Bioquímicos e reagentes

<p>2002-H20 is a growth factor that binds to insulin-like growth factor (IGF) and has been shown to have anti-cancer properties. It inhibits cell proliferation by binding to the IGF receptor, thereby inducing apoptosis in the cells. 2002-H20 also induces cell death in cancer cells through a number of mechanisms, including inhibition of protein synthesis, inhibition of transcription factors such as nuclear factor kappa B (NFκB), and induction of reactive oxygen species. The peptide binding site of 2002-H20 is highly conserved among different species and exhibits high affinity for aromatic residues. A silico analysis was performed using molecular docking studies, which showed that 2002-H20 binds with high affinity to H1299 and NQTRP receptors. These receptors are found in human cancer cells such as those from breast, prostate, and lung cancers.<br>2002-H20 also has an inhibitory effect on Alzheimer's disease through its ability to bind with h1299 receptor sites</p>

<p>Inhibitor of Aurora B kinase</p>

<p>UR 1102 is a chemical compound used primarily in biomedical research, sourced from synthetic chemical processes. It operates as a selective modulator with the ability to interact with targeted biological pathways or receptors, depending on its specific design and formulation. The mode of action includes binding to particular sites, thereby influencing signaling cascades or biochemical processes within the system.</p>

<p>Andropanolide is a natural compound that has been shown to inhibit the function of P-glycoprotein (P-gp), which is an ATP-driven efflux pump. Andropanolide also inhibits the nuclear factor kappa B (NF-κB) pathway, which is involved in inflammation and apoptosis. It does this by binding to the DNA and inhibiting transcription factors, such as NF-κB, which are required for cell proliferation and survival. Andropanolide also has an anti-inflammatory effect due to its ability to inhibit prostaglandin synthesis. Andropanolide's synergistic effects on inflammation may be related to its inhibition of both cyclooxygenase and lipoxygenase pathways.</p>

<p>Mouse monoclonal Thyroxine antibody</p>

<p>Org-26576 is a potent and selective antagonist of the neurotrophic receptor TrkB. It binds to the extracellular domain of human TrkB, blocking the interaction with its ligands, including brain-derived neurotrophic factor and basic fibroblast growth factor. Org-26576 has shown antidepressant effects in animal models of depression, but this effect is dose-dependent. The compound also inhibits glutamate neurotransmission by competitively blocking N-methyl D-aspartate receptors. Org-26576 has been shown to be safe for use in animals and humans, with no serious adverse events reported so far. Pharmacokinetic studies show that Org-26576 crosses the blood brain barrier and is rapidly absorbed after oral administration.</p>

<p>5-TAMRA-alkyne is a fluorescent dye, which is a synthetic compound derived from tetramethylrhodamine and equipped with an alkyne functional group. It operates through a fluorescence emission mechanism, where it absorbs light at a specific wavelength and re-emits it at a longer wavelength, allowing for visualization under specific conditions.</p>

<p>BMS-202 is a chemical inhibitor that inhibits the activity of enzymes involved in cellular energy metabolism, such as PD-L1 and epidermal growth factor receptor. It also has antiangiogenic properties and potent antitumor activity. BMS-202 binds to these proteins with high affinity and specificity and prevents the activation of these proteins, leading to cell death. BMS-202 has been shown to have significant cytotoxicity in liver cells, which may be due to its inhibition of mitochondrial energy metabolism. The use of this drug has been studied in a pharmacokinetics study on rats. Histological analysis showed that BMS-202 caused tissue damage in the liver microenvironment with areas of necrosis.</p>

<p>Hepsulfam is an antitumor chemotherapy drug, which is a synthetic agent derived from the class of alkylating compounds. Its source lies in the chemical modification of nitrogen mustards, and it functions by forming interstrand cross-links in DNA, leading to the disruption of DNA replication and transcription. By preventing the proper division of cancerous cells, Hepsulfam exerts cytotoxic effects primarily during the S-phase of the cell cycle.</p>

<p>Please enquire for more information about Lamotrigine 3,3-dimer including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>ARI-3099 hydrochloride is a peptide that is used as a research tool for studying ion channels and protein interactions. This peptide has been shown to activate the receptor and ligand, which leads to pharmacological effects. ARI-3099 hydrochloride is an inhibitor of protein interactions. It binds to the receptor and ligand, preventing the formation of protein complexes. ARI-3099 hydrochloride is also an inhibitor of ion channels and can be used as a research tool for studying these channels in cell biology.</p>

<p>HSD1590 is a protein kinase inhibitor that has shown promise in the treatment of cancer. It works by inducing apoptosis, or programmed cell death, in cancer cells. HSD1590 is an analog of a Chinese medicinal compound and has been found to be effective against various human cancer cell lines. This inhibitor targets specific kinases involved in the growth and proliferation of tumor cells, making it a potential anticancer agent. Studies have shown that HSD1590 can inhibit the growth of tumors in animal models, making it a promising candidate for further development as a cancer therapy. Its unique mechanism of action and potent activity make it an exciting addition to the field of oncology research.</p>

<p>Nanatinostat is a histone deacetylase inhibitor that selectively inhibits HDAC1 and HDAC2. It has been shown to be effective in the treatment of bladder cancer cells and chronic viral infections, but not in clinical development for other cancers. Nanatinostat inhibits the aminopeptidase activity of HDACs and prevents the removal of lysine residues from histones. This causes an increase in acetylation of nucleosomal histones, which results in transcriptional activation of genes that are associated with tumor suppression and apoptosis. Nanatinostat also modifies the fatty acid composition of cellular membranes by inhibiting fatty acid synthase, thereby causing lipid peroxidation-induced apoptosis.</p>

<p>Losartan-d3 carboxylic acid is a peptide that inhibits the activity of angiotensin II receptor type 1 (AT1). Losartan-d3 carboxylic acid has been shown to inhibit the binding of angiotensin II to its AT1 receptor, which prevents the activation of G-proteins and subsequent signaling pathways. It has also been shown to be an activator of G-protein coupled receptors, such as bradykinin B2 receptor. This agent has been used as a research tool to study protein interactions and has been shown to bind with high affinity to some receptors, including AT1 and beta2 adrenergic receptor.</p>

<p>Fluoren-1-ol is a colorless liquid that is insoluble in water, but soluble in organic solvents. It is used as an intermediate in the production of other chemicals, such as acetonitrile and creosote. Fluoren-1-ol can be used to catalyze reactions in organic chemistry, such as the transfer of hydrogen from a donor solvent to an acceptor solvent. When it is heated with anthracene and other compounds, it isomerizes into fluoren-2-ol. This reaction was first discovered by A. W. Hofmann in 1869, who proposed a functional theory for how the reaction occurred.</p>

<p>TAI-1 is a natural product that exhibits apoptotic and anti-cancer activities. It is orally bioavailable, binds to the molecular target TAX protein and inhibits its function, leading to cell death. TAI-1 is a potent inhibitor of cancer growth in vivo animal models, which may be due to its ability to induce apoptotic cell death. TAI-1 has a high specificity for TAX protein and does not inhibit the function of other proteins.</p>

<p>(2S,3S)-2-((R)-4-(4-(2-Hydroxyethoxy)phenyl)-2,5-dioxo-imidazolidin-1-yl)-3-phenyl-N-(4-propionylthiazol-2-yl)butyramide is an aromatic ketone that has been shown to inhibit mitogen activated protein kinase (MAPK) and mitogen activated protein kinases (MAPKs). It is a potent inhibitor of the MAPK signaling pathway. This drug binds to the ATP binding site on MAPK and blocks the exchange of ATP for MgATP, which prevents the phosphorylation of tyrosine residues on MAPK. The carboxy group in this compound reacts with the primary amino group on MAPK to form a condensation product. This reaction inhibits protein synthesis by blocking the activation of ribosomes by tRNA.</p>

<p>Loreclezole hydrochloride is a chemical compound that has both an agonist and antagonist effect on the acid receptors. It is a gamma-aminobutyric acid (GABA) receptor agonist and an insecticidal chemical. It also has no known physiological effects in humans, but it is a benzene derivative with insecticidal properties. The insecticidal composition contains juvenile hormones that inhibit the growth of insects, specifically larvae of the order Lepidoptera. The isomer of Loreclezole hydrochloride is gamma-aminobutyric acid (GABA), which is found naturally in mammals and is essential for regulating neuronal excitability.</p>

<p>ARS-1620 is a small-molecule inhibitor, which is derived from advanced medicinal chemistry efforts focused on targeting specific oncogenic mutations. This compound is synthesized with the precise intent to address challenges posed by mutant KRAS G12C, a particularly intractable target given its prevalence in various cancers such as lung and colorectal cancers.</p>

<p>Cloethocarb is a kinase inhibitor that has shown promising results in the treatment of cancer. It works by inhibiting kinases, which are enzymes that play a crucial role in cancer cell growth and survival. In Chinese hamster ovary cells, cloethocarb has been shown to inhibit hyaluronan synthesis and induce apoptosis. Additionally, it has been found to be effective in inhibiting the growth of human tumor cells and preventing the spread of cancer. Cloethocarb also acts as an analog inhibitor of somatostatin, a hormone that regulates various physiological functions such as insulin secretion and gastric acid secretion. It can be detected in urine samples and may have potential therapeutic applications in the treatment of various cancers, including those resistant to traditional chemotherapy agents.</p>

<p>GSK1059865 is a clinical candidate for the treatment of Parkinson's disease. It is a selective and potent D2 receptor agonist that has been shown to be safe and well-tolerated in humans. GSK1059865 binds to the D2 dopamine receptor, which is located on neurons in the striatum, where it inhibits glutamate release. GSK1059865 also binds to other dopamine receptors, but with much lower affinity. This drug has been shown to increase locomotor activity in wild-type mice, as well as prevent locomotor deficits induced by the administration of 6-hydroxydopamine (6-OHDA).</p>

<p>5-Hydroxymethyl-N,N-dimethyltryptamine is an inhibitor of protein interactions. It can be used as a research tool to study the interaction between proteins and peptides, as well as ion channels. In addition, 5-Hydroxymethyl-N,N-dimethyltryptamine is a ligand for a number of receptors and an activator of some ion channels. This compound is also used in the synthesis of antibodies.</p>

<p>Please enquire for more information about 4-[[2-(Octyloxy)benzoyl]amino]benzoic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Docetaxel is a chemotherapy agent that is used to treat a number of cancers, including breast cancer, prostate cancer, lung cancer, and bladder cancer. Docetaxel-d9 is a solubilized form of docetaxel that has been validated for use in the treatment of cancer. It has been shown to inhibit the growth kinetics of carcinoma cell lines in vitro. The uptake of docetaxel-d9 was studied on bladder and plasma samples. In addition, it was found that docetaxel-d9 can be detected by a Western blot assay (WST-1). Docetaxel-d9 is also soluble in water and organic solvents such as acetone or ethanol.</p>

<p>Sphingosine-d7 is an isotopically labeled sphingolipid, which is a derivative of sphingosine where seven hydrogen atoms are replaced with deuterium. This modification is typically produced through chemical synthesis that incorporates deuterium, an isotope of hydrogen, to replace specific hydrogen atoms in the sphingosine molecule. The deuterium labeling does not alter the biochemical properties of sphingosine but allows for detailed tracking in biological systems using mass spectrometry.</p>

<p>MRX-2843 is a small molecule that inhibits the tyrosine kinase activity of Flt3. Flt3 is a receptor tyrosine kinase which plays an important role in T-cell leukemia, autoimmune diseases, and inflammation. MRX-2843 also has anti-infective properties and can be used to treat bacterial infections such as tuberculosis. In preclinical studies MRX-2843 was shown to inhibit the growth of cancer cells in cell culture and xenograft models. It also showed efficacy against wild-type mice with leukemia when administered orally or intravenously, but not when given topically.</p>

<p>MK-7622 is a quinazolinone that acts as a non-selective muscarinic acetylcholine receptor antagonist. It is also an allosteric modulator, which means that it binds to the allosteric site of the acetylcholine receptor and enhances its activity. This drug has been shown to have anticholinesterase properties in mice and rats, with efficacy at doses lower than those required for other established drugs. MK-7622 has been shown to improve cognitive functions in animal models of Alzheimer's disease, Parkinson's disease, and Huntington's disease. The mechanism of action is not fully understood but may be due to the inhibition of acetylcholinesterase activity by this drug.</p>

<p>PFM01 is a glycopeptide that inhibits the synthesis of laminin, a protein that is required for cell-cell and cell-matrix adhesion. PFM01 has been shown to inhibit radiation-induced damage in cells, as well as neurodegenerative diseases such as Alzheimer's disease. PFM01 binds to the enzyme transglutaminase 2 (TG2) and prevents it from crosslinking proteins to form amyloid fibrils. The compound also inhibits the growth of tumor cells through homologous recombination and acts as a radiosensitizer.</p>

<p>c6(6-Azido) glucer (CAS No. 2260670-21-9) is an ion channel activator that binds to the extracellular domain of a receptor and activates it. It is a research tool for pharmacology and protein interactions. c6(6-Azido) glucer is a high purity, inert compound used for antibody production and cell biology studies. It can be used as an inhibitor or activator in pharmacology, protein interactions, peptides, and cell biology experiments.</p>

<p>Please enquire for more information about Dehydro olmesartan-2-trityl medoxomil including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>1-(2-Benzyl-5-methylpyrazol-3-yl)-3-(3,4-difluorophenyl)urea is a synthetic chemical compound, which is typically synthesized through a series of organic reactions involving substituted pyrazoles and urea derivatives. This compound is primarily sourced from laboratory synthesis using controlled conditions to ensure purity and stability. Its mode of action involves the inhibition of specific protein kinases, which are essential in various signaling pathways within cells. By targeting these enzymes, this compound can disrupt cell proliferation and induce apoptosis, making it a valuable tool in cancer research.</p>

<p>HC-070 is a molecule that binds to dopamine receptors and blocks the receptor from binding with dopamine, thereby blocking its effects. HC-070 has been shown to be effective in treating cancer, mental disorders, and locomotor activity. HC-070 also inhibits cation channels in carcinoma cells by binding to the channel's selectivity filter. This prevents the flow of ions through the cell membrane and leads to cell death.</p>

<p>Coenzyme A is a molecule that plays an important role in the metabolism of many different types of organisms. It is also a potent activator of lipases and acyl-coenzyme A synthetases, which are enzymes involved in lipid metabolism. Coenzyme A is necessary for the production of acetylcholine, which is an important neurotransmitter. It has been shown to inhibit ion channels and ligands by binding with high affinity to the receptor site. This product can be used as a research tool or as a cell biology inhibitor.</p>

<p>TCS 3035 is a photoinitiator, which is derived from a well-characterized synthetic process involving specialized chemical synthesis. This compound operates through a mode of action that involves the absorption of ultraviolet (UV) radiation, leading to the generation of free radicals. These radicals initiate the polymerization of monomeric or oligomeric species in UV-curable formulations.</p>

<p>LPA2 Antagonist 1 is a research tool that inhibits the activity of LPA2, a receptor protein. It can be used in the study of ligand-receptor interactions and cell biology. LPA2 Antagonist 1 binds to the LPA2 receptor and prevents it from activating intracellular signaling pathways. This product has high purity and is suitable for use as a pharmacological reagent or peptide.</p>

<p>SCH79797 is a thrombin inhibitor that blocks the conversion of pro-thrombin to thrombin. SCH79797 prevents neuronal death by inhibiting the activation of the neuronal apoptosis signal pathways and blocking signals from cytosolic calcium. This drug also inhibits the production of pro-inflammatory cytokines, including tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), by blocking toll-like receptor signaling pathways. SCH79797 has been shown to be effective in models of Parkinson's disease and other neurological disorders and is an antagonist at basic protein sites.</p>

<p>N-[3-[(Aminoiminomethyl)amino]-4-methylphenyl]-4-[(4-methyl-1-piperazinyl)methyl]benzamide is a peptide that activates AMPA receptors. It also has been shown to inhibit the interaction of proteins by binding to the receptor site, and can be used as a research tool for studying protein interactions. N-[3-[(Aminoiminomethyl)amino]-4-methylphenyl]-4-[(4-methyl-1-piperazinyl)methyl]benzamide is a high purity, ion channel activator that has an IC50 of 2.6 μM. This compound is CAS No. 581076-65-5 and is available in 1 mg/mL or 5 mg/mL solutions with 98% purity.</p>

<p>6-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]hexanoic acid is a research tool and ligand for the receptor of the Activator. It binds to the receptor with high affinity and inhibits ion channels in cells. 6-[(2-(2,6-Dioxo-3-piperidinyl)-2,3,-dihydro-1,3,-dioxo--1H--isoindol--4--yl)oxy]hexanoic acid is a synthetic compound that has been used as an antibody to study protein interactions and as a pharmacological probe to study peptides. The CAS number for this compound is 2087490–48–8.</p>

<p>Rhodblock 6 is a fatty acid that blocks the synthesis of phosphatidylcholine and other phospholipids. It has been shown to inhibit the synthesis of phosphatidylcholine in x-linked adrenoleukodystrophy (XALD) cells and primary human cells, which may be due to its action on the fatty acid elongation pathway. Rhodblock 6 also prevents the release of lysophosphatidic acid from cell membranes, which leads to decreased signaling by phospholipase A2 and an increase in intracellular calcium levels. This inhibition may lead to neurodegenerative diseases such as cancer and cell death.</p>

<p>3-Cyclopropyl-N-[(1R,2R,3R,5S)-2,6,6-trimethylbicyclo[3.1.1]hept-3-yl]-2-thiophenemethanamine is a synthetic compound belonging to the class of bicyclic amines. Originating from advanced chemical synthesis processes, this compound is designed to interact with central nervous system receptors. Its primary mode of action involves the modulation of neurotransmitter pathways, which can influence various CNS activities.</p>

<p>CXCR2-IN-1 is an inhibitor targeting the chemokine receptor CXCR2, which is synthesized through chemical methods. Its mode of action specifically involves the antagonism of the CXCR2 receptor, leading to the modulation of neutrophil recruitment and migration. This receptor is known for playing a pivotal role in inflammatory response pathways, making CXCR2-IN-1 a significant tool in experimental settings where modulation of this pathway is needed.</p>

<p>BIIL-260 hydrochloride is a research tool that can be used as an activator or ligand for receptor binding. It is a cell biology reagent that is used to study protein interactions and signal transduction. BIIL-260 hydrochloride has been shown to inhibit ion channels and may be useful for the treatment of pain, epilepsy, and other neurological disorders. BIIL-260 hydrochloride also has pharmacological properties and is used in the study of peptides.</p>

<p>Inhibitor of FGF-1 receptor tyrosine kinase</p>

<p>MEK1 and MEK2 inhibitor</p>

<p>AZ-1355 is a novel, orally bioavailable, small molecule inhibitor of collagen-specific proteinase (MMP-1) that has been shown to be effective in preventing the development of cerebral amyloidosis in hamsters. AZ-1355 is orally bioavailable and penetrates the blood brain barrier, thus reducing the amount of MMP-1 that can enter the brain. This drug has also been shown to reduce cardiac collagen deposition and improve endothelial function. AZ-1355 has not been tested on humans or animals for its potential toxicity, but it does have a toxic profile in vitro. This drug has also been shown to have damaging effects on platelets and cause death in cultured cells.</p>

<p>SKLB-23bb is a small molecule that inhibits the polymerization of microtubules. It inhibits the assembly and stability of microtubules by binding to tubulin, preventing the formation of stable polymers. SKLB-23bb has been shown to be effective in inhibiting tumor growth in xenografts in mice. It also inhibits the proliferation of cancer cells, but not normal cells, which may be due to its ability to inhibit gene transcription. This drug also has a number of modifications, such as a hydroxy group, that allow it to be orally administered and modified with colchicine. These modifications make SKLB-23bb an attractive candidate for cancer therapy.</p>

<p>Tariquidar dihydrochloride is a ligand that binds to the G protein-coupled receptor. It is a potent and selective activator of the G protein-coupled receptor, which is involved in cell signaling. Tariquidar dihydrochloride binds to the peptide sequence of the receptor and activates it by binding to its ion channels. The structure of tariquidar dihydrochloride has not been determined yet. This drug is used as a research tool for studying cell biology and pharmacology.</p>

<p>AZD 3988 is a new drug candidate that has shown to have anticancer effects. It is an oxadiazole derivative and acts as a prodrug for the formation of cytotoxic metabolites. AZD 3988 has been shown to induce ferroptosis, a type of programmed cell death, in cancer cells. Ferroptosis is characterized by the accumulation of free iron and lipid peroxidation. The endoplasmic reticulum can be targeted by AZD 3988, leading to efficient cell death in vitro. In addition, AZD 3988 may also inhibit cholesterol acyltransferase activity and increase the expression of cholesterol ester transfer protein (CETP). These activities help to reduce serum levels of low-density lipoprotein cholesterol and increase high-density lipoprotein cholesterol levels.</p>

<p>AZD7451 is a research tool that has been used to study the activation, inhibition, and binding of receptors and ion channels. It is an activator of the Ligand-gated ion channel (LGA) receptor. AZD7451 is also an inhibitor of the voltage-gated potassium channel (VGKC) subtype M2, which plays a role in epileptic seizures. The protein interactions of AZD7451 are not well understood but it has been shown to inhibit antibody binding to human cells and peptides.</p>

<p>5α-Hydroxycostic acid is a sesquiterpene lactone that has been shown to have antiangiogenic effects. It inhibits protein synthesis and cell division, leading to significant cytotoxicity in cells. 5α-Hydroxycostic acid has been shown to inhibit the phosphatase activity of the angiogenic process and to be used as an antiangiogenic therapy for cancer treatment. This compound also inhibits growth factor (e.g., vascular endothelial growth factor) expression, leading to decreased angiogenesis and reduced tumor size in mouse models of cancer. 5α-Hydroxycostic acid also inhibits angiogenesis by reducing the production of chemokines such as monocyte chemoattractant protein 1 (MCP-1).</p>

<p>Rosabulin is a conjugate of indibulin and an anticancer drug that selectively targets tumor vasculature. It is a linker that binds to the CD44 receptor on the surface of tumor cells, with human serum albumin as a carrier. The drug has been shown to suppress tumor growth in animal models by binding to CD44 receptors on tumor vessels, inhibiting the formation of new blood vessels necessary for cancer growth. Rosabulin has also been shown to be effective in treating colorectal cancer, lung and breast cancer.</p>

<p>Mambalgin 1 is a natural product that was isolated from the stem bark of the tree Moringa oleifera. It is a member of a family of cyclic peptides called mambalgins. This compound has been shown to inhibit the sp600125-induced contraction in mammalian cells, as well as to suppress expression of genes that are involved in regulating the cell cycle. Mambalgin 1 also induces conformational changes in proteins and inhibits protein synthesis. The structure of this compound was determined by chemical ligation and cryo-electron microscopy, which revealed that it has a bicyclic structure with an unusual C-terminal extension.</p>

<p>BTSA1 is a cytosolic protein that is expressed at low levels in normal cells, but can be induced to high levels in leukemic cells. BTSA1 has been shown to act as an effector protein by binding to mitochondrial superoxide and inhibiting mitochondrial membrane potential. It also inhibits the activation of caspase-9 and apoptosis pathway, which leads to apoptosis. BTSA1 has been shown to have anti-leukemic activity and may be a potential therapeutic target for cancer.</p>

<p>3-Cyclopropyl-6-[4-[(2-phenylethenyl)sulfonyl]-1-piperazinyl]-1,2,4-triazolo[4,3-b]pyridazine is a research tool that has been shown to activate receptors. This compound is a ligand that binds to the receptor and activates it. 3-Cyclopropyl-6-[4-[(2-phenylethenyl)sulfonyl]-1-piperazinyl]-1,2,4-triazolo[4,3-b]pyridazine is used in Cell Biology as an antibody or an ion channel inhibitor. It is also being studied for its pharmacological properties in peptides and life science.</p>

<p>SJB3-019A is an advanced small molecule inhibitor, which is derived from synthetic chemical libraries and designed for precise biochemical interactions. This compound operates by selectively inhibiting specific kinases involved in pivotal signaling pathways within the cell. By targeting these pathways, SJB3-019A modulates cellular functions such as proliferation, differentiation, and apoptosis.</p>

<p>Fibroblast growth factor 22 (FGF22) is a cytokine that belongs to the FGF family. FGF22 has been shown to play a role in the modulation of glucose homeostasis and the regulation of insulin secretion. FGF22 is produced by pancreatic β cells, liver, kidney, muscle, and fat tissue. It has been shown to be involved in the regulation of cellular proliferation and apoptosis, as well as the control of inflammation and immune response.</p>

<p>Edotreotide trifluoroacetate is a diagnostic agent that is used to diagnose hepatic steatosis. It is a synthetic analog of somatostatin, which can be synthesized by the reaction of trifluoroacetic acid and hydroxyl compounds. Edotreotide trifluoroacetate is radiolabeled with technetium-99m and administered intravenously. The drug binds to receptors on the surface of proximal tubule cells in the liver, causing an uptake of this radionuclide in the area of interest. This diagnostic agent has also been shown to inhibit insulin release from pancreatic beta cells and improve glucose tolerance in patients with type 2 diabetes mellitus.</p>

<p>JW55 is a pluripotent cell compound that has been shown to inhibit tankyrase1/2 in vitro. This inhibition leads to the promotion of eye disorders, such as retinal degeneration and age-related macular degeneration. JW55 also inhibits β-catenin, which plays an important role in the regulation of cellular processes such as proliferation and differentiation. JW55 has been found to have a potential drug target for body mass index (BMI) and amyloid protein, which are associated with diseases such as Alzheimer's Disease. It is believed that JW55 may be able to bind with hydrogen bonds or polymerase chain reactions (PCRs) for natural compounds.</p>

<p>5-(5-Chloro-2-methoxybenzenesulfonamido)pyridine-3-carboxamide is a phosphatase inhibitor that binds to the phosphate group of pyrophosphate. It inhibits the enzyme pyrophosphatase, which is involved in the mineralization process. This drug has been shown to be safe and effective for the treatment of pathological mineralization, such as dental plaque, urinary stones, and kidney stones. 5-(5-Chloro-2-methoxybenzenesulfonamido)pyridine-3-carboxamide also inhibits phosphatases present in extracellular fluids and thereby reduces bone resorption. The drug can be administered orally or intravenously and has been shown to increase bone mineral density in a mouse model of osteoporosis.</p>

<p>3-Methyl-4H-1,4-benzothiazine-2-carbohydrazide is a peptide that has been shown to activate the immune system by binding to the Fc receptor. It also inhibits ligand and receptor interactions, which may be useful in pharmacology studies and for developing new drugs. 3-Methyl-4H-1,4-benzothiazine-2-carbohydrazide is used as a research tool for studying protein interactions and ion channels. This compound has been shown to have high purity with an analytical purity of 99%. The CAS number for 3-Methyl-4H-1,4-benzothiazine 2 carbohydrazide is 16905847.</p>

<p>Nilotinib is a tyrosine kinase inhibitor that is used to treat chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia. It is also being studied for use in the treatment of other cancers, including breast cancer and gastrointestinal stromal tumor. Nilotinib inhibits the activity of tyrosine kinases, which are enzymes that regulate cellular processes such as cell division and differentiation. This effect causes cells to stop dividing or die. Nilotinib has been shown to be effective against chronic myeloid leukemia by inhibiting BCR-ABL, the protein associated with this disease, as well as other tyrosine kinases involved in cancer progression. The drug has proven successful in clinical trials involving patients with Philadelphia chromosome-positive acute lymphoblastic leukemia. In addition, nilotinib has been shown to inhibit the constitutive activation of c-KIT, a receptor tyrosine kinase that is overexpressed in certain types of</p>

<p>tert-Butyl N-[3-[[(1R)-1-(3-benzyl-7-chloro-4-oxoquinazolin-2-yl)-2-methylpropyl]-(4-methylbenzoyl)amino]propyl]carbamate is a peptide that is used as a research tool to study protein interactions. It is an inhibitor of ion channel proteins and has been shown to inhibit the activity of potassium channels, calcium channels, sodium channels, and glutamate receptors. It also inhibits receptor binding by ligands and has been shown to inhibit the activation of some protein kinases.</p>

<p>Arg-MCA is a synthetic peptide that activates the receptor for bradykinin. It is used as a research tool in cell biology and pharmacology to study the interactions of peptides with various receptors and ion channels. Arg-MCA has been shown to inhibit the activity of ligand-gated ion channels, such as nicotinic acetylcholine receptors and glutamate receptors.</p>

<p>Insulin is a peptide hormone that regulates the metabolism of carbohydrates, fats, and proteins. Insulin has been shown to bind to insulin receptors in the cell membrane. When insulin binds to the receptor, it triggers a series of biochemical reactions that lead to increased glucose uptake by cells and increased synthesis of glycogen in the liver. Insulin also activates ion channels, which leads to an increase in calcium influx into cells. Insulin is involved in many other functions within the body, such as promoting growth and development, regulating protein synthesis, and controlling lipid storage.<br>Insulin is used as a research tool for studying carbohydrate metabolism or as an antidiabetic drug for people who have diabetes mellitus. The most common form of insulin used today is human recombinant insulin (H-insulin). Human recombinant insulin can be synthesized from genetically engineered bacteria or yeast cultures.</p>

<p>Ac-Abu-D-Tyr-Leu-Gln-VS is a synthetic peptide that can be used as a research tool, an activator, or an inhibitor. It is a high purity product that has been extensively tested for its use in ion channels and receptor pharmacology.</p>

<p>?1-integrin agonist; improves survival of hESC after single cell dissociation</p>

<p>Amino acids 1-37 of the Human Big Endothelian-2 peptide formed as a result of furin cleavage of proendothelin which in turn is produced from EDN2 gene transcription. Due to the actions of the Endothelin-Converting Enzymes: ECE-1 and ECE-2, Big Endothelin-2 is converted into Endothelin-2 (ET-2) peptide. ET-2 has affinity for ETA and ETB G-protein coupled receptors which are found in a variety of tissues, including lungs, heart, kidneys, uterus and vasculature. It is believed that ET-2 is a potent vasoconstrictor and may play a role in cancer, immunology and heart failure. This product has is available as a 0.1mg vial and has disulfide bonds between Cys1-Cys15 and Cys3-Cys11.</p>

<p>This peptide is a specific inhibitor of human preprorenin, which is the precursor of renin. The peptide has been shown to inhibit the activation of renin with high specificity and potency.</p>

<p>Fluorescent Brightener 251 is a quaternary ammonium salt that is used as a fluorescent whitening agent. It has been shown to be safe for use with human keratin and can be identified by its ultraviolet-visible spectra. This compound is a polybasic, anionic compound that is neutralized with a diluent and then chloride. The radiation emitted by the compound triggers the emission of visible light, which is what makes it fluorescent. Fluorescent Brightener 251 emits radiation in three wavelengths: 280 nm, 350 nm, and 420 nm. The evaporation rate of this compound depends on the counterions present in the solution. Fluorescent Brightener 251 undergoes a stepwise reaction with reactive compounds.</p>

<p>RNF5 Inhibitor Inh-2 is a potent inhibitor of the RNF5 protein. It blocks the activation of the receptor by binding to its ligand and inhibits the activity of ion channels in cells. This inhibitor can be used to study various cellular functions, including ligand-receptor interactions, G protein signaling cascades, and ion channel regulation.</p>

<p>JNJ-40346527 is an anti-inflammatory drug that belongs to the group of quinoline derivatives. It has been shown to have a tumor treatment effect in cancer cell lines and also inhibits the production of inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6). JNJ-40346527 has been shown to be effective in treating bowel disease and rheumatoid arthritis. This molecule inhibits tumor growth by stimulating the release of colony-stimulating factor, which stimulates the proliferation of blood cells. The hydroxyl group on this molecule may contribute to its activity by interacting with DNA bases.</p>

<p>The HIV-1 p24 Core Recombinant is a recombinant protein made from the HIV-1 p24 core protein. It has been purified by immunoaffinity chromatography and is specific to the HIV-1 antigen, with minimal cross-reactivity to other viruses. The HIV-1 p24 Core Recombinant is found in the form of a chain of polypeptides, which are chains of amino acids that form proteins. This protein can be used as an immunoreactive reagent for detecting antibodies against HIV-1 in human serum or plasma.</p>

<p>Anti TGF-Alpha, humanSerum is a recombinant antibody that specifically binds to the ligand of the Transforming Growth Factor-alpha receptor. It is used as a research tool for protein interactions, pharmacology and cell biology.</p>

<p>Ebi-3 is a mouse monoclonal antibody that binds specifically to the extracellular domain of human β2-adrenergic receptor. Ebi-3 has been shown to inhibit the binding of ligands, such as catecholamines, to the receptor and may be useful for research in cell biology, pharmacology and pharmacogenetics.</p>

<p>1,2-Dilinoleoyl-sn-glycero-3-phosphocholine (DLPC) is a phospholipid that is used in the treatment of insulin resistance and inflammation. DLPC is a stable molecule that exhibits intermolecular hydrogen bonding and has been shown to be effective against inflammatory diseases. DLPC has been used as a liposomal formulation for the treatment of type 2 diabetes by improving insulin sensitivity, which may be due to its ability to inhibit proinflammatory cytokines such as tumor necrosis factor alpha (TNFα). It also binds to the receptor α, which are G protein coupled receptors present on cells involved in inflammatory responses. The binding of DLPC to these receptors leads to increased insulin sensitivity by inhibiting TNFα production.</p>

<p>A synthetic cone snail toxin sourced form the marine snail, conus striatus. This product has disulfide bonds between Cys1-Cys16,Cys8-Cys20, and Cys15-Cys26 and is available as a 0.5mg vial.</p>

<p>Hepcidin is a peptide hormone that regulates iron absorption in the intestine. It is secreted by hepatocytes, the primary cells of the liver. Hepcidin-Murine Compete^TM ELISA Kit (1ea) is a competitive enzyme-linked immunosorbent assay (ELISA) kit for measuring hepcidin concentrations in mouse serum. This assay has been validated to measure hepcidin concentrations up to 1000 pg/mL with sensitivity as low as 1 pg/mL. The kit can be used to diagnose iron deficiency anemia and other diseases associated with hepcidin deficiency.</p>

<p>Bz-Gly-Ala-Pro is a synthetic tripeptide. It has been shown to have a carboxypeptidase activity, which hydrolyzes the C terminal of peptides and proteins. Bz-Gly-Ala-Pro was found to be active at a pH range of 2.0 to 10.0, with optimum activity at pH 4.5 to 6.0. The enzyme was found to be stable in captopril perfusates and showed no inhibition from trypsin or pepsin digestion. This peptide binds specifically to the carboxy terminal amino acid of dietary proteins, such as casein, soy protein, and egg albumen, and may play an important role in intestinal digestion and absorption by acting on these sites as well as on other peptidases that are present in the intestinal tract.</p>

<p>Rac-Methyl ephedrine-d3 hydrochloride is a research tool that is used to study the function of ion channels. It is a high purity ligand for the alpha2 receptor, which is found in the heart and brain. Rac-Methyl ephedrine-d3 hydrochloride has been shown to activate this receptor and may be useful for the treatment of hypertension and Parkinson's disease. This compound has also been shown to inhibit protein synthesis by binding to a specific site on ribosomes.</p>

<p>A standard for use in proteomics</p>

<p>Acid Red 1 is an optical sensor that produces a change in color when it reacts with a substance. It also has fixative properties and is used to preserve biological samples. Acid Red 1 is typically made up of two components: one that absorbs light at 660 nm and another that absorbs light at 780 nm. The rate constant for the reaction between Acid Red 1 and the substance is proportional to the concentration of the substance. Acid Red 1 has been shown to have synergistic effects when combined with other dyes, such as Sudan III. This dye can be used on biological samples such as blood, skin, or hair for genotoxic activity testing or for analytical methods such as electrochemical impedance spectroscopy.</p>

<p>Zanubrutinib is a small molecule drug that inhibits the activity of epidermal growth factor receptor (EGFR), which is involved in the development and progression of cancers. It also inhibits other targets, such as HER2+ breast cancer cells. Zanubrutinib has been shown to inhibit tumor growth in a xenograft model of skin cancer. The compound was well tolerated, with no signs of toxicity or adverse events observed at doses up to 400 mg/kg.</p>

<p>Please enquire for more information about Clomiphene-d5 N-oxide including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Talosalate is a peptide that has been shown to activate antibody production. It has also been shown to block ion channels and inhibit protein interactions. Talosalate is an inhibitor of receptor-ligand interactions.</p>

<p>WAY 316606 hydrochloride is a substance that inhibits the tyrosine kinase of the Fms-like tyrosine kinase family. It is used as an inhibitor in research and development for substances with fms-like tyrosine kinase activity. WAY 316606 hydrochloride has been shown to be an effective inhibitor of human platelet aggregation and in vitro platelet function, as well as inhibiting the activity of human platelets in vivo. This drug has also been shown to inhibit fms-like tyrosine kinase, which is involved in regulating cell proliferation, differentiation, and survival.</p>

<p>6-[(3-Methoxyphenyl)methyl]-4-methyl-2-methylsulfinylthieno[3,4]pyrrolo[1,3-d]pyridazin-5-one is a potent inhibitor of the voltage gated sodium channels. It blocks the function of ion channels and inhibits the action of the neurotransmitter acetylcholine on postsynaptic neuromuscular junctions. The IC50 value for this compound is 1 µM, making it one of the most potent inhibitors of voltage gated sodium channels currently known. 6-[(3-Methoxyphenyl)methyl]-4-methyl-2-methylsulfinylthieno[3,4]pyrrolo[1,3-d]pyridazin-5-one has been used as a research tool in cell biology and pharmacology to study protein interactions and peptides.</p>

<p>Deoxyribonuclease I Bovine is an enzyme extracted from pancreas, thymus, or bovine tissue culture. It may be used to digest proteins in order to remove damaged linkages and produce a soluble protein-free extract. Deoxyribonuclease I Bovine can also be used for the removal of DNA from cells, tissues, and organs for biochemical methods such as biochemical assays, immunoassays, and nucleic acid amplification.</p>

<p>DBCO-dPEG®12-Carboxyfluorescein is a PEG compound containing a fluorescein dye used for tagging biomolecules, and serving as fluorescent probe for bioimaging applications.</p>

<p>1-[[4-(4-Chloro-3,5-dimethylphenoxy)phenyl]methyl]-6-(2-furanyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid is a potent blocker of the Kv1.2 voltage gated potassium channel. It has been shown to inhibit the growth of breast cancer cells in vitro and in vivo, and to induce apoptosis by activating caspase 3. This drug also inhibits the activation of NFκB in human monocyte cell cultures, which may be due to its ability to inhibit the binding of nuclear factor kappa B (NFκB) to DNA.</p>

<p>Gly-Phe is a kinetic glycolytic inhibitor that has antiviral properties. It has been shown to be effective against a number of viruses, including the herpes simplex virus type 1 (HSV-1), influenza virus A/PR/8/34 (PR8), and human immunodeficiency virus type 1 (HIV-1). Gly-Phe inhibits viral growth by blocking the synthesis of nucleic acids in cells infected with these viruses. The antiviral activity of Gly-Phe was demonstrated in animal models and humans, where it acted as an effective treatment for HSV-1 infection. Gly-Phe also has anti-inflammatory properties, which may be due to its ability to inhibit bacterial enzymes in the intestinal tract.</p>

<p>Please enquire for more information about 4-Desfluoro-6-fluoro dolutegravir including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>4-(3-(Methylsulfonyl)phenyl)-1-propylpiperidine is an analog that has shown promising results as an anticancer agent. It works by inhibiting protein kinases, which are enzymes involved in the growth and spread of tumors. This compound has been found to be effective against a variety of cancer cells, including those from human urine and Chinese medicinal plants. It induces apoptosis, or programmed cell death, in cancer cells by blocking the activity of specific kinases. This inhibitor shows great potential for the development of new cancer treatments.</p>

<p>ZIP is a peptide that can be used as an inhibitor of protein interactions. ZIP has been found to bind to antibodies and can be used as a research tool in cell biology and pharmacology. ZIP is a high purity, non-toxic chemical compound with high stability. ZIP is an ion channel inhibitor with a CAS number of 908012-18-0. ZIP has shown to be an activator of the following receptors: muscarinic acetylcholine receptor, nicotinic acetylcholine receptor, GABA receptor, NMDA glutamate receptor, alpha 1A-adrenergic receptor, alpha 1B-adrenergic receptor, beta 2-adrenergic receptor, dopamine D2 receptor.</p>

<p>Sulfo-SPP is a hydrophilic, cleavable succinimidyl ester linker suitable for conjugation to proteins. It allows the release of the payload under physiological conditions.</p>

<p>TL4-12 is a gene editing tool, which is a synthetic construct engineered through advanced biotechnological techniques. It operates via CRISPR-Cas9 technology, enabling the precise targeting and modification of specific genomic sequences in living cells. The Cas9 enzyme acts as molecular scissors, guided by a custom RNA sequence within TL4-12 to a unique DNA target location.</p>

<p>Anti PACAP38, humanSerum is a research tool that can be used to study the role of PACAP in various biological processes. The antibody is generated against human PACAP38 and has been shown to inhibit the activity of this peptide. The antibody also binds to the receptor for this peptide, which is a G protein-coupled receptor. This antibody can be used as an inhibitor of PACAP and its receptor in various cell types.</p>

<p>Parathyroid hormone (PTH) is a peptide hormone that regulates the calcium and phosphate concentrations in the blood. It is produced by the parathyroid gland, located near the thyroid gland in the neck. PTH has three forms: amino-terminal proparathyroid hormone (PTH 1-34), amino-terminal parathyroid hormone fragment 34-84 (PTH 1-34 amide), and carboxy-terminal parathyroid hormone fragment 84-120 (PTH 1-84). The receptor for PTH is called the parathyroid hormone receptor (PTR). The binding of PTH to its receptor leads to activation of adenylate cyclase, which increases levels of intracellular cAMP.</p>