mTOR
Os inibidores de mTOR são compostos que inibem a atividade do Alvo da Rapamicina em Mamíferos (mTOR), um regulador central do crescimento celular, proliferação, metabolismo e sobrevivência. A via de sinalização mTOR é frequentemente alterada em casos de câncer e outras doenças, tornando o mTOR um alvo crítico para intervenções terapêuticas. Inibidores de mTOR são amplamente utilizados em pesquisas relacionadas ao câncer, envelhecimento e distúrbios metabólicos. Na CymitQuimica, oferecemos uma variedade de inibidores de mTOR para apoiar sua pesquisa em transdução de sinais, oncologia e desenvolvimento terapêutico.
Foram encontrados 144 produtos de "mTOR"
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Salidroside
CAS:<p>Salidroside is a bioactive phenolic glycoside compound isolated from Rhodiola rosea and is a prolyl endopeptidase inhibitor.Cost-effective and quality-assured.</p>Fórmula:C14H20O7Pureza:97.81%Cor e Forma:Red-Brown Fine PowderPeso molecular:300.3Corynoxine
CAS:<p>Corynoxine is a tetracyclic oxindole alkaloid isolated from Uncaria macrophylla.</p>Fórmula:C22H28N2O4Pureza:96.83% - 99.93%Cor e Forma:SolidPeso molecular:384.47Mito-LND
CAS:<p>Mito-LND (Mito-Loidamine) is an orally active and mitochondria-targeted inhibitor of oxidative phosphorylation.</p>Fórmula:C43H45BrCl2N3OPPureza:97.25% - 98.34%Cor e Forma:SolidPeso molecular:801.62GNE-317
CAS:<p>GNE-317, a PI3K/mTOR inhibitor, can pass through the blood-brain barrier (BBB).</p>Fórmula:C19H22N6O3SPureza:98.42% - 99.54%Cor e Forma:SolidPeso molecular:414.48Everolimus
CAS:<p>Everolimus (SDZ-RAD) is a potent mTOR inhibitor that binds to FKBP-12. It is used alone or in combination with calcineurin inhibitors.</p>Fórmula:C53H83NO14Pureza:97.76% - 99.78%Cor e Forma:Off-White To Light Yellow PowdPeso molecular:958.2225(R,S)-Ruscogenin
CAS:<p>25(R,S)-Ruscogenin is able to regulate the PI3K/Akt/mTOR signalling pathway, and hinder the metastasis of hepatocellular carcinoma.</p>Fórmula:C27H42O4Pureza:99.32% - 99.89%Cor e Forma:SolidPeso molecular:430.62AZD-8055
CAS:<p>AZD8055 is an ATP-competitive mTOR inhibitor (IC50: 0.8 nM in MDA-MB-468 cells). It is ~1,000-fold selective for mTOR over all PI3K isoforms.</p>Fórmula:C25H31N5O4Pureza:98% - 99.69%Cor e Forma:SolidPeso molecular:465.54NV-5138 hydrochloride
<p>NV-5138 hydrochloride: a leucine analog, oral brain mTORC1 activator via Sestrin2, for antidepressant research.</p>Fórmula:C7H14ClF2NO2Cor e Forma:SolidPeso molecular:217.64Palomid 529
CAS:<p>Palomid 529 (SG 00529) has been used in trials studying the treatment of Age-Related Macular Degeneration.</p>Fórmula:C24H22O6Pureza:98.40% - 98.59%Cor e Forma:SolidPeso molecular:406.43KU-0063794
CAS:<p>KU-0063794 is a potent and highly specific dual-mTOR inhibitor of mTORC1 and mTORC2.</p>Fórmula:C25H31N5O4Pureza:98.21% - >99.99%Cor e Forma:SolidPeso molecular:465.54WYE-687 dihydrochloride
CAS:<p>WYE-687 dihydrochloride is an mTOR inhibitor with IC50 of 7 nM, also targeting PI3Kα (81 nM) and PI3Kγ (3.11 μM).</p>Fórmula:C28H34Cl2N8O3Cor e Forma:SolidPeso molecular:601.53SC99
CAS:<p>SC99 inhibits JAK2-STAT3, reducing STAT3 genes, platelet activity, and has anti-myeloma, anti-thrombotic effects.</p>Fórmula:C15H8Cl2FN3OPureza:99.56%Cor e Forma:SolidPeso molecular:336.15L-Leucine
CAS:<p>L-Leucine is an essential amino acid vital for protein synthesis, metabolism, muscle and bone repair, blood sugar control, and wound healing.</p>Fórmula:C6H13NO2Pureza:99.83%Cor e Forma:White Solid CrystallinePeso molecular:131.17Vistusertib
CAS:<p>Vistusertib (AZD2014) is an orally bioavailable inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity.</p>Fórmula:C25H30N6O3Pureza:97.08% - 99.06%Cor e Forma:SolidPeso molecular:462.54Onatasertib
CAS:<p>Onatasertib (CC223) is an orally available mTOR inhibitor with potential antitumor activity.</p>Fórmula:C21H27N5O3Pureza:99.14% - 99.97%Cor e Forma:SolidPeso molecular:397.47Voxtalisib
CAS:<p>Voxtalisib (XL765) (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.</p>Fórmula:C13H14N6OPureza:98.21% - 99.69%Cor e Forma:SolidPeso molecular:270.29PP121
CAS:<p>PP-121 inhibits PDGFR, Hck, mTOR, VEGFR2, Src, Abl, and DNA-PK with IC50 values ranging from 2 to 60 nM.</p>Fórmula:C17H17N7Pureza:98.45% - 99.67%Cor e Forma:SolidPeso molecular:319.36Polyphyllin I
CAS:<p>Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax,</p>Fórmula:C44H70O16Pureza:98% - 99.5%Cor e Forma:SolidPeso molecular:855.02Torin 1
CAS:<p>Torin 1 is an effective inhibitor of mTORC1/2 with (IC50: 2 nM/10 nM); has 1000-fold selectivity for mTOR than PI3K.</p>Fórmula:C35H28F3N5O2Pureza:98.3% - 99.33%Cor e Forma:SolidPeso molecular:607.62G5-7
CAS:<p>G5-7 is an oral JAK2 inhibitor targeting EGFR/STAT3 phosphorylation with potential for glioma research.</p>Fórmula:C22H19F2NO3Pureza:97.3%Cor e Forma:SolidPeso molecular:383.39Apitolisib
CAS:<p>Apitolisib (RG 7422) is a PI3K inhibitor, used in cancer trials, targeting PI3Kα, β, δ, γ (IC50= 5, 27, 7, 14 nM).</p>Fórmula:C23H30N8O3SPureza:98.28% - 99.64%Cor e Forma:SolidPeso molecular:498.6Daphnetin
CAS:<p>Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM),</p>Fórmula:C9H6O4Pureza:97.47% - 99.8%Cor e Forma:SolidPeso molecular:178.14GSK1059615
CAS:<p>GSK1059615 has been used in trials studying the treatment of Lymphoma, Solid Tumours, Endometrial Cancer, Solid Tumor Cancer, and Metastatic Breast Cancer.</p>Fórmula:C18H11N3O2SPureza:99.3% - ≥95%Cor e Forma:SolidPeso molecular:333.36Sapanisertib
CAS:<p>Sapanisertib (INK 128) is an oral raptor-mTOR and rictor-mTOR inhibitor with potential cancer-fighting properties.</p>Fórmula:C15H15N7OPureza:99.19% - >99.99%Cor e Forma:SolidPeso molecular:309.33Hederacolchiside A1
CAS:<p>Hederacolchiside A1 exhibits anti-leishmanial and anticancer activities by disrupting cell membranes and inducing apoptosis via the PI3K/Akt/mTOR pathway.</p>Fórmula:C47H76O16Pureza:98.76% - 99.92%Cor e Forma:SolidPeso molecular:897.1Arnicolide D
CAS:<p>Arnicolide D is a sesquiterpene lactone.</p>Fórmula:C19H24O5Pureza:96.66%Cor e Forma:SolidPeso molecular:332.39Torkinib
CAS:<p>Torkinib (PP 242) (PP 242) is a selective and ATP-competitive mTOR inhibitor (IC50: 8 nM). It also inhibits mTORC1/2 (IC50s: 30/58 nM).</p>Fórmula:C16H16N6OPureza:99.11%Cor e Forma:SolidPeso molecular:308.34Temsirolimus
CAS:<p>Temsirolimus (CCI-779) is a specific mTOR inhibitor ( IC50: 1.76 μM), used in the treatment of advanced renal cell cancer.</p>Fórmula:C56H87NO16Pureza:97.76% - >99.99%Cor e Forma:White Crystalline PowderPeso molecular:1030.29Rotundic acid
CAS:<p>Rotundic acid fights various cancers: HepG2, A375, NCI-H446, MCF-7, and HT-29.</p>Fórmula:C30H48O5Pureza:96.91% - 99.97%Cor e Forma:SolidPeso molecular:488.7TMBIM6 antagonist-1
CAS:<p>TMBIM6 antagonist-1 (BAX-inhibitor-1) is a bax inhibitor</p>Fórmula:C15H12N2O3Pureza:99.26%Cor e Forma:SolidPeso molecular:268.27Zotarolimus
CAS:<p>Zotarolimus (ABT-578), an analogue of rapamycin, inhibits FKBP-12 (IC50= 2.8 nM).</p>Fórmula:C52H79N5O12Pureza:95% - 98.01%Cor e Forma:SolidPeso molecular:966.21(+)-Usnic acid
CAS:<p>(+)-Usnic acid (D-Usnic Acid) is a naturally occurring dibenzofuran derivative found in several lichen species.</p>Fórmula:C18H16O7Pureza:98.22%Cor e Forma:SolidPeso molecular:344.32CZ415
CAS:<p>CZ415 is a potent and highly selective mTOR inhibitor.</p>Fórmula:C22H29N5O4SPureza:97.54% - 98.36%Cor e Forma:SolidPeso molecular:459.56VS-5584
CAS:<p>VS-5584 (SB2343) is a pan-PI3K/mTOR kinase inhibitor.</p>Fórmula:C17H22N8OPureza:97.82% - 99.54%Cor e Forma:SolidPeso molecular:354.41Dihydromyricetin
CAS:<p>Dihydromyricetin, a flavonoid from Ampelopsis, is an antioxidant that blocks dihydropyrimidinase (IC50: 48 μM) and activates autophagy via mTOR inhibition.</p>Fórmula:C15H12O8Pureza:96.68% - 98.229%Cor e Forma:SolidPeso molecular:320.25MHY1485
CAS:<p>MHY1485 is an mTOR activator that is cell-permeable. MHY1485 inhibits autophagosome and lysosome fusion, thereby inhibiting autophagy. Cost-effective and quality-assured.</p>Fórmula:C17H21N7O4Pureza:97.74% - >99.99%Cor e Forma:SolidPeso molecular:387.39ETP-45658
CAS:<p>ETP-45658 (ETP45658) is a PI 3-kinase inhibitor (IC50 values are 22, 30, 129 and 710 nM for PI 3-Kα, PI 3-Kδ, PI 3-Kβ and PI 3-Kγ respectively).</p>Fórmula:C16H17N5O2Pureza:99.14%Cor e Forma:SolidPeso molecular:311.34Dactolisib
CAS:<p>Dactolisib (BEZ235) is an orally bioavailable inhibitor of PI3K and mTOR (IC50s: 4 nM/5 nM/7 nM/75 nM, and 20.7 nM for p110α/p110γ/p110δ/p110β and mTOR).</p>Fórmula:C30H23N5OPureza:97.64% - 99.85%Cor e Forma:SolidPeso molecular:469.54PQR620
CAS:<p>PQR620 is a novel potent and selective, brain penetrant inhibitor of mTORC1/2.</p>Fórmula:C21H25F2N7O2Pureza:97.61%Cor e Forma:SolidPeso molecular:445.47DMH-25
CAS:<p>DMH25 is a novel covalent and potent inhibitor of mTOR and shows in vivo antitumor activity against triple-negative breast cancer cells.</p>Fórmula:C15H8Br3NO3Pureza:99.26%Cor e Forma:SolidPeso molecular:489.94Ridaforolimus
CAS:<p>Ridaforolimus (AP23573) 是亲脂性大环内酯类抗生素雷帕霉素的小分子非前药类似物，具有潜在的抗肿瘤活性。它是一种有效和选择性的 mTOR 抑制剂，在 HT-1080 细胞中抑制 S6 磷酸化的 IC50值为 0.2 nM。</p>Fórmula:C53H84NO14PPureza:90.00% - 98.55%Cor e Forma:Off-White SolidPeso molecular:990.21DIM-C-pPhOH
CAS:<p>CDIM8 (DIM-C-pPhOH) opposes NR4A1, halts TGF-β breast cancer migration, induces ROS/ER stress, and mimics Nur77 RNAi in pancreatic cancer.</p>Fórmula:C23H18N2OPureza:98.61%Cor e Forma:SolidPeso molecular:338.4CC-115
CAS:<p>CC-115 is a inhibitor of mTOR/DNA-PK (IC50= 21/ 13 nM).</p>Fórmula:C16H16N8OPureza:86.79% - 99.01%Cor e Forma:SolidPeso molecular:336.35PQR530
CAS:<p>PQR530, a potent dual PI3K/mTORC1/2 inhibitor, blocks PKB and pS6 phosphorylation (IC50: 0.07 μM) and has antitumor properties.</p>Fórmula:C18H23F2N7O2Pureza:99.5%Cor e Forma:SolidPeso molecular:407.42PKCβ inhibitor 1
CAS:<p>PKCβ inhibitor 1 (KUN79359)(KUN79359) is a potent, selective and ATP-competitive inhibitor of PKC isozymes(IC50s of 21 and 5 nM for human PKCβ1 and PKCβ2,</p>Fórmula:C24H21N5O2Pureza:99.33%Cor e Forma:SolidPeso molecular:411.46KU-0060648
CAS:<p>KU-0060648 is a dual inhibitor of DNA-PK and PI3Kα, PI3Kβ, PI3Kδ with IC50 of 8.6 nM and 4 nM, 0.5 nM, 0.1 nM respectively, less inhibition of PI3Kγ.</p>Fórmula:C33H34N4O4SPureza:98.75%Cor e Forma:SolidPeso molecular:582.71Desmethyl-VS-5584
CAS:<p>Desmethyl-VS-5584 is a dimethyl analog of VS-5584, which is a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancer.</p>Fórmula:C16H20N8OPureza:>99.99%Cor e Forma:SolidPeso molecular:340.38MHY-1685
CAS:<p>MHY-1685 is a mammalian target of rapamycin (mTOR) inhibitor and a senescence inhibitor that can rejuvenate senile hCSCs by modulating autophagy.</p>Fórmula:C11H8N2O4Pureza:99.76%Cor e Forma:SolidPeso molecular:232.19DS-7423
CAS:<p>DS-7423: a dual PI3K/mTOR inhibitor; IC50s—PI3Kα: 15.6 nM, mTOR: 34.9 nM, PI3Kβ: 1,143 nM, PI3Kγ: 249 nM, PI3Kδ: 262 nM.</p>Fórmula:C22H27F3N10O2Pureza:99.98%Cor e Forma:SolidPeso molecular:520.51Gedatolisib
CAS:<p>Gedatolisib (PF-05212384) is a highly effective dual inhibitor targeting the PI3Kα/γ (IC50: 0.4/5.4 nM)and mTOR (IC50: 1.6 nM) in the PI3K/mTOR signaling</p>Fórmula:C32H41N9O4Pureza:98% - 99.36%Cor e Forma:SolidPeso molecular:615.73
