Receptor opioide
Os receptores opioides são um grupo de receptores acoplados à proteína G que mediam os efeitos dos opioides endógenos e exógenos. Estes receptores desempenham um papel central na modulação da dor, regulação do humor e comportamentos aditivos. Agonistas e antagonistas dos receptores opioides são amplamente utilizados no manejo da dor e tratamento de dependências, bem como em pesquisas sobre distúrbios neurológicos e psiquiátricos. Na CymitQuimica, oferecemos uma seleção abrangente de moduladores de receptores opioides de alta qualidade para apoiar sua pesquisa em neurobiologia, manejo da dor e terapia de dependência.
Foram encontrados 330 produtos para "Receptor opioide".
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CAS:Potent μ-receptor antagonist, Ki=0.96nM, ineffective at δ (>10,000nM). Alters behavior in vivo, boosts K+ currents in rat neurons in vitro, μ-independent.Fórmula:C50H67N11O11S2Pureza:98%Cor e Forma:SolidPeso molecular:1062.28β-Endorphin, equine
CAS:Endorphin Beta is A substance produced in the brain, especially in the pituitary gland, Endorphin Beta blocks the sensation of pain.Fórmula:C154H248N42O44SPureza:98%Cor e Forma:SolidPeso molecular:3423.94[Nphe1]Nociceptin(1-13)NH2 TFA
[Nphe1]Nociceptin(1-13)NH2 is a selective nociceptin receptor antagonist with potential analgesic properties, pKi=8.4, pA2=6.0.Fórmula:C63H101F3N22O17Cor e Forma:SolidPeso molecular:1495.61Nocistatin
CAS:Nocistatin, a neuropeptide, blocks Nociceptin effects and inhibits 5-HT release, acting on an opioid-related receptor.Fórmula:C32H56N10O12Cor e Forma:SolidPeso molecular:772.85Nociceptin(1-7)
CAS:Bioactive metabolite of nociceptin, antagonist of nociceptin-induced hyperalgesiaFórmula:C31H41N7O9Pureza:98%Cor e Forma:SolidPeso molecular:655.709[(pF)Phe4]Nociceptin(1-13)NH2
CAS:Potent, selective OP4 agonist; pKi=10.68, pEC50=9.80. >8000x selectivity vs other opioid receptors; long-lasting in vivo effects.Fórmula:C61H99FN22O15Pureza:98%Cor e Forma:SolidPeso molecular:1399.6Clocinnamox mesylate
CAS:Clocinnamox mesylate: irreversible μ-opioid blocker; Ki: 0.7 nM (mouse μ), 1.9 nM (δ), 5.7 nM (κ).Fórmula:C30H33ClN2O7SCor e Forma:SolidPeso molecular:601.11Akuammicine
CAS:Akuammicine, as an indole alkaloid from Catharanthus roseus, can be used in cancer cell eradication.Fórmula:C20H22N2O2Cor e Forma:SolidPeso molecular:322.408Neurotransmitter Receptor Compound Library
A unique collection of 1513 neurotransmitter receptor compounds, can be used for HTS and HCS screening；
Cor e Forma:Odour SolidDermorphin Analog
Dermorphin Analog, a heptapeptide from amphibian skin, binds μ-opioid receptors selectively and strongly.Fórmula:C44H59N11O10Pureza:98%Cor e Forma:SolidPeso molecular:901.43N-Formyl-MMYALF TFA
N-Formyl-MMYALF TFA is a mitochondrial N-formyl peptide known for its ability to deplete calcium ions in the endoplasmic reticulum. Additionally, it inhibits the FPR-1-mediated chemotactic response of PMNs to bacterial peptides.Fórmula:C38H54N6O9S2·xC2HF3O2Peso molecular:803.00 (free base)PL-017
CAS:μ opioid receptor agonist; IC50: 5.5 nM (μ), >10,000 nM (δ). Induces reversible analgesia, catalepsy, hyperthermia in rats.Fórmula:C29H37N5O5Pureza:98%Cor e Forma:SolidPeso molecular:535.64KOR agonist 4
KOR agonist 4 (compound 39) is an agonist targeting the κ opioid receptor (Kappa Opioid Receptor) and activates G protein signaling. It has an EC50 of 14 nM and an Emax of 83% for binding to GTPγS. This compound demonstrates moderate to high intrinsic clearance in human liver cells and shows selectivity for the κ opioid receptor over the μ (MOR) and δ (DOR) opioid receptors by factors of 60 and 810, respectively. KOR agonist 4 is useful for research into central nervous system (CNS) disorders.Fórmula:C21H25N3Cor e Forma:SolidPeso molecular:319.44Orphanin FQ(1-11)
CAS:Nociceptin peptide fragment (1-11) with potent ORL1/KOR-3 receptor agonism (Ki = 55 nM), no opioid receptor affinity, and analgesic in mice.Fórmula:C49H75N15O14Pureza:98%Cor e Forma:SolidPeso molecular:1098.2β-Endorphin, equine TFA
β-Endorphin, equine TFA, an endogenous opioid peptide, demonstrates high affinity binding to μ/δ opioid receptors and possesses analgesic properties [1] [2] [3Fórmula:C156H249F3N42O46SCor e Forma:SolidPeso molecular:3537.96KOR agonist 6
KOR agonist 6 is a KOR agonist with a Ki value of 0.25 pM. In CHO cells, it exhibits agonistic activity on MOR and DOR and inhibits forskolin-stimulated cAMP accumulation. The compound stimulates KOR-mediated [35S]GTPγS binding in HEK293 cells expressing KOR and effectively suppresses cAMP accumulation as a potent agonist, showing lower β-arrestin recruitment efficacy. Additionally, KOR agonist 6 demonstrates analgesic effects in mice and can be employed in the study of analgesics with reduced central nervous system (CNS) side effects.Cor e Forma:Odour Solid[Nphe1]Nociceptin(1-13)NH2
CAS:Competitive nociceptin receptor antagonist with pKi=8.4; no agonist activity; blocks nociceptin effects in vitro/in vivo.Fórmula:C61H100N22O15Pureza:98%Cor e Forma:SolidPeso molecular:1381.6Frakefamide TFA
Frakefamide TFA: potent, peripherally active μ-opioid agonist; doesn't cross blood-brain barrier.Fórmula:C32H35F4N5O7Cor e Forma:SolidPeso molecular:677.64U-54494A hydrochloride
CAS:U-54494A hydrochloride is a benzamide derivative related to kappa opioid receptor agonists. U-54494A hydrochloride has anticonvulsant activity.Fórmula:C18H25Cl3N2OCor e Forma:SolidPeso molecular:391.76HINT1-IN-1
HINT1-IN-1 (compound 8) is an inhibitor of histidine triad nucleotide-binding protein 1 (HINT1) with a Ki of 1.14 μM. It influences the cross-regulation between μ-opioid receptors (MOR) and NMDA receptors (NMDAR).Fórmula:C23H24N8O5Cor e Forma:SolidPeso molecular:492.49
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