DUB
Os inibidores de DUB (desubiquitinases) são compostos que têm como alvo as enzimas que removem moléculas de ubiquitina das proteínas, regulando assim a estabilidade, localização e atividade das proteínas dentro da célula. As desubiquitinases desempenham papéis essenciais em vários processos celulares, incluindo a regulação do ciclo celular, a reparação do DNA e as respostas imunológicas. A desregulação da atividade das DUB está associada ao câncer, distúrbios neurodegenerativos e infecções virais. Inibidores de DUB podem modular esses processos, oferecendo abordagens terapêuticas potenciais para essas condições. Na CymitQuimica, oferecemos inibidores de DUB para apoiar sua pesquisa em homeostase proteica, câncer e neurobiologia.
Foram encontrados 100 produtos para "DUB".
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USP7-IN-3
CAS:USP7-IN-3 is a potent and selective allosteric inhibitor of ubiquitin-specific protease 7 (USP7).Fórmula:C29H31F3N6O3Pureza:98%Cor e Forma:SolidPeso molecular:568.59USP30 inhibitor 18
CAS:USP30 inhibitor 18 is a selective inhibitor of USP30 (IC50 = 0.02 μM). USP30 inhibitor 18 is able to accelerate mitophagy and increase protein ubiquitination.Fórmula:C26H28FN3O4SPureza:99.85%Cor e Forma:SolidPeso molecular:497.58Ref: TM-T36682
1mg137,00€5mg281,00€1mL*10mM (DMSO)309,00€10mg447,00€25mg713,00€50mg1.018,00€100mg1.369,00€500mg2.673,00€USP7-IN-1
CAS:USP7-IN-1 is a selective and reversible ubiquitin-specific protease 7 (USP7) inhibitor (IC50 = 77 μM).Fórmula:C23H24ClN3O3Pureza:99.82%Cor e Forma:White SolidPeso molecular:425.91Ref: TM-T13268
1mg84,00€5mg177,00€1mL*10mM (DMSO)195,00€10mg249,00€25mg425,00€50mg605,00€100mg800,00€CT1113
CAS:CT1113, a potent inhibitor of both USP28 and USP25, effectively reduces MYC levels in vivo and demonstrates anti-tumor efficacy in a mouse pancreatic cancer CDXFórmula:C25H29N5O2SCor e Forma:SolidPeso molecular:463.6USP7-IN-12
CAS:USP7-IN-12 (compound 1) is a potent, orally active inhibitor of Usp7, exhibiting an IC50 of 3.67 nM and demonstrating antiproliferative activity [1].Fórmula:C29H28ClFN4O2SCor e Forma:SolidPeso molecular:551.07DUB-IN-7
CAS:DUB-IN-7 (compound 43), a deubiquitinating enzyme (DUB) inhibitor, has utility in researching diseases driven by aberrant JAK2 activity, including leukemia [1].Fórmula:C17H19N5OCor e Forma:SolidPeso molecular:309.37USP7-IN-13
CAS:USP7-IN-13 (Compound 101), a USP7 inhibitor, exhibits an IC50 range of 0.2-1 μM and is applicable in researching multiple myeloma [1].Fórmula:C24H28N4O3Cor e Forma:SolidPeso molecular:420.5IMP-1710
CAS:IMP-1710 is a selective UCH-L1 inhibitor with an IC50 value of 38 nM in a fluorescence polarization assay.[1]Cost-effective and quality-assured.Fórmula:C23H19N5OPureza:99.3%Cor e Forma:White SolidPeso molecular:381.43USP1-IN-4
CAS:USP1-IN-4 (compound 10) serves as a potent inhibitor of USP1, exhibiting an IC 50 of 2.44 nM. It demonstrates anticancer properties and operates synergistically with various anticancer drugs [1].Fórmula:C26H23F3N6Cor e Forma:SolidPeso molecular:476.50USP7-797
CAS:USP7-797 is a selective non-covalent active site USP7 inhibitor, inhibiting USP7 and ubiquitin binding, with anti-tumor, oral and high efficiency properties.Fórmula:C27H28ClN3O3SPureza:95.90% - 95.90%Cor e Forma:SolidPeso molecular:510.05FT709
CAS:FT709 is a selective USP9X deubiquitinating enzyme inhibitor (IC50=82 nM) that reduces Makorin and ZNF598 levels, impairing ribosomal quality control pathways.Fórmula:C23H22N4O7SPureza:98.13%Cor e Forma:White SolidPeso molecular:498.51MTX115325
CAS:MTX115325 (Example 1) is a brain-penetrant USP30 inhibitor with an IC 50 of 12 nM, administered orally and exhibiting neuroprotective properties. It enhances ubiquitination (EC 50 =32 nM) of TOM20, a mitochondrial outer membrane protein and USP30 substrate, thereby promoting mitophagy. Additionally, MTX115325 prevents dopaminergic neuron loss and maintains striatal dopamine [1].Fórmula:C18H16N6O2Cor e Forma:SolidPeso molecular:348.36USP7 activator 1
CAS:USP7activator 1 (compound MS-8) is an activator of USP7 that interacts with the allosteric C-terminal binding pocket of USP7.Fórmula:C22H32N4O3Cor e Forma:SolidPeso molecular:400.514USP7-IN-6
CAS:USP7-IN-6 is a potent inhibitor of ubiquitin-specific protease 7 (USP7, IC50: 6.8 nM).Fórmula:C41H43N7O4SPureza:98%Cor e Forma:SolidPeso molecular:729.89USP7-IN-10
CAS:USP7-IN-10 is a potent inhibitor of ubiquitin-specific protease 7 (USP7), exhibiting an inhibition concentration half-maximal (IC50) value of 13.39 nM.Fórmula:C26H29ClN4O3SCor e Forma:SolidPeso molecular:513.05FT3967385
FT3967385: New USP30 inhibitor boosts mitochondrial ubiquitylation via PINK1-PARKIN.Fórmula:C21H19N5O2Cor e Forma:SolidPeso molecular:373.41USP1-IN-7
CAS:USP1-IN-7 (Compound 3), a potent inhibitor of ubiquitin specific peptidase 1 (USP1) and its cofactor UAF1, exhibits an inhibition concentration (IC 50) of ≤50 nM. It also effectively inhibits the proliferation of MDA-MB-436 cells at similar concentrations [1].Fórmula:C27H23F4N7O2Cor e Forma:SolidPeso molecular:553.51USP5-IN-1
USP5-IN-1, a powerful USP5 deubiquitinase inhibitor, selectively binds with 2.8 μM affinity, blocking USP5's di-ubiquitin cleavage.Fórmula:C19H20ClN3O5SPureza:99.76%Cor e Forma:SoildPeso molecular:437.9Ref: TM-T60130
1mg52,00€5mg111,00€1mL*10mM (DMSO)123,00€10mg169,00€25mg295,00€50mg447,00€100mg670,00€USP15-IN-1
CAS:USP15-IN-1 is a potent USP15 inhibitor (IC50 is 3.76 μM).Fórmula:C22H23N3O3Pureza:99.50% - 99.81%Cor e Forma:SolidPeso molecular:377.44VCPIP1-IN-1
CAS:VCPIP1-IN-1 is a VCPIP1 inhibitor used in cancer research.Fórmula:C13H15ClN2O2Pureza:99.3%Cor e Forma:White SolidPeso molecular:266.72Ref: TM-T88664
1mg47,00€5mg92,00€1mL*10mM (DMSO)101,00€10mg145,00€25mg281,00€50mg447,00€100mg715,00€200mg964,00€
