PI3K
Os inibidores de PI3K são compostos que bloqueiam a atividade das fosfoinositídeo 3-quinases (PI3Ks), uma família de enzimas envolvidas em uma ampla gama de processos celulares, incluindo crescimento, proliferação, sobrevivência e metabolismo. A via PI3K/Akt/mTOR é frequentemente desregulada no câncer, tornando o PI3K um alvo-chave para a terapia do câncer. Os inibidores de PI3K são ferramentas essenciais para estudar a transdução de sinal, a biologia do câncer e o desenvolvimento de terapias direcionadas. Na CymitQuimica, oferecemos uma variedade de inibidores de PI3K para apoiar sua pesquisa em sinalização celular, oncologia e desenvolvimento terapêutico.
Foram encontrados 231 produtos de "PI3K"
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Orobol
CAS:Orobol (3’,4’,5,7-tetrahydroxy-isoflavon) is an inhibitor of tyrosine-specific protein kinase and phosphatidylinositol turnover.Fórmula:C15H10O6Pureza:98% - 98%Cor e Forma:SolidPeso molecular:286.24Musk ketone
CAS:Musk ketone may suppress cancer cell growth, induce apoptosis, and boost glutathione S-transferase, potentially aiding cancer protection.Fórmula:C14H18N2O5Pureza:99.85%Cor e Forma:Yellow Crystals Physical Description Light Yellow Crystalline Solid Insoluble In Water (Ntp 1992)Peso molecular:294.30AS-041164
CAS:AS-041164: Oral PI3Kγ inhibitor, IC50 70 nM; weaker on PI3Kα/β/δ; anti-inflammatory.Fórmula:C11H7NO4SPureza:99.45%Cor e Forma:SolidPeso molecular:249.24PQR530
CAS:PQR530, a potent dual PI3K/mTORC1/2 inhibitor, blocks PKB and pS6 phosphorylation (IC50: 0.07 μM) and has antitumor properties.Fórmula:C18H23F2N7O2Pureza:99.5%Cor e Forma:SolidPeso molecular:407.42YM-201636
CAS:YM201636 (IC50=33 nM), a specific PIKfyve inhibitor, is less effective to p110α and insensitive to Fabl, which is yeast orthologue.Fórmula:C25H21N7O3Pureza:93.28% - 98.3%Cor e Forma:SolidPeso molecular:467.48Ref: TM-T6110
1mg46,00€2mg60,00€5mg90,00€10mg170,00€25mg340,00€50mg532,00€100mg760,00€500mg1.558,00€1mL*10mM (DMSO)92,00€Polygalasaponin F
CAS:Polygalasaponin F reduces neuroinflammation, blocks TNF-α/NO, and protects neurons by modulating NF-kB and NMDAR pathways.Fórmula:C53H86O23Pureza:98% - 99.83%Cor e Forma:SolidPeso molecular:1091.24Isorhamnetin
CAS:Isorhamnetin (3-methylquercetin) is the methylated metabolite of quercetin.
Fórmula:C16H12O7Pureza:99.20% - >99.99%Cor e Forma:SolidPeso molecular:316.26Pilaralisib
CAS:Pilaralisib (XL-147) is an orally available small molecule that selectively inhibits the activity of phosphoinositide-3 kinase (PI3K).
Fórmula:C25H25ClN6O4SPureza:98.51% - 99.61%Cor e Forma:SolidPeso molecular:541.02SF2523
CAS:SF2523 is a highly selective and potent inhibitor.Fórmula:C19H17NO5SPureza:99.1% - 99.51%Cor e Forma:SolidPeso molecular:371.41Ref: TM-T3986
1mg37,00€5mg79,00€10mg119,00€25mg274,00€50mg432,00€100mg638,00€500mg1.359,00€1mL*10mM (DMSO)87,00€LY-294002 hydrochloride
CAS:LY-294002 HCl (NSC 697286) is a stable PI3K inhibitor (IC50: 0.5-0.97 µM) and prevents autophagosome formation.Fórmula:C19H17NO3·HClPureza:99.95% - 99.98%Cor e Forma:SolidPeso molecular:343.81DS-7423
CAS:DS-7423: a dual PI3K/mTOR inhibitor; IC50s—PI3Kα: 15.6 nM, mTOR: 34.9 nM, PI3Kβ: 1,143 nM, PI3Kγ: 249 nM, PI3Kδ: 262 nM.
Fórmula:C22H27F3N10O2Pureza:99.98%Cor e Forma:SolidPeso molecular:520.51Gedatolisib
CAS:Gedatolisib (PF-05212384) is a highly effective dual inhibitor targeting the PI3Kα/γ (IC50: 0.4/5.4 nM)and mTOR (IC50: 1.6 nM) in the PI3K/mTOR signalingFórmula:C32H41N9O4Pureza:98% - 99.36%Cor e Forma:SolidPeso molecular:615.73KU-0060648
CAS:KU-0060648 is a dual inhibitor of DNA-PK and PI3Kα, PI3Kβ, PI3Kδ with IC50 of 8.6 nM and 4 nM, 0.5 nM, 0.1 nM respectively, less inhibition of PI3Kγ.Fórmula:C33H34N4O4SPureza:98.75%Cor e Forma:SolidPeso molecular:582.71Desmethyl-VS-5584
CAS:Desmethyl-VS-5584 is a dimethyl analog of VS-5584, which is a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancer.Fórmula:C16H20N8OPureza:>99.99%Cor e Forma:SolidPeso molecular:340.38Duvelisib
CAS:Duvelisib (INK1197, IPI-145) is a selective inhibitor of phosphatidylinositol 3-kinase (PI3K) and p100δ.Cost-effective and quality-assured.Fórmula:C22H17ClN6OPureza:98.87% - 99.74%Cor e Forma:SolidPeso molecular:416.86GNE-317
CAS:GNE-317, a PI3K/mTOR inhibitor, can pass through the blood-brain barrier (BBB).Fórmula:C19H22N6O3SPureza:98.42% - 99.54%Cor e Forma:SolidPeso molecular:414.48Ref: TM-T6845
2mg46,00€5mg66,00€10mg97,00€25mg202,00€50mg279,00€100mg358,00€200mg525,00€1mL*10mM (DMSO)73,00€CZC24832
CAS:CZC24832 is a selective inhibitor of PI 3-kinase γ.Fórmula:C15H17FN6O2SPureza:99.08% - 99.12%Cor e Forma:SolidPeso molecular:364.4Ref: TM-T1949
1mg50,00€2mg66,00€5mg97,00€10mg145,00€25mg240,00€50mg356,00€100mg525,00€1mL*10mM (DMSO)110,00€Deoxyelephantopin
CAS:Deoxyelephantopin: anti-inflammatory, hepatoprotective, wound healing, antitumor; blocks NF-κB, MAPK, PI3K/Akt, β-catenin pathways.Fórmula:C19H20O6Pureza:99.6% - 99.71%Cor e Forma:SolidPeso molecular:344.36Acalisib
CAS:Acalisib (CAL-120) (GS-9820) is a potent and selective inhibitor of PI3Kδ.Fórmula:C21H16FN7OPureza:98.99% - ≥95%Cor e Forma:SolidPeso molecular:401.4Parsaclisib hydrochloride
CAS:Parsaclisib hydrochloride (INCB050465 HCl) is a selectve PI3Kδ inhibitor with antitumor activity. Parsaclisib demonstrates potent activity.Fórmula:C20H23Cl2FN6O2Pureza:98%Cor e Forma:SolidPeso molecular:469.34
