AMPK
Os inibidores de AMPK são compostos que inibem a Quinase Ativada por AMP (AMPK), uma enzima que desempenha um papel crucial na homeostase energética celular. A AMPK é ativada em resposta a baixos níveis de energia nas células e ajuda a regular processos como a captação de glicose, a oxidação de ácidos graxos e a biogênese mitocondrial. Inibir a AMPK é importante para estudar seu papel em doenças metabólicas, câncer e envelhecimento. Na CymitQuimica, oferecemos uma gama de inibidores de AMPK para apoiar sua pesquisa em metabolismo, oncologia e doenças relacionadas ao envelhecimento.
Foram encontrados 168 produtos de "AMPK"
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XY221
XY221 (Compound 16o) selectively inhibits BRD4 BD2 with an IC50 of 5.8 nM. It demonstrates high selectivity for pan-BD2 and BRD4 BD2 domains, being 667 times more selective than for BRD4 BD1, and 9-32 times more selective than for BRD2/3/T BD2. XY221 can induce apoptosis in MV4-11 cells and exhibits anti-cancer activity.Fórmula:C32H34FN3O5Cor e Forma:SolidPeso molecular:559.628AMPK-IN-6
AMPK-IN-6 (compound 13a) is a potent AMPK inhibitor with an IC50 value of 0.093 µM. It induces apoptosis and suppresses autophagy. Additionally, AMPK-IN-6 exhibits antiproliferative activity and holds potential for research into pulmonary arterial hypertension.Fórmula:C18H20FN5OCor e Forma:SolidPeso molecular:341.383Flindersine
CAS:Flindersine is a useful organic compound for research related to life sciences. The catalog number is T124718 and the CAS number is 523-64-8.Fórmula:C14H13NO2Cor e Forma:SolidPeso molecular:227.263AMARA peptide
CAS:AMARA peptide: a minimal substrate for SIK, AMPK, and other protein kinases; contains AMPK phosphorylation site.Fórmula:C62H115N27O17SPureza:98%Cor e Forma:SolidPeso molecular:1542.81NUAK1-IN-2
NUAK1-IN-2 (Compound 24) is an inhibitor of NUAK1 with an IC50 of 3.162 nM, as well as an inhibitor of CDK2/4/6. It is applicable in research related to cancer, neurodevelopmental disorders, and Alzheimer's disease.Fórmula:C24H30N6OCor e Forma:SolidPeso molecular:418.535STO-609 acetate
CAS:STO-609 acetate is selective, cell-permeable inhibitor of Ca2+-calmodulin-dependent protein kinase kinase (Ki: 80/15 ng/ml, for CaM-KKα/KKβ); competes for theFórmula:C19H10N2O3·C2H4O2Pureza:99.75%Cor e Forma:SolidPeso molecular:374.35ALKBH1-IN-3 prodrug
<p>ALKBH1-IN-4 prodrug (Compound 29E) is a prodrug of an inhibitor targeting the DNA N6-methyladenine demethylase enzyme ALKBH1. It works by significantly increasing the cellular abundance of 6mA and enhancing the AMPK signaling pathway, which suppresses the vitality of gastric cancer cells. ALKBH1-IN-4 prodrug displays excellent cellular activity and favorable metabolic exposure in vivo, making it a promising candidate for research in gastric cancer-related areas.</p>Cor e Forma:Odour SolidSAMS
CAS:SAMS peptide is a specific substrate for the AMP-activated protein kinase (AMPK).Fórmula:C74H131N29O18S2Pureza:98%Cor e Forma:SolidPeso molecular:1779.15ALKBH1-IN-3
<p>ALKBH1-IN-3 is an effective inhibitor of the DNA N6-methyladenosine (6mA) demethylase ALKBH1. This compound enhances the abundance of 6mA in gastric cancer cell lines HGC27 and AGS, simultaneously inhibiting cell viability and upregulating the AMP-activated protein kinase (AMPK) signaling pathway. ALKBH1-IN-3 holds potential for use in cancer research, including studies on gastric cancer.</p>Cor e Forma:Odour SolidGlycometabolism Compound Library
<p>xnum glycometabolism-related comounds, can be used for HTS and HCT;</p>Cor e Forma:Odour SolidKanglexin
CAS:Kanglexin is an orally active novel anthraquinone compound. It inhibits NLRP3 inflammasome activation and pyroptosis, offering cardioprotective benefits. By stimulating the FGFR1/ERK signaling pathway, Kanglexin promotes angiogenesis and accelerates wound healing in diabetes. Additionally, it has lipid-lowering effects and inhibits vascular smooth muscle cell dedifferentiation, making it a potential compound for studying hyperlipidemia, fatty liver, and atherosclerosis.Fórmula:C21H18O8Peso molecular:398.36Anti-Phospho-AMPKα (Thr172) Antibody (3O988)
Anti-Phospho-AMPKα (Thr172) Antibody (3O988) is a Rabbit antibody targeting Phospho-AMPKα (Thr172). Anti-Phospho-AMPKα (Thr172) Antibody (3O988) can be used in WB.Cor e Forma:Odour LiquidMetformin-d6 hydrochloride
CAS:Metformin-d6 hydrochloride (Metformin-d6 hydrochloride) is a deuteride of Metformin, which can be used to study Metformin metabolism in vivo.Fórmula:C4H12ClN5Pureza:98.1%Cor e Forma:SolidPeso molecular:171.66Teneligliptin hydrobromide hydrate
CAS:Teneligliptin hydrobromide hydrate: potent, long-lasting DPP-4 inhibitor with ~1 nM IC50.Fórmula:C22H33BrN6O2SCor e Forma:SolidPeso molecular:525.51Pyraclostrobin (Standard)
CAS:Pyraclostrobin (Standard) is the standard substance of Pyraclostrobin, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Pyraclostrobin is one of the most heavily used fungicides that inhibits mitochondrial complex III of fungal and mammalian cells.Fórmula:C19H18ClN3O4Peso molecular:387.826-Azuridine
CAS:<p>6-Azauridine is a purine analog with antitumor effects, inhibiting DNA synthesis and inducing apoptosis in lymphatic cancers.</p>Fórmula:C8H11N3O6Pureza:>99.99%Cor e Forma:SolidPeso molecular:245.19BC1618
CAS:<p>BC1618 (2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-) is an orally active Fbxo48 inhibitor that stimulates Ampk-dependent signaling.</p>Fórmula:C24H24F3NO2Pureza:99.95%Cor e Forma:SolidPeso molecular:415.45Metformin
CAS:<p>Metformin (1,1-Dimethylbiguanide) is an AMPK activator with blood-brain barrier permeability.</p>Fórmula:C4H11N5Pureza:99.77% - >99.99%Cor e Forma:SolidPeso molecular:129.16COH-SR4
CAS:<p>COH-SR4 (COH-SR4 (Mitochondria uncoupler SR4)) is a uncoupler of mitochondrial oxidative phosphorylation.</p>Fórmula:C13H8Cl4N2OPureza:98.96%Cor e Forma:SolidPeso molecular:350.03Kahweol
CAS:Kahweol has anticarcinogenic, anti-angiogenic,and anti-inflammatory activities, it can block the LPS-induced activation of NF-kappaB by preventing IkappaBFórmula:C20H26O3Pureza:99.26% - 99.86%Cor e Forma:Off-White To Yellow SolidPeso molecular:314.42
