Receptor opioide
Os receptores opioides são um grupo de receptores acoplados à proteína G que mediam os efeitos dos opioides endógenos e exógenos. Estes receptores desempenham um papel central na modulação da dor, regulação do humor e comportamentos aditivos. Agonistas e antagonistas dos receptores opioides são amplamente utilizados no manejo da dor e tratamento de dependências, bem como em pesquisas sobre distúrbios neurológicos e psiquiátricos. Na CymitQuimica, oferecemos uma seleção abrangente de moduladores de receptores opioides de alta qualidade para apoiar sua pesquisa em neurobiologia, manejo da dor e terapia de dependência.
Foram encontrados 327 produtos de "Receptor opioide"
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Boc-ypgflt(O-tbu)
CAS:Boc-ypgflt(O-tbu) is a delta-receptor-selective opioid antagonist.Fórmula:C44H64N6O11Cor e Forma:SolidPeso molecular:853.01[DPro10] Dynorphin A (1-11)acetate,porcine
[DPro10] Dynorphin A (1-11)acetate,porcine is a highly potent κ-opioid receptor agonist with a Ki value of 0.13 nM.Fórmula:C65H107N21O15Pureza:99.59%Cor e Forma:SoildPeso molecular:1422.7Neurotransmitter Receptor Compound Library
A unique collection of 1513 neurotransmitter receptor compounds, can be used for HTS and HCS screening；
Cor e Forma:Odour SolidOrphanin FQ(1-11)
CAS:Nociceptin peptide fragment (1-11) with potent ORL1/KOR-3 receptor agonism (Ki = 55 nM), no opioid receptor affinity, and analgesic in mice.Fórmula:C49H75N15O14Pureza:98%Cor e Forma:SolidPeso molecular:1098.2[Arg14,Lys15]Nociceptin
CAS:Potent NOP agonist (EC50 = 1 nM), >875x selective vs opioid receptors; outperforms nociceptin in vivo, increases pain perception, reduces movement.Fórmula:C82H137N31O22Pureza:98%Cor e Forma:SolidPeso molecular:1909.18Axelopran
CAS:Axelopran (TD-1211) treats opioid constipation; it's a potent, selective peripheral opioid blocker.Fórmula:C26H39N3O4Cor e Forma:SolidPeso molecular:457.61ICI 174,864
CAS:Selective δ opioid antagonist. Exhibits partial agonist in vitro activity at δ receptors at high concentrations.Fórmula:C38H53N5O7Pureza:98%Cor e Forma:White SolidPeso molecular:691.87DAMGO (TFA)
CAS:DAMGO is a selective peptide agonist of the µ-opioid receptor .Fórmula:C28H36F3N5O8Pureza:98%Cor e Forma:SolidPeso molecular:627.61KOR agonist 5
KOR agonist 5 (Compound 10a) is both a KOR/MOR modulator, exhibiting agonistic effects on KOR and antagonistic effects on MOR. It effectively blocks morphine-induced antinociception and gastrointestinal motility inhibition. KOR agonist 5 is applicable in research related to substance use disorder (SUD).Fórmula:C38H38N2O5Cor e Forma:SolidPeso molecular:602.72[Nphe1]Nociceptin(1-13)NH2
CAS:Competitive nociceptin receptor antagonist with pKi=8.4; no agonist activity; blocks nociceptin effects in vitro/in vivo.Fórmula:C61H100N22O15Pureza:98%Cor e Forma:SolidPeso molecular:1381.6UFP-101
CAS:Strong, selective NOP receptor antagonist with pKi=10.24; >3000x selectivity over δ, μ, κ receptors; blocks nociceptin effects.
Fórmula:C82H138N32O21Pureza:98%Cor e Forma:SolidPeso molecular:1908.19HINT1-IN-1
HINT1-IN-1 (compound 8) is an inhibitor of histidine triad nucleotide-binding protein 1 (HINT1) with a Ki of 1.14 μM. It influences the cross-regulation between μ-opioid receptors (MOR) and NMDA receptors (NMDAR).Fórmula:C23H24N8O5Cor e Forma:SolidPeso molecular:492.49KOR agonist 4
KOR agonist 4 (compound 39) is an agonist targeting the κ opioid receptor (Kappa Opioid Receptor) and activates G protein signaling. It has an EC50 of 14 nM and an Emax of 83% for binding to GTPγS. This compound demonstrates moderate to high intrinsic clearance in human liver cells and shows selectivity for the κ opioid receptor over the μ (MOR) and δ (DOR) opioid receptors by factors of 60 and 810, respectively. KOR agonist 4 is useful for research into central nervous system (CNS) disorders.Fórmula:C21H25N3Cor e Forma:SolidPeso molecular:319.44β-Endorphin, equine TFA
β-Endorphin, equine TFA, an endogenous opioid peptide, demonstrates high affinity binding to μ/δ opioid receptors and possesses analgesic properties [1] [2] [3Fórmula:C156H249F3N42O46SCor e Forma:SolidPeso molecular:3537.96Akuammicine
CAS:Akuammicine, as an indole alkaloid from Catharanthus roseus, can be used in cancer cell eradication.Fórmula:C20H22N2O2Cor e Forma:SolidPeso molecular:322.408Nociceptin(1-7)
CAS:Bioactive metabolite of nociceptin, antagonist of nociceptin-induced hyperalgesiaFórmula:C31H41N7O9Pureza:98%Cor e Forma:SolidPeso molecular:655.709[(pF)Phe4]Nociceptin(1-13)NH2
CAS:Potent, selective OP4 agonist; pKi=10.68, pEC50=9.80. >8000x selectivity vs other opioid receptors; long-lasting in vivo effects.Fórmula:C61H99FN22O15Pureza:98%Cor e Forma:SolidPeso molecular:1399.6Dermorphin Analog
Dermorphin Analog, a heptapeptide from amphibian skin, binds μ-opioid receptors selectively and strongly.Fórmula:C44H59N11O10Pureza:98%Cor e Forma:SolidPeso molecular:901.43β-Naltrexamine dihydrochloride
CAS:β-Naltrexamine dihydrochloride is an orally administered, irreversible opioid receptor antagonist. Its derivatives exhibit optimised subtype selectivity and can be used for pain research.Fórmula:C20H28Cl2N2O3Pureza:95.98%Cor e Forma:SoildPeso molecular:415.35PL-017
CAS:μ opioid receptor agonist; IC50: 5.5 nM (μ), >10,000 nM (δ). Induces reversible analgesia, catalepsy, hyperthermia in rats.Fórmula:C29H37N5O5Pureza:98%Cor e Forma:SolidPeso molecular:535.64
![[DPro10] Dynorphin A (1-11)acetate,porcine](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTM%2Fthumb-webp%2FT76341L.webp&w=3840&q=75)
![[Arg14,Lys15]Nociceptin](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTM%2Fthumb-webp%2FTP1986.webp&w=3840&q=75)
![[Nphe1]Nociceptin(1-13)NH2](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTM%2Fthumb-webp%2FTP1987.webp&w=3840&q=75)
![[(pF)Phe4]Nociceptin(1-13)NH2](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTM%2Fthumb-webp%2FTP1885.webp&w=3840&q=75)
