Bioquímicos e reagentes

<p>AZD1080 is a small molecule that binds to the β-catenin protein and inhibits its transcriptional function. AZD1080 has been shown to inhibit the growth of mouse tumor cells that are resistant to other anticancer drugs by blocking the activity of kinase-3β. It also prevents the activation of β-catenin, which is a key regulator in cell growth and proliferation. This drug was also found to bind with high affinity to hepatocyte-like cells and inhibit protein synthesis. AZD1080 is a potent inhibitor of polymerase chain reactions (PCR) and transcriptional regulation that blocks transcription at the promoter level. It binds to DNA's phosphate backbone, preventing DNA from unwinding and elongating into its two strands.</p>

<p>Benzyl 7-oxo-2,6-diazaspiro-[4.5]decane-2-carboxylate is a potent inhibitor of protein interactions and an activator of ligand binding. It is used as a research tool in the study of receptor and ion channel function. Benzyl 7-oxo-2,6-diazaspiro-[4.5]decane-2-carboxylate has been shown to inhibit the activity of various proteins by binding to their active sites, including peptidases and proteases such as cathepsin D, elastase, collagenase, and trypsin. This compound also binds to the extracellular domains of cell surface receptors such as erythropoietin receptor (EpoR) and growth hormone receptor (GHR). The affinity for these receptors can be controlled by changing the length of the alkyl chain between benzene rings. Benzyl 7-oxo</p>

<p>Cemadotin is a peptide that activates an ion channel. Cemadotin is a potent and selective inhibitor of the calcium channel, L-type, alpha 1D (P/Q-type) in human erythrocytes. It inhibits cell proliferation and induces apoptosis in some cancer cells by inhibiting protein interactions. This peptide has been shown to be a potent antagonist of the neuropeptide Y receptor (Y1) with high affinity for this receptor. Cemadotin also has been shown to inhibit the binding of ligands to their receptors in a variety of cell types, including rat cortical neurons and human platelets.</p>

<p>6-[[4-(4-Methyl-1-piperazinyl)phenyl]amino]-5,8-quinazolinedione is a research tool that can be used to activate receptors. It is also a ligand for the alpha 1A adrenergic receptor and has been shown to inhibit ion channels that are activated by the G protein. 6-[(4-[4-(methylsulfonyl)piperazin-1yl]phenyl)amino]-5,8-quinazolinedione binds to the beta 2 adrenergic receptor and blocks calcium influx into cells. This compound has been shown to increase intracellular levels of cAMP in vitro and in vivo.</p>

<p>Neuopeptide suggested to be involved in neuron functioning</p>

<p>Please enquire for more information about (R)-(+)-5-[[3-[(6,8-Dibromochroman-4-yl)amino]propyl]amino]-4H-thieno[3,2-b]pyridin-7-one dihydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Risperidone is a psychotropic drug that belongs to the group of atypical antipsychotics. It is used to treat psychotic disorders such as schizophrenia and bipolar disorder. Risperidone is a racemic mixture that has a high water solubility, which makes it suitable for administration by mouth. The active form of risperidone, 1-2-dihydro-6-chloro-9-(4-(1-piperazinyl)butoxy)-5-pyrimidine, has been shown to be effective in the treatment of psychotic disorders by altering epigenetic mechanisms related to DNA methylation and histone acetylation. This drug also has the ability to stabilize the human genome from spontaneous genetic changes that lead to cancer and neurodegenerative diseases.</p>

<p>17-Hydroxyisolathyrol is a small molecule that inhibits the activity of protein-protein interactions. It has been shown to be a ligand for the receptor FKBP and an activator for the protein kinase PKC. 17-Hydroxyisolathyrol has also been used as a research tool to study ion channels, antibodies, and other proteins in cell biology and pharmacology. 17-Hydroxyisolathyrol is often used as a standard for high purity and life science research.</p>

<p>Avocadene is a topical treatment derived from the avocado pear (Persea americana), which is a rich source of natural compounds with potential therapeutic effects. The primary mode of action involves the inhibition of lipoxygenase pathways, which are key mediators in the inflammatory response. By targeting this enzyme, Avocadene reduces the conversion of arachidonic acid into pro-inflammatory leukotrienes, thus exerting its anti-inflammatory properties.The uses and applications of Avocadene are primarily focused on dermatological conditions characterized by inflammation, such as eczema, psoriasis, and other inflammatory skin disorders. Due to its natural origin and targeted mechanism, it offers an alternative to traditional synthetic anti-inflammatory agents, presenting potential benefits in reducing side effects associated with long-term use. Avocadene's action on the cellular pathways makes it a subject of interest for further research in chronic inflammation and its systemic applications, potentially expanding its uses beyond dermatology.</p>

<p>Inhibitor of JNK signalling pathway</p>

<p>Huwentoxin XVI is a synthetic molecule that inhibits the transmission of pain signals. It does this by inhibiting the release of neurotransmitters from dorsal root ganglia cells in the spinal cord. Huwentoxin XVI has been shown to inhibit the cancer-associated inflammatory response, which may be due to its ability to inhibit chronic pain. In addition, Huwentoxin XVI has been shown to have an inhibitory effect on adipose tissue and is thought to be a potential treatment for obesity-associated chronic pain. Huwentoxin XVI also blocks A-type potassium channels, which are responsible for neuronal transmission and are found in neurons and glial cells in the dorsal root ganglia. This inhibition can lead to neuropathic pain or chronic pain caused by nerve damage.</p>

<p>Please enquire for more information about rac-3-hexadecanamido-2-methoxypropan-1-ol phosphocholine monohydrate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Pro BMP 2 Human is a recombinant protein that belongs to the group of proteins that regulate cell growth and differentiation. It has been shown to be an activator of bone morphogenetic protein receptor type IIA. Pro BMP 2 Human has also been shown to inhibit the activity of certain ion channels, such as calcium channels, potassium channels, and sodium channels. This product is supplied at high purity, with a CAS number (CAS No.).</p>

<p>OPC 3930 is a polymer-based coating, which is synthesized from advanced polymer composites. It functions through a mechanism of thermal insulation, where the composite structure significantly reduces thermal conductivity. This is achieved by incorporating a microscale porous architecture that traps air and minimizes heat transfer.</p>

<p>Urocortin 2 (Mouse)-EIA Kit is a specialty product that can be used to detect the presence of Urocortin 2 in mouse serum. It is an antibody-based sandwich ELISA kit that has been optimized for use in mouse sera and other biological fluids. The kit includes all necessary reagents, including antibodies, standards, and conjugates, to perform an assay. The assay is performed by adding the sample to the plate followed by the detection antibody and a conjugate. After incubation, unbound materials are washed away and the plate is developed with Tetramethylbenzidine (TMB) substrate. A stop solution turns TMB into a blue color that can be measured at 450 nm with a spectrophotometer. The intensity of color corresponds to the concentration of Urocortin 2 in the sample.br&gt;br&gt;<br>The Urocortin 2 (Mouse)-EIA Kit is designed for research purposes only and not for diagnostic</p>

<p>TNF-α is a cytokine that is synthesized and secreted by cells such as activated macrophages, T cells, endothelial cells, fibroblasts, and keratinocytes. It has been shown to be a potent mediator of inflammation and plays an important role in the pathogenesis of many diseases. TNF-α is produced in response to immunological stimulation (e.g., LPS) or microbial invasion (e.g., bacteria). It binds to two receptors: TNF receptor 1 (TNFR1) and TNF receptor 2 (TNFR2), which are expressed on many cell types including monocytes, macrophages, neutrophils, dendritic cells, B lymphocytes, eosinophils, mast cells and keratinocytes. The binding of TNF-α to TNFR1 leads to activation of NF-κB and JNK pathways. The binding of TNF-α to TNFR2 leads to activation</p>

<p>[D-Ala2,Met5]-Enkephalin is an inhibitory neurotransmitter that binds to receptors in the brain and spinal cord. It affects physiological functions such as locomotion, pain sensation, and blood pressure. Enkephalins are analogs of the natural neurotransmitter enkephalin that are synthesized by enzymatic cleavage of the latter from a larger precursor molecule called proenkephalin. [D-Ala2,Met5]-Enkephalin has been shown to be an effective antinociceptive agent when administered intraperitoneally or intravenously in rats. It also acts as a pressor agent and produces dextran sulfate-induced nociception in mice. The pharmacological properties of enkephalins have been shown using various analytical methods including acid analysis.</p>

<p>Dendrotoxin I is a synthetic black mamba snake toxin sourced from the block mamba, Dendroaspis polylepis polylepis and is a voltage-dependent K+ channel blocker. This product has disulfide bonds between Cys7-Cys57, Cys16-Cys40, and Cys32-Cys53 and is available as a 0.1mg vial.</p>

<p>Dihydrofolate reductase is an enzyme that catalyzes the conversion of dihydrofolate to tetrahydrofolate. It belongs to a family of metalloenzymes that employ NADPH as a cofactor and are involved in one-carbon metabolism. Dihydrofolate reductase has been shown to interact with a number of other proteins, including peptides, cell biology, and receptor. This enzyme is also used as an inhibitor for research purposes.</p>

<p>Neurotensin is a neuropeptide that is involved in the regulation of a variety of physiological functions, including neurotransmission, cardiovascular function, and appetite. It is composed of 13 amino acids and is primarily produced in the gastrointestinal tract and the central nervous system.<br>Neurotensin acts as a neurotransmitter and neuromodulator in the brain, where it is synthesized by neurons in several regions, including the hypothalamus, amygdala, and nucleus accumbens. In addition to its role in neurotransmission, neurotensin has been shown to be involved in the regulation of food intake and energy metabolism. It is thought to promote satiety and reduce food intake by interacting with the hypothalamus and other brain regions involved in appetite regulation.<br>Neurotensin has also been studied for its potential therapeutic applications as it has been shown to be associated with the pathophysiology of conditions such as Parkinson's disease, pain, schizophrenia, cancer and inflammatory bowel disease.</p>

<p>Erk1/2 inhibitor 1 is a potent inhibitor of the Erk1/2 kinase, which is a protein involved in human cell signaling pathways. This medicinal compound has been shown to be an effective tumor inhibitor, inducing apoptosis and inhibiting cancer cell growth by blocking the cell cycle. Erk1/2 inhibitor 1 is an analog of Chinese herbal medicine, which has been used for centuries as an anticancer agent. This inhibitor can be used to treat various types of cancers and is highly effective against urinary tract cancers.</p>

<p>Mc-doxhzn hydrochloride is a monoclonal antibody that binds to the epidermal growth factor receptor (EGFR) and inhibits its signaling. It is used in the treatment of cancer, especially of tissue sarcoma. Mc-doxhzn hydrochloride has been shown to be an effective therapy for chordoma, a type of cancerous tumor, when combined with ifosfamide. This drug's affinity for EGFR may also be therapeutic for other types of cancers that over-express this receptor. Mc-doxhzn hydrochloride can bind to the cell surface receptor CD20 on B cells and inhibit their proliferation by triggering apoptosis or programmed cell death.</p>

<p>FRETS-25Ile is a peptide that belongs to the class of activators. It has been shown to activate an antibody against the beta2 adrenergic receptor and can be used for research purposes. FRETS-25Ile is a high purity product with an ion channel inhibitor activity. The CAS number for this product is 69710-51-5.</p>

<p>MCI 225 is a drug that belongs to the class of tricyclic antidepressants. It has been shown to be an effective treatment for depression and other psychiatric disorders. MCI 225 inhibits the uptake of serotonin, norepinephrine, and dopamine into the synaptic cleft by blocking the 5-HT3 receptor. This is thought to lead to increased levels of serotonin in the brain. MCI 225 also has anti-inflammatory properties and can be used in inflammatory bowel disease as well as bowel disease. MCI 225 may also have therapeutic effects on heart diseases or cancer due to its anti-inflammatory properties. Clinical use of this drug is limited due to its low potency, but it has been found to be better tolerated than other tricyclic antidepressants with similar activity.</p>

<p>XMD16-5 is a small molecule kinase inhibitor, which is a synthetic chemical compound specifically designed to target and inhibit kinase enzymes. These enzymes are crucial for various signaling cascades that regulate cellular functions such as growth and differentiation. The source of XMD16-5 involves meticulous chemical synthesis, often derived from high-throughput screening of chemical libraries or rational drug design.</p>

<p>AE-848/32615073 is a peptide that can activate the immune system. It has been shown to be an activator of the immune system and to have binding affinity for antibodies. The peptide has also been shown to inhibit ion channels and protein interactions. AE-848/32615073 is a high purity, water-soluble compound with a CAS number of 1049986-31-3. It is used as a research tool in cell biology and pharmacology.</p>

<p>IL-7 is a cytokine that belongs to the IL-2 family. It is a lymphokine that regulates cell proliferation and differentiation of immune cells, such as T and B cells. IL-7 activates these cells by binding to the IL-7 receptor on their surface. The active form of IL-7 is a homodimeric glycoprotein consisting of two subunits, alpha and beta. The alpha subunit has an N-terminal sequence of amino acids (Lysine - Proline - Glycine) while the beta subunit has a C-terminal sequence (Serine - Asparagine). This protein can be purchased as a research tool, antibody, or purified peptide in high purity from Sigma Aldrich.</p>

<p>MNKI-85 is a small molecule that inhibits the activity of the mapk protein kinase and has minimal toxicity. MNKI-85 induces tumor regression in animal models and is being developed for the treatment of cancer. MNKI-85 induces apoptotic cell death by inhibiting translation, cellular transformation, and tumorigenesis. This drug also reduces leukemia cells by inhibiting protein synthesis and causing apoptotic cell death. Clinical trials are currently underway to assess the efficacy of this drug in patients with cancer.</p>

<p>Inhibitor of STAT3 transcriptional machinery</p>

<p>Neuromedin S Precursor-Related Peptide 37 (Rat) is a peptide that is used as a research tool. It has been shown to stimulate the release of calcitonin gene-related peptide and substance P from sensory neurons. Neuromedin S Precursor-Related Peptide 37 (Rat) is also an inhibitor of ion channels, including voltage-gated sodium channels and potassium channels. This peptide also interacts with proteins such as the receptor for neuromedin S precursor, which may be involved in the regulation of pain sensation, and the ligand for this receptor, which may play a role in regulating appetite.</p>

<p>Iberiotoxin is a neurotoxin that is synthesized by the bacterium Clostridium botulinum. It inhibits the activity of a number of enzymes, including protein kinase C and cyclase, but has no effect on phosphatases. Iberiotoxin has been shown to be effective against models systems of bowel disease, such as colonic inflammation and ulceration. Iberiotoxin binds to specific neuronal receptors in the central nervous system, leading to inhibition of intracellular calcium levels, which may play an important role in the mechanisms of action for this toxin.</p>

<p>CU-115 is an advanced anti-corrosion compound, which is a chemical formulation designed to protect metal surfaces. It is sourced from specialized synthesis processes involving corrosion inhibitors and binders that offer high efficacy in harsh environments. The mode of action involves forming a protective layer over metal surfaces, preventing exposure to moisture and corrosive agents, thus inhibiting oxidation and degradation.</p>

<p>RIP2 Kinase inhibitor 2 is a protein kinase inhibitor that inhibits the activity of RIP2 kinases. It has been shown to regulate apoptosis and cell cycle progression in cancer cells. The effectiveness of this drug has been demonstrated in animal models. A potential side effect of this drug is its ability to inhibit normalizing signals from the immune system, which may lead to an increased risk for autoimmune disorders. The effective dose for RIP2 kinase inhibitor 2 is unknown, but it can be monitored using analytical methods such as HPLC with UV detection or LC-MS/MS.</p>

<p>CCMI is a fatty acid that is found on the surface of Pseudomonas aeruginosa. It has been shown to have inhibitory activity against nitrite reductase, which may be a potential biomarker for this bacterium. CCMI also inhibits the growth of P. aeruginosa in a model system and can be used as an inhibitor of water vapor transport properties. CCMI has also been shown to have an inhibitory effect on chemical pesticides and can function as a chaperone in cells. CCMI has been found to have an inhibitory effect on cell lysis due to its disulfide bond.</p>

<p>Fluprostenol is a prostaglandin that binds to the nuclear receptor PPAR-α, which regulates lipid and glucose metabolism. Fluprostenol also inhibits the production of leukemia inhibitory factor in 3T3-L1 preadipocytes. It has been shown to possess antimicrobial activity against gram-negative bacteria and eye disorders. Fluprostenol has chemical stability, with a half-life of about 2 hours in human serum, which makes it suitable for use as an ophthalmic preparation. Fluprostenol has properties that are similar to other prostaglandins, such as low potency and pharmacokinetic properties. The LC-MS/MS method is used to measure fluprostenol concentrations in plasma. This method can be used for sample preparation with low potency compounds because it separates compounds based on molecular weight and not polarity or solubility.</p>

<p>KAN0438757 is a research compound that is being developed as a potential treatment for cancer. It has been shown to have anti-proliferative effects in vitro, and it has also been shown to inhibit transcription and translation of genes. KAN0438757 inhibits the activity of transcriptional regulators that are involved in tumorigenesis and metastasis, such as NF-κB, STAT3, and PI3K. KAN0438757 was found to be metabolically stable, with significant effects on the long-term efficacy of the drug. This compound may have translational significance because it could potentially be used for the treatment of different types of cancer.</p>

<p>GMC 2-118 is a receptor inhibitor that inhibits the binding of nitro compounds to the c1-6 alkyl group, which has been shown to have synergistic effects. GMC 2-118 has been shown to inhibit laminitis in horses, although its mechanism of action is unknown. GMC 2-118 may be an effective treatment for cancer, as it inhibits serotonin. It also has a heterocyclic ring with a nitrogen atom and a phenyl ring with a cisplatin group attached, which may help it bind to DNA.</p>

<p>Inhibitor of epigenetic regulator EZH2</p>

<p>Please enquire for more information about Benzyl benzoate-d12 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Agonist of metabotropic glutamate receptors (mGluR2/3)</p>

<p>CP-409092 is a drug that is used in colonoscopy to visualize the inner lining of the colon. It belongs to the molecule class, which is an aminophylline derivative that has been shown to be effective in humans. CP-409092 inhibits mitochondrial oxidases and can be used for the treatment of diseases such as Alzheimer's disease, Parkinson's disease, and Huntington's disease. CP-409092 also inhibits serotonin reuptake, which leads to its anti-depressant effects.</p>

<p>Compound 3a is a synthetic herbicide, which is a laboratory-engineered chemical agent with a unique mode of action. It is derived through an intricate process involving chemical synthesis techniques that target specific biochemical pathways in plants. The mode of action of Compound 3a involves the inhibition of a critical enzyme in the photosynthetic pathway, leading to disrupted energy production and ultimately plant death.</p>

<p>HDAC enzyme inhibitor; antineoplastic</p>

<p>PKC-IN-1 is a highly specific protein kinase C (PKC) inhibitor, which is synthetically derived to target PKC isoforms selectively. Its mode of action involves the inhibition of PKC activity through competitive binding at the ATP-binding site, effectively modulating the phosphorylation of downstream substrates. This regulatory effect on PKC activity makes it an essential tool for elucidating the role of PKC in various signaling pathways.</p>

<p>5-Chloro-3-pyridinyl 1H-indole-4-carboxylate is a small molecule that has been shown to inhibit the activity of ion channels and ligand binding receptors. This compound has been shown to be an activator of protein interactions and is a high purity, research tool with a CAS No. 1087243-14-8.</p>

<p>TC-P 262 is a synthetic chemical reagent, classified as an organic compound, which is derived from a series of controlled laboratory processes ensuring high purity and stability. This product exhibits its function primarily through catalytic properties, enabling the acceleration of specific chemical reactions without itself being consumed. Its mode of action involves facilitating the transition state of a reaction, thereby lowering the activation energy and increasing reaction efficiency.</p>

<p>N-{3-[(2-Chloro-acetyl)-(4-nitro-phenyl)-amino]-propyl}-2,2,2-trifluoro-acetamide is a synthetic compound that has been shown to inhibit the function of ion channels in vitro. This product can be used as a research tool for pharmacology and protein interactions. It has also been used as an inhibitor to study the effects of peptides on cell biology.</p>

<p>tert-Butyl 2-(4-{[4-(3-azidopropoxy)phenyl]azo}benzamido)ethylcarbamate is a ligand with high purity and good solubility. It has been used in research as an inhibitor of antibody, cell biology, and peptides. This compound binds to the receptor and blocks ion channels.</p>

<p>Anti TNF-Alpha (Rat) Monoclonal Antibody is a recombinant rat monoclonal antibody that binds to the TNF-α. It inhibits the effects of TNF-α and has been shown to protect against acute renal failure in rats. Anti TNF-Alpha (Rat) Monoclonal Antibody is a research tool for studying the function of TNF-α, and is used in pharmacological studies as an inhibitor of the enzyme protein kinase C. This antibody can be used for purification of proteins from cell culture or tissue samples.</p>

<p>Z-Gly-Gly-Arg-MCA is a peptide that is used as an activator. It binds to the receptor and activates the ion channel, which can lead to cell death. Z-Gly-Gly-Arg-MCA has been shown to inhibit protein interactions and has been used in research on cell biology and pharmacology.</p>

<p>Anti CRF (3-41), humanSerum is a peptide that belongs to the class of receptor ligands. It has been shown to inhibit the binding of CRF to its receptor and reduce the activity of ion channels. This molecule also inhibits protein interactions, specifically with chemokine receptors. The purity of this product is high, with a CAS number of 1027-87-0. CRF (3-41) is an antagonist that can be used as a research tool for pharmacology and cell biology studies. It has been shown to inhibit the binding of CRF to its receptor and reduce the activity of ion channels, which may lead to anti-inflammatory effects.</p>

<p>3-Nitrotetrazolium blue chloride is a potent inhibitor of bacterial growth in the presence of azide. It inhibits the production of xanthine oxidase by S. typhimurium and has been shown to have potent inhibitory activity against arvensis and rhamnocitrin, both of which are important for bacterial cell wall synthesis. 3-Nitrotetrazolium blue chloride also has antioxidant effects, which may be due to its ability to scavenge reactive oxygen species (e.g., superoxide) or its ability to reduce nitric oxide radicals. The flavonoids found in this compound are responsible for these effects. 3-Nitrotetrazolium blue chloride can also act as an antimutagen when it is incubated with DNA damage induced by ultraviolet light or a mutagenic chemical such as 2-nitrofluorene.</p>

<p>High quality, quantitated heavy/light peptide calibrator for angiotensinogen in Mass Spectroscopy research</p>

<p>N-Acetyl-3,4-dihydro-2-(2,6-dioxo-3-piperidinopyrimidin-1(2H)-yl)isoindoline-4-carboxylic acid is a potent immunostimulatory and anticancer drug. It is a homologous compound that induces activation of the immune system through h3 acetylation. NAA [N-Acetyl-3,4-dihydro-2-(2,6-dioxo-3piperidinopyrimidin 1(2H)-yl)isoindoline 4 carboxylic acid] has been shown to have regulatory effects on a number of other cell types. In vitro studies with MDA MB231 breast cancer cells showed that NAA induced apoptosis in these cells through the inhibition of histone h3 acetylation and increased expression of effector proteins such as all trans ret</p>

<p>The spontaneous death of cells is a ubiquitous phenomenon in living organisms. Cell death is an important biological process that occurs in many diseases and conditions, including cancer. The cell death process can be monitored by using fluorescent probes to detect the DNA damage resulting from ionizing radiation or chemotherapeutic drugs. Cells are manually lysed and then subjected to high-throughput analysis using a microarray. Fluorescent probes can also be used for detection of apoptotic cells, which are cells programmed to self-destruct due to stress or other factors. Quantigene is a microarray designed for the simultaneous detection of changes in gene expression as well as phosphatase activity, two key events in apoptosis. Quantigene has been used to study how women respond to radiotherapy and chemotherapy treatments for breast cancer.</p>

<p>3,4,5-Trihydroxycinnamic acid decyl ester is a cell-permeable and potent inhibitor of protein interactions. It has been shown to inhibit the activity of ligands such as ATP, ADP, and AMP. 3,4,5-Trihydroxycinnamic acid decyl ester can also be used as an activator for some receptors including cholinergic receptors and histamine H1 receptors. 3,4,5-Trihydroxycinnamic acid decyl ester is a high purity research tool that can be used in ion channel research. This compound has been used in antibody production studies.</p>

<p>A-192621 is a selective blocker of T-type calcium channels, which is a synthetic compound. It specifically interacts with the alpha-1G subtype of calcium channels, thereby inhibiting calcium ion influx through these channels. This blockade allows researchers to study the physiological and pathological roles of T-type calcium channels in the central nervous system and peripheral tissues.</p>

<p>Clomipramine-d3 HCl is a research tool. It is an activator of the receptor and ion channels, which may be used for cell biology research. Clomipramine-d3 HCl binds to various receptors, including those for serotonin and dopamine. This ligand is also a high-purity reagent with a purity of 99%. This product is intended for use in cell biology research that requires an activator or ligand that binds to receptors or ion channels.</p>

<p>Voruciclib hydrochloride is a selective inhibitor of the proteasome that has been shown to inhibit the production of cancer-causing proteins. It inhibits the activity of both cysteine and aspartyl proteases in the human proteasome. Voruciclib hydrochloride has been shown to be effective against breast, lung, prostate, and colon cancers. This drug is also an antiviral agent that can inhibit coronavirus replication. Voruciclib hydrochloride is used for treatment of malignant tumors due to its ability to inhibit proliferation and induce apoptosis in a number of cell lines. This drug has also been shown to be effective against SARS-CoV, which is a type of coronavirus.</p>

<p>FRETS-25Arg (1 umol) is a peptide that has been shown to activate the serotonin 2C receptor. The peptide is a high purity product with a CAS number of 9078-02-5. FRETS-25Arg (1 umol) can be used as a research tool for studying the protein interactions, receptor binding, and ion channels.</p>

<p>VU0463271 is a benzodiazepine receptor ligand that has been shown to inhibit neuronal function in vitro. VU0463271 has been found to increase the membrane potential of cells in a fluorescence assay and inhibits actin polymerization in vitro. It also inhibits the chronic treatment-induced decrease in chloride currents, which suggests a possible therapeutic effect for epilepsy. In vivo, VU0463271 has been found to have an inhibitory effect on the hippocampus of mice, as well as on extracellular chloride levels. This drug can be used for the treatment of neurological disorders such as epilepsy or anxiety.</p>

<p>Secretin (Porcine) Antiserum is a research tool that is used to activate the secretin receptor. Secretin is an inhibitor of ion channels, which may be due to its ability to bind to the secretin receptor and inhibit its activity. The purified protein has a high purity and can be used in antibody experiments, cell biology, or pharmacology.</p>

<p>Inhibitor of fatty acid amide hydrolase</p>

<p>Cantharidic acid is an anticancer agent that inhibits the energy metabolism of cancer cells by inhibiting the activity of key enzymes, such as phosphatase and cyclase. It has been shown to be effective in inducing antibody response in mice and reducing the number of regulatory T-cells. Cantharidic acid also induces apoptosis through a regulatory element, which may be responsible for the potent immunosuppressive effects of cantharidic acid. Clinical studies have found cantharidic acid to be effective against infectious diseases caused by bacteria, such as Salmonella and Staphylococcus.</p>

<p>2-(3,5-Dimethyl-1H-pyrazol-1-yl)-5-methylphenol is a potent kinase inhibitor that has been shown to inhibit the activity of various kinases in human cancer cells. This compound has shown promising anticancer activity and induces apoptosis in tumor cells. It is a medicinal analog of a Chinese herbal medicine and has been studied extensively for its potential use as an anticancer agent. 2-(3,5-Dimethyl-1H-pyrazol-1-yl)-5-methylphenol has been found to be effective against several types of cancer, including breast, lung, and colon cancer. Additionally, this inhibitor has been detected in urine samples from patients with cancer, indicating its potential as a biomarker for cancer diagnosis and prognosis. Its protein-binding properties make it an ideal candidate for further research into novel anticancer therapies.</p>

O-Desmorpholinopropyl-o-methyl-gefitinib is a cytotoxic drug that activates cancer cells. This compound has been shown to be reactive with colon cancer cells, inducing apoptosis and inhibiting the growth of cancer cells in vitro. O-Desmorpholinopropyl-o-methyl-gefitinib induces cell death in colon cancer cells by activating caspase 9 and caspase 3, which are enzymes that cleave proteins that activate other downstream effectors of apoptosis. O-Desmorpholinopropyl-o-methyl-gefitinib also inhibits the proliferation of human colorectal cancer cells (HCT116) and SW620 colon cancer cells.

<p>Sniper ER-87 is a potent and selective activator of the TRPM2 ion channel. Sniper ER-87 binds to TRPM2 with high affinity, and activates the channel with an EC50 of 0.4 μM in a cell-based assay. Sniper ER-87 is also able to inhibit activation of the TRPM2 ion channel by cold stimuli. The antibody can be used as a research tool for studying TRPM2 protein interactions, as well as pharmacological studies on TRPM2 ligands.</p>

<p>RNA Binding Motif Protein 3 (RBMY3) is a high-quality research peptide that is commonly used in scientific studies. It is a recombinant protein derived from Escherichia Coli. RBMY3 plays a crucial role in RNA metabolism and regulation, specifically in the binding and processing of RNA molecules. This protein is highly purified and has been extensively tested for its quality and functionality. Researchers rely on RBMY3 to study various cellular processes, including gene expression, mRNA splicing, and post-transcriptional modifications. With its exceptional purity and reliability, RBMY3 is an essential tool for any laboratory conducting cutting-edge research in the field of RNA biology.</p>

<p>Anti Humanin Serum is a research tool that can be used as a pharmacological reagent or as a research tool. It is an antibody that can be used to study protein interactions, such as receptor-ligand binding, and the effects of peptides on ion channels. This product is composed of high purity humanin antibodies with no detectable cross-reactivity with other proteins.</p>

<p>Thalidomide-o-amido-C6-NH2 TFA is an antibody that has been shown to interact with peptides, ligands, and receptors. Thalidomide-o-amido-C6-NH2 TFA is a high purity reagent used in cell biology research. It is a potent activator and inhibitor of ion channels and can be used to study the effect of ion channel inhibition on cellular function. It also has been shown to inhibit the activity of protein kinase C and phospholipase C as well as other receptor tyrosine kinases.</p>

<p>β-Pompilidotoxin is a neurotoxin that is found in the venom of the scorpion Pompilus. It binds to the ryanodine receptor, which is a type of calcium channel protein that regulates intracellular calcium levels. β-Pompilidotoxin blocks the release of calcium from the sarcoplasmic reticulum and inhibits the entry of calcium into cells by blocking voltage-gated sodium channels. It has been shown to be cytotoxic to ventricular myocytes and cerebellar purkinje neurons. β-Pompilidotoxin also has a physiological function in regulating glomerular filtration rate and preventing accumulation of intracellular calcium, which can lead to overload.</p>

<p>This is a research reagent that is an activator of the Ligand-Gated Ion channels. It has been shown to bind to the receptor and activate ion channels. PHA690509 is a potent inhibitor of GABA receptors, which are most likely involved in neuronal inhibition. It also inhibits ion channels for potassium and calcium ions, which are important for nerve cell function. PHA690509 is a high purity protein that does not contain any contaminating proteins or peptides. This product can be used as an antibody or ligand to study protein interactions, pharmacology, and peptide reactions.</p>

<p>Solvent Green 3 is a sulfa drug with bactericidal activity. It binds to the bacterial cell wall and prevents the production of folic acid, which is vital for bacterial growth. The binding of Solvent Green 3 to the cell wall increases thermal expansion, causing lysis of the bacteria. Solvent Green 3 has been used in sample preparation for analytical methods that require high sensitivity and accuracy. It has also been used to measure hydrochloric acid in food samples, as well as boron nitride in paint products. This drug also has acute toxicities and can be used as an analytical chemistry reagent for determining p-hydroxybenzoic acid and acyl chain content in various materials such as cell culture media or human plasma.</p>

<p>SPAI-1 is a protein that is found in the cytosol and nucleus of cells. It belongs to the family of inhibitor proteins, which regulate the activity of other proteins. SPAI-1 inhibits the activity of many different types of protein kinases. Inhibitors such as SPAI-1 are often used as research tools for studying protein interactions, activators, ligands, and receptors. This antibody can be used as a reagent to detect and locate SPAI-1 in cells or tissues by immunohistochemistry.</p>

<p>(4E, 8E)-Sphingadienine-c18-1-phosphate is a phospholipid derived from sphingadienine. It inhibits the activation of ion channels and ligand binding to receptors. (4E, 8E)-Sphingadienine-c18-1-phosphate also blocks the activity of protein kinases and enzymes involved in cellular signaling pathways. This may be due to its ability to inhibit the enzyme ATPase, which is responsible for hydrolyzing ATP molecules. (4E, 8E)-Sphingadienine-c18-1-phosphate has been shown to bind to both peptides and antibodies with high affinity.</p>

<p>BI 689648 is an amide drug that has been shown to be effective in treating hypertension in nonhuman primates. It is structurally similar to angiotensin II and blocks the binding of angiotensin II to its receptor, the mineralocorticoid receptor. This binding prevents the activation of the receptor and therefore reduces blood pressure. BI 689648 has a number of other effects, including inducing vasodilatation and inhibiting salt reabsorption, as well as blocking the production of aldosterone, which can lead to sodium loss. BI 689648 also binds to and inhibits mineralocorticoid receptors in cardiovascular tissue, which may help prevent cardiovascular diseases.</p>

<p>6-((1H-Pyrazolo[4,3-b]pyridin-3-yl)amino)-N-(3,3-difluorocyclobutyl)benzo[D]isothiazole-3-carboxamide is a peptide that has been shown to be an inhibitor of several protein interactions. 6-[(1H-pyrazolo[4,3-b]pyridin-3-yl)amino]-N-(3,3-difluorocyclobutyl)benzo[D]isothiazole 3 carboxamide has been shown to activate the Ligand and Receptor with high affinity. It is also used as a research tool for investigating ion channels and antibody production.</p>

<p>B-[(1E)-3-Chloro-1-propen-1-yl]boronic acid is a biologically active molecule that inhibits the synthesis of dopamine by competing with L-DOPA. It is used as a fluorescent probe for dopamine. B-[(1E)-3-Chloro-1-propen-1-yl]boronic acid has been shown to inhibit the activity of various enzymes, including human serum albumin and human alpha amylase. It can be used in polymerase chain reaction (PCR) and electrochemical impedance spectroscopy (EIS) to detect dopamine in biological samples.</p>

<p>Huwentoxin IV is a potent analgesic that has been shown to have antinociceptive properties in animals. Huwentoxin IV blocks the voltage-gated sodium channel NaV1.8 and prevents the transmission of pain signals to the brain. This drug has also been shown to inhibit the activity of voltage-gated potassium channels KV1.3 and KV1.5, which are involved in neuronal excitability, suggesting that huwentoxin IV may have other therapeutic applications. Huwentoxin IV interacts with disulfide bonds and is an effective inhibitor of voltage-gated sodium channels, but not voltage-gated potassium channels, at low concentrations (10 μM).</p>

<p>VIC (Mouse) is a peptide that is used as an inhibitor, activator, or ligand in research. It has the CAS number 120928-04-3 and the molecular weight of 4.5 kDa. VIC (Mouse) is a high purity product and can be used in life science research for characterization of receptor and ion channels. VIC (Mouse) can also be used as an antibody to study protein interactions as well as for cell biology research.</p>

<p>(4R)-Dorzolamide is a medicinal compound that acts as an inhibitor of kinases, a class of proteins that play important roles in cellular signaling pathways. This compound has been shown to be effective in inhibiting the growth of cancer cells in Chinese hamster ovary cells and human tumor cell lines. (4R)-Dorzolamide is an analog of other anticancer inhibitors, such as imatinib, and has been shown to induce apoptosis, or programmed cell death, in cancer cells. Additionally, this compound has been found in urine samples from patients receiving treatment for cancer, indicating its potential use as a diagnostic tool for detecting cancer. Overall, (4R)-Dorzolamide shows great promise as a potential anticancer agent with significant therapeutic potential.</p>

<p>1-Oleoyl-2-cholesterylhemisuccinoyl-sn-glycero-3-phosphocholine (1OCP) is a synthetic lipoprotein that can be used as a diagnostic agent for the diagnosis of cancer. 1OCP has been shown to bind to the lipoprotein lipase, an antigen specific to cancer cells. This binding allows for the detection and identification of cancer cells in biological samples. 1OCP can also be used as a diagnostic agent for citrullinemia and mycolic acid synthesis. It is also detectable by antibody response and can be used to study the expression of messenger RNA sequences in mammalian cells.</p>

<p>TCS-OX2-29 is an oxygen permeability analyzer, which is a scientific instrument designed to accurately measure the rate at which oxygen gas passes through barrier materials. It leverages precise electrochemical or coulometric sensors, which serve as the core technology for detecting and quantifying oxygen transmission rates under controlled conditions.</p>

<p>Er 27319 maleate is a diagnostic agent which may be used for the diagnosis of various cancers. It is an epithelial-mesenchymal transition (EMT) marker that activates the fatty acid receptor, PPARγ. Er 27319 maleate has been shown to have anticancer activity in a number of pre-clinical cancer models, including lymphocytic leukemia, pancreatic tumor cells, and prostate cancer cells. In addition to its anticancer activities, Er 27319 maleate has been shown to inhibit proliferation in a number of other cell types, such as activated T cells and heart cells. Er 27319 maleate also inhibits cholesterol synthesis and lowers plasma cholesterol levels in animals with hyperlipidemia.</p>

<p>PAF-AN-1 is a peptide that has been shown to activate ion channels. PAF-AN-1 is a potent inhibitor of the ion channel TRPM2 and has been shown to inhibit the interaction between TRPV4 and its ligand, menthol. PAF-AN-1 has also been shown to inhibit the activation of voltage gated potassium channels. This peptide can be used as a research tool for studying protein interactions and receptor signaling pathways.</p>

<p>SR-4995 is a synthetic, potent, and selective inhibitor of triglyceride lipase that blocks cellular uptake and breakdown of fatty acids. It has been shown to potently inhibit the release of fatty acids from adipose tissue and to reduce thermogenesis in rodents. SR-4995 is not active against antifungal drug resistant strains such as Candida albicans or Candida glabrata. SR-4995 also inhibits the synthesis of proteins involved in lipid metabolism and has been shown to reduce intracellular levels of fat in tissues such as liver, heart, kidney, and muscle.</p>

<p>FAUC-346 is a potent anticancer agent that induces apoptosis in cancer cells. It belongs to the class of inhibitors that target tumor growth and is used as a medicinal compound for cancer treatment. FAUC-346 is an analog of lincomycin, which has been shown to be an effective inhibitor of protein synthesis in bacteria. In cancer cells, FAUC-346 inhibits kinase activity and promotes apoptosis, leading to cell death. This drug has been tested on Chinese hamster ovary cells and human urine-derived bladder cancer cells, showing significant inhibition of tumor growth. FAUC-346 is a promising new drug candidate for the treatment of various types of cancer.</p>

<p>Myelin Oligodendrocyte Glycoprotein (MOG) is a glycoprotein that is expressed by oligodendrocytes and is essential for the myelinization of axons in the central nervous system. MOG has been associated with the development of multiple sclerosis and demyelinating diseases. Freeze-dried MOG is reconstituted with water before use, which may be beneficial for patients who cannot swallow pills or capsules. The reconstituted protein can be injected intravenously as an allograft. Myelin Oligodendrocyte Glycoprotein can also be used long-term after desiccating to prevent its degradation and loss of biological activity. The expansion of the chromosome carrying the gene for MOG has been shown to be associated with multiple sclerosis and other neurologic diseases.</p>

<p>BMS-753 is a synthetic retinoid that acts as an immunomodulatory agent. It has been shown to inhibit cell proliferation in muscle cells and suppress inflammatory bowel disease. BMS 753 is also able to inhibit the growth of opportunistic fungal infections, such as Candida albicans. The drug is a synthetic analog of all-trans retinoic acid (ATRA), which binds DNA and regulates gene transcription. It has been shown to decrease mitochondrial membrane potential and increase the expression of pluripotent stem cells in vitro. BMS 753 has been shown to have hepatocyte-like properties, including increased mitochondrial membrane potential and decreased lipid accumulation in liver cells, which may be due to its ability to regulate lipid metabolism.<br>BMS-753 has also been shown to prevent hepatic steatosis by inhibiting the synthesis of fatty acids in the liver, which may be due to its ability to regulate lipid metabolism.</p>

<p>Please enquire for more information about Lubiprostone-d7 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Cinaciguat is a pharmacological agent that activates guanylate cyclase. It has been shown to increase the level of intracellular cGMP, a second messenger that is involved in the regulation of diverse physiological processes, including blood pressure and heart rate. Cinaciguat has been shown to be effective for treatment of pulmonary hypertension and severe chronic heart failure. Cinaciguat may be an experimental biomarker for these conditions and other diseases with similar symptoms. The mechanism of action of cinaciguat is not fully understood, but it can be speculated that it inhibits the enzyme adenylyl cyclase by binding to its regulatory site on the beta-subunit of the enzyme.</p>

<p>WST-3 is a water-soluble tetrazolium dye. It is reduced by NADH in the presence of an electron mediator, such as 1-methoxy-5-methylphenazinium, to WST-3 formazan producing a dark red colour, which displays an absorption maxima of 433 nM.</p>

<p>α-Synuclein is a protein that is encoded by the SNCA gene, and is one of the main components of Lewy bodies, which are found in neurons in people with Parkinson's Disease. α-Synuclein has been shown to protect cells from stress and prevent their death. It also acts as a chaperone for other proteins, regulating their activity. This protein has been shown to be able to bind to GTPase activators and inhibit them from activating GTPases. The molecular weight of α-synuclein is 25 kDa and it has a pI value of 4.5. It has an acidic C-terminus and its shift on gel electrophoresis is 11.5 kDa</p>

<p>IL-11 is a cytokine that is synthesized by cells of the immune system and functions as an autocrine growth factor for cells of the myeloid lineage. IL-11's receptor is a protein that binds to the IL-11 peptide and this binding activates intracellular signaling pathways.</p>

<p>Anti Nociceptin / Orphanin FQ (Human, Rat) Serum is a peptide that belongs to the family of orphanin FQ peptides. It has been shown to activate ion channels and ligand-gated channels. Anti Nociceptin / Orphanin FQ (Human, Rat) Serum is a high purity, pharmacology research tool for use in cell biology and receptor studies.</p>

<p>PF-06649283 is an antibody-drug conjugate (ADC), which is a targeted biopharmaceutical agent designed to deliver cytotoxic agents specifically to cancer cells. This innovative product is derived from a combination of a monoclonal antibody, which is utilized for its ability to bind selectively to specific antigens on tumor cells, and a potent cytotoxic drug, which is linked to the antibody. The mode of action involves the ADC binding to its target antigen on the cancer cell surface, followed by internalization of the ADC-antigen complex. Once inside the cell, the cytotoxic drug is released, leading to disruption of critical cellular functions and subsequent cancer cell death.</p>

<p>Bay 41-4109 racemate is a small molecule inhibitor, which is synthetically derived, with a specific mode of action that involves the modulation of cGMP-dependent protein kinase (PKG) pathways. This modulation affects various cellular processes, particularly those related to viral replication and protein expression.</p>

<p>Mobocertinib is a small molecule that binds to the receptor tyrosine kinase AXL and blocks the activation of this protein. It has been shown to inhibit tumor growth in mouse models of different cancers, including lung, breast, pancreatic and ovarian tumors. Mobocertinib also inhibits the activity of other proteins that are involved in cancer cell signaling, such as LYN, SYK and SLP-76. This drug is highly purified and can be used as a research tool to study protein interactions.</p>

<p>Hexakis(p-bromophenoxy)cyclotriphosphazene is a peptide that belongs to the group of activators. It is used in research as a tool for studying ion channels and protein interactions. Hexakis(p-bromophenoxy)cyclotriphosphazene has been found to be an inhibitor of the activation of ion channels by G proteins, binding to the receptor and blocking its ability to bind G proteins. This molecule has also been shown to act as a ligand for receptors, binding with high affinity and specificity.</p>

<p>Pirlindole is a reversible inhibitor of cholinesterase that is used for the treatment of infectious diseases. Pirlindole is an acetylcholine esterase inhibitor and has been shown to inhibit growth factor-induced cell proliferation in human cancer cells. It has also been shown to have antiviral activity against certain viruses such as herpes simplex virus types 1 and 2, vesicular stomatitis virus, reovirus type 3, and influenza A virus. Pirlindole has also been found to have anti-inflammatory properties because it inhibits prostaglandin synthesis.</p>

<p>MK2 Inhibitor III is a pharmacological agent, specifically a selective inhibitor, that intervenes in the MAPKAPK2 (MK2) signaling pathway. It is derived through chemical synthesis, designed to obstruct the activity of the mitogen-activated protein kinase-activated protein kinase 2 (MK2). This inhibition occurs through competitive binding at the ATP-binding site of MK2, effectively reducing the activity of this kinase involved in the stress response pathway.</p>

<p>BET-BAY 002 is a small molecule that binds to the BET family of bromodomain proteins. Bromodomain proteins are found in a number of cell types and are involved in transcriptional regulation, DNA repair, and cell proliferation. BET-BAY 002 has been shown to inhibit the growth of cancer cells by blocking the homologous recombination repair pathway. The clinical trials revealed that BET-BAY 002 has no effect on healthy cells and is therefore safe for use in humans.</p>