gsk-3
Os inibidores da GSK-3 são compostos que alvo a Glicogênio Sintase Quinase 3 (GSK-3), uma enzima envolvida em numerosos processos celulares, incluindo o metabolismo do glicogênio, a transcrição genética e a proliferação celular. A GSK-3 está implicada em várias doenças, como diabetes, distúrbios neurodegenerativos e câncer. Os inibidores da GSK-3 são ferramentas importantes para explorar essas vias e desenvolver potenciais terapias. Na CymitQuimica, oferecemos inibidores da GSK-3 para apoiar sua pesquisa em doenças metabólicas, neurobiologia e oncologia.
Foram encontrados 110 produtos de "gsk-3"
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7BIO
CAS:7BIO triggers nonapoptotic death, blocks FLT3, DYRK1A/2, Aurora B/C kinases.
Fórmula:C16H10BrN3O2Pureza:99.67%Cor e Forma:SolidPeso molecular:356.174-Chloro-2'-bromoacetophenone
CAS:4-Chloro-2'-bromoacetophenone against glycogen synthase kinase-3 (GSK-3beta).Fórmula:C8H6BrClOPureza:98.34% - 99.41%Cor e Forma:White To Beige SolidPeso molecular:233.49KenPaullone
CAS:KenPaullone (9-Bromopaullone), a potent CDK1, CDK2 and CDK5 inhibitor, as new enhancer for iTreg cell differentiation.Fórmula:C16H11BrN2OPureza:97.14% - 98.99%Cor e Forma:Tan SolidPeso molecular:327.18Ref: TM-T2247
1mg35,00€2mg50,00€5mg66,00€10mg89,00€25mg178,00€50mg303,00€100mg449,00€500mg1.018,00€1mL*10mM (DMSO)71,00€VP3.15 dihydrobromide
CAS:VP3.15 dihydrobromide: potent, oral, CNS-penetrant PDE7/GSK3 inhibitor; IC50s: PDE7- 1.59 μM, GSK- 0.88 μM.Fórmula:C20H24Br2N4OSPureza:99.67% - ≥95%Cor e Forma:SolidPeso molecular:528.3CHIR-98014
CAS:CHIR-98014 (CT98014) is a selective GSK3 inhibitor; potentiate insulin activation of glucose transport and utilization in vitro and in vivo.
Fórmula:C20H17Cl2N9O2Pureza:97.25% - 99.59%Cor e Forma:SolidPeso molecular:486.31ALSTERPAULLONE
CAS:Alsterpaullone is a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells Through Apoptosis-Inducing EffecFórmula:C16H11N3O3Pureza:99.8%Cor e Forma:SolidPeso molecular:293.28Ref: TM-T7426
1mg55,00€5mg110,00€10mg173,00€25mg296,00€50mg424,00€100mg587,00€200mg792,00€1mL*10mM (DMSO)105,00€CHIR 98024
CAS:CHIR 98024: strong GSK-3α/β blocker, IC50 0.65/0.58 nM, selective over Cdc2/ERK2.Fórmula:C20H17Cl2N9O2Pureza:99.45%Cor e Forma:SolidPeso molecular:486.31Ref: TM-T3074
1mg44,00€2mg55,00€5mg96,00€10mg153,00€25mg298,00€50mg487,00€100mg705,00€1mL*10mM (DMSO)97,00€1-Azakenpaullone
CAS:1-Azakenpaullone (azakenpaullone) is a potent and selective GSK-3β inhibitor with IC50 of 18 nM, >100-fold selectivity over CDK1/cyclin B and CDK5/p25.Fórmula:C15H10BrN3OPureza:99.73%Cor e Forma:Tan SolidPeso molecular:328.16Ref: TM-T6358
1mg79,00€5mg160,00€10mg250,00€25mg464,00€50mg655,00€100mg938,00€200mg1.264,00€1mL*10mM (DMSO)187,00€Dihydronarwedine
CAS:Dihydronarwedine is a metabolite of Galanthamine, an inhibitor of glycogen synthase kinase 3β (GSK3β)Fórmula:C17H21NO3Cor e Forma:SolidPeso molecular:287.35Cazpaullone
CAS:Cazpaullone inhibits GSK-3 and briefly boosts Pax4 mRNA expression.Fórmula:C16H10N4OCor e Forma:SolidPeso molecular:274.28BRD1652
CAS:BRD1652 is a highly selective and potent GSK3 inhibitor.Fórmula:C20H20F3N3OPureza:98%Cor e Forma:SolidPeso molecular:375.39TWS-119
CAS:TWS-119 blocks GSK-3β, prompting neuronal formation in mouse stem cells.Fórmula:C22H16F6N4O6Cor e Forma:SolidPeso molecular:546.38PfGSK3/PfPK6-IN-2
CAS:PfGSK3/PfPK6-IN-2 inhibits Plasmodium falciparum GSK3/PK6 (IC50: 172 nM/11 nM) for Malaria research.Fórmula:C24H25Cl2N5OSCor e Forma:SolidPeso molecular:502.46PIMPC
CAS:PIMPC, a compound endowed with antioxidant and metal-chelating properties, acts as a novel inhibitor of glycogen synthase kinase 3 (GSK-3), and exhibitsFórmula:C21H19N5OPureza:98%Cor e Forma:SolidPeso molecular:357.41VP3.15
CAS:VP3.15 is an orally bioavailable and CNS-penetrant dual inhibitor of phosphodiesterase (PDE)7- GSK3 (IC50s: 1.59 μM and 0.88 μM for PDE7 and GSK-3).Fórmula:C20H22N4OSPureza:98%Cor e Forma:SolidPeso molecular:366.48ZDWX-25
CAS:ZDWX-25, a strong GSK-3β & DYRK1A inhibitor, kills SH-SY5Y/HL-7702 cells, may aid Alzheimer's research; IC50: 71 nM for GSK-3β.Fórmula:C17H15N3O3Cor e Forma:SolidPeso molecular:309.32TCS 2002
CAS:GSK-3β inhibitor 9b: potent, selective, oral, IC50=35 nM, good pharmacokinetics, BBB-permeable, researched for Alzheimer's.Fórmula:C18H14N2O3SCor e Forma:SolidPeso molecular:338.38GSK-3β inhibitor 12
CAS:GSK-3β inhibitor 12 is a selective GSK-3β inhibitor.GSK-3β inhibitor 12 inhibits 49.11% of 25 μM GSK-3β activity and 37.11% of 50 μM GSK-3β activity.GSK-3βFórmula:C14H13N3OSPureza:98.58%Cor e Forma:SolidPeso molecular:271.343F8
CAS:3F8 is a selective GSK-3β inhibitor that can be used as a new tool and potential therapeutic candidate compound for GSK3-related diseases, and can be used inFórmula:C15H14N2O4Pureza:98.14% - 98.25%Cor e Forma:SolidPeso molecular:286.28
