PI3K
Os inibidores de PI3K são compostos que bloqueiam a atividade das fosfoinositídeo 3-quinases (PI3Ks), uma família de enzimas envolvidas em uma ampla gama de processos celulares, incluindo crescimento, proliferação, sobrevivência e metabolismo. A via PI3K/Akt/mTOR é frequentemente desregulada no câncer, tornando o PI3K um alvo-chave para a terapia do câncer. Os inibidores de PI3K são ferramentas essenciais para estudar a transdução de sinal, a biologia do câncer e o desenvolvimento de terapias direcionadas. Na CymitQuimica, oferecemos uma variedade de inibidores de PI3K para apoiar sua pesquisa em sinalização celular, oncologia e desenvolvimento terapêutico.
Foram encontrados 231 produtos para "PI3K".
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Flupentixol dihydrochloride
CAS:Flupentixol dihydrochloride is used in therapy of schizophrenia as well as in anxiolytic and depressive disorders.Fórmula:C23H27Cl2F3N2OSPureza:98.76% - 99.82%Cor e Forma:White SolidPeso molecular:507.43VS-5584
CAS:VS-5584 (SB2343) is a pan-PI3K/mTOR kinase inhibitor.Fórmula:C17H22N8OPureza:97.82% - 99.54%Cor e Forma:White SolidPeso molecular:354.411-Deoxynojirimycin hydrochloride
CAS:1-Deoxynojirimycin hydrochloride (Moranoline) is a potent and selective inhibitor of alpha-glucosidase, most commonly found in mulberry leaves.Fórmula:C6H14ClNO4Pureza:99.88%Cor e Forma:SolidPeso molecular:199.63Rigosertib
CAS:Rigosertib, a multi-kinase inhibitor targeting PLK1 (IC50: 9 nM), induces apoptosis and G2/M arrest by disrupting PI3K/Akt.Fórmula:C21H25NO8SPureza:99.53%Cor e Forma:White SolidPeso molecular:451.49Alpelisib
CAS:Alpelisib (BYL-719) is a PI3Kα inhibitor (IC50=5 nM) with selective, potent, and oral activity.Fórmula:C19H22F3N5O2SPureza:98% - 99.65%Cor e Forma:White SolidPeso molecular:441.47Ref: TM-T1921
2mg37,00€5mg52,00€1mL*10mM (DMSO)57,00€10mg69,00€25mg82,00€50mg90,00€100mg145,00€500mg424,00€Omipalisib
CAS:Omipalisib (GSK2126458) is a small-molecule pyridylsulfonamide inhibitor of phosphatidylinositol 3-kinase (PI3K) with potential antineoplastic activity.Fórmula:C25H17F2N5O3SPureza:98% - 99.8%Cor e Forma:Yellow SolidPeso molecular:505.5AZD-7648
CAS:AZD-7648 is an inhibitor of DNA-dependent protein kinase (DNA-PK) with the IC50 of 0.63 nM in an enzyme assay,has anti-tumor activity.Fórmula:C18H20N8O2Pureza:99.03% - 99.85%Cor e Forma:SolidPeso molecular:380.4Ref: TM-T7122
1mg38,00€5mg84,00€1mL*10mM (DMSO)93,00€10mg113,00€25mg177,00€50mg295,00€100mg447,00€200mg650,00€Erucic acid
CAS:Increased levels of erucic acid (22:1n9) have been found in the red blood cell membranes of autistic subjects with developmental regression (PMID: 16581239 ).Fórmula:C22H42O2Pureza:99.64%Cor e Forma:White SolidPeso molecular:338.57GNE-493
CAS:GNE-493 is potent, selective, and orally available PI3K and mTOR inhibitor with potential anticancer activity.IC50s of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM forFórmula:C17H20N6O2SPureza:98%Cor e Forma:SolidPeso molecular:372.44PIK-294
CAS:PIK-294 is a excellently specific p110δ inhibitor(IC50=10 nM).Fórmula:C28H23N7O2Pureza:97.22% - >99.99%Cor e Forma:SolidPeso molecular:489.53Desmethylglycitein
CAS:Desmethylglycitein (6,7,4'-Trihydroxyisoflavone) , is a novel inhibitor of PKCα in suppressing solar UV-induced matrix metalloproteinase 1, which hasFórmula:C15H10O5Pureza:97.93%Cor e Forma:SolidPeso molecular:270.24Taurolithocholic acid sodium salt
CAS:Taurolithocholic acid sodium salt (Sodium taurolithocholate) is the major human metabolite, a bile acid which inhibits radioligand binding to muscarinic M1, butFórmula:C26H44NNaO5SPureza:99.79% - 99.93%Cor e Forma:White SolidPeso molecular:505.69ZSTK474
CAS:PI3K Inhibitor ZSTK474 is an orally available, s-triazine derivative, ATP-competitive phosphatidylinositol 3-kinase (PI3K) inhibitor with potentialFórmula:C19H21F2N7O2Pureza:98.29% - 99.95%Cor e Forma:SolidPeso molecular:417.41PI-103
CAS:PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of PI3K family members (IC50s: 2/3/3/15/30/23 nM for p110α/β/δ/γ, mTOR, and DNA-PK).Fórmula:C19H16N4O3Pureza:97.79% - 99.30%Cor e Forma:Yellow SolidPeso molecular:348.36GNE-317
CAS:GNE-317, a PI3K/mTOR inhibitor, can pass through the blood-brain barrier (BBB).Fórmula:C19H22N6O3SPureza:98.42% - 99.54%Cor e Forma:White SolidPeso molecular:414.48Ref: TM-T6845
2mg43,00€5mg63,00€1mL*10mM (DMSO)70,00€10mg92,00€25mg192,00€50mg264,00€100mg339,00€200mg497,00€Flavanomarein
CAS:Flavanomarein: Antioxidant with radical scavenging, lipid peroxidation inhibition, and lipid-lowering in HepG2 cells.Fórmula:C21H22O11Pureza:98.63% - 99.54%Cor e Forma:SolidPeso molecular:450.39Hederacolchiside A1
CAS:Hederacolchiside A1 exhibits anti-leishmanial and anticancer activities by disrupting cell membranes and inducing apoptosis via the PI3K/Akt/mTOR pathway.Fórmula:C47H76O16Pureza:98.76% - 99.92%Cor e Forma:SolidPeso molecular:897.1Ref: TM-T2P2806
1mg46,00€5mg114,00€1mL*10mM (DMSO)161,00€10mg167,00€25mg268,00€50mg408,00€100mg587,00€200mg825,00€TASP0415914
CAS:TASP0415914 is an orally potent inhibitor of phosphoinositide 3-kinase γ (PI3Kγ). TFórmula:C13H17N5O3SPureza:98.14%Cor e Forma:SolidPeso molecular:323.37Ref: TM-T7879
1mg52,00€5mg111,00€1mL*10mM (DMSO)127,00€10mg177,00€25mg299,00€50mg424,00€100mg587,00€200mg792,00€Fimepinostat
CAS:Fimepinostat (CUDC 907) is an orally bioavailable inhibitor of both PI3K class I and pan-HDAC enzymes, with potential antineoplastic activity.Fórmula:C23H24N8O4SPureza:98.27% - 99.87%Cor e Forma:SolidPeso molecular:508.55Ref: TM-T2078
2mg44,00€5mg66,00€1mL*10mM (DMSO)74,00€10mg92,00€25mg172,00€50mg295,00€100mg485,00€500mg1.035,00€Idelalisib
CAS:Idelalisib (GS-1101) is a small molecule inhibitor of the PI3K catalytic subunit p110δ (IC50: 2.5 nM).Fórmula:C22H18FN7OPureza:98% - 99.39%Cor e Forma:White SolidPeso molecular:415.42Ref: TM-T1894
5mg34,00€10mg48,00€1mL*10mM (DMSO)50,00€25mg71,00€50mg88,00€100mg103,00€200mg133,00€500mg213,00€
