PI3K
Os inibidores de PI3K são compostos que bloqueiam a atividade das fosfoinositídeo 3-quinases (PI3Ks), uma família de enzimas envolvidas em uma ampla gama de processos celulares, incluindo crescimento, proliferação, sobrevivência e metabolismo. A via PI3K/Akt/mTOR é frequentemente desregulada no câncer, tornando o PI3K um alvo-chave para a terapia do câncer. Os inibidores de PI3K são ferramentas essenciais para estudar a transdução de sinal, a biologia do câncer e o desenvolvimento de terapias direcionadas. Na CymitQuimica, oferecemos uma variedade de inibidores de PI3K para apoiar sua pesquisa em sinalização celular, oncologia e desenvolvimento terapêutico.
Foram encontrados 231 produtos de "PI3K"
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(3S)-GSK-F1
CAS:(3S)-GSK-F1 is a selective small molecule inhibitor of Type III Phosphatidylinositol 4‑Kinase Alpha (PI4KIIIα), pIC50=8.3.Fórmula:C27H18F5N5O4SPureza:99.04%Cor e Forma:SoildPeso molecular:603.52Ref: TM-T67837
1mg70,00€5mg133,00€10mg210,00€25mg371,00€50mg532,00€100mg837,00€1mL*10mM (DMSO)182,00€IHMT-PI3Kδ-372 S-isomer
CAS:<p>IHMT-PI3Kδ-372 S-isomer is a potent and selective PI3Kδ inhibitor with an IC50 of 14 nM.</p>Fórmula:C26H23F2N7O2Pureza:99.97%Cor e Forma:SoildPeso molecular:503.5PI3Kα-IN-25
PI3Kα-IN-25 (Compound Djh1) is a selective inhibitor of PI3Kα, suitable for research in triple-negative breast cancer.Fórmula:C21H19ClN4O4Cor e Forma:SolidPeso molecular:426.853PI3K-IN-57
PI3K-IN-57 (Compound 4a) is a PI3K inhibitor that shows strong inhibitory effects on the proliferation of HeLa tumor ectopic xenografts in vivo. It holds promise for anticancer agent research.Cor e Forma:Odour SolidPI3Kδ-IN-14
<p>PI3Kδ-IN-14 (Compound (S)-29), a selective PI3Kδ inhibitor with an IC50 of 0.8 nM and a Kd of 84.8 nM, targets the ATP-binding site within the kinase domain of</p>Fórmula:C26H20ClFN8OPureza:98%Cor e Forma:SolidPeso molecular:514.94PF-06843195
CAS:PF-06843195 is a potent and selective PI3Kα inhibitor prevents it catalyzing the conversion of PIP2 to PIP3, inhibit the activation of AKT, anti-tumor .Fórmula:C20H25F3N8O4Pureza:98.01%Cor e Forma:SolidPeso molecular:498.46Periplocin
CAS:Periplocin fights lung cancer, induces apoptosis, stunts growth via beta-catenin/Tcf, and treats rheumatoid arthritis/traditional ailments.Fórmula:C36H56O13Pureza:99.66% - 99.74%Cor e Forma:SolidPeso molecular:696.82Ref: TM-T5S1982
1mg35,00€5mg77,00€10mg106,00€25mg170,00€50mg253,00€100mg375,00€500mg892,00€1mL*10mM (DMSO)107,00€Flupentixol dihydrochloride
CAS:Flupentixol dihydrochloride is used in therapy of schizophrenia as well as in anxiolytic and depressive disorders.Fórmula:C23H27Cl2F3N2OSPureza:98.76% - >99.99%Cor e Forma:White Or Off-White SolidPeso molecular:507.43PIK-108
CAS:PIK-108 is an allosteric inhibitor of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunits β and δ (PI3Kβ/δ).Fórmula:C22H24N2O3Pureza:98.92%Cor e Forma:SolidPeso molecular:364.44Ref: TM-T28416
1mg40,00€2mg57,00€5mg97,00€10mg156,00€25mg255,00€50mg368,00€100mg510,00€200mg700,00€1mL*10mM (DMSO)105,00€Apitolisib
CAS:Apitolisib (RG 7422) is a PI3K inhibitor, used in cancer trials, targeting PI3Kα, β, δ, γ (IC50= 5, 27, 7, 14 nM).Fórmula:C23H30N8O3SPureza:98.28% - 99.64%Cor e Forma:SolidPeso molecular:498.6Brevianamide F
CAS:<p>Brevianamide F (Cyclo(L-Pro-L-Trp)), also known as cyclo-(L-Trp-L-Pro), belongs to a class of naturally occurring 2,5-diketopiperazines.</p>Fórmula:C16H17N3O2Pureza:97.30% - 98.82%Cor e Forma:SolidPeso molecular:283.33Alpelisib
CAS:Alpelisib (BYL-719) is a PI3Kα inhibitor (IC50=5 nM) with selective, potent, and oral activity.Fórmula:C19H22F3N5O2SPureza:98% - 99.73%Cor e Forma:SolidPeso molecular:441.47Ref: TM-T1921
2mg39,00€5mg55,00€10mg72,00€25mg87,00€50mg96,00€100mg154,00€500mg447,00€1mL*10mM (DMSO)60,00€PIK-75 hydrochloride
CAS:PIK-75 hydrochloride (PIK-75 HCl) is a p110α inhibitor, isoform-specific mutants at Ser773, and potently inhibits DNA-PK with IC50 of 2 nM in cell-free assay.Fórmula:C16H14BrN5O4S·HClPureza:97.82%Cor e Forma:SolidPeso molecular:488.74Glaucocalyxin A
CAS:<p>Glaucocalyxin A improves drug delivery, activates apoptosis, inhibits cell growth, with potential as an antiplatelet agent.</p>Fórmula:C20H28O4Pureza:99.55% - 99.80%Cor e Forma:SolidPeso molecular:332.43YS-49
CAS:YS-49 is an activator of PI3K/Akt (a downstream target of RhoA).Fórmula:C20H20BrNO2Pureza:99.65%Cor e Forma:SolidPeso molecular:386.28Ref: TM-T13376
1mg48,00€2mg62,00€5mg90,00€10mg144,00€25mg274,00€50mg408,00€100mg590,00€500mg1.216,00€1mL*10mM (DMSO)97,00€NIBR-17
CAS:NIBR-17 is a pan class I PI3K inhibitor. NIBR-17 inhibits PI3KKα, PI3KKβ, PI3KKγ, and PI3KKδ with IC50 of 1 nM, 9.2 nM, 9 nM, and 20 nM respectively.Fórmula:C18H20N8O2Pureza:97.79%Cor e Forma:SolidPeso molecular:380.4Rigosertib
CAS:<p>Rigosertib, a multi-kinase inhibitor targeting PLK1 (IC50: 9 nM), induces apoptosis and G2/M arrest by disrupting PI3K/Akt.</p>Fórmula:C21H25NO8SPureza:99.53%Cor e Forma:SolidPeso molecular:451.49Erucic acid
CAS:Increased levels of erucic acid (22:1n9) have been found in the red blood cell membranes of autistic subjects with developmental regression (PMID: 16581239 ).Fórmula:C22H42O2Pureza:99.64%Cor e Forma:Needles From Alcohol Liquid OthersolidPeso molecular:338.571-Deoxynojirimycin hydrochloride
CAS:1-Deoxynojirimycin hydrochloride (Moranoline) is a potent and selective inhibitor of alpha-glucosidase, most commonly found in mulberry leaves.Fórmula:C6H14ClNO4Pureza:99.88%Cor e Forma:SolidPeso molecular:199.63AZD-7648
CAS:AZD-7648 is an inhibitor of DNA-dependent protein kinase (DNA-PK) with the IC50 of 0.63 nM in an enzyme assay,has anti-tumor activity.Fórmula:C18H20N8O2Pureza:99.03% - 99.85%Cor e Forma:SolidPeso molecular:380.4Ref: TM-T7122
1mg40,00€5mg88,00€10mg119,00€25mg187,00€50mg311,00€100mg472,00€200mg687,00€1mL*10mM (DMSO)87,00€
