Receptor Endotelina
Os receptores de endotelina são GPCRs que mediam os efeitos das endotelinas, potentes peptídeos vasoconstritores que desempenham um papel significativo na regulação do tônus vascular, controle da pressão arterial e proliferação celular. Antagonistas dos receptores de endotelina são usados no tratamento de condições como hipertensão arterial pulmonar e insuficiência cardíaca. Esses receptores também são alvos importantes na pesquisa sobre doenças cardiovasculares e câncer. Na CymitQuimica, oferecemos uma seleção de moduladores de receptores de endotelina de alta qualidade para apoiar sua pesquisa em biologia cardiovascular, oncologia e fisiologia vascular.
Foram encontrados 76 produtos de "Receptor Endotelina"
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Sulfisoxazole
CAS:<p>Sulfisoxazole: a short-acting antibacterial targeting gram-positive/negative bacteria and inhibits breast cancer exosome by affecting endothelin receptor A.</p>Fórmula:C11H13N3O3SPureza:99.87% - 99.98%Cor e Forma:White To Cream PowderPeso molecular:267.30Enrasentan
CAS:<p>Enrasentan (sb-217242) is a mixed antagonist of ET(A) and ET(B) receptors that reduces blood pressure and protects myocardial function.</p>Fórmula:C29H30O8Pureza:97.9% - 98.39%Cor e Forma:SolidPeso molecular:506.54Sarafotoxin S6c
CAS:<p>Highly selective ETB endothelin receptor agonist (Ki values are 0.29 and 28000 nM at ETB and ETA receptors respectively).</p>Fórmula:C103H147N27O37S5Pureza:98%Cor e Forma:SolidPeso molecular:2516PD 142893
CAS:<p>PD 142893 is a functional endothelin-stimulated vasoconstriction antagonist.</p>Fórmula:C50H65N7O10Pureza:98%Cor e Forma:SolidPeso molecular:924.09IRL-1620
CAS:<p>IRL-1620 is an effective and selective agonist of endothelin receptor type B (ETB) (Ki: 16 pM).</p>Fórmula:C86H117N17O27Pureza:98%Cor e Forma:SolidPeso molecular:1820.974BQ-3020 ammonium
<p>BQ-3020 ammonium, a selective endothelin receptor (ET B receptor) agonist, demonstrates inhibition of [125 I] ET-1 binding to ET B receptors with an IC50 of 0.2</p>Fórmula:C96H140N20O25S·xNH3Pureza:98%Cor e Forma:SolidPeso molecular:2006.32 (free base)Atrial natriuretic peptide (3-28) (human)
CAS:<p>Atrial natriuretic peptide (3-28) (human) (ANP (3-28) (human)), a peptide hormone produced by the atrial myocardium, plays a critical role in the regulation of</p>Fórmula:C118H187N43O36S3Pureza:98%Cor e Forma:SolidPeso molecular:2880.21IRL-1620 acetate
<p>IRL-1620 acetate is an effective and selective agonist of Endothelin B receptor (ETB) with a Ki of 16 pM which is more selective than ETA with a Ki of 19 μM.</p>Fórmula:C88H121N17O29Pureza:96.64%Cor e Forma:SolidPeso molecular:1881IRL-1038 TFA
<p>IRL-1038 TFA is an ETB receptor antagonist used in the study of cardiovascular disease.</p>Fórmula:C70H93F3N14O17S2Pureza:98.79%Cor e Forma:SolidPeso molecular:1523.7Atrial natriuretic factor (1-28) (rat) TFA
<p>ANP (1-28), rat (TFA) inhibits Ang II-induced endothelin-1 secretion; main circulating ANP form in rats.</p>Fórmula:C130H206N45F3O41S2Pureza:98%Cor e Forma:SolidPeso molecular:3176.43Atrial Natriuretic Peptide (ANP) (1-28), rat
CAS:<p>Atrial Natriuretic Peptide (1-28), rat is the major circulating form of ANP in rats.</p>Fórmula:C128H205N45O39S2Pureza:98%Cor e Forma:SolidPeso molecular:3062.41ACT-373898
CAS:<p>ACT-373898 is a metabolite of the endothelin (ET) receptor type A (ETA) and ETBdual antagonist macitentan .1</p>Fórmula:C15H17BrN4O5SCor e Forma:SolidPeso molecular:445.29IRL-1038 acetate
<p>IRL-1038 acetate is a potent ETB endothelin receptor antagonist.</p>Fórmula:C70H96N14O17S2Pureza:97.51%Cor e Forma:SoildPeso molecular:1469.73IRL-1038
CAS:<p>ETB endothelin receptor antagonist</p>Fórmula:C68H92N14O15S2Pureza:98%Cor e Forma:SolidPeso molecular:1409.67[Ala1,3,11,15]-Endothelin
CAS:<p>Selective ETB endothelin receptor agonist (IC50 values are 0.33 and 2200 nM for displacing [125I]-ET-1 from ETB and ETA receptors respectively).</p>Fórmula:C109H163N25O32SPureza:98%Cor e Forma:SolidPeso molecular:2368Nebentan
CAS:<p>Nebentan (YM598) is an oral, selective ETA antagonist; Ki: 0.697 nM (ETA), 569 nM (ETB); may slow cor pulmonale, myocardial infarction.</p>Fórmula:C24H21N5O5SCor e Forma:SolidPeso molecular:491.52Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate
CAS:<p>Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate is an NPR-A agonist and ANP hormone. Carperitide increases cGMP levels and reduces the heart's workload.</p>Fórmula:C129H207N45O41S3Pureza:99.78%Cor e Forma:SoildPeso molecular:3140.5SB234551
CAS:<p>SB234551 is a selective antagonist of endothelin ETA receptor.</p>Fórmula:C34H34N2O9Cor e Forma:SolidPeso molecular:614.64[Lys4] Sarafotoxin S6c
CAS:<p>[Lys4] Sarafotoxin S6c: potent partial endothelin receptor agonist; causes pig coronary contraction, EC50=1.5 nM.</p>Fórmula:C105H153N27O36S5Cor e Forma:SolidPeso molecular:2529.82Sulfatroxazole
CAS:<p>Sulfatroxazole (Isosulfafurazole) (compound 12) is a selective antagonist of the ETA receptor with an IC50 of 0.26 μM.</p>Fórmula:C11H13N3O3SCor e Forma:SolidPeso molecular:267.3IRL-3630
CAS:<p>IRL 3460 is an enantiomer.</p>Fórmula:C31H40N4O6SPureza:98%Cor e Forma:SolidPeso molecular:596.74Endothelin 1 (swine, human), Alexa Fluor 488-labeled
<p>Synthetic human/swine Endothelin 1 peptide, tagged with Alexa Fluor 488, acts as a strong vasoconstrictor via ET A/B receptors.</p>Cor e Forma:SolidPeso molecular:2848.4Sarafotoxin S6a
CAS:<p>Endothelin receptor agonist (EC50 values are 7.5 and > 150 nM for contraction of pig coronary artery and guinea pig aorta respectively). Nociceptive in vivo.</p>Fórmula:C105H156N28O34S5Pureza:98%Cor e Forma:SolidPeso molecular:2514.85Sarafotoxin S6b
CAS:<p>non-selective endothelin receptor agonist</p>Fórmula:C110H163N27O34S5Pureza:98%Cor e Forma:SolidPeso molecular:2567.96[Ala2] Endothelin-3, human
CAS:<p>[Ala2] Endothelin-3, a linear ET-3 analog with Ala replacing Cys, stimulates endothelial cell migration.</p>Fórmula:C120H166N26O32S4Cor e Forma:SolidPeso molecular:2613.02BQ-123 TFA
<p>BQ-123 TFA: Potent ETA antagonist, IC50 = 7.3 nM, Ki = 25 nM, inhibits ET-1 cell proliferation, lowers rat BP.</p>Fórmula:C33H43F3N6O9Cor e Forma:SolidPeso molecular:724.72Endothelin 1 (swine, human)
CAS:<p>Endothelin 1, a strong vasoconstrictor, targets ETA/ETB receptors, with a synthetic human/swine peptide sequence.</p>Fórmula:C109H159N25O32S5Cor e Forma:White PowderPeso molecular:2491.9Endothelin-3 (Rat,Human) (TFA)
<p>Endothelin-3 (Rat, Human) (TFA) is a 21-amino acid vasoactive peptide of endothelial origi, an agonist for the endothelin receptor type B (EDNRB).</p>Fórmula:C123H169F3N26O35S4·xC2HF3O2Pureza:98%Cor e Forma:SolidPeso molecular:2757.07 (free base)Bosentan (hydrate)
CAS:<p>Bosentan hydrate (Ro 47-0203) is a competitive and dual antagonist of endothelin-1 at the endothelin-A (ET-A) and endothelin-B (ET-B) receptors.</p>Fórmula:C27H29N5O6S·H2OPureza:99.31% - 99.86%Cor e Forma:White PowderPeso molecular:569.63Macitentan
CAS:<p>Macitentan (ACT-064992) is an endothelin receptor antagonist that is used in the therapy of pulmonary arterial hypertension (PAH).</p>Fórmula:C19H20Br2N6O4SPureza:98% - >99.99%Cor e Forma:SolidPeso molecular:588.27Darusentan
CAS:<p>Darusentan (Lu-135252) is a potent inhibitor of endothelin signaling and function in both large and small arteries</p>Fórmula:C22H22N2O6Pureza:98.72%Cor e Forma:SolidPeso molecular:410.43Ambrisentan sodium
CAS:<p>Ambrosentan (BSF 208075) sodium is a selective and oral effective antagonist of ET type A receptor ( ETAR ).</p>Fórmula:C22H21N2NaO4Cor e Forma:SolidPeso molecular:400.41BQ-788 sodium salt
CAS:<p>BQ-788 sodium salt is a potent and selective antagonist of ETB receptor(ETB receptors with an IC50 of 1.2 nM in human Girrardi heart cells).</p>Fórmula:C34H51N5NaO7Cor e Forma:SolidPeso molecular:664.8Atrasentan
CAS:<p>Atrasentan (ABT-627) is an endothelin receptor antagonist that can inhibit the activity of ETA.Cost-effective and quality-assured.</p>Fórmula:C29H38N2O6Pureza:97.65% - 99.08%Cor e Forma:SolidPeso molecular:510.62Sparsentan
CAS:<p>Sparsentan (DARA-a) is a first-in-class orally active and highly potent dual endothelin A and angiotensin II receptor antagonist(Ki of 9.3 and 0.8 nM,</p>Fórmula:C32H40N4O5SPureza:97.94% - 98.69%Cor e Forma:SolidPeso molecular:592.75BMS 182874 hydrochloride
CAS:<p>BMS 182874 hydrochloride is a nonpeptide endothelin (El) receptor antagonist.</p>Fórmula:C17H20ClN3O3SPureza:97.01%Cor e Forma:SolidPeso molecular:381.88Endothelin-2 (49-69), human
CAS:<p>Endothelin-2 (49-69), human (Human endothelin-2) is a 21-amino acid vasoactive peptide that binds to G-protein-linked transmembrane receptors, ET-RA and ET-RB.</p>Fórmula:C115H160N26O32S4Pureza:98.26%Cor e Forma:SolidPeso molecular:2546.92Sitaxsentan sodium
CAS:<p>Sitaxsentan sodium (TBC11251 sodium salt) is a highly selective antagonist of endothelin A receptors.</p>Fórmula:C18H14ClN2O6S2·NaPureza:98.39% - 99.01%Cor e Forma:SolidPeso molecular:476.89Aprocitentan
CAS:<p>Aprocitentan (ACT-132577) is ETA and ETB antagonist .</p>Fórmula:C16H14Br2N6O4SPureza:99.17%Cor e Forma:SolidPeso molecular:546.19BQ-123
CAS:<p>BQ-123 is a selective endothelin A receptor (ETA) antagonist with IC50 of 7.3 nM. Phase 2.</p>Fórmula:C31H42N6O7Pureza:99.22% - ≥95%Cor e Forma:SolidPeso molecular:610.7ANP(1-28) Acetate (human, porcine)
CAS:<p>Carperitide acetate: 28-amino acid hormone from human heart, counters cardiac injury/stretch, reduces endothelin-1.</p>Fórmula:C129H207N45O41S3Pureza:98.24%Cor e Forma:SolidPeso molecular:3140.5RO 46-8443
CAS:<p>RO 46-8443: First non-peptide ETB receptor antagonist, >2000-fold ETB selectivity in binding and function.</p>Fórmula:C31H35N3O8SPureza:98.77% - 99.77%Cor e Forma:SolidPeso molecular:609.69Ambrisentan
CAS:<p>Ambrisentan, an endothelin antagonist for PAH, has a low risk of liver enzyme elevation, not linked to acute liver injury.</p>Fórmula:C22H22N2O4Pureza:99.65% - 99.86%Cor e Forma:SolidPeso molecular:378.42Ro 46-2005
CAS:<p>Ro 46-2005: Synthetic non-peptide, blocks 125I-ET-1 at ETA receptors on human vascular cells (IC50: 220 nM).</p>Fórmula:C23H27N3O6SPureza:98.02% - 98.8%Cor e Forma:SolidPeso molecular:473.54Bosentan
CAS:<p>Bosentan is a competitive endothelin receptor antagonist, used for treating pulmonary arterial hypertension.</p>Fórmula:C27H29N5O6SPureza:99.74% - 99.84%Cor e Forma:Pale Yellow To Off-White SolidPeso molecular:551.614Nebentan potassium
CAS:<p>Nebentan potassium (YM598) is an ETA receptor antagonist that inhibits pulmonary arterial hypertension and is used in the study of neurologic diseases.</p>Fórmula:C24H20KN5O5SPureza:99.05%Cor e Forma:SolidPeso molecular:529.61Zibotentan
CAS:<p>Zibotentan (ZD4054) (ZD4054) is a specific Endothelin (ET)A antagonist with IC50 of 21 nM, exhibiting no activity at ETB. Phase 3.</p>Fórmula:C19H16N6O4SPureza:97.00% - 97.02%Cor e Forma:SolidPeso molecular:424.43CH 141
CAS:<p>CH 141 is a new type of peripheral vasodilator.</p>Fórmula:C19H21N3OCor e Forma:SolidPeso molecular:307.39ZD-1611
CAS:<p>ZD-1611 is an effective and selective ETA receptor antagonist. It is used for the research of ischemic stroke.</p>Fórmula:C22H24N4O5SPureza:98%Cor e Forma:SolidPeso molecular:456.51WS 009B
CAS:<p>WS 009B is an antagonist of the endothelin receptor.</p>Fórmula:C24H25NO11SPureza:98%Cor e Forma:SolidPeso molecular:535.52Daglutril
CAS:<p>Daglutril is a NEP/ECE inhibitor for treating hypertension, heart failure, and pulmonary issues, blocking big endothelin-1 conversion.</p>Fórmula:C31H38N2O6Cor e Forma:SolidPeso molecular:534.64WS 009A
CAS:<p>WS 009A is an antagonist of the endothelin receptor.</p>Fórmula:C24H25NO10SPureza:98%Cor e Forma:SolidPeso molecular:519.52ETA antagonist 1
CAS:<p>ETA antagonist 1 is an antagonist of ETA selective (IC50 of 0.08 μM).</p>Fórmula:C20H25N3O3SPureza:98%Cor e Forma:SolidPeso molecular:387.5Aminaftone
CAS:<p>Aminaftone, a derivative of 4-aminobenzoic acid, inhibits endothelin-1 (ET-1) production and can be used to study hypertension and systemic sclerosis.</p>Fórmula:C18H15NO4Pureza:96.31% - 99.39%Cor e Forma:SolidPeso molecular:309.32Atrasentan hydrochloride
CAS:<p>Atrasentan hydrochloride (ABT-627 hydrochloride) is an antagonist of the endothelin receptor(IC50 = 55.1 μM for ETA).</p>Fórmula:C29H39ClN2O6Pureza:99.75%Cor e Forma:SolidPeso molecular:547.08PD-156707
CAS:<p>PD-156707 is a selective antagonist of endothelin A receptor.</p>Fórmula:C28H26NaO9Pureza:98%Cor e Forma:SolidPeso molecular:529.497CI 1020
CAS:<p>endothelin-A receptor (ETA) antagonist</p>Fórmula:C28H26O9Pureza:98%Cor e Forma:SolidPeso molecular:506.5TBC3711
CAS:<p>TBC3711 is an endothelin receptor modulator. It is used for the research of endothelin-mediated disorders.</p>Fórmula:C20H21N3O5S2Pureza:98%Cor e Forma:SolidPeso molecular:447.53BMS-193884
CAS:<p>BMS-193884 is an oral endothelin antagonist for the treatment of congestive heart failure (CHF) and pulmonary arterial hypertension.</p>Fórmula:C20H17N3O4SCor e Forma:SolidPeso molecular:395.43PD-159020
CAS:<p>PD-159020 is a non-selective antagonist of ETA/ETB(hETA and hETB with IC50s of 30 and 50 nM , respectively).</p>Fórmula:C32H25NO8Pureza:98%Cor e Forma:SolidPeso molecular:551.54ABT-546
CAS:<p>ABT-546 is a potent, selective endothelin ETA receptor antagonist, Ki 0.46 nM for [125I]ET-1 binding.</p>Fórmula:C30H48N2O6Pureza:98%Cor e Forma:SolidPeso molecular:532.71Avosentan
CAS:<p>Avosentan（Ro 67-0565; SPP-301） is a potent endothelin receptor (ETA) antagonist.Cost-effective and quality-assured.</p>Fórmula:C23H21N5O5SPureza:98.31% - 99.47%Cor e Forma:SolidPeso molecular:479.51FR 139317
CAS:<p>highly potent and selective ETA endothelin receptor antagonist</p>Fórmula:C33H44N6O5Pureza:98%Cor e Forma:SolidPeso molecular:604.74Edonentan
CAS:<p>Edonentan is A potent endothelin A (ETA) receptor antagonist that can be used to study heart failure.</p>Fórmula:C28H32N4O5SPureza:98.07% - 99.6%Cor e Forma:SolidPeso molecular:536.64Sitaxsentan
CAS:<p>Sitaxsentan (TBC-11251), a selective ETA receptor antagonist, prevents vasoconstriction by blocking endothelin.</p>Fórmula:C18H15ClN2O6S2Pureza:97.99% - 98.71%Cor e Forma:SolidPeso molecular:454.9SB-209670
CAS:<p>SB-209670 is a selective endothelin receptor antagonist that inhibits the activity of ET(B) receptors in rat vascular endothelium and vascular smooth muscle.</p>Fórmula:C29H28O9Pureza:97.80% - 99.40%Cor e Forma:SolidPeso molecular:520.53BMS 182874
CAS:<p>BMS 182874: Oral ETA antagonist, IC50=0.150 μM, Ki=0.055 μM, lowers hypertension in rats.</p>Fórmula:C17H19N3O3SPureza:98.38%Cor e Forma:SolidPeso molecular:345.42L-749329
CAS:<p>L-749329 is a ligand of ET(A) and ET(B) endothelin receptor.</p>Fórmula:C28H29NO8SPureza:98%Cor e Forma:SolidPeso molecular:539.6Clazosentan
CAS:<p>Clazosentan (Ro 61-1790) is a selective ET_A receptor antagonist that inhibits ET-1 vasoconstriction and prevents cerebral vasospasm.</p>Fórmula:C25H23N9O6SPureza:95.39% - >99.99%Cor e Forma:SolidPeso molecular:577.57BMS-248360
CAS:<p>BMS-248360: Oral dual hAT1/hETA antagonist with Kis of 10nM & 1.9nM, respectively; treats hypertension.</p>Fórmula:C36H45N5O5SPureza:98%Cor e Forma:SolidPeso molecular:659.84Tezosentan
CAS:<p>Tezosentan is an antagonist of the endothelin receptor (pA2s: 9.5, 7.7 for ETA and ETB receptors, respectively).</p>Fórmula:C27H27N9O6SPureza:98%Cor e Forma:SolidPeso molecular:605.63K-8794
CAS:<p>K-8794 is an orally active and selective endothelin receptor ETB antagonist that can be utilized in cardiovascular disease research.</p>Fórmula:C36H38N6O6SCor e Forma:SolidPeso molecular:682.789IRL 2500
CAS:<p>IRL 2500 is an antagonist of Endothelin receptor with IC50s of 1.3 and 94 nM for Endothelin A receptor and Endothelin B receptor.</p>Fórmula:C36H35N3O4Pureza:99.36%Cor e Forma:White Crystalline SolidPeso molecular:573.68Macitentan (n-butyl analogue)
CAS:<p>Macitentan n-butyl analogue, an oral ETA/ETB receptor blocker, may treat IPF and PAH.</p>Fórmula:C20H21Br2N5O4SPureza:98%Cor e Forma:SolidPeso molecular:587.29BQ-788
CAS:<p>BQ-788 is an ETB receptor antagonist with potential hypertensive activity that inhibits exogenous ET-1-induced elevation of coronary perfusion pressure.</p>Fórmula:C34H51N5O7Pureza:98.81%Cor e Forma:SolidPeso molecular:641.8Patecibart
CAS:<p>Patecibart is a humanized immunoglobulin G4-kappa monoclonal antibody that functions as an antagonist to the endothelin receptor A (EDNRA).</p>Pureza:98%Cor e Forma:Liquid
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