DUB
Os inibidores de DUB (desubiquitinases) são compostos que têm como alvo as enzimas que removem moléculas de ubiquitina das proteínas, regulando assim a estabilidade, localização e atividade das proteínas dentro da célula. As desubiquitinases desempenham papéis essenciais em vários processos celulares, incluindo a regulação do ciclo celular, a reparação do DNA e as respostas imunológicas. A desregulação da atividade das DUB está associada ao câncer, distúrbios neurodegenerativos e infecções virais. Inibidores de DUB podem modular esses processos, oferecendo abordagens terapêuticas potenciais para essas condições. Na CymitQuimica, oferecemos inibidores de DUB para apoiar sua pesquisa em homeostase proteica, câncer e neurobiologia.
Foram encontrados 100 produtos para "DUB".
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USP28-IN-2
CAS:USP28-IN-2 selectively inhibits USP28 (IC50=0.3 μM), degrades c-Myc, kills cancer cells, lowers ankyrin-1/2, and enhances Regorafenib effects.Fórmula:C23H20Cl2N2O3SCor e Forma:SolidPeso molecular:475.39LCAHA
CAS:LCAHA is a USP2a inhibitor. LCAHA inhibits growth of cyclin D1-dependent cells.Fórmula:C24H41NO3Cor e Forma:SolidPeso molecular:391.59BAP1-IN-1
CAS:BAP1-IN-1 is an inhibitor of the catalytic activity of BRCA1-associated protein 1 (BAP1), which is related to cancer and can be used to study cancer.Fórmula:C18H16N2O2Pureza:98.11%Cor e Forma:SolidPeso molecular:292.33I-138
CAS:I-138 is an orally active and reversible inhibitor of USP1-UAF1.I-138 induces mono-ubiquitination of FANCD2 and PCNA and inhibits USP1 auto-cleavage in cells.Fórmula:C26H23F3N6OPureza:99.66%Cor e Forma:SolidPeso molecular:492.5Ref: TM-T73560
1mg105,00€5mg210,00€1mL*10mM (DMSO)230,00€10mg295,00€25mg424,00€50mg587,00€100mg880,00€FT827
CAS:FT827 is a covalent inhibitor of USP7 that targets the catalytic center of the autoinhibitory apolipoprotein form of USP7 for cancer research.Fórmula:C27H28N6O5SPureza:98.76%Cor e Forma:White SolidPeso molecular:548.61USP7-IN-4
CAS:USP7-IN-4 is a non-competitive, potent and selective inhibitor of USP7, up-regulates p53 and p21, down-regulates MDM2,anti-proliferativity RS4;11 (leukemia) .Fórmula:C29H34N6O3Pureza:98.27% - 99.09%Cor e Forma:SolidPeso molecular:514.62HBX28258
CAS:HBX28258, a human USP7 inhibitor, binds covalently and selectively deactivates USP7 in colon cancer and kidney cells.Fórmula:C26H30ClN3OPureza:98%Cor e Forma:SolidPeso molecular:435.996RK73
CAS:6RK73 is a covalent irreversible and specific UCHL1 inhibitor (IC50: 0.23 µM). 6RK73 shows almost no inhibition of UCHL3 (IC50: 236 µM).Fórmula:C13H17N5O2SPureza:99.91%Cor e Forma:SolidPeso molecular:307.37Ref: TM-T10188
1mg137,00€5mg281,00€1mL*10mM (DMSO)310,00€10mg484,00€25mg782,00€50mg1.071,00€100mg1.431,00€500mg2.898,00€P22074
CAS:P22074 is a USP7 inhibitor. It is not an active antagonist like its halogenated related compounds. p22074 has antitumour activity.Fórmula:C12H9NO3S2Pureza:99.97%Cor e Forma:SolidPeso molecular:279.33Ref: TM-T28284
1mg137,00€1mL*10mM (DMSO)239,00€5mg314,00€10mg427,00€25mg600,00€50mg798,00€100mg1.099,00€200mg1.468,00€USP30 inhibitor 11
CAS:USP30 inhibitor 11 (USP30-IN-11) is a USP30 inhibitor that inhibits SVA and can be used in studies of cancer, mitochondrial dysfunction and Parkinson's.Fórmula:C17H16N6O2SPureza:98.49% - 98.84%Cor e Forma:SolidPeso molecular:368.41GSK2643943A
CAS:GSK2643943A is a deubiquitylating enzyme (DUB) inhibitor, with an IC 50 of 160 nM for USP20/Ub-Rho. GSK2643943A has anti-tumor efficacy.Fórmula:C17H12FN3Pureza:97.09%Cor e Forma:SolidPeso molecular:277.3Ref: TM-T11485
1mg39,00€2mg50,00€5mg82,00€1mL*10mM (DMSO)90,00€10mg120,00€25mg236,00€50mg356,00€100mg537,00€200mg762,00€OTUB1/USP8-IN-1
CAS:OTUB1/USP8-IN-1 is an OTUB1/USP8 inhibitor with anticancer activity for the study of non-small cell lung cancer.Fórmula:C22H16ClFN2O4Pureza:98.59%Cor e Forma:SolidPeso molecular:426.83SJB3-019A
CAS:SJB3-019A is a potent, potent and novel ubiquitin-specific protease 1 (USP1) inhibitor, which promotes ID1 degradation and cytotoxicity in K562 cells 5 timesFórmula:C16H8N2O3Pureza:99.72%Cor e Forma:Yellow SolidPeso molecular:276.25Ref: TM-T12926
1mg77,00€2mg101,00€5mg168,00€10mg253,00€25mg416,00€50mg580,00€100mg783,00€200mg1.054,00€USP22-IN-1
CAS:USP22-IN-1 is a ubiquitin-specific peptidase 22 (USP22) inhibitor that can be used to treat proliferative diseases or cancer.Fórmula:C22H18N4Pureza:99.37%Cor e Forma:SolidPeso molecular:338.41LDN-91946
CAS:LDN-91946 is an effective and selective inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) (Ki = 2.8 μM).Fórmula:C15H10N2O4SPureza:97.12%Cor e Forma:SolidPeso molecular:314.32FT206
CAS:FT206 is a carboxamide inhibitor of ubiquitin-specific protease[1].Fórmula:C25H29N5OSCor e Forma:SolidPeso molecular:447.6USP1-IN-3
CAS:USP1-IN-3 is a selective inhibitor of USPI that inhibits USPI-UAFI (IC50<30 nM). USP1-IN-3 can be used to study cancer.Fórmula:C27H24F3N7OCor e Forma:SolidPeso molecular:519.52USP1-IN-5
CAS:USP1-IN-5 (compound 10) is a potent inhibitor of both USP1, with an IC50 of less than 50 nM, and MDA-MB-436 cells, where it also exhibits an IC50 of less thanFórmula:C27H23F3N8OCor e Forma:SolidPeso molecular:532.52USP1-IN-6
CAS:USP1-IN-6 (Compound 11) functions as a potent USP1 inhibitor, exhibiting an IC50 value of less than 50 nM.Fórmula:C29H27F3N8OCor e Forma:SolidPeso molecular:560.57FT671
CAS:FT671 is a non-covalent, selective USP7 inhibitor, disrupts the stability of USP7 substrates including MDM2, elevates p53, induces p21, inhibits tumor growth.Fórmula:C24H23F4N7O3Pureza:99.76%Cor e Forma:SolidPeso molecular:533.48
