PI3K
Os inibidores de PI3K são compostos que bloqueiam a atividade das fosfoinositídeo 3-quinases (PI3Ks), uma família de enzimas envolvidas em uma ampla gama de processos celulares, incluindo crescimento, proliferação, sobrevivência e metabolismo. A via PI3K/Akt/mTOR é frequentemente desregulada no câncer, tornando o PI3K um alvo-chave para a terapia do câncer. Os inibidores de PI3K são ferramentas essenciais para estudar a transdução de sinal, a biologia do câncer e o desenvolvimento de terapias direcionadas. Na CymitQuimica, oferecemos uma variedade de inibidores de PI3K para apoiar sua pesquisa em sinalização celular, oncologia e desenvolvimento terapêutico.
Foram encontrados 231 produtos para "PI3K".
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GNE-493
CAS:GNE-493 is potent, selective, and orally available PI3K and mTOR inhibitor with potential anticancer activity.IC50s of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM forFórmula:C17H20N6O2SPureza:98%Cor e Forma:SolidPeso molecular:372.44NIH-12848
CAS:NIH-12848 is a putative inhibitor of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) with an IC50 of 1 μM.Fórmula:C20H14F3N3SPureza:99.87% - 99.9%Cor e Forma:SolidPeso molecular:385.41Ref: TM-T3556
2mg35,00€5mg51,00€1mL*10mM (DMSO)55,00€10mg75,00€25mg133,00€50mg225,00€100mg323,00€200mg447,00€TASP0415914
CAS:TASP0415914 is an orally potent inhibitor of phosphoinositide 3-kinase γ (PI3Kγ). TFórmula:C13H17N5O3SPureza:98.14%Cor e Forma:SolidPeso molecular:323.37Ref: TM-T7879
1mg52,00€5mg111,00€1mL*10mM (DMSO)127,00€10mg177,00€25mg299,00€50mg424,00€100mg587,00€200mg792,00€BGT226
CAS:BGT226 (NVP-BGT226) is a novel dual PI3K / mTOR inhibitor, it acts on PI3K α/β/γ with IC50 of 4 nM / 63 nM / 38 nM, respectively.Fórmula:C28H25F3N6O2Pureza:95.74% - 99.78%Cor e Forma:White SolidPeso molecular:534.53Ref: TM-T6072L
1mg47,00€2mg62,00€5mg92,00€1mL*10mM (DMSO)107,00€10mg147,00€25mg295,00€50mg485,00€100mg737,00€Rigosertib sodium
CAS:Rigosertib sodium (ON-01910), a non-ATP-competitive inhibitor of PLK1(IC50=9 nM), exhibits 30-fold higher specificity activity over Plk2 and no effect on Plk3.Fórmula:C21H24NNaO8SPureza:98% - 99.37%Cor e Forma:SolidPeso molecular:473.47Flavanomarein
CAS:Flavanomarein: Antioxidant with radical scavenging, lipid peroxidation inhibition, and lipid-lowering in HepG2 cells.Fórmula:C21H22O11Pureza:98.63% - 99.54%Cor e Forma:SolidPeso molecular:450.39ZSTK474
CAS:PI3K Inhibitor ZSTK474 is an orally available, s-triazine derivative, ATP-competitive phosphatidylinositol 3-kinase (PI3K) inhibitor with potentialFórmula:C19H21F2N7O2Pureza:98.29% - 99.95%Cor e Forma:SolidPeso molecular:417.41SKI V
CAS:SKI V is a potent and noncompetitive non-lipid sphingosine kinase (SPHK; SK) inhibitor (GST-hSK,IC50 : 2 μM), and is a PI3K inhibitor(hPI3k,IC50 : 6 μM),Fórmula:C15H10O4Pureza:98.78%Cor e Forma:Yellow SolidPeso molecular:254.24Ref: TM-T8461
1mg87,00€5mg178,00€1mL*10mM (DMSO)203,00€10mg281,00€25mg485,00€50mg708,00€100mg1.044,00€Fimepinostat
CAS:Fimepinostat (CUDC 907) is an orally bioavailable inhibitor of both PI3K class I and pan-HDAC enzymes, with potential antineoplastic activity.Fórmula:C23H24N8O4SPureza:98.27% - 99.87%Cor e Forma:SolidPeso molecular:508.55Ref: TM-T2078
2mg44,00€5mg66,00€1mL*10mM (DMSO)74,00€10mg92,00€25mg172,00€50mg295,00€100mg485,00€500mg1.035,00€Idelalisib
CAS:Idelalisib (GS-1101) is a small molecule inhibitor of the PI3K catalytic subunit p110δ (IC50: 2.5 nM).Fórmula:C22H18FN7OPureza:98% - 99.39%Cor e Forma:White SolidPeso molecular:415.42Ref: TM-T1894
5mg34,00€10mg48,00€1mL*10mM (DMSO)50,00€25mg71,00€50mg88,00€100mg103,00€200mg133,00€500mg213,00€Vps34-PIK-III
CAS:Vps34-PIK-III (VPS34-IN2), a selective inhibitor of VPS34 enzymatic activity, inhibits autophagy and results in the stabilization of autophagy substrates.Fórmula:C17H17N7Pureza:98.39% - 98.43%Cor e Forma:White SolidPeso molecular:319.36Euscaphic acid
CAS:Euscaphic acid has anti-diabetic and anti-inflammatory effects, blocking IKK/MAPKs and NF-κB activation by disrupting TRAF6/IRAK1/TAK1 clustering.Fórmula:C30H48O5Pureza:98.93%Cor e Forma:White SolidPeso molecular:488.7Arnicolide D
CAS:Arnicolide D is a sesquiterpene lactone.Fórmula:C19H24O5Pureza:96.66% - 99.93%Cor e Forma:White SolidPeso molecular:332.39Oroxin B
CAS:Oroxin B (Hypocretin-2) has antioxidant activity.Fórmula:C27H30O15Pureza:98.22% - 99.87%Cor e Forma:Yellow SolidPeso molecular:594.52PIK-294
CAS:PIK-294 is a excellently specific p110δ inhibitor(IC50=10 nM).Fórmula:C28H23N7O2Pureza:97.22% - >99.99%Cor e Forma:SolidPeso molecular:489.53PF-4989216
CAS:PF-4989216 is a potent and selective PI3K inhibitor with IC50 of 2 nM, 142 nM, 65 nM, 1 nM, and 110 nM for p110α, p110β, p110γ, p110δ, and VPS34, respectively.Fórmula:C18H13FN6OSPureza:99.85%Cor e Forma:SolidPeso molecular:380.4Ref: TM-T6938
2mg37,00€5mg62,00€1mL*10mM (DMSO)64,00€10mg96,00€25mg177,00€50mg311,00€100mg376,00€200mg535,00€Bimiralisib
CAS:Bimiralisib (PI3K-IN-2) is an orally bioavailable pan inhibitor of PI3K and inhibitor of the mTOR, with potential antineoplastic activity.Fórmula:C17H20F3N7O2Pureza:97.58% - 98.92%Cor e Forma:SolidPeso molecular:411.38Omipalisib
CAS:Omipalisib (GSK2126458) is a small-molecule pyridylsulfonamide inhibitor of phosphatidylinositol 3-kinase (PI3K) with potential antineoplastic activity.Fórmula:C25H17F2N5O3SPureza:98% - 99.8%Cor e Forma:Yellow SolidPeso molecular:505.51-Deoxynojirimycin
CAS:1-Deoxynojirimycin (Moranoline) is a potent α-glucosidase inhibitor, suppressing postprandial blood glucose, thereby possibly preventing diabetes mellitus.Fórmula:C6H13NO4Pureza:99.65% - 99.98%Cor e Forma:SolidPeso molecular:163.17Ref: TM-T3675
2mg43,00€1mL*10mM (DMSO)57,00€5mg58,00€10mg74,00€25mg140,00€50mg248,00€100mg321,00€500mg773,00€Wortmannin
CAS:Wortmannin (SL-2052) is a PI3K inhibitor (IC50=3 nM) that is covalent and irreversible.Fórmula:C23H24O8Pureza:95.84% - 99.77%Cor e Forma:White SolidPeso molecular:428.43
