AMPK
Os inibidores de AMPK são compostos que inibem a Quinase Ativada por AMP (AMPK), uma enzima que desempenha um papel crucial na homeostase energética celular. A AMPK é ativada em resposta a baixos níveis de energia nas células e ajuda a regular processos como a captação de glicose, a oxidação de ácidos graxos e a biogênese mitocondrial. Inibir a AMPK é importante para estudar seu papel em doenças metabólicas, câncer e envelhecimento. Na CymitQuimica, oferecemos uma gama de inibidores de AMPK para apoiar sua pesquisa em metabolismo, oncologia e doenças relacionadas ao envelhecimento.
Foram encontrados 168 produtos de "AMPK"
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YKL-06-061
CAS:YKL-06-061 is a selective salt-inducible kinase (SIK) inhibitor with IC50 values of 6.56 nM/1.77 nM/20.5 nM for SIK1/2/3, respectively.Fórmula:C30H37N7O2Pureza:99.52% - 99.79%Cor e Forma:SolidPeso molecular:527.66Tizoxanide
CAS:Tizoxanide (Desacetyl-nitazoxanide) is a metabolite of lamivudine.Fórmula:C10H7N3O4SPureza:98.89% - 99.28%Cor e Forma:SolidPeso molecular:265.25Kudinoside D
CAS:Kudinoside D exerts anti-adipogenic effects through modulation of adipogenic transcription factors via AMPK signaling pathway.Fórmula:C47H72O17Pureza:99.66% - 99.92%Cor e Forma:SolidPeso molecular:909.06Annaosanchun
CAS:<p>Annaosanchun (YC-6) is potentially for the treatment of acute ischemic stroke (AIS).</p>Fórmula:C19H32O3Pureza:99.58%Cor e Forma:SolidPeso molecular:308.46ASP4132
CAS:ASP4132 is an orally active AMPK activator (EC50 : 18 nM), has anti-cancer activity.Fórmula:C46H51F3N6O8S2Pureza:98.34%Cor e Forma:SolidPeso molecular:937.06HTH-01-015
CAS:<p>HTH-01-015 is a selective NUAK1 inhibitor (IC50=100 nM).</p>Fórmula:C26H28N8OPureza:98.38% - 99.70%Cor e Forma:SolidPeso molecular:468.55Buformin hydrochloride
CAS:Buformin hydrochloride, an oral biguanide antidiabetic, activates AMPK, enhances insulin sensitivity, and inhibits hepatic glucose production.Fórmula:C6H16ClN5Pureza:97.83%Cor e Forma:SolidPeso molecular:193.68PF-06409577
CAS:PF-06409577 is an effective, orally active, and specific allosteric activator of AMPK (EC50: 7 nM, for α1β1γ1).Fórmula:C19H16ClNO3Pureza:95.17% - 98.21%Cor e Forma:SolidPeso molecular:341.797-Methoxyisoflavone
CAS:7-Methoxyisoflavone is an activator of adenosine monophosphate-activated protein kinase (AMPK).Fórmula:C16H12O3Pureza:99.93% - 99.94%Cor e Forma:SolidPeso molecular:252.26Methyl cinnamate
CAS:<p>Methyl cinnamate, a tyrosinase inhibitor and a flavoring compound, has antimicrobial, antiadipogenic, vasorelaxant, and anti-inflammatory effects.</p>Fórmula:C10H10O2Pureza:99.88%Cor e Forma:Colorless To Pale Yellow Solid CrystallinePeso molecular:162.19Cimiracemoside C
CAS:Cimiracemoside C (Cimicifugoside M) is an active component of Cimicifuga racemosa. It activates AMPK and has the potential activity against diabetes.Fórmula:C35H56O9Pureza:99.95%Cor e Forma:SolidPeso molecular:620.81Karanjin
CAS:Karanjin, a flavonoid from karanja seeds, boosts GLUT4, AMPK in muscles, and triggers cancer cell apoptosis.Fórmula:C18H12O4Pureza:99.01%Cor e Forma:SolidPeso molecular:292.298-Chloroadenosine
CAS:8-Chloroadenosine (NSC-354258) is a 5' AMP-activated protein kinase agonist potentially for the treatment of chronic lymphocytic leukemia.Fórmula:C10H12ClN5O4Pureza:98.75% - 99.84%Cor e Forma:SolidPeso molecular:301.69EX229
CAS:EX229 (C991) is an allosteric activator of AMPK, with Kds of 0.06 μM, 0.06 μM and 0.51 μM for α1β1γ1, α2β1γ1, and α1β2γ1, respectively.Fórmula:C24H18ClN3O3Pureza:99.20% - 99.36%Cor e Forma:SolidPeso molecular:431.87A-769662
CAS:A-769662 is an effective, reversible AMPK activator(EC50=0.8 μM).Fórmula:C20H12N2O3SPureza:97.52% - 99.58%Cor e Forma:SolidPeso molecular:360.39RGX-202
CAS:RGX-202 (β-GPA) is an orally active inhibitor of the SLC6A8 transport protein. RGX-202 is a creatine analog that alters skeletal muscle energy expenditure.Fórmula:C4H9N3O2Pureza:99.67% - 99.8%Cor e Forma:SolidPeso molecular:131.13Chromium(III) acetate
CAS:Chromium(III) acetate （Chromium acetate） is a small molecule ionic crosslinker that is used as a feedstock for the synthesis of other compounds.Fórmula:C2H3O2CrPureza:99.9%Cor e Forma:Blue-Green Powder Environment Immediate Steps Should Be Taken To Limit Its Spread To The Environment It Is Used InPeso molecular:76.37Doxorubicin
CAS:Doxorubicin (Adriamycin) is a Topoisomerase II (Top2) inhibitor with antineoplastic activity.Fórmula:C27H29NO11Pureza:99.31%Cor e Forma:Red Crystalline Solid SolidPeso molecular:543.52AD1058
CAS:<p>AD1058 is a selective ATR inhibitor that crosses the blood-brain barrier with in vivo anticancer activity, used in the study of brain and CNS metastasis.</p>Fórmula:C19H20N6O3SPureza:98.24%Cor e Forma:SolidPeso molecular:412.47Asteltoxin
CAS:Asteltoxin is a useful organic compound for research related to life sciences. The catalog number is T124203 and the CAS number is 79663-49-3.Fórmula:C23H30O7Cor e Forma:SolidPeso molecular:418.486TMPA
CAS:TMPA is a nuclear receptor Nur77 and LKB1 interaction antagonist.Fórmula:C21H32O6Pureza:99.21%Cor e Forma:SolidPeso molecular:380.48AMPK activator 9
CAS:AMPK activator 9 (ZM-6) is a potent α2β1γ1 agonist with an EC50 of 1.1 µM, potential for type 2 diabetes research.Fórmula:C31H28F4N4O4Cor e Forma:SolidPeso molecular:596.57ML753286
CAS:ML753286 has high permeability and low to medium clearance in rodent and human liver S9 fractions.Fórmula:C20H25N3O3Pureza:98%Cor e Forma:SolidPeso molecular:355.43ULK1-IN-2
CAS:<p>ULK1-IN-2, a potent anticancer agent, inhibits ULK1, induces apoptosis, blocks autophagy, and shows high cytotoxicity with an IC50 of 1.94 μM in A549 cells.</p>Fórmula:C19H16BrFN4O6Pureza:99.25% - 99.25%Cor e Forma:SolidPeso molecular:495.26JJO-1
CAS:JJO-1 is a bi-quinoline activating all AMPK αβγ isoforms except γ3; it requires low ATP and is unaffected by γ mutations or β deletions.Fórmula:C19H13N3Cor e Forma:SolidPeso molecular:283.33AMPK activator 8
CAS:AMPK activator 8 targets rAMPK α1β1γ1/α2β1γ1/α1β2γ1 (EC50: 11/27/4 nM) for type 2 diabetes research.Fórmula:C25H21ClN2O6Cor e Forma:SolidPeso molecular:480.9AMDE-1
CAS:<p>AMDE-1, an autophagy modulator, triggers Atg5-dependent autophagy, recruits Atg16, and induces LC3 lipidation.</p>Fórmula:C18H8ClF6N3Pureza:90%Cor e Forma:SolidPeso molecular:415.72SMTIN-T140
CAS:SMTIN-T140: strong TRAP1 inhibitor, IC50=1.646μM, anticancer; disrupts mitochondria, boosts ROS, activates AMPK, shrinks PC3 tumors, no in vivo toxicity.Fórmula:C36H34BrClFN5OPPureza:98%Cor e Forma:SolidPeso molecular:718.02IND 1316
CAS:IND 1316 is an activator of AMP-activated protein kinase (AMPK).Fórmula:C22H17NO3Cor e Forma:SolidPeso molecular:343.38OSU-53
CAS:OSU-53 is an AMPK activator, inhibiting mTOR signaling and autophagy stimulation. OSU-53 also activates mutations in RAS or BRAF.Fórmula:C25H24F3N3O6S2Cor e Forma:SolidPeso molecular:583.6AMPK activator 4
CAS:Potent, selective AMPK activator 4 enhances glucose tolerance and insulin sensitivity without affecting mitochondrial complex I.Fórmula:C24H21ClN2O3Pureza:99.97% - 99.99%Cor e Forma:SolidPeso molecular:420.89AMPK activator 1
CAS:AMPK activator 1 is an AMPK activator(compound No.1-75, EC50: <0.1μM).Fórmula:C32H33F3N4O3Pureza:98%Cor e Forma:SolidPeso molecular:578.62HL271
CAS:HL271, a derivative of metformin, is a potent AMPK activator that increases AMPK phosphorylation. HL271 attenuates aging-associated cognitive impairment.Fórmula:C13H17ClF3N5OPureza:98%Cor e Forma:SolidPeso molecular:351.76GL-V9
CAS:GL-V9 is an AMPK activator, protecting against colitis-associated colorectal cancer by limiting NLRP3 inflammasome through autophagy.Fórmula:C24H27NO5Cor e Forma:SolidPeso molecular:409.47Galegine hydrochloride
CAS:Galegine hydrochloride, from G. officinalis, leads to weight loss, activates AMPK in various cells, and has antibacterial properties.Fórmula:C6H14ClN3Cor e Forma:SolidPeso molecular:163.65LRRK2/NUAK1/TYK2-IN-1
CAS:LRRK2/NUAK1/TYK2-IN-1 inhibits LRRK2, TYK2, NUAK1 with IC50 < 10 nM, useful in autoimmune research.Fórmula:C20H11F3N6Cor e Forma:SolidPeso molecular:392.34MARK-IN-4
CAS:MARK-IN-4 inhibits microtubule kinase (MARK) effectively (IC50: 1 nM), a target for Alzheimer's therapy.Fórmula:C21H23N7OSCor e Forma:SolidPeso molecular:421.52AMPK activator 12
CAS:AMPK activator 12 is an AMPK activator and GDF15 inducer that elevates the expression level of GDF15 protein for cancer research.Fórmula:C23H24BrNO2Pureza:99.55%Cor e Forma:SolidPeso molecular:426.35AMPK activator 11
CAS:AMPK Activator 11 is a nanomolar potent inhibitor of cell proliferation in various colorectal carcinomas (CRCs), acting through the selective activation of AMP-Fórmula:C25H20N4O2Pureza:98%Cor e Forma:SolidPeso molecular:408.45AMPK activator 6
CAS:AMPK activator 6 stimulates AMPK, lowers lipids in cells, and reduces serum TC, LDL-C, and TG. Useful for NAFLD and metabolic research.Fórmula:C25H28O5Cor e Forma:SolidPeso molecular:408.49XMD-17-51
CAS:XMD-17-51 has DCLK1 kinase inhibitory activity, inhibits DCLK1 and cell proliferation, and can be used in lung cancer research.Fórmula:C21H24N8OPureza:99.04%Cor e Forma:SoildPeso molecular:404.47PF-739
CAS:PF-739 is an AMPK agonist that has been shown to activate AMPK in hepatocytes and skeletal muscle.Fórmula:C23H23ClN2O5Pureza:98%Cor e Forma:SolidPeso molecular:442.89YM-53601 free base
CAS:YM-53601 free base is an inhibitor of squalene synthetase which suppresses lipogenic biosynthesis and lipid secretion in rodents.Fórmula:C21H21FN2OPureza:98%Cor e Forma:SolidPeso molecular:336.4DK419
CAS:DK419 is an orally active inhibitor of Wnt/β-catenin signaling, with an IC50 of 0.19 μM.Fórmula:C16H8ClF6N3OPureza:99.63%Cor e Forma:SolidPeso molecular:407.7YLF-466D
CAS:YLF-466D (C24) is a newly developed AMPK activator, which inhibits platelet aggregation.Fórmula:C29H20ClNO3Pureza:97.74%Cor e Forma:SolidPeso molecular:465.93PF-249
CAS:PF-249 (PF-06685249) is a β1-selective AMPK with an EC50 of 12 nM for AMPK α1β1γ1 and can be used in studies about diabetic nephropathy.Fórmula:C17H16ClN3O3Pureza:97.01%Cor e Forma:SolidPeso molecular:345.78MRT199665
CAS:MRT199665, a selective MARK/SIK/AMPK inhibitor, blocks SIK CRTC3 S370 phosphorylation and triggers apoptosis in AML cells.Fórmula:C28H31N5O2Cor e Forma:SolidPeso molecular:469.58Butylate
CAS:Butylate is a herbicide of thiocarbamate.Fórmula:C11H23NOSCor e Forma:Less Liquid Which Darkens Upon Exposure To Light Air And Moisture Colorless Liquid Which Darkens Upon Exposure To Light Air And MoisturePeso molecular:217.37ZLN024
CAS:<p>ZLN024 is an activator of AMPK allosteric.</p>Fórmula:C13H13BrN2OSPureza:99.751%Cor e Forma:SolidPeso molecular:325.22MARK-IN-1
CAS:MARK-IN-1 is a potent microtubule affinity regulating kinase (MARK) inhibitor, (IC50<0.25 nM).Fórmula:C22H23F2N7OSPureza:98%Cor e Forma:SolidPeso molecular:471.53AMPK-α1β1γ1 activator 1
CAS:AMPK-α1β1γ1 activator 1 (M1), an acyl glucuronide metabolite derived from an Indole-3-carboxylic Acid-based AMPK activator, selectively activates the β1Fórmula:C25H24ClNO9Pureza:98%Cor e Forma:SolidPeso molecular:517.91Demethyleneberberine chloride
CAS:Demethyleneberberine chloride, a natural mitochondria-targeted antioxidant, mitigates colitis in mice and suppresses inflammatory responses by blocking the NF-Fórmula:C19H18ClNO4Pureza:98%Cor e Forma:SolidPeso molecular:359.8Ampkinone
CAS:Ampkinone is an indirect AMPK activator.Fórmula:C31H23NO6Pureza:98%Cor e Forma:SolidPeso molecular:505.52MARK-IN-2
CAS:MARK-IN-2 is a potent microtubule affinity regulating kinase (MARK) inhibitor,(IC50:5 nM).Fórmula:C18H18ClF2N5OSPureza:98%Cor e Forma:SolidPeso molecular:425.88PF-06679142
CAS:PF-06679142 is an effective AMPK activator. PF-06679142 exhibited robust activation of AMPK in rat kidneys as well as desirable oral absorption.Fórmula:C20H17F2NO3Pureza:98%Cor e Forma:SolidPeso molecular:357.35AMPK-IN-1
CAS:AMPK-IN-1 is an activator of the AMP-activated protein kinase (AMPK) enzyme, specifically targeting the α2β2γ1 isoform with an EC50 of 551 nM.Fórmula:C24H18ClN3O3Cor e Forma:SolidPeso molecular:431.8710Z-Hymenialdisine
CAS:Pan kinase inhibitorFórmula:C11H10BrN5O2Pureza:98%Cor e Forma:Light Yellow SolidPeso molecular:324.13MK-0626
CAS:MK-0626 is an orally available dipeptidyl peptidase IV (DPP-4) inhibitor enhancing AMP, restoring the expression of GLP-1R. promoting neoangiogenesis.Fórmula:C22H24F2N6O2Pureza:99.47% - >99.99%Cor e Forma:SolidPeso molecular:442.46AMPK activator 7
CAS:<p>AMPK activator 7 (I-3-24, EC50: 8.8 nM) targets AMPK-related disorders like type 2 diabetes and obesity.</p>Fórmula:C23H22F3N3O5Cor e Forma:SolidPeso molecular:477.43EGFR-IN-146
CAS:EGFR-IN-146 is an EGFR inhibitor that suppresses the EGFR signaling pathway and improves insulin sensitivity by activating the AMPK pathway. It effectively reduces blood glucose levels and body weight, showing great potential in the study of diabetes and obesity.Fórmula:C20H16N4Cor e Forma:SolidPeso molecular:312.368HDAC11-IN-2
CAS:HDAC11-IN-2 (compound B6) is a highly selective inhibitor of Histone Deacetylase 11 (HDAC11). It demonstrates IC50 values of 51.1 ×10^-3 μM for HDAC11 and 5 μM for HDAC8. HDAC11-IN-2 reduces de novo lipogenesis (DNL) and enhances fatty acid oxidation, which alleviates hepatic lipid accumulation and pathological symptoms in MASLD mice. By inhibiting HDAC11, HDAC11-IN-2 enhances the phosphorylation of AMPKα1 at the Thr172 site, thereby modulating de novo lipogenesis and fatty acid oxidation in the liver.Fórmula:C25H35N3O3Cor e Forma:SolidPeso molecular:425.564Galegine hemisulfate
CAS:Galegine hemisulfate, a guanidine derivative, aids in weight reduction in mice. It activates AMPK in 3T3-L1 adipocytes, L6 myotubes, H4IIE rat hepatoma cells, and HEK293 human renal cell lines. Galegine hemisulfate also exhibits antibacterial activity, with a minimum inhibitory concentration of 4 mg/L against Staphylococcus aureus strains.Fórmula:C6H15N3O4SCor e Forma:SolidPeso molecular:225.27Equisetin
CAS:Equisetin: a QSI from Fusarium equiseti, curbs P. aeruginosa virulence, fights Gram-positive bacteria & HIV-1 integrase; not antibacterial to Gram-negative.Fórmula:C22H31NO4Pureza:98%Cor e Forma:SolidPeso molecular:373.49NPC26
CAS:<p>NPC26 is a small molecule that disrupts mitochondrial function and exhibits antitumor activity. It shows significant antiproliferative and cytotoxic effects on CRC cell lines (HCT-116, DLD-1, and HT-29). NPC26 induces mitochondrial permeability transition pore (mPTP) opening, generates reactive oxygen species (ROS), and triggers cell death. Additionally, NPC26 kills CRC cells by activating the AMP-activated protein kinase (AMPK) signaling pathway.</p>Fórmula:C19H23N3O5S2Cor e Forma:SolidPeso molecular:437.533Aldometanib
CAS:Aldometanib (LXY-05-029) is an oral aldolase inhibitor that maintains metabolic balance by blocking FBP and activating lysosomal AMPK.Fórmula:C27H43Cl2IN2Pureza:99.32% - 99.55%Cor e Forma:SolidPeso molecular:593.46XMD-17-51 Trifluoroacetate
CAS:XMD-17-51 Trifluoroacetate is a pyrimido-diazepinone compound that regulates protein kinases.Fórmula:C23H25F3N8O3Pureza:99.65%Cor e Forma:SolidPeso molecular:518.49AMPK activator C2
CAS:AMPK activator C2 is an AMPK allosteric activator.Fórmula:C7H6NO6PPureza:98%Cor e Forma:SolidPeso molecular:231.1
