gsk-3
Os inibidores da GSK-3 são compostos que alvo a Glicogênio Sintase Quinase 3 (GSK-3), uma enzima envolvida em numerosos processos celulares, incluindo o metabolismo do glicogênio, a transcrição genética e a proliferação celular. A GSK-3 está implicada em várias doenças, como diabetes, distúrbios neurodegenerativos e câncer. Os inibidores da GSK-3 são ferramentas importantes para explorar essas vias e desenvolver potenciais terapias. Na CymitQuimica, oferecemos inibidores da GSK-3 para apoiar sua pesquisa em doenças metabólicas, neurobiologia e oncologia.
Foram encontrados 110 produtos de "gsk-3"
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MRT80
CAS:MRT80 is an inhibitor of GSK-3 in vitro. MRT80 de-stabilizes MDM2 and stabilizes p53 protein and E2F-1.Fórmula:C15H15N5OPureza:98%Cor e Forma:SolidPeso molecular:281.31BRD3731
CAS:BRD3731 selectively inhibits GSK3β with IC50 of 15 nM; it's promising for PTSD, psychiatric issues, diabetes, and neurodegeneration.Fórmula:C24H31N3OCor e Forma:SolidPeso molecular:377.52GSK3-IN-2
CAS:GSK3-IN-2 is a potent GSK3 inhibitor for the treatment of diabetes and neurodegenerative diseases.Fórmula:C17H19N3OSPureza:99.51%Cor e Forma:SolidPeso molecular:313.42BRD0209
CAS:BRD0209 is a highly selective and potent GSK3 inhibitor.
Fórmula:C22H25N3OPureza:99.92%Cor e Forma:SolidPeso molecular:347.4518BIOder
CAS:18BIOder is a neuroprotective inhibitor of GSK-3β, highly selectively inhibiting HIV-1. It is the second generation derivative of 6BIO.Fórmula:C9H7ClN2O2Pureza:98%Cor e Forma:SolidPeso molecular:210.62ABC1183
CAS:ABC1183, an oral diaminothiazole, inhibits GSK3α/β, CDK9, hinders cancer cell growth, induces G2/M arrest, and modulates phosphorylation.
Fórmula:C18H14N4OSPureza:98.92%Cor e Forma:SolidPeso molecular:334.39GSK-3β inhibitor 11
CAS:GSK-3β inhibitor 11 (compound 21) is a potent inhibitor of glycogen synthase kinase-3β (GSK-3β) with an inhibitory concentration (IC50) of 10.02 μM.
Fórmula:C20H15N3O4SPureza:97.33%Cor e Forma:SolidPeso molecular:393.42GSK-3 Inhibitor XIII
CAS:GSK-3 InhibitorXIII, an ATP-competitive GSK-3 inhibitor (Ki: 24 nM), can be used to study diabetes and obesity.Fórmula:C18H15N5Pureza:99.85% - 99.86%Cor e Forma:SolidPeso molecular:301.35Ref: TM-T78578
1mg106,00€5mg243,00€10mg437,00€25mg934,00€50mg1.283,00€100mg1.730,00€200mg2.337,00€1mL*10mM (DMSO)251,00€GSK-3β inhibitor 2
CAS:GSK-3β inhibitor 2 (5-Thiazolecarboxamide,2-[2-[(cyclopropylcarbonyl)amino]-4-pyridinyl]-4-methoxy-) is a BBB-crossing and selective inhibitor of GSK-3β (IC50
Fórmula:C14H14N4O3SPureza:99.08%Cor e Forma:SolidPeso molecular:318.35BIP-135
CAS:BIP-135 is a potent and selective ATP-competitive GSK-3 inhibitor.
Fórmula:C21H13BrN2O3Pureza:99.93%Cor e Forma:SolidPeso molecular:421.24BRD5648
CAS:BRD5648 ((R)-BRD0705) is an inactive (R)-enantiomer of BRD0705.Fórmula:C20H23N3OPureza:99.89%Cor e Forma:SolidPeso molecular:321.42PT-65
CAS:PT-65, a potent and selective GSK3 degrader, demonstrates the highest degradation capacity for GSK3α (DC50 = 28.3 nM) and GSK3β (DC50 = 34.2 nM) in SH-SY5Y cells, making it applicable for Alzheimer's disease research [1].Fórmula:C51H63N13O12SCor e Forma:SolidPeso molecular:1082.19Antitrypanosomal agent 14
CAS:Antitrypanosomal agent 14 (Compound 1), a potent T.Fórmula:C14H23N3OSPureza:98%Cor e Forma:SolidPeso molecular:281.42SAR502250
CAS:SAR502250: potent, selective GSK3 inhibitor, IC50=12nM, oral, brain-penetrant, potential for AD research, antidepressant-like properties.Fórmula:C19H18FN5O2Cor e Forma:SolidPeso molecular:367.38GSK-3β inhibitor 8
CAS:GSK-3β inhibitor 8 (GSK3β Inhibitor XVIII) is a potent and selective GSK-3β inhibitor with an IC50 value of 64 nM.GSK-3β inhibitor 8 is a thienopyrimidineFórmula:C20H20ClN5OSPureza:98.46%Cor e Forma:SolidPeso molecular:413.92(Rac)-BRD0705
CAS:(Rac)-BRD0705 is a less active racemate of BRD0705. BRD0705 is an effective and selective inhibitor of GSK3α.Fórmula:C20H23N3OPureza:99.7%Cor e Forma:SolidPeso molecular:321.42Ref: TM-T12664
1mg96,00€5mg212,00€10mg316,00€25mg510,00€50mg695,00€100mg940,00€1mL*10mM (DMSO)155,00€A 1070722
CAS:A 1070722: potent GSK-3 inhibitor, Ki = 0.6 nM for both α/β isoforms, crosses BBB, potential brain GSK-3 PET radiotracer.Fórmula:C17H13F3N4O2Pureza:99.9%Cor e Forma:SolidPeso molecular:362.31TCS 21311
CAS:TCS 21311 (NIBR3049) selectively inhibits JAK3 (IC50: 8 nM) and PKCα/θ & GSK3β; >100x selective over JAK1, JAK2, TYK2.Fórmula:C27H25F3N4O4Pureza:99.39% - ≥98%Cor e Forma:SolidPeso molecular:526.515-Iodo-indirubin-3'-monoxime
CAS:5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase (IC50sFórmula:C16H10IN3O2Cor e Forma:SolidPeso molecular:403.17GSK-3 inhibitor 1
CAS:GSK-3 inhibitor 1 is a GSK-3 inhibitor.Fórmula:C22H17ClFN5O2Pureza:98.42%Cor e Forma:SolidPeso molecular:437.85
