PI3K
Os inibidores de PI3K são compostos que bloqueiam a atividade das fosfoinositídeo 3-quinases (PI3Ks), uma família de enzimas envolvidas em uma ampla gama de processos celulares, incluindo crescimento, proliferação, sobrevivência e metabolismo. A via PI3K/Akt/mTOR é frequentemente desregulada no câncer, tornando o PI3K um alvo-chave para a terapia do câncer. Os inibidores de PI3K são ferramentas essenciais para estudar a transdução de sinal, a biologia do câncer e o desenvolvimento de terapias direcionadas. Na CymitQuimica, oferecemos uma variedade de inibidores de PI3K para apoiar sua pesquisa em sinalização celular, oncologia e desenvolvimento terapêutico.
Foram encontrados 237 produtos para "PI3K".
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PI3Kα-IN-25
PI3Kα-IN-25 (Compound Djh1) is a selective inhibitor of PI3Kα, suitable for research in triple-negative breast cancer.Fórmula:C21H19ClN4O4Cor e Forma:SolidPeso molecular:426.853740 Y-P acetate
740 Y-P acetate (740YPDGFR acetate) is a potent and cell-permeable PI3K activator.740 Y-P acetate tends to bind to GST fusion proteins containing the N- and C-Fórmula:C143H226N43O41PS3Pureza:99.92%Cor e Forma:SoildPeso molecular:3330.79IHMT-PI3Kδ-372 S-isomer
CAS:IHMT-PI3Kδ-372 S-isomer is a potent and selective PI3Kδ inhibitor with an IC50 of 14 nM.Fórmula:C26H23F2N7O2Pureza:99.97%Cor e Forma:White SolidPeso molecular:503.5Ref: TM-T60196
1mg109,00€2mg163,00€5mg241,00€1mL*10mM (DMSO)294,00€10mg354,00€25mg532,00€50mg745,00€100mg1.018,00€PROTAC PI3K/110β degrader-1
CAS:PROTACPI3K/110β degrader-1 (J-9) acts as a PROTAC degrader specifically targeting PI3K/110β.Fórmula:C51H65N9O9SCor e Forma:SolidPeso molecular:980.18D-106669
CAS:D-106669 (comppun 150) is a potent inhibitor of PI3Kα, with an IC50 value of 0.129 μM, and plays a significant role in cancer research.Fórmula:C17H18N6OCor e Forma:SolidPeso molecular:322.36GSK251
CAS:GSK251 is a novel, orally bioavailable inhibitor of PI3Kδ, exhibiting high potency and selectivity, with a unique binding mode.Fórmula:C29H37FN6O4SPureza:99.8%Cor e Forma:White SolidPeso molecular:584.71PI3Kδ-IN-12
PI3Kδ-IN-12 (compound 13), a PI3Kδ inhibitor with a pIC50 of 5.8, exhibits differential binding affinities with pKi values of 8.0 for PI3Kδ, 6.5 for PI3Kγ, 6.4Fórmula:C20H15Cl2N5O3Pureza:98%Cor e Forma:SolidPeso molecular:444.27PI3K-IN-47
PI3K-IN-47 (Compound 27) is a potent bivalent inhibitor targeting the phosphoinositide 3-kinases (PI3K) family, exhibiting inhibitory concentration (IC50)Fórmula:C50H46F4N8O8S2Pureza:98%Cor e Forma:SolidPeso molecular:1027.07PF-06843195
CAS:PF-06843195 is a potent and selective PI3Kα inhibitor prevents it catalyzing the conversion of PIP2 to PIP3, inhibit the activation of AKT, anti-tumor .Fórmula:C20H25F3N8O4Pureza:98.01%Cor e Forma:White SolidPeso molecular:498.46PIP4K-IN-a131
CAS:PIP4K-IN-a131 is a PIP4K inhibitor with antiproliferative effects.Fórmula:C20H13N3Cor e Forma:Yellow SolidPeso molecular:295.35TGX-221
CAS:TGX-221, an effective, specific, and cell membrane permeable inhibitor of the PI3K p110β catalytic subunit, is utilized for cancer treatment.Fórmula:C21H24N4O2Pureza:99.60% - >99.99%Cor e Forma:White SolidPeso molecular:364.44Periplocin
CAS:Periplocin fights lung cancer, induces apoptosis, stunts growth via beta-catenin/Tcf, and treats rheumatoid arthritis/traditional ailments.Fórmula:C36H56O13Pureza:99.66% - 99.96%Cor e Forma:White SolidPeso molecular:696.82Ref: TM-T5S1982
1mg34,00€5mg73,00€10mg101,00€1mL*10mM (DMSO)102,00€25mg167,00€50mg240,00€100mg355,00€500mg845,00€GSK1059615
CAS:GSK1059615 has been used in trials studying the treatment of Lymphoma, Solid Tumours, Endometrial Cancer, Solid Tumor Cancer, and Metastatic Breast Cancer.Fórmula:C18H11N3O2SPureza:99.3% - ≥95%Cor e Forma:White SolidPeso molecular:333.36PIK-75 hydrochloride
CAS:PIK-75 hydrochloride (PIK-75 HCl) is a p110α inhibitor, isoform-specific mutants at Ser773, and potently inhibits DNA-PK with IC50 of 2 nM in cell-free assay.Fórmula:C16H14BrN5O4S·HClPureza:97.82%Cor e Forma:SolidPeso molecular:488.74Glaucocalyxin A
CAS:Glaucocalyxin A improves drug delivery, activates apoptosis, inhibits cell growth, with potential as an antiplatelet agent.Fórmula:C20H28O4Pureza:99.55% - 99.80%Cor e Forma:White SolidPeso molecular:332.43PIK-108
CAS:PIK-108 is an allosteric inhibitor of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunits β and δ (PI3Kβ/δ).Fórmula:C22H24N2O3Pureza:98.92%Cor e Forma:SolidPeso molecular:364.44Ref: TM-T28416
1mg38,00€2mg54,00€5mg92,00€1mL*10mM (DMSO)100,00€10mg147,00€25mg241,00€50mg349,00€100mg482,00€200mg662,00€Esculetin
CAS:Esculetin: a coumarin from plants with anti-edema, anti-inflammatory, anti-tumor properties; inhibits LOs.Fórmula:C9H6O4Pureza:98.03% - 99.76%Cor e Forma:Yellow SolidPeso molecular:178.14Brevianamide F
CAS:Brevianamide F (Cyclo(L-Pro-L-Trp)), also known as cyclo-(L-Trp-L-Pro), belongs to a class of naturally occurring 2,5-diketopiperazines.Fórmula:C16H17N3O2Pureza:97.30% - 98.82%Cor e Forma:SolidPeso molecular:283.33NIBR-17
CAS:NIBR-17 is a pan class I PI3K inhibitor. NIBR-17 inhibits PI3KKα, PI3KKβ, PI3KKγ, and PI3KKδ with IC50 of 1 nM, 9.2 nM, 9 nM, and 20 nM respectively.Fórmula:C18H20N8O2Pureza:97.79%Cor e Forma:White SolidPeso molecular:380.4Ref: TM-T22377
10mgA consultar25mgA consultar50mgA consultar100mgA consultar1mg34,00€1mL*10mM (DMSO)89,00€5mg92,00€YS-49
CAS:YS-49 is an activator of PI3K/Akt (a downstream target of RhoA).Fórmula:C20H20BrNO2Pureza:99.65%Cor e Forma:SolidPeso molecular:386.28Ref: TM-T13376
1mg46,00€2mg58,00€1mL*10mM (DMSO)92,00€5mg95,00€10mg137,00€25mg260,00€50mg386,00€100mg560,00€500mg1.153,00€
