PI3K
Os inibidores de PI3K são compostos que bloqueiam a atividade das fosfoinositídeo 3-quinases (PI3Ks), uma família de enzimas envolvidas em uma ampla gama de processos celulares, incluindo crescimento, proliferação, sobrevivência e metabolismo. A via PI3K/Akt/mTOR é frequentemente desregulada no câncer, tornando o PI3K um alvo-chave para a terapia do câncer. Os inibidores de PI3K são ferramentas essenciais para estudar a transdução de sinal, a biologia do câncer e o desenvolvimento de terapias direcionadas. Na CymitQuimica, oferecemos uma variedade de inibidores de PI3K para apoiar sua pesquisa em sinalização celular, oncologia e desenvolvimento terapêutico.
Foram encontrados 241 produtos de "PI3K"
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GNE-493
CAS:<p>GNE-493 is potent, selective, and orally available PI3K and mTOR inhibitor with potential anticancer activity.IC50s of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM for</p>Fórmula:C17H20N6O2SPureza:98%Cor e Forma:SolidPeso molecular:372.44NIH-12848
CAS:<p>NIH-12848 is a putative inhibitor of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) with an IC50 of 1 μM.</p>Fórmula:C20H14F3N3SPureza:99.84% - 99.9%Cor e Forma:SolidPeso molecular:385.41Sapanisertib
CAS:<p>Sapanisertib (INK 128) is an oral raptor-mTOR and rictor-mTOR inhibitor with potential cancer-fighting properties.</p>Fórmula:C15H15N7OPureza:99.19% - >99.99%Cor e Forma:SolidPeso molecular:309.33PF-04691502
CAS:<p>PF-04691502 is a potent and selective inhibitor of PI3K and mTOR kinases with antitumor activity.</p>Fórmula:C22H27N5O4Pureza:96.27% - ≥95%Cor e Forma:SolidPeso molecular:425.48BGT226
CAS:<p>BGT226 (NVP-BGT226) is a novel dual PI3K / mTOR inhibitor, it acts on PI3K α/β/γ with IC50 of 4 nM / 63 nM / 38 nM, respectively.</p>Fórmula:C28H25F3N6O2Pureza:95.74% - 99.51%Cor e Forma:SolidPeso molecular:534.53Fimepinostat
CAS:<p>Fimepinostat (CUDC 907) is an orally bioavailable inhibitor of both PI3K class I and pan-HDAC enzymes, with potential antineoplastic activity.</p>Fórmula:C23H24N8O4SPureza:98.27% - 99.87%Cor e Forma:SolidPeso molecular:508.55Rigosertib sodium
CAS:<p>Rigosertib sodium (ON-01910), a non-ATP-competitive inhibitor of PLK1(IC50=9 nM), exhibits 30-fold higher specificity activity over Plk2 and no effect on Plk3.</p>Fórmula:C21H24NNaO8SPureza:98% - 99.37%Cor e Forma:SolidPeso molecular:473.47TASP0415914
CAS:<p>TASP0415914 is an orally potent inhibitor of phosphoinositide 3-kinase γ (PI3Kγ). T</p>Fórmula:C13H17N5O3SPureza:98.14%Cor e Forma:SolidPeso molecular:323.37Arnicolide D
CAS:<p>Arnicolide D is a sesquiterpene lactone.</p>Fórmula:C19H24O5Pureza:96.66%Cor e Forma:SolidPeso molecular:332.39PI-3065
CAS:<p>PI-3065 is a novel potent and selective PI3K p110δ inhibitor.</p>Fórmula:C27H31FN6OSPureza:99.84% - ≥95%Cor e Forma:SolidPeso molecular:506.64Wortmannin
CAS:<p>Wortmannin (SL-2052) is a PI3K inhibitor (IC50=3 nM) that is covalent and irreversible.</p>Fórmula:C23H24O8Pureza:95.84% - 99.76%Cor e Forma:White SolidPeso molecular:428.43GDC0084
CAS:<p>GDC0084 (RG7666) is a PI3K inhibitor with potential antineoplastic activity.</p>Fórmula:C18H22N8O2Pureza:99.72% - 99.87%Cor e Forma:SolidPeso molecular:382.42AS-252424
CAS:<p>AS-252424 is a potent and selective inhibitor of PI3Kγ with IC50 of 33 nM; >10 fold selectivity for PI3Kγ versus PI3Kα.</p>Fórmula:C14H8FNO4SPureza:99.06% - 99.09%Cor e Forma:SolidPeso molecular:305.28Hederacolchiside A1
CAS:<p>Hederacolchiside A1 exhibits anti-leishmanial and anticancer activities by disrupting cell membranes and inducing apoptosis via the PI3K/Akt/mTOR pathway.</p>Fórmula:C47H76O16Pureza:98.76% - 99.92%Cor e Forma:SolidPeso molecular:897.1PI3K-IN-1
CAS:<p>PI3K-IN-1 (Voxtalisib Analogue) is a dual inhibitor of mTOR/PI3K, mostly for p110γ , also inhibits DNA-PK and mTOR.</p>Fórmula:C31H29N5O6SPureza:97.03% - 98%Cor e Forma:SolidPeso molecular:599.66PF-4989216
CAS:PF-4989216 is a potent and selective PI3K inhibitor with IC50 of 2 nM, 142 nM, 65 nM, 1 nM, and 110 nM for p110α, p110β, p110γ, p110δ, and VPS34, respectively.Fórmula:C18H13FN6OSPureza:99.85%Cor e Forma:SolidPeso molecular:380.4Leniolisib
CAS:<p>Leniolisib (CDZ173) (CDZ173) is a potent and selective PI3Kδ inhibitor (IC50: 11 nM).</p>Fórmula:C21H25F3N6O2Pureza:99.88%Cor e Forma:SolidPeso molecular:450.46Copanlisib
CAS:<p>Copanlisib (BAY 80-6946), a PI3K inhibitor, may block tumor growth and improve cancer treatment efficacy.</p>Fórmula:C23H28N8O4Pureza:99% - 99.88%Cor e Forma:SolidPeso molecular:480.52(E)-Akt inhibitor-IV
CAS:<p>(E)-Akt inhibitor-IV ((E)-AKTIV) ((E)-AKTIV) is an inhibitor of PI3K-Akt.</p>Fórmula:C31H29IN4SPureza:99.74% - 99.9%Cor e Forma:SolidPeso molecular:616.56BQR-695
CAS:<p>BQR-695 (NVP-BQR695) is a PI4K inhibitor with IC50s of 80 and 3.5 nM for human PI4KIIIβ and Plasmodium variant of PI4KIIIβ, respectively.</p>Fórmula:C19H20N4O3Pureza:98.91% - 99.69%Cor e Forma:SolidPeso molecular:352.39
