XL-188
CAS:XL-188: Potent, selective USP7 inhibitor, IC50 = 193 nM (domain), 90 nM (full). Boosts p53, p21; degrades HDM2. Unique among DUB inhibitors.Fórmula:C32H42N6O4Cor e Forma:SolidPeso molecular:574.71USP28-IN-3
CAS:USP28-IN-3 is a USP28 inhibitor with anticancer activity that dose-dependently down-regulates cellular levels of c-Myc via the ubiquitin-proteasome system.Fórmula:C23H20Cl2N2O3SPureza:99.77%Cor e Forma:White SolidPeso molecular:475.39USP28-IN-2
CAS:USP28-IN-2 selectively inhibits USP28 (IC50=0.3 μM), degrades c-Myc, kills cancer cells, lowers ankyrin-1/2, and enhances Regorafenib effects.Fórmula:C23H20Cl2N2O3SCor e Forma:SolidPeso molecular:475.39LCAHA
CAS:LCAHA is a USP2a inhibitor. LCAHA inhibits growth of cyclin D1-dependent cells.Fórmula:C24H41NO3Cor e Forma:SolidPeso molecular:391.5872FT827
CAS:FT827 is a covalent inhibitor of USP7 that targets the catalytic center of the autoinhibitory apolipoprotein form of USP7 for cancer research.Fórmula:C27H28N6O5SPureza:98.63%Cor e Forma:White SolidPeso molecular:548.613Capzimin
CAS:Capzimin is a selective inhibitor of proteasome isopeptidase Rpn11.Fórmula:C30H24N6O2S4Pureza:98.31% - 99.27%Cor e Forma:SolidPeso molecular:628.811MF-095
CAS:MF-095 is a control probe for MF-094, which is a potent inhibitor of ubiquitin specific protease 30.Fórmula:C27H31N3O4SCor e Forma:SolidPeso molecular:493.62USP30 inhibitor 11
CAS:USP30 inhibitor 11 (USP30-IN-11) is a USP30 inhibitor that inhibits SVA and can be used in studies of cancer, mitochondrial dysfunction and Parkinson's.Fórmula:C17H16N6O2SPureza:98.49% - 98.84%Cor e Forma:SolidPeso molecular:368.413P22074
CAS:P22074 is a USP7 inhibitor. It is not an active antagonist like its halogenated related compounds. p22074 has antitumour activity.Fórmula:C12H9NO3S2Pureza:99.97%Cor e Forma:SolidPeso molecular:279.335OTUB1/USP8-IN-1
CAS:OTUB1/USP8-IN-1 is an OTUB1/USP8 inhibitor with anticancer activity for the study of non-small cell lung cancer.Fórmula:C22H16ClFN2O4Pureza:97.75%Cor e Forma:SolidPeso molecular:426.825SJB3-019A
CAS:SJB3-019A is a potent, potent and novel ubiquitin-specific protease 1 (USP1) inhibitor, which promotes ID1 degradation and cytotoxicity in K562 cells 5 timesFórmula:C16H8N2O3Pureza:99.72%Cor e Forma:Yellow SolidPeso molecular:276.2463USP22-IN-1
CAS:USP22-IN-1 is a ubiquitin-specific peptidase 22 (USP22) inhibitor that can be used to treat proliferative diseases or cancer.Fórmula:C22H18N4Pureza:99.37%Cor e Forma:SolidPeso molecular:338.40516RK73
CAS:6RK73 is a covalent irreversible and specific UCHL1 inhibitor (IC50: 0.23 µM). 6RK73 shows almost no inhibition of UCHL3 (IC50: 236 µM).Fórmula:C13H17N5O2SPureza:99.91%Cor e Forma:SolidPeso molecular:307.371
