GPCR19
GPCR19, também conhecido como GPR19, é um membro da família dos receptores acoplados à proteína G, com funções que ainda estão sendo elucidadas em vários processos fisiológicos. Embora menos caracterizado do que outros GPCRs, o GPCR19 é de interesse em pesquisas focadas na descoberta de novos alvos terapêuticos para doenças metabólicas, câncer e distúrbios neurológicos. Na CymitQuimica, oferecemos uma seleção de ferramentas de pesquisa e reagentes para apoiar suas investigações sobre as funções e potenciais aplicações terapêuticas do GPCR19.
Foram encontrados 33 produtos de "GPCR19"
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Hyodeoxycholic acid
CAS:<p>Hyodeoxycholic acid (NSC 60672) has been used in trials studying the treatment of Hypercholesterolemia.</p>Fórmula:C24H40O4Pureza:97.29% - 98.82%Cor e Forma:SolidPeso molecular:392.57Deoxycholic acid
CAS:Deoxycholic acid (Cholanoic Acid) is a bile acid formed by bacterial action from cholate.Fórmula:C24H40O4Pureza:99.91% - 99.91%Cor e Forma:Crystals From Alc SolidPeso molecular:392.57Ursodeoxycholic acid
CAS:Ursodeoxycholic acid (UDCA) is a potent inhibitor of liver-specific fatty acid transporter 5 (FATP5),inhibits cholesterol absorption. High-Quality, Low-Cost!Fórmula:C24H40O4Pureza:99.74% - ≥95%Cor e Forma:White - Almost White Solid PowderPeso molecular:392.57Cholic Acid 7-sulfate
CAS:Cholic acid 7-sulfate: a cholic acid metabolite with added sulfate at position 7, increased in feces of male mice with specific diets.Fórmula:C24H40O8SCor e Forma:SolidPeso molecular:488.64TGR5 agonist 1
Compound 18 (TGR5 agonist 1) is a potent agonist of TGR5, exhibiting an EC50 value of 0.31 µM [1].Fórmula:C28H48NNaO6SCor e Forma:SolidPeso molecular:549.74TGR5 agonist 4
TGR5 agonist 4 (compound 19), a derivative of cholic acid, selectively activates the TGR5 receptor with an effective concentration (EC50) of 4 μM [1].Fórmula:C24H38F2O5Cor e Forma:SolidPeso molecular:444.555-HT7R antagonist 1 free base
CAS:5-HT7R antagonist 1 (free base) is a G protein-biased antagonist for the 5-HT 7 R receptor, with a dissociation constant (K i) of 6.5 nM.Fórmula:C14H17ClN4Cor e Forma:SolidPeso molecular:276.77PEN (human)
CAS:PEN (human) is an Endogenous peptide GPR83 agonist. ProSAAS-derived neuropeptide.Fórmula:C97H159N27O32Pureza:98%Cor e Forma:SolidPeso molecular:2215.49PEN (rat)
CAS:PEN (rat) is an Endogenous peptide GPR83 agonist. ProSAAS-derived neuropeptide.Fórmula:C102H169N27O33Pureza:98%Cor e Forma:SolidPeso molecular:2301.62TGR5 agonist 2
TGR5 agonist 2 (compound 19) serves as a highly potent agonist of TGR5, demonstrating an EC50 value of 0.27 µM [1].Fórmula:C29H50NNaO6SCor e Forma:SolidPeso molecular:563.77TGR5 agonist 6
CAS:Compound 22b, also known as TGR5 agonist 6, is a non-systemic, intestine-targeted TGR5 agonist that demonstrates significant and sustained blood glucose-lowering effects with an acceptable safety profile.Fórmula:C42H48Cl2N6O6Cor e Forma:SolidPeso molecular:803.77TGR5 agonist 7
TGR5 agonist 7 (Compound 22-Na) is an intestine-restricted, orally active agonist of the G protein-coupled bile acid receptor TGR5 (GPBAR1 or GPR131) with an EC50 of less than 1 μM. In mouse models, it demonstrates blood glucose-lowering effects, making it useful for diabetes research.Fórmula:C37H59N2NaO9SCor e Forma:SolidPeso molecular:730.93Neuromedin S (human)
CAS:Neuromedin S (human) is a 33-amino acid neuropeptide identified as an endogenous ligand for the orphan G-protein coupled receptor (GPCR) FM-4/TGR-1, acting onTriamterene
CAS:Triamterene is a barosensitive epithelial sodium channel (ENaC) blocker with a diuretic effect. It can also act as an inhibitor of the TGR5 receptor, reducing GLP-1 secretion and cAMP level increases induced by TGR5 activation in a dose-dependent manner.Fórmula:C12H11N7Pureza:99.77%Cor e Forma:Yellow Yellow SolidPeso molecular:253.26Deoxycholic acid sodium salt
CAS:<p>Deoxycholic acid sodium salt (Sodium deoxycholate) can activate the G protein-coupled bile acid receptor TGR5 that stimulates BAT thermogenic activity.</p>Fórmula:C24H39NaO4Pureza:97.88% - 99.75%Cor e Forma:Cream Crystalline PowderPeso molecular:414.56TC-G 1005
CAS:TC-G 1005 is a potent and selective GPBA agonist (EC50 :0.72 nM; hTGR5).Fórmula:C25H25N3O2Pureza:98.60% - 99.78%Cor e Forma:SolidPeso molecular:399.48SBI-115
CAS:SBI-115 is an antagonist of TGR5. SBI-115 decreases hepatic cystogenesis with polycystic liver diseases via inhibiting TGR5Fórmula:C14H13ClN2O4SPureza:99.53% - 99.78%Cor e Forma:SolidPeso molecular:340.78SB756050
CAS:SB756050 is a specific TGR5 agonist.Fórmula:C21H28N2O8S2Pureza:98.78% - >99.99%Cor e Forma:SolidPeso molecular:500.59BAR502
CAS:BAR502 is a dual GPBAR1 and FXR agonist (IC50s: 0.4 μM and 2 μM).Fórmula:C25H44O3Pureza:99.95%Cor e Forma:SolidPeso molecular:392.62TGR5 Receptor Agonist
CAS:TGR5 is a potent TGR5(GPCR19) agonist.Fórmula:C18H14Cl2N2O2Pureza:99.77% - ≥95%Cor e Forma:SolidPeso molecular:361.22
