PI3K
Os inibidores de PI3K são compostos que bloqueiam a atividade das fosfoinositídeo 3-quinases (PI3Ks), uma família de enzimas envolvidas em uma ampla gama de processos celulares, incluindo crescimento, proliferação, sobrevivência e metabolismo. A via PI3K/Akt/mTOR é frequentemente desregulada no câncer, tornando o PI3K um alvo-chave para a terapia do câncer. Os inibidores de PI3K são ferramentas essenciais para estudar a transdução de sinal, a biologia do câncer e o desenvolvimento de terapias direcionadas. Na CymitQuimica, oferecemos uma variedade de inibidores de PI3K para apoiar sua pesquisa em sinalização celular, oncologia e desenvolvimento terapêutico.
Foram encontrados 231 produtos para "PI3K".
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GSK1059615
CAS:GSK1059615 has been used in trials studying the treatment of Lymphoma, Solid Tumours, Endometrial Cancer, Solid Tumor Cancer, and Metastatic Breast Cancer.Fórmula:C18H11N3O2SPureza:99.3% - ≥95%Cor e Forma:White SolidPeso molecular:333.36Glaucocalyxin A
CAS:Glaucocalyxin A improves drug delivery, activates apoptosis, inhibits cell growth, with potential as an antiplatelet agent.Fórmula:C20H28O4Pureza:99.55% - 99.80%Cor e Forma:White SolidPeso molecular:332.43PIK-108
CAS:PIK-108 is an allosteric inhibitor of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunits β and δ (PI3Kβ/δ).Fórmula:C22H24N2O3Pureza:98.92%Cor e Forma:SolidPeso molecular:364.44Ref: TM-T28416
1mg38,00€2mg54,00€5mg92,00€1mL*10mM (DMSO)100,00€10mg147,00€25mg241,00€50mg349,00€100mg482,00€200mg662,00€Esculetin
CAS:Esculetin: a coumarin from plants with anti-edema, anti-inflammatory, anti-tumor properties; inhibits LOs.Fórmula:C9H6O4Pureza:98.03% - 99.76%Cor e Forma:Yellow SolidPeso molecular:178.14Brevianamide F
CAS:Brevianamide F (Cyclo(L-Pro-L-Trp)), also known as cyclo-(L-Trp-L-Pro), belongs to a class of naturally occurring 2,5-diketopiperazines.Fórmula:C16H17N3O2Pureza:97.30% - 98.82%Cor e Forma:SolidPeso molecular:283.33PIK-75 hydrochloride
CAS:PIK-75 hydrochloride (PIK-75 HCl) is a p110α inhibitor, isoform-specific mutants at Ser773, and potently inhibits DNA-PK with IC50 of 2 nM in cell-free assay.Fórmula:C16H14BrN5O4S·HClPureza:97.82%Cor e Forma:SolidPeso molecular:488.74NIBR-17
CAS:NIBR-17 is a pan class I PI3K inhibitor. NIBR-17 inhibits PI3KKα, PI3KKβ, PI3KKγ, and PI3KKδ with IC50 of 1 nM, 9.2 nM, 9 nM, and 20 nM respectively.Fórmula:C18H20N8O2Pureza:97.79%Cor e Forma:White SolidPeso molecular:380.4YS-49
CAS:YS-49 is an activator of PI3K/Akt (a downstream target of RhoA).Fórmula:C20H20BrNO2Pureza:99.65%Cor e Forma:SolidPeso molecular:386.28Ref: TM-T13376
1mg46,00€2mg58,00€1mL*10mM (DMSO)92,00€5mg95,00€10mg137,00€25mg260,00€50mg386,00€100mg560,00€500mg1.153,00€1-Deoxynojirimycin hydrochloride
CAS:1-Deoxynojirimycin hydrochloride (Moranoline) is a potent and selective inhibitor of alpha-glucosidase, most commonly found in mulberry leaves.Fórmula:C6H14ClNO4Pureza:99.88%Cor e Forma:SolidPeso molecular:199.63Apitolisib
CAS:Apitolisib (RG 7422) is a PI3K inhibitor, used in cancer trials, targeting PI3Kα, β, δ, γ (IC50= 5, 27, 7, 14 nM).Fórmula:C23H30N8O3SPureza:98.28% - 99.64%Cor e Forma:SolidPeso molecular:498.6Flupentixol dihydrochloride
CAS:Flupentixol dihydrochloride is used in therapy of schizophrenia as well as in anxiolytic and depressive disorders.Fórmula:C23H27Cl2F3N2OSPureza:98.76% - 99.82%Cor e Forma:White SolidPeso molecular:507.43VS-5584
CAS:VS-5584 (SB2343) is a pan-PI3K/mTOR kinase inhibitor.Fórmula:C17H22N8OPureza:97.82% - 99.54%Cor e Forma:White SolidPeso molecular:354.41Rigosertib
CAS:Rigosertib, a multi-kinase inhibitor targeting PLK1 (IC50: 9 nM), induces apoptosis and G2/M arrest by disrupting PI3K/Akt.Fórmula:C21H25NO8SPureza:99.53%Cor e Forma:White SolidPeso molecular:451.49Alpelisib
CAS:Alpelisib (BYL-719) is a PI3Kα inhibitor (IC50=5 nM) with selective, potent, and oral activity.Fórmula:C19H22F3N5O2SPureza:98% - 99.65%Cor e Forma:White SolidPeso molecular:441.47Ref: TM-T1921
2mg37,00€5mg52,00€1mL*10mM (DMSO)57,00€10mg69,00€25mg82,00€50mg90,00€100mg145,00€500mg424,00€Erucic acid
CAS:Increased levels of erucic acid (22:1n9) have been found in the red blood cell membranes of autistic subjects with developmental regression (PMID: 16581239 ).Fórmula:C22H42O2Pureza:99.64%Cor e Forma:White SolidPeso molecular:338.57AZD-7648
CAS:AZD-7648 is an inhibitor of DNA-dependent protein kinase (DNA-PK) with the IC50 of 0.63 nM in an enzyme assay,has anti-tumor activity.Fórmula:C18H20N8O2Pureza:99.03% - 99.85%Cor e Forma:SolidPeso molecular:380.4Ref: TM-T7122
1mg38,00€5mg84,00€1mL*10mM (DMSO)93,00€10mg113,00€25mg177,00€50mg295,00€100mg447,00€200mg650,00€AMG 511
CAS:AMG 511: oral class I PI3K inhibitor (α, β, δ, γ Kis: 4, 6, 2, 1 nM), anti-tumor in mouse glioblastoma model, reduces p-Akt (Ser473).Fórmula:C22H28FN9O3SPureza:≥98%Cor e Forma:SolidPeso molecular:517.58HS-173
CAS:HS-173 is an effective PI3Kα inhibitor (IC50: 0.8 nM).Fórmula:C21H18N4O4SPureza:99.33% - 99.64%Cor e Forma:SolidPeso molecular:422.46Ref: TM-T2308
2mg34,00€5mg52,00€1mL*10mM (DMSO)52,00€10mg77,00€25mg128,00€50mg200,00€100mg296,00€200mg425,00€TG100-115
CAS:TG100-115 is a PI3Kγ/δ inhibitor (IC50: 83/235 nM), with fewer effects on PI3Kα/β.Fórmula:C18H14N6O2Pureza:99.22% - 99.26%Cor e Forma:SolidPeso molecular:346.34Ref: TM-T2672
1mg40,00€5mg80,00€1mL*10mM (DMSO)87,00€10mg109,00€25mg200,00€50mg358,00€100mg557,00€500mg1.153,00€Sophocarpine
CAS:Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.Fórmula:C15H22N2OPureza:99.89%Cor e Forma:SolidPeso molecular:246.35PF-04691502
CAS:PF-04691502 is a potent and selective inhibitor of PI3K and mTOR kinases with antitumor activity.Fórmula:C22H27N5O4Pureza:96.27% - ≥95%Cor e Forma:SolidPeso molecular:425.48Ref: TM-T6251
1mg34,00€2mg43,00€5mg63,00€1mL*10mM (DMSO)65,00€10mg88,00€25mg117,00€50mg187,00€100mg333,00€AS-252424
CAS:AS-252424 is a potent and selective inhibitor of PI3Kγ with IC50 of 33 nM; >10 fold selectivity for PI3Kγ versus PI3Kα.Fórmula:C14H8FNO4SPureza:99.06% - 99.09%Cor e Forma:Orange SolidPeso molecular:305.28Ref: TM-T6208
1mg37,00€2mg52,00€5mg77,00€1mL*10mM (DMSO)84,00€10mg128,00€25mg205,00€50mg309,00€100mg447,00€500mg973,00€Desmethylglycitein
CAS:Desmethylglycitein (6,7,4'-Trihydroxyisoflavone) , is a novel inhibitor of PKCα in suppressing solar UV-induced matrix metalloproteinase 1, which hasFórmula:C15H10O5Pureza:97.93%Cor e Forma:SolidPeso molecular:270.24Taurolithocholic acid sodium salt
CAS:Taurolithocholic acid sodium salt (Sodium taurolithocholate) is the major human metabolite, a bile acid which inhibits radioligand binding to muscarinic M1, butFórmula:C26H44NNaO5SPureza:99.79% - 99.93%Cor e Forma:White SolidPeso molecular:505.69Ref: TM-T4727
5mg46,00€1mL*10mM (DMSO)49,00€10mg50,00€25mg73,00€50mg92,00€100mg137,00€500mg331,00€200mg990,00€PI-103
CAS:PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of PI3K family members (IC50s: 2/3/3/15/30/23 nM for p110α/β/δ/γ, mTOR, and DNA-PK).Fórmula:C19H16N4O3Pureza:97.79% - 99.30%Cor e Forma:Yellow SolidPeso molecular:348.36GNE-317
CAS:GNE-317, a PI3K/mTOR inhibitor, can pass through the blood-brain barrier (BBB).Fórmula:C19H22N6O3SPureza:98.42% - 99.54%Cor e Forma:White SolidPeso molecular:414.48Ref: TM-T6845
2mg43,00€5mg63,00€1mL*10mM (DMSO)70,00€10mg92,00€25mg192,00€50mg264,00€100mg339,00€200mg497,00€1,3-Dicaffeoylquinic acid
CAS:1,3-Dicaffeoylquinic acid (CYNARIN) is a natural product. It shows antioxidant and choleretic properties and is a potential immunosuppressive agent.Fórmula:C25H24O12Pureza:98% - 98.81%Cor e Forma:SolidPeso molecular:516.45Ref: TM-T5736
1mg37,00€5mg71,00€10mg90,00€1mL*10mM (DMSO)103,00€25mg147,00€50mg208,00€100mg309,00€200mg447,00€3-Methyladenine
CAS:3-Methyladenine (3-MA) is a PI3K inhibitor that selectively inhibits class IB PI3Kγ (IC50=60 μM) and class III VPS34 (IC50=25 μM).Fórmula:C6H7N5Pureza:98% - 99.51%Cor e Forma:White SolidPeso molecular:149.15Hederacolchiside A1
CAS:Hederacolchiside A1 exhibits anti-leishmanial and anticancer activities by disrupting cell membranes and inducing apoptosis via the PI3K/Akt/mTOR pathway.Fórmula:C47H76O16Pureza:98.76% - 99.92%Cor e Forma:SolidPeso molecular:897.1Ref: TM-T2P2806
1mg46,00€5mg114,00€1mL*10mM (DMSO)161,00€10mg167,00€25mg268,00€50mg408,00€100mg587,00€200mg825,00€iMDK
CAS:iMDK quarterhydrate, a PI3K inhibitor, blocks MDK growth factor and enhances NSCLC treatment with MEK inhibitors, sparing normal cells.Fórmula:C21H13FN2O2SPureza:99.99%Cor e Forma:White SolidPeso molecular:376.4GNE-493
CAS:GNE-493 is potent, selective, and orally available PI3K and mTOR inhibitor with potential anticancer activity.IC50s of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM forFórmula:C17H20N6O2SPureza:98%Cor e Forma:SolidPeso molecular:372.44NIH-12848
CAS:NIH-12848 is a putative inhibitor of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) with an IC50 of 1 μM.Fórmula:C20H14F3N3SPureza:99.87% - 99.9%Cor e Forma:SolidPeso molecular:385.41Ref: TM-T3556
2mg35,00€5mg51,00€1mL*10mM (DMSO)55,00€10mg75,00€25mg133,00€50mg225,00€100mg323,00€200mg447,00€TASP0415914
CAS:TASP0415914 is an orally potent inhibitor of phosphoinositide 3-kinase γ (PI3Kγ). TFórmula:C13H17N5O3SPureza:98.14%Cor e Forma:SolidPeso molecular:323.37Ref: TM-T7879
1mg52,00€5mg111,00€1mL*10mM (DMSO)127,00€10mg177,00€25mg299,00€50mg424,00€100mg587,00€200mg792,00€BGT226
CAS:BGT226 (NVP-BGT226) is a novel dual PI3K / mTOR inhibitor, it acts on PI3K α/β/γ with IC50 of 4 nM / 63 nM / 38 nM, respectively.Fórmula:C28H25F3N6O2Pureza:95.74% - 99.78%Cor e Forma:White SolidPeso molecular:534.53Ref: TM-T6072L
1mg47,00€2mg62,00€5mg92,00€1mL*10mM (DMSO)107,00€10mg147,00€25mg295,00€50mg485,00€100mg737,00€Rigosertib sodium
CAS:Rigosertib sodium (ON-01910), a non-ATP-competitive inhibitor of PLK1(IC50=9 nM), exhibits 30-fold higher specificity activity over Plk2 and no effect on Plk3.Fórmula:C21H24NNaO8SPureza:98% - 99.37%Cor e Forma:SolidPeso molecular:473.47Flavanomarein
CAS:Flavanomarein: Antioxidant with radical scavenging, lipid peroxidation inhibition, and lipid-lowering in HepG2 cells.Fórmula:C21H22O11Pureza:98.63% - 99.54%Cor e Forma:SolidPeso molecular:450.39ZSTK474
CAS:PI3K Inhibitor ZSTK474 is an orally available, s-triazine derivative, ATP-competitive phosphatidylinositol 3-kinase (PI3K) inhibitor with potentialFórmula:C19H21F2N7O2Pureza:98.29% - 99.95%Cor e Forma:SolidPeso molecular:417.41SKI V
CAS:SKI V is a potent and noncompetitive non-lipid sphingosine kinase (SPHK; SK) inhibitor (GST-hSK,IC50 : 2 μM), and is a PI3K inhibitor(hPI3k,IC50 : 6 μM),Fórmula:C15H10O4Pureza:98.78%Cor e Forma:Yellow SolidPeso molecular:254.24Ref: TM-T8461
1mg87,00€5mg178,00€1mL*10mM (DMSO)203,00€10mg281,00€25mg485,00€50mg708,00€100mg1.044,00€Fimepinostat
CAS:Fimepinostat (CUDC 907) is an orally bioavailable inhibitor of both PI3K class I and pan-HDAC enzymes, with potential antineoplastic activity.Fórmula:C23H24N8O4SPureza:98.27% - 99.87%Cor e Forma:SolidPeso molecular:508.55Ref: TM-T2078
2mg44,00€5mg66,00€1mL*10mM (DMSO)74,00€10mg92,00€25mg172,00€50mg295,00€100mg485,00€500mg1.035,00€Idelalisib
CAS:Idelalisib (GS-1101) is a small molecule inhibitor of the PI3K catalytic subunit p110δ (IC50: 2.5 nM).Fórmula:C22H18FN7OPureza:98% - 99.39%Cor e Forma:White SolidPeso molecular:415.42Ref: TM-T1894
5mg34,00€10mg48,00€1mL*10mM (DMSO)50,00€25mg71,00€50mg88,00€100mg103,00€200mg133,00€500mg213,00€Vps34-PIK-III
CAS:Vps34-PIK-III (VPS34-IN2), a selective inhibitor of VPS34 enzymatic activity, inhibits autophagy and results in the stabilization of autophagy substrates.Fórmula:C17H17N7Pureza:98.39% - 98.43%Cor e Forma:White SolidPeso molecular:319.36Euscaphic acid
CAS:Euscaphic acid has anti-diabetic and anti-inflammatory effects, blocking IKK/MAPKs and NF-κB activation by disrupting TRAF6/IRAK1/TAK1 clustering.Fórmula:C30H48O5Pureza:98.93%Cor e Forma:White SolidPeso molecular:488.7Arnicolide D
CAS:Arnicolide D is a sesquiterpene lactone.Fórmula:C19H24O5Pureza:96.66% - 99.93%Cor e Forma:White SolidPeso molecular:332.39Oroxin B
CAS:Oroxin B (Hypocretin-2) has antioxidant activity.Fórmula:C27H30O15Pureza:98.22% - 99.87%Cor e Forma:Yellow SolidPeso molecular:594.52PIK-294
CAS:PIK-294 is a excellently specific p110δ inhibitor(IC50=10 nM).Fórmula:C28H23N7O2Pureza:97.22% - >99.99%Cor e Forma:SolidPeso molecular:489.53PF-4989216
CAS:PF-4989216 is a potent and selective PI3K inhibitor with IC50 of 2 nM, 142 nM, 65 nM, 1 nM, and 110 nM for p110α, p110β, p110γ, p110δ, and VPS34, respectively.Fórmula:C18H13FN6OSPureza:99.85%Cor e Forma:SolidPeso molecular:380.4Ref: TM-T6938
2mg37,00€5mg62,00€1mL*10mM (DMSO)64,00€10mg96,00€25mg177,00€50mg311,00€100mg376,00€200mg535,00€Bimiralisib
CAS:Bimiralisib (PI3K-IN-2) is an orally bioavailable pan inhibitor of PI3K and inhibitor of the mTOR, with potential antineoplastic activity.Fórmula:C17H20F3N7O2Pureza:97.58% - 98.92%Cor e Forma:SolidPeso molecular:411.38Omipalisib
CAS:Omipalisib (GSK2126458) is a small-molecule pyridylsulfonamide inhibitor of phosphatidylinositol 3-kinase (PI3K) with potential antineoplastic activity.Fórmula:C25H17F2N5O3SPureza:98% - 99.8%Cor e Forma:Yellow SolidPeso molecular:505.51-Deoxynojirimycin
CAS:1-Deoxynojirimycin (Moranoline) is a potent α-glucosidase inhibitor, suppressing postprandial blood glucose, thereby possibly preventing diabetes mellitus.Fórmula:C6H13NO4Pureza:99.65% - 99.98%Cor e Forma:SolidPeso molecular:163.17Ref: TM-T3675
2mg43,00€1mL*10mM (DMSO)57,00€5mg58,00€10mg74,00€25mg140,00€50mg248,00€100mg321,00€500mg773,00€Wortmannin
CAS:Wortmannin (SL-2052) is a PI3K inhibitor (IC50=3 nM) that is covalent and irreversible.Fórmula:C23H24O8Pureza:95.84% - 99.77%Cor e Forma:White SolidPeso molecular:428.43
