Antibacteriano

<p>Mtb-IN-10 (Compound P15) is an Rv1625c/Cya activator that influences the growth of Mycobacterium tuberculosis (Mtb) by modulating cAMP metabolism. It demonstrates an anti-tuberculosis activity with an EC50 of 1.96 µM in Mtb-infected macrophage models and achieves an oral bioavailability of 58.0% when administered orally to mice at 20 mg/kg. Mtb-IN-10 potentially regulates intracellular signaling and disrupts cholesterol metabolism within Mtb, thereby inhibiting bacterial proliferation. It holds promise for tuberculosis (TB) research, particularly targeting multidrug-resistant (MDR-TB) and extensively drug-resistant (XDR-TB) strains of Mtb.</p>

<p>QST4 possessed antitubercular and antifungal activities with a MIC value of 6.25 μM in Mycobacterium tuberculosis Mycobacterium tuberculosis H37Rv.</p>

<p>KT5823 is a cGMP-dependent protein kinase (PKG) inhibitor that increases iodide ion uptake by regulating the expression of sodium iodide symporter protein.</p>

<p>Ascr#18: nematode hormone boosts infection resistance in plants like Arabidopsis, tomato, potato, barley.</p>

<p>FLGFVGQALNALLGKL-NH2, an antimicrobial peptide derived from frogs, exhibits activity against Staphylococcus aureus ATCC 29213 with a minimum inhibitory</p>

<p>FASN-IN-6 (compound 44), a potent fatty acid biosynthesis (FAB) inhibitor, serves as an antibacterial agent, exhibiting minimum inhibitory concentrations (MICs</p>

<p>RvD4, derived from docosahexaenoic acid, reduces neutrophil infiltration and promotes phagocytosis/clearance by human cells.</p>

<p>ONX-0914 (PR-957) TFA is a selective LMP7 inhibitor, blocking cytokines and arthritis progression, and reactivates HIV-1.</p>

<p>Antibacterial agent 40 is an antibacterial agent.</p>

<p>Temporin F exhibits antimicrobial activity against Legionella pneumophila [1].</p>

<p>DNA gyrase/Topo IV-IN-1 (Compound 27) is an inhibitor of DNA gyrase and topoisomerase IV with antibacterial properties. It exhibits IC50 values of 11 and 17 nM against the DNA gyrase of Escherichia coli and methicillin-resistant Staphylococcus aureus, respectively, and IC50 values of 83 and 21 nM against topoisomerase IV of the same organisms. DNA gyrase/Topo IV-IN-1 is applicable in anti-infective research.</p>

<p>Trimethoprim hydrochloride: oral, broad-spectrum antibiotic, DHFR inhibitor, treats UTIs, shigellosis, pneumocystis pneumonia, may block Influenza A with zinc.</p>

<p>Phanerosporic acid, from P. chrysosporum, fights bacteria like B. cereus and fungi including C. cladosporioides; used in macrolide synthesis.</p>

<p>Zifanocycline: 3rd-gen aminomethylcycline antibiotic, broad-spectrum against resistant bacteria, oral/injectable, for various infections.</p>

<p>Ansatrienin B: antibiotic, antifungal, inhibits PTH-induced calcium release and protein synthesis, enhances certain chemotherapies.</p>

<p>Antibacterial agent 153 is a broad-spectrum agent that eradicates bacteria by targeting their cell membranes and is employed in research on bacterial infections</p>

<p>Monactin is a Marcrotetrolide antibiotic produced by cycloheximide producing species of Streptomyces. It is a homolog of nonactin from the same species.</p>

<p>Actinorhodin is a blue pigment and a redox-active microbial secondary metabolite. It is a potent, antibacterial, pH-responsive antibiotic (antibiotic) exhibiting antimicrobial activity against Gram-positive bacteria.</p>

<p>Eremomycin, an antibiotic, can be used intramuscularly due to low toxicity.</p>

<p>Spiramycin III is an antibiotic within the erythromycin/carbomycin group of compounds.</p>

<p>Lysozyme chloride: enzyme that kills gram-positive bacteria; used in HIV, emphysema research.</p>

<p>Chrysomycin B is an antibiotic isolated from Streptomyces sp.</p>

<p>3′-Omethyl-5′-hydroxydiplacone (compound 2), a C-6-geranylflavonoid isolated from the ethanol extract of Paulownia tomentosa fruits, exhibits antibacterial</p>

<p>Siomycin A: thiopeptide antibiotic, selectively inhibits FOXM1, anti-tumor, induces apoptosis.</p>

<p>Pyrindamycin B is an antibiotic,and actives against gram-positive and gram-negative bacterias</p>

<p>Enzyme-IN-2 (compound 15) serves as a potent urease inhibitor, exhibiting anti-ureolytic activity with a K i of 2.36 µM and an IC 50 of 0.75 µM [1].</p>

<p>Loloatin B 10 is a bioactive chemical.</p>

<p>Antibacterial agent 142, an aromatic hydrazide, exhibits bacteriostatic antibacterial activity and inhibits biofilm formation [1].</p>

<p>AAA-10 is an orally active inhibitor of bile salt hydrolase (BSH) in B. intestinalis that acts on B. thetarBSH (IC50: 10 nM) and B. longumrBSH (IC50: 80 nM).</p>

<p>Aurein 2.6, an antibiotic antimicrobial peptide, exhibits activity against various Gram-positive bacteria with minimum inhibitory concentrations (MIC) of 25, 25</p>

<p>Urease-IN-18 (compound 13a) is a non-competitive urease inhibitor with an IC50 value of 1.6 μM. Urease plays a role in maintaining an alkaline environment that supports the survival and proliferation of certain pathogens within the host.</p>

<p>Iboxamycin: potent, orally active antibiotic effective against Gram-positive and Gram-negative bacteria in mice.</p>

<p>XT-1, an antimicrobial peptide sourced from Xenopus tropicalis skin secretions, exhibits potent activity against S.</p>

<p>Elf18 is an N-terminal segment of the bacterial elongation factor Tu. In Arabidopsis, it acts as a pathogen-associated molecular pattern (PAMP) recognized by pattern recognition receptors (PRR), thereby triggering an immune response.</p>

<p>Caprazene is a precursor molecule of semi-synthetic antibacterial antibiotics and an anti-mycobacterial compound used for tuberculosis and Mycobacterium avium complex infection research. It can be isolated from the acid-treated caprazamycin (CPZ) A-G mixture.</p>

<p>Tetrahydrobostrycin is a secondary metabolite produced by Aspergillus sp., demonstrating mild inhibitory effects against Staphylococcus aureus and Escherichia coli, with inhibition zones measuring 15 mm and 9.2 mm respectively (100 mg/disc).</p>

<p>Ashimycin B is a streptomycin analogue that exhibits broad-spectrum antibacterial activity.</p>

<p>Somantadine has antiviral activities and can be used for research on preventing and treating coronavirus-related diseases.</p>

<p>Antibacterialagent 274 (Compound 18b) is an antibacterial agent that targets bacterial cell membranes, exhibiting a minimum inhibitory concentration (MIC) of 8 μg/mL against Acinetobacter baumannii ATCC 17978. It functions by disrupting membrane integrity, causing intracellular accumulation of ROS, which leads to DNA and protein leakage, thereby exerting its antibacterial effects. Antibacterialagent 274 is applicable in research on infections caused by Gram-negative bacteria.</p>

<p>Antimicrobial Agent-10 demonstrates exceptional antibacterial activity and inhibits SARS-CoV-2, positioning it as a potent antimicrobial compound [1].</p>

<p>Apigravin, a potent antibacterial compound, demonstrates activity against Bacillus subtilis, exhibiting a minimum inhibitory concentration (MIC) value of 61 μM</p>

<p>DNA gyrase B-IN-2 (Compound E), a 2-aminobenzothiazole derivative, serves as a potent inhibitor of DNA gyrase B with substantial efficacy against ESKAPE</p>

<p>Antimicrobial agent-36 (Compound 8b) is an antimicrobial compound that significantly inhibits DNA gyrase with an IC50 value of 4.56 µM. It is also utilized in the preparation of nanoparticle drug formulations and can be employed in the research and development of new antibiotics.</p>

<p>Antibacterial agent 31 exhibits (shows) efficacy (activity) in combating (against) rice bacterial leaf streak.</p>

<p>Deethylindanomycin, a polyether antibiotic from S. setonii, combats Gram-positive bacteria and in vitro coccidia; ionophore selective for K+ ions.</p>

<p>LL-C 10037alpha is a gamma-aminoepoxysemiquinone isolated from Streptomyces.</p>

<p>Calpinactam, from M. alpina, fights M. smegmatis (MIC 0.78 μg/ml), boosts silkworm survival, but ineffective against 13 other species.</p>

<p>JAK05 exhibits inhibitory activity against Helicobacter pylori, effectively suppressing strains J63, J196, and J107, with a MIC of 3-5 µg/mL. It shows affinity for binding to H+/K+-ATPase, COX-1/2, TNF-α, and PGE2, and possesses antioxidant and anti-inflammatory properties. In a rat model of ethanol-induced gastric ulcers, JAK05 demonstrates anti-ulcer activity.</p>

<p>Aurein 3.3 is an antimicrobial peptide with antibiotic properties and exhibits anticancer activity [1].</p>

<p>Compound Fr13643, with CAS No. 622-62-8, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound Fr13643 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.</p>

<p>Antitubercular agent-35 (42l) inhibits Mtb H37Rv (MIC 90=1.25 μg/mL) and M. Marinum (MIC 90=2 μg/mL), resists liver degradation, for TB research.</p>

<p>Crabrolin is a 13-peptide that can be extracted from the venom of the European hornet (Vespa crabro). Its minimum inhibitory concentration/minimum bactericidal concentration (MIC/MBC) values against Staphylococcus aureus (S. aureus) (NCTC 10788), methicillin-resistant Staphylococcus aureus (MRSA) (NCTC 12493), and Enterococcus faecium (E. faecium) (NTCC 12697) are 2/2, 16/64, and 4/8 μM, respectively.</p>

<p>Razupenem (SMP-601, PTZ601), a broad-spectrum injectable carbapenem, counters antibiotic-resistant bacteria.</p>

<p>Ibezapolstat hydrochloride is an antibacterial agent.</p>

<p>Amino acids 17-41 of lactoferrin, lactoferricin B, enhance anti-fungal effects, targeting Candida Albicans.</p>

<p>Luteoreticulin, a nitro-containing bacterial metabolite first isolated from S. luteoreticuli, exhibits mosquitocidal activity against A. aegypti at a concentration of 6.25 mg/L and nematocidal activity against C. elegans.</p>

<p>Lienomycin is a pentaene macrolide antitumor antibiotic generated by Actinomyces vendargensis Struyk et Stheeman. It has inonphore-like action.</p>

<p>Ceftiofur hydrochloride (U-67279A) is a stable, broad-spectrum 3rd-gen cephalosporin with antibacterial properties.</p>

<p>7-Oxoganoderic acid Z is a useful organic compound for research related to life sciences. The catalog number is T123920 and the CAS number is 929248-72-6.</p>

<p>Antistaphylococcal agent 3 is an antistaphylococcal therapeutic agent.</p>

<p>Valclavam is a biochemical.</p>

<p>Nafcillin sodium: an antibiotic, β-lactamase inhibitor, treats staph infections.</p>

<p>Adenoregulin (Dermaseptin b2), an antimicrobial peptide antibiotic, exhibits efficacy against both Gram-negative and Gram-positive bacteria, as well as yeast</p>

<p>Antibacterialagent 260 (Compound 4r) exhibits broad-spectrum antibacterial activity, effectively inhibiting P. aeruginosa and S. aureus with a minimum inhibitory concentration (MIC) of 0.0076 μM. Additionally, Antibacterialagent 260 serves as a herbicide, hindering the growth of radish (Raphanus sativus L.) seed roots and stems.</p>

<p>Dactimicin, a new pseudodisaccharide aminoglycoside, exhibits antibacterial properties and resists aminoglycoside 3-acetyltransferase better than astromicin.</p>

<p>Repromicin is a chemical compound whose derivatives have strong antibacterial characteristics.</p>

<p>Pyrrocidine A, an antibiotic known for its antibacterial properties, can be isolated from LL-Cyan426.</p>

<p>Vecantoxatug is a humanized monoclonal antibody designed to target Clostridium tetani toxin (TeNT, a neurotoxin). It specifically binds to the tetanus toxin, preventing the toxin from interacting with cell receptors and thus exhibits antitoxin activity. Vecantoxatug holds potential for tetanus research.</p>

<p>Fortimicin C is a bioactive chemical.</p>

<p>ROS inducer 8 (Compound 11g) acts as an inhibitor of glutathione (GSH) and promotes the accumulation of reactive oxygen species (ROS) in Enterococcus faecalis, exhibiting antibacterial properties. It is capable of disrupting biofilms and inhibiting S. aureus and E. faecalis with minimum inhibitory concentrations (MICs) of 8 μg/mL and 2 μg/mL, respectively, demonstrating a post-antibiotic effect. Additionally, ROS inducer 8 shows low hemolytic toxicity on sheep red blood cells with an HC50 greater than 1280 μg/mL.</p>

<p>"Ribostamycin (Vistamycin) is a broad-spectrum antibiotic, effective against many bacteria and inhibits PDI."</p>

<p>Clovibactin, a novel antibiotic, effectively eradicates drug-resistant bacterial pathogens and demonstrates no discernible resistance.</p>

<p>Meleagrin: Penicillium-derived alkaloid, inhibits FabI and c-Met, targets breast cancer metastasis, antimicrobial.</p>

<p>NagZ-IN-1 (Compound 11h) is a β-N-acetylglucosaminidase inhibitor with a Ki of 3.3 μM. It is applicable in antibacterial research, especially for studies related to Pseudomonas aeruginosa infections.</p>

<p>Antimicrobial-IN-1 (compound 17) demonstrates potent antibacterial activity against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli), exhibiting inhibition zone diameters of 18 mm/mg and 16 mm/mg, respectively.</p>

<p>Lymecycline is a semisynthetic antibiotic. It is related to TETRACYCLINE.</p>

<p>XT-2 peptide, an antimicrobial agent sourced from the skin secretions of Xenopus tropicalis, exhibits potent activity against E.</p>

<p>AVX 13616: potent antibacterial vs. drug-resistant Staph, similar to mupirocin with single-use efficiency. MIC: 2-4 ug/ml. Targets various staph, MRSA.</p>

<p>Lankacyclinol A is a Lankacidin antibiotic.</p>

<p>Oral nitroimidazole antibiotic; treats anaerobic infections; may cause inflammation and muscle contractions with long-term use.</p>

<p>Antifungalagent 123 (Compound 4b) demonstrates strong affinity for the oxidoreductase of Staphylococcus aureus or membrane proteins of Candida albicans, exhibiting both antibacterial and antifungal properties. Additionally, it is capable of scavenging free radicals, showcasing antioxidant effects. Antifungalagent 123 also inhibits the TLR signaling pathway and possesses anti-inflammatory activity.</p>

<p>Erythromycin aspartate is a enzyme.</p>

<p>Menaquinone 6, an active product found in *Wolinella succinogenes*, is a form of vitamin K2 with antimicrobial activity [1].</p>

<p>MRV03-037 inhibits ClbP, blocking colibactin's genotoxic impact on cells, and stops gut bacterial genotoxin production.</p>

<p>4-Methoxycoumarine has antitumour effects.</p>

<p>IPMCL-28b is an antimicrobial agent targeting bacterial cell membranes, with a minimum inhibitory concentration (MIC) of 1.56 μg/mL for Staphylococcus aureus ATCC 25923 and an MIC of 6.25 μg/mL for methicillin-resistant Staphylococcus aureus (MRSA). IPMCL-28b shows potential for research in the field of infection control.</p>

<p>Oxytetracycline calcium is a tetracycline antibiotic effective against Gram-negative and Gram-positive bacteria, inhibits protein synthesis, and fights HSV-1.</p>

<p>Furazolidone (Furoxone), a nitrofuran derivative, inhibits AML1-ETO transformed cells with IC50 value of 12.7 μM.</p>

<p>Mycobacterium Tuberculosis-IN-8 (Compound 6g) is a selective inhibitor of Mycobacterium tuberculosis (MTB), with a MIC value of 6.25 µg/mL against MTB H37Rv. It demonstrates potent antitubercular activity by inhibiting mycolic acid biosynthesis, which is crucial for maintaining bacterial cell wall integrity. Mycobacterium Tuberculosis-IN-8 holds potential for research in antitubercular agents.</p>

<p>Flurithromycin is an orally active, broad-spectrum antibiotic for bacterial infection research.</p>

<p>BMS 180680 is a novel catechol-containing monolactam antibacterial active agent, which is the most effective compound against many species of Enterobacteriaceae</p>

<p>Ro 24-6778 is a dual action cephalosporin with antimicrobial activity.</p>

<p>3-Phenyl-1H-indole has antibacterial activity and can inhibit Klebsiella pneumoniae, Escherichia coli, Candida albicans, Staphylococcus aureus, etc.</p>

<p>Diaporthein B, a potent pimarane diterpene, inhibits M. tuberculosis (MIC: 3.1 μg/mL) and combats colon cancer cells (IC50: 1.5-3 μM/L).</p>

<p>Neoabietic acid, from Pinus palustris resin, is acid-sensitive and has antibacterial properties.</p>

<p>Arisostatin B is a tetracycline antibiotic (antibiotic) with activity against Gram-positive bacteria and tumor cells.</p>

<p>Fuscin, a quinonoid from O. fuscum, inhibits ADP/ATP translocase, depletes glutathione, disrupts NADH oxidation, and blocks MIP-1α/CCR5 binding (IC50: 21µM).</p>

<p>Amycolatopsin A, a macrolide from Amycolatopsis, fights M. bovis/tuberculosis and some cancers, not effective on common bacteria.</p>

<p>DprE1-IN-7 (Compound 64) is a DprE1 inhibitor with potent anti-tuberculosis (TB) activity, demonstrating a minimum inhibitory concentration (MIC) of 1 μM</p>

<p>MraY-IN-1 (compound 12a) is a potent inhibitor of MraY, exhibiting an IC50 of 140 µM.</p>

<p>Dapdiamide A is an antibiotic identified in the Pantoea agglomerans CU0119 strain, displaying antibacterial activity and offering potential for research in anti-infective treatments.</p>

<p>Kyotorphin is a Morphine-like dipeptide.</p>

<p>Demethyl linezolid, an impurity in linezolid (WO199500721A1, ex. 9), has antimicrobial effects on human and veterinary pathogens.</p>

<p>K 41 is a polycyclic polyether antibiotic from Streptomyces hygroscopicus.</p>

<p>Aurein 2.4, an antibiotic antimicrobial peptide, exhibits activity against Gram-positive bacteria [1] [2].</p>

<p>Tur1A, an antimicrobial peptide sourced from the bottlenose dolphin (Tursiops truncates), impedes bacterial protein synthesis.</p>