Bioquímicos e reagentes

<p>Angiotensin IV trifluoroacetate is an active analogue of angiotensin. It has been shown to have a high affinity for AT1 receptors and is able to enhance the uptake of angiotensin in proximal tubules, which may be due to its ability to bind DNA. Angiotensin IV trifluoroacetate has also been shown to have beneficial effects on skin cells, such as the reduction of skin inflammation and alleviation of pain. Angiotensin IV trifluoroacetate has shown anti-inflammatory activities, which may be due to its ability to reduce pro-inflammatory cytokines such as IL-6 and TNF-α. This drug also binds to the CD4 receptor, thereby inhibiting inflammatory responses in autoimmune diseases.</p>

<p>Endothelin-3 (ET-3) is a protein that belongs to the large family of endothelin peptides which activate the G-protein coupled receptors ETA and ETB. However ET-3 has lower affinity for the ETA receptors compared to Endothelin-1 (ET-1) and Endothelin-2 (ET-2), whereas all three endothelins have similar affinity for ETB receptors. As ETB receptors make up around 90% of the endothelin receptors found in the cerebral cortex in humans, ET-3 can be nicknamed the ‘brain endothelin’. Also through ET-3’s activation of ETB receptors, ET-3 is involved in the development of the enteric nervous system which controls within the gut, blood flow, secretion and intestinal motility. This product has disulfide bonds between Cys1-Cys and Cys3-Cys11, is sourced from Porcine, Rat and Rabbit and is available as a 0.5mg vial</p>

<p>Propargyl amine is a biologically active compound that has been shown to induce neuronal death in hl-60 cells. It also inhibits the production of neurotrophic factors and induces the formation of coumarin derivatives. Propargyl amine is structurally related to other known neurotoxic compounds, such as coumarin and pyridine. The mechanism of action is currently unknown, but it may involve interactions with ubiquitin ligases or receptor activity. Propargyl amine was found to be an active analogue for the treatment of skin cancer and has shown good analytical properties for use in quantitative analysis. This product should be stored at room temperature in a dry place away from light in order to avoid chemical degradation.</p>

<p>GSK3145095 is a small molecule inhibitor, which is a synthetic compound developed by GlaxoSmithKline. It functions as a targeted inhibitor of receptor-interacting serine/threonine-protein kinase 1 (RIPK1), a crucial mediator in the signaling pathways that control inflammation and cell death. The source of GSK3145095 is a chemical synthesis designed to inhibit the kinase activity associated with RIPK1.</p>

<p>D-Arginyl-[Hyp3,Thi5,D-Tic7,Oic8]-Bradykinin is a synthetic peptide that is used as a research tool. It has been shown to activate ion channels and receptor proteins in studies on cell biology and pharmacology. This peptide also inhibits the binding of ligands to their receptors, which may be due to its structural similarity with other peptides that bind to the same receptor. D-Arginyl-[Hyp3,Thi5,D-Tic7,Oic8]-Bradykinin is an inhibitor of protein interactions.</p>

<p>PU 23 is a liquid crystal catheter that has been developed for the dynamic measurement of blood flow in large arteries. The device consists of a liquid crystal cavity with a distal sensor and an optical probe that is inserted into the distal end of the cavity. The probe detects changes in luminance, which are transmitted to the sensor. This sensor decodes these changes and transmits them to a data acquisition system or computer to measure flow rate, pressure, and velocity. PU 23 has been used successfully in both animal models and human subjects to measure blood flow in peripheral arteries as well as in coronary arteries.</p>

<p>DOTA(tBu)3-OH is a Building Block that is used in peptide synthesis. It can be used as a condensation reagent or as a building block for the synthesis of peptides and antibodies. DOTA(tBu)3-OH is also an additive for labelling and building blocks for peptide synthesis. DOTA(tBu)3-OH is stable and not toxic to cells, making it useful in cell culture applications. It has been shown to react with the side chain amino groups of lysine residues on proteins, including antibody molecules.</p>

<p>Verdalia A is an anticancer compound that acts as a kinase inhibitor by binding to cyclin-dependent kinases and preventing the phosphorylation of target proteins. This inhibition leads to apoptosis, or programmed cell death, in human cancer cells. Verdalia A has been shown to be effective against a variety of cancers, including Chinese hamster ovary (CHO) cells and human tumor cell lines. It also has glutathione analog activity, which may contribute to its anticancer properties. As a promising new class of kinase inhibitors, Verdalia A holds great potential for the development of novel cancer therapies.</p>

<p>Iprodione-d5 is a medicinal analog of Iprodione, a kinase inhibitor used in cancer treatment. It has been shown to induce apoptosis in cancer cells by inhibiting kinases that are crucial for tumor growth and survival. This compound has been tested in Chinese hamster ovary cells and human cancer cell lines, demonstrating potent anticancer activity. Iprodione-d5 is excreted primarily through urine, making it a viable option for systemic delivery. Its potential as an anticancer agent makes it a promising area of research for the development of new protein kinase inhibitors.</p>

<p>ORM-10962 is a potent inhibitor of human kinases that has been shown to be effective against a variety of cancer cell lines. It inhibits the activity of several kinases, including quetiapine and somatostatin, which are involved in tumor growth and proliferation. ORM-10962 induces apoptosis in cancer cells by blocking the kinase activity required for cell survival. This analog has been shown to inhibit the growth of Chinese hamster ovary cells in vitro and to reduce tumor size in vivo. ORM-10962 has also been found to inhibit hyaluronan synthesis, which is involved in cancer cell migration and invasion. In addition, ORM-10962 has potential as a biomarker for cancer diagnosis due to its presence in urine samples from cancer patients.</p>

<p>Fmoc-OSu is a synthetic amino acid that is used in the synthesis of peptides and other biomolecules. It can be synthesized by solid-phase peptide synthesis using Fmoc chemistry, which involves an acid-labile protecting group. Fmoc-OSu has been shown to inhibit cancer cell growth, although its mechanism is not known.<br>Fmoc-OSu has been shown to have anti-inflammatory effects by inhibiting the proinflammatory cytokine TNFα.<br>Fmoc-OSu has also been shown to have glycan binding properties, which may be due to its ability to bind with sialic acid residues on glycoproteins or glycolipids.</p>

<p>Ibogamine is a naturally occurring alkaloid, which is derived from the root bark of the Tabernanthe iboga plant, native to Central Africa. This compound is part of the class of indole alkaloids and is chemically related to ibogaine. It acts primarily as a psychoactive agent, influencing serotonin and other neuroreceptor pathways in the central nervous system.</p>

<p>Nociceptin is a peptide that binds to the NOP receptor and activates it, which inhibits neuronal activity. It has been shown to inhibit protein interactions by acting as an inhibitor of the enzyme proteasome. Nociceptin activates the Ligand-gated ion channels, which are involved in pain perception. Nociceptin also has been used as a research tool for investigating protein interactions and antibody production.</p>

<p>Please enquire for more information about 3,12-Diimino-2,4,11,13-tetraazatetradecanediamide including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 3,4,5-Trimethoxyamphetamine hydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>antigen</p>

<p>SPOP-IN-6b is a research tool used to study protein interactions. SPOP-IN-6b can be used as an inhibitor of Kv1.3, a voltage-gated potassium channel that is important for the regulation of neuronal excitability and seizure activity. SPOP-IN-6b binds to the ligand binding site on Kv1.3, preventing activation by potassium ions. This inhibits neuronal excitability and the development of seizures in animal models.</p>

<p>Oclacitinib Maleate is a small molecule that binds to the receptor, activator of nuclear factor kappa-B ligand (RANKL). Oclacitinib Maleate is an inhibitor of RANKL-induced osteoclast differentiation and activation. It inhibits the activation of NF-κB. Oclacitinib Maleate can be used as a research tool for receptor binding and cellular signal transduction studies. It is also used in cell biology research to study ion channels and ligands.</p>

<p>4,4'-Dihydroxy-2,6-dimethoxydihydrochalcone is a small molecule that can be used as a research tool for studying ion channels and their interactions with ligands. This compound has been shown to activate the potassium channel Kv1.5 and inhibit neuronal voltage-gated sodium channels at micromolar concentrations. 4,4'-Dihydroxy-2,6-dimethoxydihydrochalcone is also a high purity inhibitor of the serine protease thrombin.</p>

<p>Secorapamycin A is a small molecule activator of the protein tyrosine phosphatase-1b (PTP-1B). Secorapamycin A binds to PTP-1B and increases its activity, resulting in inhibition of the nuclear factor kappa B (NF-κB) pathway. Secorapamycin A has been shown to inhibit ion channels, such as potassium channels, and to bind to antibodies. This drug also binds to receptors, including ligand binding domain on the human epidermal growth factor receptor 2 (HER2), which is expressed in some breast cancer cells. Secorapamycin A has also been found to inhibit cell proliferation by inhibiting protein synthesis.</p>

<p>Bifeprunox is a small-molecule drug that blocks the activity of the GABA receptor. It has pharmacological and biological effects in various systems, including inhibition of GABA binding to its receptors, activation of the GABA receptor, modulation of cell proliferation and migration, and modulation of protein interactions. Bifeprunox binds to an allosteric site on the GABA receptor and modulates the binding affinity for GABA at this site. It is used as a research tool for studying neurotransmitter receptors.</p>

<p>JAK2 inhibitor with potential antineoplastic activity</p>

<p>Antagonist of purinoreceptor P2Y11</p>

<p>Please enquire for more information about 4-Methyl-2-biphenylcarbonyl chloride including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>A molluscan cardioexcitatory neuropeptide which has the potential to be used itn cell biology, pharmacological, and protein-protein interaction studies.</p>

<p>Flupentixol is an inhibitor of cell cycle kinases that has been shown to induce apoptosis in cancer cells. It has been found to be effective against a number of different types of tumors, including those of the breast, lung, and prostate. Flupentixol has also been found to inhibit the growth of cancer cells in human urine samples and in Chinese medicinal plant extracts. This drug works by inhibiting protein kinases, which are enzymes that play a key role in regulating cell growth and division. By blocking these enzymes, flupentixol can prevent cancer cells from dividing and growing, ultimately leading to their death.</p>

<p>[Tyr34]-Parathyroid Hormone (Bovine, 7-34 amide) is a product sourced from bovine, is available as a 0.5mg vial and is related to the peptide hormone Parathyroid Hormone (PTH). During abnormal serum calcium levels PTH is secreted from the parathyroid gland, thus regulating calcium and phosphate levels in the body. PTH binds to its PTH receptor which is a G-protein coupled receptor that activated adenylate cyclase or phospholipase C to activate pathways involved in the mediation of bone resorption and bone formation.</p>

<p>Phenanthrene-[U-13C] is an analog of phenanthrene that has been labeled with a stable carbon isotope. This compound has shown potential as an anticancer agent due to its ability to induce apoptosis in cancer cells. Phenanthrene-[U-13C] has been shown to be a potent inhibitor of kinases, including nintedanib, which is used in the treatment of certain types of cancer. It also exhibits inhibitory activity against tumor growth and proliferation. Studies have demonstrated that this compound can be detected in human urine, indicating its potential for use as a biomarker for cancer diagnosis and monitoring. Additionally, Phenanthrene-[U-13C] has been found to bind to specific proteins in Chinese hamster ovary cells, suggesting its potential as a therapeutic target for cancer treatment.</p>

<p>This drug is a basic compound that has been shown to inhibit the activity of histamine, a substance that causes allergic reactions. It is thought to work by blocking the effects of histamine at the H1 receptor site in the nose and throat. This drug also inhibits other substances that cause allergies, such as leukotrienes, prostaglandins, and proteases. The mechanism of action for this drug is not known.</p>

<p>Beta-bisabolol is a natural compound that has been found to have anticancer properties. It induces apoptosis, or programmed cell death, in cancer cells by inhibiting the activity of certain kinases and disrupting the cell cycle. Beta-bisabolol is an analog of alpha-bisabolol, which is derived from the essential oil of Chinese medicinal plants. It has been shown to have potent anticancer activity against various types of tumors, including breast, lung, and colon cancer. Beta-bisabolol also inhibits xylanase activity, which may contribute to its anticancer effects by reducing the growth and proliferation of cancer cells. This compound has potential as a therapeutic agent for the treatment of human cancers.</p>

<p>GDC-0575 is a small molecule inhibitor that specifically targets the Ataxia-Telangiectasia and Rad3-related protein (ATR) kinase. This compound, developed from a synthetic chemical source, functions by selectively inhibiting the ATR kinase, a key regulator of the DNA damage response pathway. By binding to the active site of ATR, GDC-0575 disrupts its ability to activate downstream effectors involved in DNA repair processes.</p>

<p>Please enquire for more information about (E/Z)-Eltrombopag 13C including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Formetanate is a potent inhibitor of tumor kinase activity in humans and Chinese hamsters. It has demonstrated its ability to induce apoptosis, or programmed cell death, in cancer cells. This medicinal compound is excreted primarily in urine and has shown promising results as an anticancer agent. Formetanate is an analog of other protein kinase inhibitors and has been shown to be effective against a range of different cancers. Its mechanism of action involves inhibiting the activity of kinases, which are enzymes that play a key role in the regulation of cellular processes such as proliferation, differentiation, and survival. By blocking this activity, formetanate can prevent the growth and spread of cancer cells.</p>

<p>Tetradecyl coenzyme A (ammonium salt) is an antibody that recognizes the peptide sequence of a protein. It can be used to study the interactions between proteins and antibodies, as well as ion channels in cells. Tetradecyl coenzyme A (ammonium salt) has been used in research on receptor-ligand interactions, neuroscience, and cell biology. This antibody has high purity and can be used as a research tool for life science.<br>Tetradecyl coenzyme A (ammonium salt) binds to a specific ligand and is an inhibitor of the enzyme phospholipase C. The CAS number for this compound is 852043-48-2.</p>

<p>ORM-3819 is a novel cardiac drug that increases the force of contraction and the rate of relaxation in the heart. It was discovered as an endogenous compound in porcine heart tissue, which led to its synthesis and evaluation as a therapeutic agent for treatment of cardiovascular disease. ORM-3819 has been shown to increase cardiac contractility, induce hyperpolarization, and reduce systolic pressure in animal models. Magnetic resonance spectroscopy assays have also shown that it does not affect cardiac function or myocardial perfusion. The mechanism of action is not yet known, but may be due to natriuretic effects on muscle cells.</p>

<p>Suc-Gly-Pro-Leu-Gly-Pro-AMC is a high purity, monoclonal antibody that can be used as a research tool or as an inhibitor. It has been shown to inhibit ion channels and protein interactions. Suc-Gly-Pro-Leu-Gly-Pro-AMC is also known as a ligand for the receptor. It has been shown to activate the receptor and cause a change in the cell membrane permeability by increasing calcium flux, which leads to an increase in intracellular calcium levels. Suc-Gly-Pro-Leu-Gly-Pro-AMC is found in Cell Biology and Pharmacology research studies.</p>

<p>DS-6930 is a peptide that can be used as a research tool to study the function of ion channels and receptors in cell biology. It is also an inhibitor of protein interactions, including receptor-ligand and antibody-antigen interactions. DS-6930 is a high purity reagent with CAS No. 1242328-82-0, which can be used for pharmacology studies.</p>

<p>Calcitonin is a hormone produced by the C cells (also known as parafollicular cells) in the thyroid gland. Its main function is to regulate the levels of calcium and phosphate in the blood. Calcitonin works by inhibiting the activity of osteoclasts, which are cells that break down bone tissue and release calcium and phosphate into the bloodstream. This leads to a decrease in the amount of calcium and phosphate in the blood.<br>Calcitonin is released in response to high levels of calcium in the blood, and it acts to reduce these levels by increasing the excretion of calcium by the kidneys and inhibiting the absorption of calcium by the intestines. It also promotes the storage of calcium in the bones, which helps to maintain their strength and density.<br>Calcitonin may be used therapeutically to treat conditions such as osteoporosis and hypercalcemia (high levels of calcium in the blood) or even diagnostically as a marker for tumors in medullary thyroid cancer.<br>This product has a disulfide bond between Cys1-Cys7 and is available as a 0.5mg vial.</p>

<p>N-(3,4-dimethylphenyl)-2-oxo-3,4-dihydro-1H-quinoline-6-sulfonamide is a small molecule that has been shown to inhibit the activity of protein tyrosine phosphatase 1B (PTP1B) and to activate the insulin receptor. It is also used as a research tool in cell biology and pharmacology experiments. N-(3,4-dimethylphenyl)-2-oxo-3,4-dihydro-1H-quinoline-6-sulfonamide binds to receptors on the cell surface and blocks their activation by ligands such as hormones or neurotransmitters. This drug also has an effect on ion channels in cells.</p>

<p>Boc-Leu-Ser-Thr-Arg-AMC is a fluorescent peptide used as a research tool to study protein interactions. It can be used to activate or inhibit ion channels. Boc-Leu-Ser-Thr-Arg-AMC is a high purity, water soluble peptide that has been purified by HPLC and characterized for its purity and integrity by mass spectrometry and amino acid analysis.</p>

<p>BMS-986242 is a potent inhibitor of protein kinases that have been implicated in tumor growth and progression. It has demonstrated anticancer activity by inhibiting the cyclin-dependent kinase (CDK) pathway, which is essential for cell cycle progression and survival. BMS-986242 has been shown to induce apoptosis in human cancer cells, including Chinese hamster ovary cells. This inhibitor has potential as a medicinal compound for the treatment of various types of cancer. Its specificity towards protein kinases makes it a promising candidate for targeted therapies against cancer.</p>

<p>ANP (1-28) is a peptide that is secreted by the human heart and has been shown to act as an inhibitor of ion channels and receptors. ANP (1-28) binds to the receptor, which then changes its shape. The receptor then becomes more sensitive to other ligands and it can activate or inhibit cell signaling pathways. ANP (1-28) also binds to antibodies that are used in research tools for cell biology, pharmacology, and protein interactions. This peptide has a high purity level of &gt; 95% with a CAS number of 91917-63-4.</p>

<p>Inhibitor of BTK tyrosine kinase</p>

<p>Methionyl-Lysyl-Bradykinin is a peptide inhibitor that has been shown to inhibit the activity of protein kinase C (PKC). PKC is involved in a number of cellular functions, including the regulation of ion channels and the activation of other enzymes. Methionyl-Lysyl-Bradykinin can be used as an inhibitor in research tool experiments. It can also be used as an activator or ligand in receptor binding experiments. The high purity and specificity of this product make it suitable for use as a research reagent.</p>

<p>Calcitonin is a hormone produced by the C cells (also known as parafollicular cells) in the thyroid gland. Its main function is to regulate the levels of calcium and phosphate in the blood. Calcitonin works by inhibiting the activity of osteoclasts, which are cells that break down bone tissue and release calcium and phosphate into the bloodstream. This leads to a decrease in the amount of calcium and phosphate in the blood.<br>Calcitonin is released in response to high levels of calcium in the blood, and it acts to reduce these levels by increasing the excretion of calcium by the kidneys and inhibiting the absorption of calcium by the intestines. It also promotes the storage of calcium in the bones, which helps to maintain their strength and density.<br>Calcitonin may be used therapeutically to treat conditions such as osteoporosis and hypercalcemia (high levels of calcium in the blood) or even diagnostically as a marker for tumors in medullary thyroid cancer.<br>This product has a disulfide bond between Cys1-Cys7 and is available as a 0.1mg vial.</p>

<p>CGRP (Human, 8-37) is a peptide derived from the calcitonin gene-related peptide (CGRP) that is found in the nervous system and other tissues in humans. It is a truncated form of the full-length CGRP peptide, consisting of the last 30 amino acids of the CGRP sequence (amino acids 8-37).<br>CGRP is a potent vasodilator and plays a key role in regulating blood flow and blood pressure. It is also involved in pain perception, inflammation, and neurogenic inflammation. CGRP (Human, 8-37) is an antagonist of CGRP, meaning that it binds to the CGRP receptor without activating it, thereby blocking the effects of CGRP.<br>CGRP (Human, 8-37) has been used as a research tool to study the physiological and pathological roles of CGRP in various tissues and diseases, such as migraine headaches, cardiovascular diseases, and inflammatory disorders. It has also been investigated as a potential therapeutic agent for these conditions, as well as for the treatment of pain and other neurological disorders.<br>This product is available as a 0.5mg vial.</p>

<p>[Val5]-Angiotensin I (Bovine) is a peptide that activates angiotensin receptors. It is used as a research tool in the study of ion channels and protein interactions. The antibody recognizes the C-terminal region of angiotensin I, which can be used to inhibit the activation of these receptors by preventing binding to their ligands.</p>

<p>Suc-Ala-Ala-Ala-pNA is a peptide that binds to the acetylcholine receptor and activates it. This peptide has been shown to have potential as a research tool for studying the pharmacology of acetylcholine receptors in vitro. It has also been used as an inhibitor of neuronal ion channels, such as potassium channels, that are involved in the transmission of nerve impulses. Suc-Ala-Ala-Ala-pNA is not suitable for use in humans because it would be broken down by proteases before it could reach its target, but this peptide has applications in cell biology and neuroscience.</p>

<p>Ac-Asp-Glu-Val-Asp-AMC is an ion channel activator. It binds to the receptor site of the ligand, which causes a conformational change in the protein that leads to the opening of the ion channel. Ac-Asp-Glu-Val-Asp-AMC is a peptide with a molecular weight of 927.6 and is soluble in water. This product has been shown to be stable under various conditions and can be used as research tool or pharmacological agent. Ac-Asp-Glu-Val-Asp-AMC is also an antibody that binds to an epitope on human CD8 protein and can be used for cell biology studies, such as activation and inhibition of these proteins.</p>

<p>ST1326 is a carnitine-based compound that has been shown to exhibit anti-cancer activity. It was found to reduce the mitochondrial membrane potential in prostate cancer cells, as well as inhibit the growth of these cells. ST1326 also reduces the expression of an amp-activated protein kinase, which can lead to apoptosis, and inhibits transcriptional regulation. ST1326 has also been shown to have a direct effect on cervical cancer by inhibiting the phosphorylation of c-Jun N-terminal kinase (JNK) and reducing its downstream signaling pathways. This drug binds to fatty acids and can be used for the treatment of diabetic patients with congestive heart failure.</p>

<p>Bz-Arg-AMC is a fluorescent probe that binds to the nicotinic acetylcholine receptor (nAChR) in the presence of calcium ions and emits light when excited by ultraviolet light. It can be used to study the activation of nAChRs, as well as their interactions with other proteins such as peptides. Bz-Arg-AMC has a molecular weight of 551.9 g/mol, with a purity of &gt; 98% and an optical purity of &gt; 99%. This product can be used for research purposes only, not for diagnostic or therapeutic purposes.</p>

<p>Nami-A is an experimental drug that has been shown to have significant cytotoxicity against carcinoma cell lines and solid tumours. Nami-A is a small molecule that binds to integrin receptors on the surface of cells, inhibiting the production of matrix metalloproteinase-9 (MMP-9). In vivo studies with Nami-A in mice showed that mitochondrial membrane potential was reduced and there was a decrease in redox potentials. The MMP-9 inhibition by Nami-A may be due to its ability to inhibit oxidative stress.</p>

<p>[Asn1,Val5]-Angiotensin II is a peptide that is used as a research tool to study the effects of angiotensin II on ion channels, ligand-receptor interactions and protein interactions. It is also used as an antibody to measure the level of angiotensin II in cells. This peptide has been shown to be an activator of potassium channels and inhibits calcium channels. The high purity of this product makes it suitable for use in pharmacology and cell biology research.</p>

<p>Angiotensin I (Bovine) is a synthetic substrate that is used for the measurement of Angiotensin I-converting enzyme activity in vitro. It has been incubated with rat or bovine tissue and can be used as a chromatographic standard. This substrate binds to the active site of the enzyme and undergoes hydrolysis, which generates an increase in pH. The resulting product is then measured fluorimetrically by measuring the decrease in absorbance at 350 nm. This peptide has been found to have a pressor effect and an inhibitory effect on acid secretion.</p>

<p>Anti Retinoblastoma (RB) (901-928) Human Serum is a research tool that can be used for the study of cell biology, protein interactions, and pharmacology. Anti Retinoblastoma (RB) (901-928) Human Serum is a ligand that can bind to the receptor and activate its function. It has been found to inhibit ion channels, which are proteins that regulate the flow of ions in cells. It also has been shown to have an effect on cell growth and differentiation.</p>

<p>As a member of the tachykinin neuropeptide family, Neurokinin B is involved in the dilation of blood vessels, the contraction of smooth muscles and the excitation of neurons. This product can be applied as a NK3 receptors selective agonist and is available as a 0.5mg vial.</p>

<p>4,7,8,9-Ac4-Neu5Troc(2→O)-O-C(CF3)=NPh Methyl Ester is a glycosylated peptide that is conjugated with an acetate ester. This compound is a member of the Acetyl Neu5Ac family of glycoconjugates that are found on the surface of cells and are involved in cell-cell interactions and immune responses. 4,7,8,9-Ac4-Neu5Troc(2→O)-O-C(CF3)=NPh Methyl Ester has been shown to inhibit bacterial growth by interfering with the synthesis of bacterial cell walls.</p>

<p>Pyr-AMC is a novel research tool that can be used to activate or inhibit ion channels, receptors, and other proteins. Pyr-AMC is a ligand for the nicotinic acetylcholine receptor (nAChR) and can be used to study the pharmacology of nAChRs. Pyr-AMC is also a potent inhibitor of voltage-gated potassium channels, which are important for regulating nerve cell membrane potentials. Pyr-AMC has been shown to bind to many types of proteins that play an important role in cell biology. This includes antibodies, ion channels, receptors, and peptides. It has been shown that pyr-amc binds to life sciences products such as antibodies, peptides, and enzymes.</p>

<p>Z-Arg-Arg-AMC is an activator of the receptor tyrosine kinase (RTK) system. It binds to the extracellular domain of RTKs, such as epidermal growth factor receptors (EGFR) and fibroblast growth factor receptors (FGFR), and activates these receptors. This compound has been shown to activate EGFR and FGFR at low concentrations and inhibit their activation at high concentrations. Z-Arg-Arg-AMC has also been shown to be a potent inhibitor of protein interactions with a Kd of approximately 1 μM, which makes it a useful research tool for studying protein interactions.</p>

<p>Phenacetin-d3 is a radioactive isotope of phenacetin that has been used to study drug metabolism. It is reconstituted with a deuterium atom at the 3 position. Phenacetin-d3 binds to the membrane transporter protein, P-glycoprotein, and it does not bind to other transporters such as MRP1 and BCRP. The binding of phenacetin-d3 to P-glycoprotein alters the activity of the transporter in a manner that is dependent on the concentration of drugs in plasma. This effect has been shown using both chemical ionization mass spectrometry and liquid chromatography tandem mass spectrometry techniques with plasma samples from patients who are taking statins.</p>

<p>Somatostatin is a peptide hormone that is produced by the hypothalamus and inhibits the release of growth hormones, stimulates the release of insulin from the pancreas, and inhibits the release of glucagon from the pancreas. Somatostatin also has biological properties that inhibit neuronal death in combination therapy groups. It has been shown to have cell factor activity which may contribute to its antitumor activity. Somatostatin also has pro-apoptotic properties in vitro assays at physiological levels, making it an excellent target for cancer therapy.</p>

<p>Amino acids 1-42 of the Amyloid beta-protein (Aβ), a major plaque component in Alzheimer's Disease, a neurodegenerative disorder that affects memory and cognitive function. It is thought that these Aβ peptides can aggregate to form insoluble fibrils that are a hallmark of Alzheimer's disease and may contribute to neurodegeneration and cognitive decline.<br>Research is ongoing to better understand the mechanisms underlying Aβ-induced neurodegeneration and to develop therapies that target Aβ to prevent or treat Alzheimer's disease. Aβ peptides, particularly Aβ(1-42), are commonly used in research as a model for Alzheimer's disease to investigate the pathogenesis and potential therapeutic approaches.<br>This product is available in the trifluoroacetate salt form and as a 0.5mg vial.</p>

<p>Morphine tolerance peptide is a cyclic peptide analog of morphine. It has been shown to have an affinity for the kappa-opioid receptor that is similar to that of morphine, but it has a higher potency and a longer duration of action. The molecular modeling study indicates that the analog interacts with the receptor in a similar manner as morphine and exhibits high selectivity for this receptor. The analog also shares many of the same features as morphine in terms of depressant effect and locomotor activity, but does not produce any kind of withdrawal syndrome.</p>

<p>Pyr-Ala is a peptide that has been shown to be effective in treating inflammatory diseases. It specifically targets the group P2 sequences of the inflammatory cytokine IL-1β. Pyr-Ala also inhibits IL-6 and TNF-α activity by binding to the amide bond of these molecules, inhibiting their catalysis and preventing their formation. Pyr-Ala has also shown efficacy in autoimmune diseases, such as rheumatoid arthritis, by inhibiting the production of proinflammatory cytokines including IL-1β and TNF-α. This drug binds to the bacterial enzyme that catalyzes the conversion of L -alanine into pyruvic acid, preventing its function and inhibiting bacterial growth.</p>

<p>LYN-1604 HCl is a research tool for studying receptor-ligand interactions. It is a potent and selective activator of nicotinic acetylcholine receptors, as well as a novel ligand for the alpha-7 nicotinic acetylcholine receptor. LYN-1604 HCl has been shown to activate ion channels and inhibit the activity of high-voltage activated potassium channels in neuronal cells. The binding affinity of LYN-1604 HCl to alpha-7 nicotinic acetylcholine receptors was found to be similar to that of nicotine, making it a potential candidate for the treatment of conditions such as Alzheimer's disease and schizophrenia.</p>

<p>CoV-2 Spike (1000-1200) is a ProSpec that is used for the detection of Angiotensin Converting Enzyme 2 (ACE-2). The spike protein binds to ACE-2, which can be found in the human blood plasma. The CoV-2 Spike (1000-1200) can be used for the detection of coronavirus such as MERS-CoV and SARS-CoV. It can also be used to detect Proteins in samples such as COVID-19.</p>

<p>Z-Tyr-ONp is a synthetic, water soluble, non-toxic fibrinogen activator. It has been shown to be effective at low concentrations in the activation of fibrinogen and in the prevention of clotting. Z-Tyr-ONp hydrolyzes fibrinogen to form fibrin clots, which are needed for blood coagulation. This process is mediated by the enzyme alpha-thrombin and is dependent on calcium ions. Z-Tyr-ONp also exhibits surfactant properties that allow it to stabilize micelles that contain lipase enzymes and bile salts, which are required for digestion of dietary fats. The presence of lipase enzymes can enhance the proteolytic activity of Z-Tyr-ONp and increase its ability to dissolve clots.</p>

<p>Amino acids 39-68 of the Parathyroid Hormone (PTH) which is a peptide hormone that is secreted from the parathyroid gland in the event of abnormal serum calcium levels and it ultimately regulates calcium and phosphate levels in the body. The PTH exerts its activity through binding to the G-protein coupled receptor type 1 PTH receptor, which activates adenylate cyclase or phospholipase C thus activating pathways involved in the mediation of bone resorption and bone formation. This product is suitable for life science applications and is available as a 0.5mg vial.</p>

<p>Portion of HCMV</p>

<p>2-Deoxy-2-Phthalimido-3,4,6-Tri-O-Acetyl-α-D-Glucopyranosyl Fluoride is a glycosyl compound that is used as a fluorinating agent. It reacts with proteins to form glycosyl fluorides by the action of fluoride ion, which introduces fluorine atoms into the carbohydrate side chains of proteins. This product is specifically designed for use in peptide synthesis. 2DGTGF may be used in the preparation of peptides for use in protein sequencing and mapping techniques.</p>

<p>Adrenomedullin (human) is a research tool that has been shown to activate the ligand receptor. It is a member of the vasoactive peptide family, which includes adrenalin and noradrenaline. Adrenomedullin binds to the cell surface receptors on smooth muscle cells and endothelial cells and activates ion channels. This research tool is also known as AM.</p>

<p>Z-Gly-Pro-Arg-AMC is a synthetic peptide that can inhibit the activity of various enzymes. It has been shown to be an inhibitor of protein interactions, activator of ligand, and receptor. This peptide is used as a research tool in cell biology and pharmacology studies. Z-Gly-Pro-Arg-AMC is also used in high purity applications (e.g., ion channels) and antibody production.</p>

<p>[Pmp1, Tyr(Me)2]-Arg8-vasopressin is a peptide that has been shown to activate the V2 receptor and inhibit vasopressin-induced water retention. It has also been shown to inhibit the binding of vasopressin to its receptor. The peptide is an excellent research tool for studying the interaction between the V2 receptor and vasopressin. The peptide is supplied at high purity in lyophilized form and can be reconstituted with water or buffer before use.</p>

<p>Bismuth subcitrate potassium is a viscous, biodegradable, diagnostic contrast agent that has been used in the diagnosis of gastrointestinal tract diseases. It is also used as a pump inhibitor to treat gastric ulcers and other conditions. Bismuth subcitrate potassium has been shown to have anti-cancer effects, which may be due to its ability to inhibit the growth of cancer cells by interfering with H2 receptor signaling. The drug's mechanism of action is not fully understood but it may be related to its bacterial antibiotic activity. Bismuth subcitrate potassium binds galacturonic acid in mammalian tissue and bacteria, inhibiting their growth. This drug also has some antibacterial activity against wild-type strains of Escherichia coli and Staphylococcus aureus but does not kill mutant strains that are resistant to bismuth salts or antibiotics.</p>

<p>CU-CPT17e is a monoclonal antibody that binds to the C-terminal region of human cytomegalovirus (HCMV) glycoprotein B. This antibody has been shown to activate CMV-specific T cells in vitro and in vivo, leading to an increase in the production of cytokines such as IFN-γ and IL-2. CU-CPT17e also induces apoptosis in HCMV infected monocytic THP1 cells. It has been hypothesized that this activation of apoptosis is due to CU-CPT17e binding to the molecule on the cell surface that activates proinflammatory responses.</p>

<p>Karenitecin is a diagnostic agent with minimal toxicity. It is used to detect granulosa cells in human serum and is also an immunohistochemical marker for the diagnosis of gliomas. Karenitecin binds to α1-acid glycoprotein, which is found at high levels in plasma and cerebrospinal fluid, and has been shown to have potent antitumor activity. The drug can be administered intravenously or intra-arterially, with a low risk of toxicity. Karenitecin has been shown to have antineoplastic properties by inhibiting mitochondrial membrane potential, which may be due to its ability to bind to the a-ring of ATP synthase.</p>

<p>N-(Cyanomethyl)-4-methyl-2-[[2,2,2-trifluoro-1-[4-(4-methylsulfonylphenyl)phenyl]ethyl]amino]pentanamide is a nonbasic penetrant compound that has been shown to reduce the rate of bone resorption in vivo. It has been shown to inhibit the activity of collagenases and other enzymes involved in bone resorption. The compound can be used as a potential therapeutic for osteoporosis and other diseases that affect bone turnover. This compound was developed through optimization studies with rhesus macaques and cell based assays. The pharmacological treatment with this drug has also been tested on cells from human osteoblasts.</p>

<p>Somatostatin is a peptide hormone that is widely expressed throughout the body; in the gastrointestinal (GI) tract, hypothalamus, pancreas and the central nervous system. It has been found to inhibit pituitary growth hormone release as well as endocrine, pancreatic and GI secretions. In the central nervous system somatostatin plays a role in neurotransmission modification and it has also demonstrated to be effective against a number of cancers such as squamous carcinoma. This product contains disulfide bonds between Cys3-Cys14.</p>

<p>Tuftsin is a cyclic peptide that has been shown to have various biological properties, including anti-inflammatory and immunosuppressive activity. Tuftsin has been shown to inhibit the production of proinflammatory cytokines such as IL-10 by T cells in vitro. Tuftsin also inhibits the activation of toll-like receptors (TLR) and may have a role in inhibiting mycobacterial infection. This drug was found to be well tolerated in humans with congestive heart failure, and is currently being evaluated for its potential use as an adjunct therapy for inflammatory bowel disease. It has also been shown to be effective against opportunistic fungal infections, such as Candida albicans, Cryptococcus neoformans, and Aspergillus fumigatus. Tuftsin can be measured using analytical methods such as titration calorimetry or polymerase chain reaction (PCR).</p>

<p>17:0(2R-OH) ceramide is a synthetic type of ceramide, which is a subclass of sphingolipids. It is typically derived from bioengineered sources and manufactured through sophisticated chemical synthesis techniques to ensure high purity and specific stereochemistry. This compound is characterized by a saturated 17-carbon acyl chain with a hydroxyl group at the second carbon, which plays a crucial role in its biochemical behavior.</p>

<p>Sar1, Ile4,8]-Angiotensin II is a peptide that belongs to the class of angiotensins. It has been shown to activate angiotensin receptors and is used as a research tool in pharmacology and cell biology. Sar1, Ile4,8]-Angiotensin II interacts with ligands such as heparin-binding EGF-like growth factor (HB-EGF) and angiopoietin 1 (ANGPT1). The antibody against Sar1, Ile4,8]-Angiotensin II blocks the receptor binding activity of this peptide. Sar1, Ile4,8]-Angiotensin II has been shown to be an inhibitor of ion channels such as inward rectifier potassium channels.</p>

<p>Corticotropin-Releasing Factor (CRF) (Human, Rat) is a peptide hormone product that is available as a 0.5mg vial and has the potential to be used as a research tool to study the effects of CRF in the body. CRF is a natural hormone that regulates many physiological processes, such as blood pressure, temperature control, and food intake. CRF binds to receptors on cells and triggers a number of cellular responses within the cell. This peptide can be used for pharmacological studies or for antibody production.</p>

<p>Ac-Tyr-Val-Ala-Asp-AMC is a peptide that is used as a research tool to activate ion channels in cells and study the effects of ligands on these channels. It is also used in cell biology to study protein interactions, although it does not bind to any specific receptor. Ac-Tyr-Val-Ala-Asp-AMC belongs to the group of inhibitors and can be used for pharmacological purposes. The chemical structure of this peptide consists of a covalent bond between an amino acid and an acetylated form of a fluorescent molecule, which makes it suitable for use in fluorescence microscopy. Acetylated Tyr (Ac-Tyr) is one of the six amino acids found in proteins and has the ability to inhibit the activity of ion channels by binding to their external cavity. Acetylation at position 2 or 3 on Tyr can increase its affinity for calcium ion channels and affect their activation or de</p>

<p>Secretin (human) is a peptide hormone that is produced in the duodenum and is involved in the regulation of pancreatic bicarbonate, gastric acid and osmoregulation. Secretin binds to secretin receptors which are G-protein coupled receptors and are expressed in pancreatic centroacinar cells. Secretin binds to these receptors and activates adenylate cyclase which converts ATP into cAMP which results in the secretion of bicarbonate from the pancreas. Secretin plays a role in osmoregulation through its effects on the kidney, pituitary gland and the hypothalamus. This product is available as a 0.5mg vial.</p>

<p>Antipain is a proteolytic enzyme that hydrolyzes peptide bonds in proteins. It is a member of the papain family of proteases and has been shown to activate peptides and inhibit ion channels, both of which are important for cell biology research. Antipain, an inhibitor of protein synthesis, is also used as a research tool in cell biology and biochemistry.</p>

<p>COVID-19 is a recombinant protein that was derived from the SARS-CoV. It is an antibody, which binds to the SARS-CoV and prevents it from infecting cells. COVID-19 is a monoclonal antibody that targets the glycoprotein spike of the coronavirus. The 319-529 region of this protein shows high binding affinity for SARS-CoV and SARS-CoV/SARS-CoV-2, which are two types of coronaviruses. This region can be used as a diagnostic marker for these viruses. COVID-19 may also have therapeutic potential as it has shown to neutralize SARS in cell culture and protect mice against lethal challenge with the virus.</p>

<p>Ac-Ile-Glu-Thr-Asp-H (aldehyde) is a peptide fragment of the human calcitonin gene. It is a research tool used in immunology and cell biology. Ac-Ile-Glu-Thr-Asp-H (aldehyde) binds to different types of ion channels, including ligand gated ion channels, voltage gated ion channels, and receptor activated ion channels. Ac-Ile-Glu-Thr-Asp-H (aldehyde) can also bind to membrane receptors such as the muscarinic acetylcholine receptor and the alpha adrenergic receptor. Acetylcholine is a neurotransmitter that activates the muscarinic acetylcholine receptor, which leads to an increase in intracellular levels of cyclic AMP. Alpha adrenergic receptors are located on the surface of blood vessels and activate vasoconstriction by inhibiting adenylyl cyclase activity.</p>

<p>BH3I-1 is a potent inhibitor of the Bcl-2 family of proteins that are involved in apoptosis. It has been shown to be effective against a range of tumor cell lines, including prostate cancer cells and human leukemia cells. The molecular target for BH3I-1 is the mitochondrial membrane potential, which is required for the production of ATP and maintenance of cellular homeostasis. In a panel of radiation-resistant tumor cell lines, BH3I-1 potently inhibited growth and induced morphological changes. This molecule also inhibits dimorphic fungi such as Candida glabrata, which can cause opportunistic infections in immunocompromised patients.</p>

<p>This product which is available as a 0.5mg vial is amino acids 1-31 of the 84 amino acid parathyroid hormone (PTH) and can be used as an adenylate cyclase and bone growth stimulating peptide.<br>PTH is a peptide hormone that is secreted from the parathyroid gland in the event of abnormal serum calcium levels and it ultimately regulates calcium and phosphate levels in the body. The PTH exerts its activity through binding to the G-protein coupled receptor type 1 PTH receptor, which activates adenylate cyclase or phospholipase C thus activating pathways involved in the mediation of bone resorption and bone formation. This product is suitable for life science applications.</p>

<p>Peptide product related to the 1-34 amino acids of the Parathyroid Hormone (PTH) and available as a 0.5mg vial.<br>PTH is a peptide hormone that is secreted from the parathyroid gland in the event of abnormal serum calcium levels and it ultimately regulates calcium and phosphate levels in the body. The PTH exerts its activity through binding to the G-protein coupled receptor type 1 PTH receptor, which activates adenylate cyclase or phospholipase C thus activating pathways involved in the mediation of bone resorption and bone formation. This product is suitable for life science applications.</p>

<p>Bradykinin is a peptide hormone that can be formed from the breakdown of kininogen. It works by binding to specific receptors found on the surface of cells and activating a G-protein coupled receptor. Bradykinin stimulates the secretion of gastric acid, increases the permeability of capillaries in the lungs, and causes contraction of smooth muscle in many organs. Bradykinin also has an important role in regulating blood pressure and heart rate. Des-Arg9-[Leu8]-Bradykinin (D-BK) is a potent inhibitor of this activity and is used as an antihypertensive agent. D-BK prevents the activation of G-proteins by binding to receptors with high affinity and specificity. When it binds to its receptor, it inhibits cyclic AMP production, which leads to decreased cell activity and vasodilation. This inhibition reduces blood pressure by reducing cardiac output and increasing systemic vascular resistance.</p>

<p>Luteinizing hormone-releasing hormone (LH-RH), also known as Gonadotropin-Releasing Hormone (GnRH), stimulates the pituitary gland’s production and secretion of luteinizing hormone and follicle-stimulating hormone. LHRH is a decapeptide and is itself secreted by the hypothalamus. It is crucial for human reproduction and is heavily involved in the regulation of ovulation, sexual development and the onset of puberty.<br>When secreted, GNRH binds to the G-protein coupled receptor, gonadotropin-releasing hormone receptor (GNRHR) located on pituitary gonadotrophic cells in the anterior pituitary.<br>Medically, the understanding of GnRH is paramount, due to its involvement in the pathogensis of central hypogonadism. Any obstructions to its function in the reproductive system can result in the development of human pathologically conditions. It is important to note that analogs of GnRH can be used in pharmacology, in the treatment of gynaecological diseases, through blocking the secretion of estrogen secretion from the ovary. Additional GNRH analogs can be used to treat ovarian cancer, hormone-dependent cancers, endometriosis and modality in infertility. Therefore this product is a useful research tool and is available in a 0.5mg vial.</p>

<p>E-64-c is a research tool that is used to activate the receptor of a cell. This ligand can bind to the receptor and form a complex, which will then be able to interact with other proteins in the cell. This process can lead to changes in ion channel activity, protein synthesis, or gene expression. E-64-c has been shown to inhibit the activity of ion channels such as calcium channels and potassium channels, as well as protein synthesis. It also binds to antibodies and blocks their binding sites on cells.br&gt;<br>E-64-c is a high purity ligand that can be used for studying protein interactions or pharmacological purposes. The potency of this ligand has been tested by measuring its ability to inhibit the binding of various peptides such as vasopressin and angiotensin II.</p>

<p>Neuromedin B is a neuropeptide that has been shown to activate the TRPC ion channels in mammalian cells. It also has been shown to bind to receptors and have a potent effect on cell biology, as well as being used as a research tool for studying protein interactions. Neuromedin B is found in humans, pigs, and rats, where it is expressed primarily in the brain and gastrointestinal tract. This peptide has been shown to be an inhibitor of some types of ion channels.</p>

<p>DSP-2230 is a study drug that is designed to block the sodium channel. It has been shown to be safe and well tolerated in humans, with no significant side effects. DSP-2230 showed potential to reduce symptoms of neuropathic pain in human subjects and was tested for its ability to block radiation-induced damage to DNA. In addition, it inhibits the activity of ultraviolet (UV) radiation on women's skin. The mechanism of action in this case is not known, but may involve inhibiting the production of reactive oxygen species and/or blocking UV-induced increases in DNA strand breaks.</p>

<p>TopFluor Lyso PA is a fluorescently labeled lipid analog, derived from a lysophosphatidic acid (LPA) source, designed to facilitate the study of lipid-protein and lipid-lipid interactions. Its mode of action involves the integration of a fluorescent moiety onto the LPA backbone, enabling visualization and tracking within biological systems.</p>

<p>Sky peptide trifluoroacetate salt is a high purity, peptide ligand that can be used as a research tool. It is an activator of ion channels and has been shown to bind to the acetylcholine receptor. This compound may also inhibit protein interactions, such as those between antibodies and antigens. Sky peptide trifluoroacetate salt is available in CAS No. 1877294-92-2.</p>

<p>Ac-Val-Glu-Ile-Asp-AMC is a peptide that binds to the acetylcholine receptor, which is a protein that plays an important role in the transmission of nerve signals. Ac-Val-Glu-Ile-Asp-AMC is used as a research tool to study the binding of ligands and receptors. It can be purchased from Sigma Aldrich with purity greater than 98%.</p>

<p>(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-Amino-5-carbamimidamidopentanamido]-5-carbamimidamidopentanamido]-5-carbamimidamidopentanamido]-5-car bamimidamido-N-[(1S)-1-{[(1S)-1-carbamoyl-2-(1H-indol-3)ethyl]carbamoyl}-2-(1Hindol)ethyl]pentanamide (TRAMPCP) is a cation channel activator that may have therapeutic potential for the treatment of bladder and ovary disorders. TRAMPCP is a potent activator of calcium release from intracellular stores and an inhibitor of voltage gated calcium channels. It has been shown to be active in tissue culture, and to cause</p>

<p>Guanylin is a human gastrointestinal hormone which can be used to activate the transmembrane receptor Guanylate Cyclase C on the intestinal epithelial cells surface. This product contains disulfide bonds between Cys4-Cys12 and Cys7-Cys15 and is available as a 0.1mg vial.</p>