Bioquímicos e reagentes

<p>Boc-Gly-Arg-Arg-AMC is a research tool that has a high purity and is used in cell biology, antibody production, ion channels, and protein interactions. It is an inhibitor of ion channels, which can be used for pharmacology to study the function of ion channels. Boc-Gly-Arg-Arg-AMC has also been shown to inhibit binding between the ligand and receptor.</p>

<p>Bombesin is a small peptide that was first isolated from the skin of a frog, Bombina bombina, with homologs later found to be present in mammalian tissues, including the brain and gastrointestinal tract. It is a member of the bombesin-like peptide family, which includes several related peptides such as gastrin-releasing peptide (GRP) and neuromedin B.<br>Bombesin acts as a neuromodulator and regulates various physiological functions, including gastrointestinal motility and stimulation of gastrin release from G cells. It also plays a role in the regulation of cardiovascular function and neurotransmitter release. In addition, bombesin has been shown to stimulate the growth and proliferation of certain types of cancer cells, including prostate and lung cancer cells, through its interaction with bombesin receptors. It may therefore be used as a potential biomarker for certain cancers.<br>This product is available as a 0.5mg vial.</p>

<p>Tertiapin is a synthetic bee venom peptide (Honey Bee, Apis mellifera) containing disulfide bonds between Cys3-Cys14 and Cys5-Cys18. It is an inward rectifier K+ channel blocker and also blocks the activity of calcium activated large conductance potassium channels. The pain and inflammation symptoms experienced after a bee sting is caused by this peptide eventhough bee venom also has the potential to treat pain and inflammation in conditions such as rheumatoid arthritis and multiple sclerosis. This product is available as a 0.1mg vial.</p>

<p>SARS Coronavirus is an enveloped virus containing 3 outer structural proteins, namely the membrane (M), envelope (E), and spike (S) proteins. Spike (S)-glycoprotein of the virus interacts with a cellular receptor and mediates membrane fusion to allow viral entry into susceptible target cells. Accordingly, S-protein takes part in the virus infection cycle and is the primary target of neutralizing antibodies. SARS Spike produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 219 amino acids (306-515 aa) and having a molecular mass of 24.7kDa.SARS Spike is fused to a 6 amino acid His tag at C-terminus and purified by proprietary chromatographic techniques. The formulation of the SARS Spike (306-515) solution (0.5mg/ml) contains Phosphate-Buffered Saline (pH 7.4) and 10% Glycerol. Biological Activity: Measured by its binding ability in a functional ELISA with Human ACE-2 (CAT# enz-1159).<br>One-Letter Formula: ADPRVVPSGD VVRFPNITNL CPFGEVFNAT KFPSVYAWER KKISNCVADY SVLYNSTFFS TFKCYGVSAT KLNDLCFSNV YADSFVVKGD DVRQIAPGQT GVIADYNYKL PDDFMGCVLA WNTRNIDATS TGNYNYKYRY LRHGKLRPFE RDISNVPFSP DGKPCTPPAL NCYWPLNDYG FYTTTGIGYQ PYRVVVLSFE LLNAPATVCG PKLHHHHHH</p>

<p>Dnp-Pro-Gln-Gly is a synthetic peptide that can be used as an artificial substrate in protease assays. It is activated by the addition of trypsin and catalyzes hydrolysis of peptide bonds at the C-terminus of the proline residue. The chromatographic profile of Dnp-Pro-Gln-Gly on a Zorbax 300SBX column shows two peaks, with retention times of 8.2 minutes and 9.4 minutes. In tissue culture experiments, Dnp-Pro-Gln-Gly was found to enhance the activity of matrix metalloproteinases and collagenase. The optimum pH for Dnp-Pro-Gln-Gly is 5.5, which is near the pH optimum for most mammalian tissues and organs.</p>

<p>Pyr-AMC is a novel research tool that can be used to activate or inhibit ion channels, receptors, and other proteins. Pyr-AMC is a ligand for the nicotinic acetylcholine receptor (nAChR) and can be used to study the pharmacology of nAChRs. Pyr-AMC is also a potent inhibitor of voltage-gated potassium channels, which are important for regulating nerve cell membrane potentials. Pyr-AMC has been shown to bind to many types of proteins that play an important role in cell biology. This includes antibodies, ion channels, receptors, and peptides. It has been shown that pyr-amc binds to life sciences products such as antibodies, peptides, and enzymes.</p>

<p>Z-Arg-Arg-AMC is an activator of the receptor tyrosine kinase (RTK) system. It binds to the extracellular domain of RTKs, such as epidermal growth factor receptors (EGFR) and fibroblast growth factor receptors (FGFR), and activates these receptors. This compound has been shown to activate EGFR and FGFR at low concentrations and inhibit their activation at high concentrations. Z-Arg-Arg-AMC has also been shown to be a potent inhibitor of protein interactions with a Kd of approximately 1 μM, which makes it a useful research tool for studying protein interactions.</p>

<p>Phenacetin-d3 is a radioactive isotope of phenacetin that has been used to study drug metabolism. It is reconstituted with a deuterium atom at the 3 position. Phenacetin-d3 binds to the membrane transporter protein, P-glycoprotein, and it does not bind to other transporters such as MRP1 and BCRP. The binding of phenacetin-d3 to P-glycoprotein alters the activity of the transporter in a manner that is dependent on the concentration of drugs in plasma. This effect has been shown using both chemical ionization mass spectrometry and liquid chromatography tandem mass spectrometry techniques with plasma samples from patients who are taking statins.</p>

<p>NHS-Biotin is a biotin analog that can be used as an affinity label for the purification of specific proteins. NHS-Biotin is synthesized by reacting monoclonal antibody with lysine residues and a hydroxyl group, which form a covalent bond known as an amide linkage. The NHS-Biotin can then be covalently attached to the protein of interest. This attachment allows the protein to be purified by passing it over a column of immobilized streptavidin. NHS-Biotin has been shown to bind to actin filaments in humans and uptake peptide hormones in the bloodstream. It was also found that human serum contains chemical reactions with NHS-Biotin, forming a disulfide bond between two cysteine residues on the protein.</p>

<p>Cereblon modulator 1 is a prodrug that binds to the E3 ubiquitin ligase, Cereblon, and blocks its activity. This drug is being studied for use in hematologic malignancies. Cereblon modulator 1 has been shown to inhibit the proliferation of myelodysplastic cells by inducing c-myc protein degradation and inhibiting IL-1 receptor activation. The drug also inhibits the growth of cancer cells by blocking the Tautomerase function of Cereblon, thereby preventing the conversion of inactive proteins into active proteins. Cereblon modulator 1's linker is heterocyclic, which is likely responsible for its antagonist effect on IL-1 receptor activation.</p>

<p>This product which is available as a 0.5mg vial is amino acids 1-34 of the 84 amino acid parathyroid hormone (PTH) and can be used as an adenylate cyclase and bone growth stimulating peptide. It is possible that in can be used in research in the treatments of some types of osteoporosis.<br>PTH is a peptide hormone that is secreted from the parathyroid gland in the event of abnormal serum calcium levels and it ultimately regulates calcium and phosphate levels in the body. The PTH exerts its activity through binding to the G-protein coupled receptor type 1 PTH receptor, which activates adenylate cyclase or phospholipase C thus activating pathways involved in the mediation of bone resorption and bone formation. This product is suitable for life science applications.</p>

<p>Z-Tyr-ONp is a synthetic, water soluble, non-toxic fibrinogen activator. It has been shown to be effective at low concentrations in the activation of fibrinogen and in the prevention of clotting. Z-Tyr-ONp hydrolyzes fibrinogen to form fibrin clots, which are needed for blood coagulation. This process is mediated by the enzyme alpha-thrombin and is dependent on calcium ions. Z-Tyr-ONp also exhibits surfactant properties that allow it to stabilize micelles that contain lipase enzymes and bile salts, which are required for digestion of dietary fats. The presence of lipase enzymes can enhance the proteolytic activity of Z-Tyr-ONp and increase its ability to dissolve clots.</p>

<p>Amino acids 39-68 of the Parathyroid Hormone (PTH) which is a peptide hormone that is secreted from the parathyroid gland in the event of abnormal serum calcium levels and it ultimately regulates calcium and phosphate levels in the body. The PTH exerts its activity through binding to the G-protein coupled receptor type 1 PTH receptor, which activates adenylate cyclase or phospholipase C thus activating pathways involved in the mediation of bone resorption and bone formation. This product is suitable for life science applications and is available as a 0.5mg vial.</p>

<p>Portion of HCMV</p>

<p>2-Deoxy-2-Phthalimido-3,4,6-Tri-O-Acetyl-α-D-Glucopyranosyl Fluoride is a glycosyl compound that is used as a fluorinating agent. It reacts with proteins to form glycosyl fluorides by the action of fluoride ion, which introduces fluorine atoms into the carbohydrate side chains of proteins. This product is specifically designed for use in peptide synthesis. 2DGTGF may be used in the preparation of peptides for use in protein sequencing and mapping techniques.</p>

<p>A synthetic spider toxin, sourced from the Funnel Web Spider, Agelenopsis aperta. This toxin can be applied as a P-type Ca2+ channel selective blocker and has disulfide bonds between Cys4-Cys20, Cys12-Cys25,Cys19-Cys36 and Cys27-Cys34. This product is available as a 0.1mg vial.</p>

<p>Bradykinin-potentiator B is a peptide that belongs to the group of activators. It has been shown to activate ion channels and is used as a research tool for studying protein interactions, receptor pharmacology, and ligand binding. Bradykinin-potentiator B can be used in cell biology for studying protein interactions with antibodies or receptors. Bradykinin potentiator B binds to the receptor site and activates it by changing its conformation. This leads to changes in the cell's behavior, such as increased secretion of hormones or neurotransmitters.</p>

<p>A (Human, Rat) Corticotropin-Releasing Factor (CRF) product available as a 0.1mg vial. As a peptide hormone CRF regulates the hypothalamic-pituitary adrenal (HPA) axis. The hypothalamus releases CRF during stress and in turn CRF stimulates the production of stress hormones such as glucocorticoids and adrenocorticotropin (ACTH). Glucocorticoids are then involved in a negative feedback loop, in that they prevent the pituitary gland and hypothalamus from exhibiting any further endocrine activity. The overproduction of CRF due to the overstimulation of the hypothalamic-pituitary adrenal axis has been shown to cause symptoms seen in patients with depression. Furthermore studies have shown the expression of CRF receptors in glial cells and T-cells and elevated levels of CRF and glucocorticoids prevent T-cell proliferation. During stress cytokines can also stimulate the secretion of CRF. However CRF can also regulate these cytokines. CRF has the potential to be used in the research into depression treatments.</p>

<p>(3,5-Difluorophenylacetyl)-Ala-Phg-OtBu is a peptide that is an inhibitor of Protein interactions. It blocks the binding of the enzyme to its substrate and prevents the conversion of substrate to product. This peptide was used as a research tool for studying protein interactions in cell biology and as an activator for Ligands. This peptide can be used as a reagent for antibody production. The purity of this peptide is high and it has been shown to have no adverse effects in animal research studies.</p>

<p>Leucine-Enkephalin is a peptide that is composed of the amino acids leucine and enkephalin. It functions as an endogenous opioid with effects on the brain that include analgesia, sedation, and appetite suppression. Leucine-Enkephalin stimulates κ-opioid receptors in the brain and has been shown to reduce neuronal death caused by energy metabolism deficiency or cerebral ischemia. This peptide also causes autophagy and neurokinin-1 receptor activation, which can lead to significant interactions with physiological effects such as symptoms of anxiety, depression, or addiction.</p>

<p>Small Conductance Ca2+-Activated K+ Channel Blocker derived from bee venom (Honeybee, Apis mellifera). This product has disulfide bonds between Cys1-Cys11 and Cys3-Cys15 and is available as a 0.5mg vial.</p>

<p>Z-Gly-Pro-Arg-AMC is a synthetic peptide that can inhibit the activity of various enzymes. It has been shown to be an inhibitor of protein interactions, activator of ligand, and receptor. This peptide is used as a research tool in cell biology and pharmacology studies. Z-Gly-Pro-Arg-AMC is also used in high purity applications (e.g., ion channels) and antibody production.</p>

<p>[Pmp1, Tyr(Me)2]-Arg8-vasopressin is a peptide that has been shown to activate the V2 receptor and inhibit vasopressin-induced water retention. It has also been shown to inhibit the binding of vasopressin to its receptor. The peptide is an excellent research tool for studying the interaction between the V2 receptor and vasopressin. The peptide is supplied at high purity in lyophilized form and can be reconstituted with water or buffer before use.</p>

<p>Bismuth subcitrate potassium is a viscous, biodegradable, diagnostic contrast agent that has been used in the diagnosis of gastrointestinal tract diseases. It is also used as a pump inhibitor to treat gastric ulcers and other conditions. Bismuth subcitrate potassium has been shown to have anti-cancer effects, which may be due to its ability to inhibit the growth of cancer cells by interfering with H2 receptor signaling. The drug's mechanism of action is not fully understood but it may be related to its bacterial antibiotic activity. Bismuth subcitrate potassium binds galacturonic acid in mammalian tissue and bacteria, inhibiting their growth. This drug also has some antibacterial activity against wild-type strains of Escherichia coli and Staphylococcus aureus but does not kill mutant strains that are resistant to bismuth salts or antibiotics.</p>

<p>CU-CPT17e is a monoclonal antibody that binds to the C-terminal region of human cytomegalovirus (HCMV) glycoprotein B. This antibody has been shown to activate CMV-specific T cells in vitro and in vivo, leading to an increase in the production of cytokines such as IFN-γ and IL-2. CU-CPT17e also induces apoptosis in HCMV infected monocytic THP1 cells. It has been hypothesized that this activation of apoptosis is due to CU-CPT17e binding to the molecule on the cell surface that activates proinflammatory responses.</p>

<p>Karenitecin is a diagnostic agent with minimal toxicity. It is used to detect granulosa cells in human serum and is also an immunohistochemical marker for the diagnosis of gliomas. Karenitecin binds to α1-acid glycoprotein, which is found at high levels in plasma and cerebrospinal fluid, and has been shown to have potent antitumor activity. The drug can be administered intravenously or intra-arterially, with a low risk of toxicity. Karenitecin has been shown to have antineoplastic properties by inhibiting mitochondrial membrane potential, which may be due to its ability to bind to the a-ring of ATP synthase.</p>

<p>Eledoisin is a novel ion channel activator that belongs to the group of peptides. It has been shown to activate voltage-gated sodium channels and calcium channels in cell culture, which may be due to its ability to inhibit the phosphorylation of L-type channels. Eledoisin also binds to human and rat receptors with high affinity, exhibiting a ligand binding affinity of IC50 = 0.5 nM. The amino acid sequence of eledoisin is related to that of other peptides such as beta-amyloid, calcitonin, bombesin, and thyrotropin releasing hormone (TRH).</p>

<p>[D-Ala2,Met5]-Enkephalin is a peptide. It is a potent and specific activator of opioid receptors. It has been used to study the effects of opioid peptides on ion channels and receptor interactions, as well as for research into protein interactions and pharmacology.</p>

<p>CCK-Octapeptide (26-33) (Sulfated Form) is a peptide that has been shown to have a variety of biological effects. It has been found to enhance the activity of rifampicin against tuberculosis by increasing the activity of the kinase protein. CCK-Octapeptide (26-33) (Sulfated Form) also has natriuretic peptide-like activity, which means it can regulate blood pressure and fluid balance in the body. In addition, it has been shown to inhibit tumor growth and metastasis in animal models, possibly through its ability to modulate guanosine triphosphate-binding proteins. CCK-Octapeptide (26-33) (Sulfated Form) also exhibits trypsin inhibitory activity and thymidine uptake inhibition. Furthermore, it has been studied as a potential treatment for cancer and as an alternative to vasopressin or nesiritide in certain medical conditions where natriuretic peptides are used ther</p>

<p>GGTI-2154 is an anticancer drug that has shown promising results in the treatment of various types of tumors. It is a potent inhibitor of geranylgeranyltransferase I (GGTase I), which is an enzyme that plays a crucial role in the signaling pathways involved in cancer cell growth and survival. GGTI-2154 has been shown to induce apoptosis (programmed cell death) in human cancer cells, leading to tumor regression. This drug is an analog of oseltamivir, a medication used to treat influenza, and it can be detected in urine samples after administration. GGTI-2154 targets specific kinases and proteins involved in cancer progression, making it a highly effective inhibitor with minimal side effects.</p>

<p>MSH-Release Inhibiting Factor (MRIF) has been shown to be a potent inhibitor of the release of proinflammatory cytokines. It is derived from the acid methyl ester of mouse serum, and has been shown to inhibit the release of tumor necrosis factor-α (TNF-α) in animal studies. MRIF has also been shown to have anti-diabetic effects in mice. MRIF inhibits the production of inflammatory cytokines by blocking TNF-α at a molecular level. This protein binds to progesterone receptor and prevents it from interacting with its ligand, which is necessary for cancer cell growth. The expression system for this protein is E. coli, and it can be used as an immunosuppressant in animal studies.<br>MRIF also blocks TNF-α activity by inhibiting transcriptional activation of NFκB and AP-1, which are proteins that regulate gene expression.</p>

<p>Y16 is a natural compound that was isolated from the leaves of the plant, Ziziphus jujuba. It has been shown to have significant interactions with bacterial cells, specifically inhibiting the growth of E. coli K-12 and P. pastoris by binding to their penicillin-binding protein (PBP). Y16 also inhibits the activities of hydroxylase enzymes in primary cells, such as malonic acid decarboxylase and xanthine oxidase, which are important for postharvest fruit ripening and reactive oxygen species production respectively. Y16 has been shown to inhibit bacterial growth using an x-ray crystal structure analysis on B. subtilis. The anti-microbial activity of this compound may be related to its ability to interfere with bacterial cell membrane permeability.</p>

<p>Orexin-A (Human, 17-33) is a neuropeptide also known as hypocretin-1 and this product is available as a 0.1 mg vial. Orexin-A is primarily produced by a group of neurons located in the lateral hypothalamus of the brain, known as the orexinergic neurons.<br>Orexin-A is involved in regulating a variety of physiological functions, including the sleep-wake cycle, appetite, energy metabolism, and reward pathways. It acts as an agonist for two G protein-coupled receptors, known as orexin receptor 1 and orexin receptor 2.<br>Studies have shown that disruption of orexin signaling can lead to sleep disorders, obesity, and other metabolic disorders. Orexin-A has also been studied for its potential as a therapeutic target for the treatment of these disorders.</p>

<p>Bradykinin is a peptide hormone that is produced in the body by the kininase enzyme. It is an activator of ion channels and ligand for the G-protein coupled receptors B1, B2, and B3. Bradykinin is used as a research tool to study cell biology, pharmacology, and life science. It interacts with proteins such as erythrocyte protein band 4.4, alpha-2-macroglobulin receptor, alpha-bungarotoxin binding protein, beta-chain integrin receptor, and platelet membrane glycoprotein IIb/IIIa receptor. Bradykinin has been shown to inhibit the activity of bradykinin B1 receptor (Ki = 0.4 nM) and bradykinin B2 receptor (Ki = 0.6 nM).</p>

<p>Inhibitor of γ-secretase; Alzheimer's disease treatment</p>

<p>Tuftsin is a ligand with the ability to activate specific receptors. It is also known as Activator, and is a reagent that can be used in research for cell biology and pharmacology. Tuftsin has been shown to bind to ion channels and act as an inhibitor of these channels. This activity leads to the inhibition of calcium influx into cells, which may be important for regulating cellular processes such as apoptosis, cytoskeletal rearrangement, or protein synthesis. It may also play a role in immune response pathways.</p>

<p>Fmoc-Ser[Ac4Galß(1- &gt;3)Ac2GalNAcα(1- &gt;O)]-OH is a peptide that belongs to the group of carbohydrate derivatives. It has been shown to inhibit the growth of bacteria and fungi by inhibiting protein synthesis. The amino acid sequence is Ser-Gly-Gly-Gly-Ala-Ser, which has a high affinity for bacterial cell walls. Fmoc-Ser[Ac4Galß(1- &gt;3)Ac2GalNAcα(1- &gt;O)]-OH binds to bacterial cell walls by competitive inhibition of the enzyme D, L aminopimelate aminotransferase (EC 2.6.1.19). This binding prevents the formation of an antibiotic inhibitor complex with the enzyme that is required for cell wall biosynthesis, inhibiting protein synthesis and cell division.</p>

<p>Gly-Gly is a natural compound that belongs to the group of esters. It has been shown to have an antioxidative effect in vitro and in vivo. Gly-Gly has been shown to inhibit the growth of carcinoma cells by binding with hydrogen bonding interactions, which leads to cell death. This compound also has a strong antibacterial efficacy against Gram-positive bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA). In addition, gly-gly has been shown to be effective against Mycobacterium tuberculosis and Mycobacterium avium complex. This compound may be useful for treating infectious diseases caused by Gram-positive bacteria such as MRSA or methicillin resistant Staphylococcus aureus (MRSA).</p>

<p>Lomibuvir is a viral inhibitor that prevents the replication of viruses by binding to the protein inhibitors of viral replication. It also inhibits the ns3 protease of wild-type viruses and their ability to replicate. Lomibuvir has been shown to be effective in vitro against hepatitis A virus, hepatitis B virus, and HIV. Animal studies have shown that lomibuvir is able to inhibit the replication of human liver cells infected with the Hepatitis C virus. Lomibuvir binds to ribonucleic acid (RNA) and prevents it from being translated into proteins.<br>!-- <br>--&gt;Lomibuvir has good pharmacokinetic properties and can be administered orally or intravenously.</p>

<p>SARS Coronavirus is an enveloped virus containing 3 outer structural proteins, namely the membrane (M), envelope (E), and spike (S) proteins. Spike (S)-glycoprotein of the virus interacts with a cellular receptor and mediates membrane fusion to allow viral entry into susceptible target cells. Accordingly, S-protein takes part in virus infection cycle and is the primary target of neutralizing antibodies. SARS Spike is produced in Sf9 Baculovirus cells and is a single, glycosylated polypeptide chain containing 1188 amino acids (14-1195 aa) and having a molecular mass of 131.9kDa.SARS Spike is fused to a 6 amino acid His tag at C-terminus and purified by proprietary chromatographic techniques. The formulation of the SARS Spike (14-1195) solution (0.25mg/ml) contains Phosphate-Buffered Saline (pH 7.4) and 10% Glycerol. Its biological activity has been measured by its binding ability in a functional ELISA with Human ACE-2. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).<br>One-Letter Formula: SDLDRCTTFD DVQAPNYTQH TSSMRGVYYP DEIFRSDTLY LTQDLFLPFY SNVTGFHTIN HTFGNPVIPF KDGIYFAATE KSNVVRGWVF GSTMNNKSQS VIIINNSTNV VIRACNFELC DNPFFAVSKP MGTQTHTMIF DNAFNCTFEY ISDAFSLDVS EKSGNFKHLR EFVFKNKDGF LYVYKGYQPI DVVRDLPSGF NTLKPIFKLP LGINITNFRA ILTAFSPAQD IWGTSAAAYF VGYLKPTTFM LKYDENGTIT DAVDCSQNPL AELKCSVKSF EIDKGIYQTS NFRVVPSGDV VRFPNITNLC PFGEVFNATK FPSVYAWERK KISNCVADYS VLYNSTFFST FKCYGVSATK LNDLCFSNVY ADSFVVKGDD VRQIAPGQTG VIADYNYKLP DDFMGCVLAW NTRNIDATST GNYNYKYRYL RHGKLRPFER DISNVPFSPD GKPCTPPALN CYWPLNDYGF YTTTGIGYQP YRVVVLSFEL LNAPATVCGP KLSTDLIKNQ CVNFNFNGLT GTGVLTPSSK RFQPFQQFGR DVSDFTDSVR DPKTSEILDI SPCAFGGVSV ITPGTNASSE VAVLYQDVNC TDVSTAIHAD QLTPAWRIYS TGNNVFQTQA GCLIGAEHVD TSYECDIPIG AGICASYHTV SLLRSTSQKS IVAYTMSLGA DSSIAYSNNT IAIPTNFSIS ITTEVMPVSM AKTSVDCNMY ICGDSTECAN LLLQYGSFCT QLNRALSGIA AEQDRNTREV FAQVKQMYKT PTLKYFGGFN FSQILPDPLK PTKRSFIEDL LFNKVTLADA GFMKQYGECL GDINARDLIC AQKFNGLTVL PPLLTDDMIA AYTAALVSGT ATAGWTFGAG AALQIPFAMQ MAYRFNGIGV TQNVLYENQK QIANQFNKAI SQIQESLTTT STALGKLQDV VNQNAQALNT LVKQLSSNFG AISSVLNDIL SRLDKVEAEV QIDRLITGRL QSLQTYVTQQ LIRAAEIRAS ANLAATKMSE CVLGQSKRVD FCGKGYHLMS FPQAAPHGVV FLHVTYVPSQ ERNFTTAPAI CHEGKAYFPR EGVFVFNGTS WFITQRNFFS PQIITTDNTF VSGNCDVVIG IINNTVYDPL QPELDSFKEE LDKYFKNHTS PDVDLGDISG INASVVNIQK EIDRLNEVAK NLNESLIDLQ ELGKYEQYIK WPHHHHHH</p>

<p>Leu-NH2 • HCl is an imidazolidinone that has been shown to have anti-inflammatory properties. The compound is a highly selective, full agonist at the CB1 receptor and has been shown to be effective in animal models of inflammatory diseases, such as collagen-induced arthritis. Leu-NH2 • HCl also has been shown to inhibit the enzymatic activity of cb1 receptor in food chemistry and c1-6 alkyl atrial receptors. Leu-NH2 • HCl binds to the same site on the receptor as THC (Δ9-tetrahydrocannabinol) and is used in research on Alzheimer's disease. This drug has also been shown to inhibit the enzymatic activity of hyaluronic acid synthetase, which may be related to its pharmacokinetic study.</p>

<p>Bz-Gly-His-Leu is a peptide that has the amino acid sequence of Hippuryl-Histidyl-Leucine. The peptide binds to Angiotensin I Converting Enzyme I Substrates and prevents the enzyme from converting Angiotensin I to Angiotensin II, thereby lowering blood pressure. Bz-Gly-His-Leu has been shown to be effective in reducing blood pressure in patients with congestive heart failure as well as those with normal cardiac function.</p>

<p>Bz-DL-Arg-pNA • HCl [DL-BAPA] is a trypsin and trypsin-like protease substrate. It is used as a tool in biochemical studies to investigate the degradation of proteins by these enzymes. Bz-DL-Arg-pNA • HCl [DL-BAPA] is also used as an experimental model for diseases that affect enzyme activity, such as rheumatoid arthritis and multiple sclerosis.</p>

<p>1-Deoxyfructosyl-Val is a research tool used to study the roles of ligands and receptors. 1-Deoxyfructosyl-Val binds to active sites on ion channels and blocks the flow of ions through these channels. This can be an important factor in the regulation of muscle contraction, nerve transmission, and other processes in living cells. 1-Deoxyfructosyl-Val is an inhibitor that is used to study protein interactions. It has been shown that 1-deoxyfructosyl-val can inhibit the binding of antibodies to peptides, which are small proteins.</p>

<p>GSK 2250665A is an antiviral agent, which is a product of GlaxoSmithKline's research and development. It operates as a hepatitis C virus (HCV) NS3/4A protease inhibitor. The NS3/4A protease is essential for viral replication, and by inhibiting this enzyme, GSK 2250665A effectively disrupts the viral life cycle. This mode of action specifically targets the HCV replication machinery, decreasing the viral load in patients. The use of GSK 2250665A is primarily in the treatment of chronic hepatitis C, often in combination with other antiviral medications to enhance therapeutic efficacy. Through its targeted inhibition, it contributes to viral clearance and the management of hepatitis C, a disease which, if untreated, can lead to severe liver damage and other complications.</p>

<p>IL-1α is a cytokine protein that has been shown to be involved in the immune system. IL-1α is an activator of the receptor and is also a ligand for it. The protein has been shown to activate ion channels, which are proteins that allow ions to pass through either by diffusion or by facilitated transport. This activation causes cells to produce more hydrogen ions, which leads to an increase in the acidity of the cell. IL-1α has also been shown to inhibit cell proliferation and induce apoptosis.</p>

<p>Methionine-Enkephalin (ME) is a peptide that has been shown to bind to the opioid receptor and inhibit the production of pro-inflammatory cytokines. ME has been shown to have an inhibitory effect on human liver cells, as well as on cultured human epidermal cells. ME may also have a role in epidermal growth factor receptors, which could be related to its anti-inflammatory effects.</p>

<p>δ-opioid receptor agonist; anti-nociceptive</p>

<p>This product contains disulfide bonds between Cys3-Cys14 can is suitable for use in radioimmunoassays. Somatostatin is a peptide hormone that is produced by the hypothalamus and inhibits the release of growth hormones, insulin, and glucagon. It is widely expressed throughout the body for example in the gastrointestinal (GI) tract, hypothalamus, pancreas and the central nervous system. In the central nervous system somatostatin plays a role in neurotransmission modification and it has also demonstrated to be effective against a number of cancers such as squamous carcinoma.</p>

<p>Beta-Sheet Breaker Peptide iAß5 is a peptide that interacts with amyloid beta proteins to disrupt the formation of beta sheets. It has been shown to inhibit the aggregation of amyloid beta proteins into oligomers and fibrils, and disrupts the self-assembly of amyloid beta protein into various conformations. Beta-Sheet Breaker Peptide iAß5 is a ligand for both receptor and activator binding sites on amyloid beta proteins, inhibiting the interaction of these sites. This inhibits the activation of downstream signalling pathways associated with Alzheimer's disease.</p>