Receptor Endotelina
Os receptores de endotelina são GPCRs que mediam os efeitos das endotelinas, potentes peptídeos vasoconstritores que desempenham um papel significativo na regulação do tônus vascular, controle da pressão arterial e proliferação celular. Antagonistas dos receptores de endotelina são usados no tratamento de condições como hipertensão arterial pulmonar e insuficiência cardíaca. Esses receptores também são alvos importantes na pesquisa sobre doenças cardiovasculares e câncer. Na CymitQuimica, oferecemos uma seleção de moduladores de receptores de endotelina de alta qualidade para apoiar sua pesquisa em biologia cardiovascular, oncologia e fisiologia vascular.
Foram encontrados 86 produtos de "Receptor Endotelina"
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Sulfisoxazole
CAS:Sulfisoxazole: a short-acting antibacterial targeting gram-positive/negative bacteria and inhibits breast cancer exosome by affecting endothelin receptor A.Fórmula:C11H13N3O3SPureza:99.87% - 99.98%Cor e Forma:White To Cream PowderPeso molecular:267.30Enrasentan
CAS:Enrasentan (sb-217242) is a mixed antagonist of ET(A) and ET(B) receptors that reduces blood pressure and protects myocardial function.Fórmula:C29H30O8Pureza:97.9% - 98.39%Cor e Forma:SolidPeso molecular:506.54Atrial Natriuretic Peptide (ANP) (1-28), rat
CAS:Atrial Natriuretic Peptide (1-28), rat is the major circulating form of ANP in rats.Fórmula:C128H205N45O39S2Pureza:98%Cor e Forma:SolidPeso molecular:3062.41Atrial natriuretic factor (1-28) (rat) TFA
ANP (1-28), rat (TFA) inhibits Ang II-induced endothelin-1 secretion; main circulating ANP form in rats.Fórmula:C130H206N45F3O41S2Pureza:98%Cor e Forma:SolidPeso molecular:3176.43ACT-373898
CAS:ACT-373898 is a metabolite of the endothelin (ET) receptor type A (ETA) and ETBdual antagonist macitentan .1Fórmula:C15H17BrN4O5SCor e Forma:SolidPeso molecular:445.29IRL-1038
CAS:ETB endothelin receptor antagonistFórmula:C68H92N14O15S2Pureza:98%Cor e Forma:SolidPeso molecular:1409.67[Ala1,3,11,15]-Endothelin
CAS:Selective ETB endothelin receptor agonist (IC50 values are 0.33 and 2200 nM for displacing [125I]-ET-1 from ETB and ETA receptors respectively).Fórmula:C109H163N25O32SPureza:98%Cor e Forma:SolidPeso molecular:2368Nebentan
CAS:Nebentan (YM598) is an oral, selective ETA antagonist; Ki: 0.697 nM (ETA), 569 nM (ETB); may slow cor pulmonale, myocardial infarction.Fórmula:C24H21N5O5SCor e Forma:SolidPeso molecular:491.52SB234551
CAS:SB234551 is a selective antagonist of endothelin ETA receptor.Fórmula:C34H34N2O9Cor e Forma:SolidPeso molecular:614.64IRL-3630
CAS:IRL 3460 is an enantiomer.Fórmula:C31H40N4O6SPureza:98%Cor e Forma:SolidPeso molecular:596.74Sarafotoxin S6b
CAS:non-selective endothelin receptor agonistFórmula:C110H163N27O34S5Pureza:98%Cor e Forma:SolidPeso molecular:2567.96Sarafotoxin S6c
CAS:Highly selective ETB endothelin receptor agonist (Ki values are 0.29 and 28000 nM at ETB and ETA receptors respectively).Fórmula:C103H147N27O37S5Pureza:98%Cor e Forma:SolidPeso molecular:2516PD 142893
CAS:PD 142893 is a functional endothelin-stimulated vasoconstriction antagonist.Fórmula:C50H65N7O10Pureza:98%Cor e Forma:SolidPeso molecular:924.09IRL-1620
CAS:IRL-1620 is an effective and selective agonist of endothelin receptor type B (ETB) (Ki: 16 pM).Fórmula:C86H117N17O27Pureza:98%Cor e Forma:SolidPeso molecular:1820.974Sarafotoxin S6a
CAS:Endothelin receptor agonist (EC50 values are 7.5 and > 150 nM for contraction of pig coronary artery and guinea pig aorta respectively). Nociceptive in vivo.Fórmula:C105H156N28O34S5Pureza:98%Cor e Forma:SolidPeso molecular:2514.85BQ-123 TFA
BQ-123 TFA: Potent ETA antagonist, IC50 = 7.3 nM, Ki = 25 nM, inhibits ET-1 cell proliferation, lowers rat BP.Fórmula:C33H43F3N6O9Cor e Forma:SolidPeso molecular:724.72[Ala2] Endothelin-3, human
CAS:[Ala2] Endothelin-3, a linear ET-3 analog with Ala replacing Cys, stimulates endothelial cell migration.Fórmula:C120H166N26O32S4Cor e Forma:SolidPeso molecular:2613.02Endothelin 1 (swine, human), Alexa Fluor 488-labeled
Synthetic human/swine Endothelin 1 peptide, tagged with Alexa Fluor 488, acts as a strong vasoconstrictor via ET A/B receptors.Cor e Forma:SolidPeso molecular:2848.4[Lys4] Sarafotoxin S6c
CAS:[Lys4] Sarafotoxin S6c: potent partial endothelin receptor agonist; causes pig coronary contraction, EC50=1.5 nM.Fórmula:C105H153N27O36S5Cor e Forma:SolidPeso molecular:2529.82Endothelin-2 (49-69), human TFA
Endothelin-2 (49-69), human (TFA) is a 21-amino acid vasoactive peptide that binds to ET-RA and ET-RB.Fórmula:C117H161N26F3O34S4Pureza:98%Cor e Forma:SolidPeso molecular:2660.94Methylsolfonyl 25(S)-Δ7-dafachronic acid
Methylsulfonyl 25(S)-Δ7-dafachronic acid (compound 3) is a selective ssDAF-12 agonist with an IC50 value of 0.41 μM. It exhibits low cytotoxicity in HepG2 cells, with an IC50 value greater than 200 μM. Methylsulfonyl 25(S)-Δ7-dafachronic acid is applicable in the study of parasitic diseases.Fórmula:C28H45NO4SPeso molecular:491.30693Endothelin 1 (swine, human) (TFA)
CAS:Synthetic human/swine Endothelin 1 (TFA) peptide; a potent vasoconstrictor acting on ET A and ET B receptors.Fórmula:C111H160F3N25O34S5Peso molecular:2605.93Bosentan-d4
CAS:Bosentan-d4: deuterium version of Bosentan, competitive ET A/B antagonist, Ki: 4.7nM (ET A), 95nM (ET B) in human SMC.Fórmula:C27H25D4N5O6SCor e Forma:SolidPeso molecular:555.64ANP (1-30), frog
CAS:ANP (1-30), frog, a peptide fragment sourced from atrial natriuretic peptide of frog origin, exhibits natriuretic, diuretic, and vasorelaxant properties.Fórmula:C131H217N49O41S4Cor e Forma:SolidPeso molecular:3262.69Big endothelin-1 (rat 1-39)
CAS:Big endothelin-1 (rat 1-39), a 39-residue peptide, induces a diuretic and natriuretic response in conscious Sprague-Dawley rats and elevates blood pressure inCor e Forma:Solid[Asn18] Endothelin-1, human
CAS:[Asn18] Endothelin-1, human, a peptide, represents a predominant isoform of Endothelin, significantly contributing to the regulation of vascular function [1].Fórmula:C109H164N26O31S5Peso molecular:2494.96Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate
CAS:Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate is an NPR-A agonist and ANP hormone. Carperitide increases cGMP levels and reduces the heart's workload.Fórmula:C129H207N45O41S3Pureza:99.78%Cor e Forma:SoildPeso molecular:3140.5IRL-1038 acetate
IRL-1038 acetate is a potent ETB endothelin receptor antagonist.Fórmula:C70H96N14O17S2Pureza:97.51%Cor e Forma:SoildPeso molecular:1469.73IRL-1038 TFA
IRL-1038 TFA is an ETB receptor antagonist used in the study of cardiovascular disease.Fórmula:C70H93F3N14O17S2Pureza:98.79%Cor e Forma:SolidPeso molecular:1523.7IRL-1620 acetate
IRL-1620 acetate is an effective and selective agonist of Endothelin B receptor (ETB) with a Ki of 16 pM which is more selective than ETA with a Ki of 19 μM.Fórmula:C88H121N17O29Pureza:96.64%Cor e Forma:SolidPeso molecular:1881Atrial natriuretic peptide (3-28) (human)
CAS:Atrial natriuretic peptide (3-28) (human) (ANP (3-28) (human)), a peptide hormone produced by the atrial myocardium, plays a critical role in the regulation ofFórmula:C118H187N43O36S3Pureza:98%Cor e Forma:SolidPeso molecular:2880.21Sulfatroxazole
CAS:Sulfatroxazole (Isosulfafurazole) (compound 12) is a selective antagonist of the ETA receptor with an IC50 of 0.26 μM.Fórmula:C11H13N3O3SCor e Forma:SolidPeso molecular:267.3BQ-3020 ammonium
BQ-3020 ammonium, a selective endothelin receptor (ET B receptor) agonist, demonstrates inhibition of [125 I] ET-1 binding to ET B receptors with an IC50 of 0.2Fórmula:C96H140N20O25S·xNH3Pureza:98%Cor e Forma:SolidPeso molecular:2006.32 (free base)Endothelin-3 (Rat,Human) (TFA)
Endothelin-3 (Rat, Human) (TFA) is a 21-amino acid vasoactive peptide of endothelial origi, an agonist for the endothelin receptor type B (EDNRB).Fórmula:C123H169F3N26O35S4·xC2HF3O2Pureza:98%Cor e Forma:SolidPeso molecular:2757.07 (free base)Sitaxsentan sodium
CAS:Sitaxsentan sodium (TBC11251 sodium salt) is a highly selective antagonist of endothelin A receptors.Fórmula:C18H14ClN2O6S2·NaPureza:98.39% - 99.01%Cor e Forma:SolidPeso molecular:476.89Bosentan
CAS:Bosentan is a competitive endothelin receptor antagonist, used for treating pulmonary arterial hypertension.Fórmula:C27H29N5O6SPureza:99.74% - 99.84%Cor e Forma:Pale Yellow To Off-White SolidPeso molecular:551.614Ref: TM-T6264
10mg35,00€25mg52,00€50mg77,00€1mL*10mM (DMSO)84,00€100mg120,00€200mg195,00€500mg294,00€Darusentan
CAS:Darusentan (Lu-135252) is a potent inhibitor of endothelin signaling and function in both large and small arteriesFórmula:C22H22N2O6Pureza:98.72%Cor e Forma:SolidPeso molecular:410.43Ref: TM-T5458
2mg43,00€5mg65,00€1mL*10mM (DMSO)67,00€10mg100,00€25mg173,00€50mg288,00€100mg414,00€200mg583,00€BQ-123
CAS:BQ-123 is a selective endothelin A receptor (ETA) antagonist with IC50 of 7.3 nM. Phase 2.Fórmula:C31H42N6O7Pureza:99.22% - ≥95%Cor e Forma:SolidPeso molecular:610.7Ambrisentan sodium
CAS:Ambrosentan (BSF 208075) sodium is a selective and oral effective antagonist of ET type A receptor ( ETAR ).Fórmula:C22H21N2NaO4Cor e Forma:SolidPeso molecular:400.41BQ-788 sodium salt
CAS:BQ-788 sodium salt is a potent and selective antagonist of ETB receptor(ETB receptors with an IC50 of 1.2 nM in human Girrardi heart cells).Fórmula:C34H51N5NaO7Cor e Forma:SolidPeso molecular:664.8Atrasentan sodium
CAS:Atrasentan (ABT-627) is an oral ETA receptor blocker with potential cancer-fighting properties, inhibiting angiogenesis and tumor growth.Fórmula:C29H37N2NaO6Cor e Forma:SolidPeso molecular:532.61Ro 46-2005
CAS:Ro 46-2005: Synthetic non-peptide, blocks 125I-ET-1 at ETA receptors on human vascular cells (IC50: 220 nM).Fórmula:C23H27N3O6SPureza:98.02% - 98.8%Cor e Forma:SolidPeso molecular:473.54RO 46-8443
CAS:RO 46-8443: First non-peptide ETB receptor antagonist, >2000-fold ETB selectivity in binding and function.Fórmula:C31H35N3O8SPureza:98.77% - 99.77%Cor e Forma:SolidPeso molecular:609.69Bosentan (hydrate)
CAS:Bosentan hydrate (Ro 47-0203) is a competitive and dual antagonist of endothelin-1 at the endothelin-A (ET-A) and endothelin-B (ET-B) receptors.Fórmula:C27H29N5O6S·H2OPureza:99.31% - 99.86%Cor e Forma:White PowderPeso molecular:569.63Ambrisentan
CAS:Ambrisentan, an endothelin antagonist for PAH, has a low risk of liver enzyme elevation, not linked to acute liver injury.Fórmula:C22H22N2O4Pureza:99.65% - 99.86%Cor e Forma:SolidPeso molecular:378.42Atrasentan
CAS:Atrasentan (ABT-627) is an endothelin receptor antagonist that can inhibit the activity of ETA.Cost-effective and quality-assured.Fórmula:C29H38N2O6Pureza:97.65% - 99.08%Cor e Forma:SolidPeso molecular:510.62Ref: TM-TQ0259
1mg46,00€5mg90,00€1mL*10mM (DMSO)109,00€10mg130,00€25mg250,00€50mg356,00€100mg580,00€200mg798,00€Aprocitentan
CAS:Aprocitentan (ACT-132577) is ETA and ETB antagonist .Fórmula:C16H14Br2N6O4SPureza:99.17%Cor e Forma:SolidPeso molecular:546.19Ref: TM-T7817
1mg58,00€5mg116,00€1mL*10mM (DMSO)142,00€10mg170,00€25mg311,00€50mg439,00€100mg655,00€200mg887,00€Sparsentan
CAS:Sparsentan (DARA-a) is a first-in-class orally active and highly potent dual endothelin A and angiotensin II receptor antagonist(Ki of 9.3 and 0.8 nM,Fórmula:C32H40N4O5SPureza:97.94% - 98.69%Cor e Forma:SolidPeso molecular:592.75Ref: TM-T5355
2mg37,00€5mg55,00€1mL*10mM (DMSO)73,00€10mg89,00€25mg161,00€50mg245,00€100mg360,00€200mg512,00€BMS 182874 hydrochloride
CAS:BMS 182874 hydrochloride is a nonpeptide endothelin (El) receptor antagonist.Fórmula:C17H20ClN3O3SPureza:97.01%Cor e Forma:SolidPeso molecular:381.88Ref: TM-T21790
1mg77,00€2mg92,00€5mg140,00€1mL*10mM (DMSO)146,00€10mg205,00€25mg343,00€50mg477,00€100mg665,00€200mg897,00€ANP(1-28) Acetate (human, porcine)
CAS:Carperitide acetate: 28-amino acid hormone from human heart, counters cardiac injury/stretch, reduces endothelin-1.Fórmula:C129H207N45O41S3Pureza:98.24%Cor e Forma:SolidPeso molecular:3140.5Ref: TM-TP1220L
1mg185,00€5mg459,00€10mg657,00€25mg1.026,00€50mg1.388,00€100mg1.872,00€200mg2.527,00€
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