Reagentes Sintéticos

<p>Applications The (R)-enantiomer intermediate in the preparation of Oxiracetam (O846905).<br>References Kondepudi, D., et al.: Science, 250 975 (1990), Di Silvestro, G., et al.: J. Pharm. Sci., 82, 758 (1993),<br></p>

<p>Applications Epacadostat is a potent and novel indoleamine 2,3-dioxygenase (IDO1) inhibitor with IC50 of 10 nM. It has high selectivity over IDO2 and tryptophan 2,3-dioxygenase (TDO).<br>References Yue, Eddy W., et al.: ACS Med. Chem. Lett., 8, 486 (2017);<br></p>

<p>Applications MDL 29951 is an allosteric inhibitor of the enzyme fructose 1,6-bisphosphatase.<br>References Wright, S., et. al.: Bioorg. Med. Chem. Lett., 13, 2055 (2003)<br></p>

<p>Applications Intermediate in the production of mutagenic pyrolyzates.<br>References Grassy, G., et al.: Eur. J. Med. Chem., 17, 109 (1982),<br></p>

<p>Applications 2-amino-3-methylpentan-1-ol (cas# 24629-25-2) is a useful research chemical.<br></p>

<p>Applications 1-Methyl-2-indolone is a reactant for preparation of fluorescent analogues of strigolactones as affectors of parasitic weed germination and fungal branching, irreversible Nek2 Kinase Inhibitors and anticancer agents.<br>References Prandi, C., et al.: Eur. J. Org. Chem., 3781, Henise, J., et al.: J. Med. Chem., 54, 4133 (2011); Kamal, A., et al.: Eur. J. Med. Chem., 46, 2427 (2011)<br></p>

<p>Applications 11-Bromo-1-undecene acts as a reagent used in the chemoenzymatic synthesis of macrolide antibiotics for the treatment of common bacteria infection.<br>References Chatterjee, S., et al.: RSC Adv., 4, 42697 (2014)<br></p>

<p>Applications Gabexate Mesylate is a serine protease inhibitor. Gabexate Mesylate inhibits trypsin, plasmin, plasma kallikrein and thrombin. Gabexate Mesylate inhibits lipopolysaccharide-induced tumor necrosis factor-α (TNF-α) production through nuclear factor-κB and activator protein-1 activation. Neuroresearch &amp; Neuroprotective Product.<br>References Yuksel, M. et al.: J. Pharmacol. Exp. Therap., 305, 298 (2003); Tamura, Y. et al.: Biochim. Biophys. Acta, 484, 417 (1977); Ohno, H. et al.: Thromb. Res., 24, 445 (1981);<br></p>

<p>Applications (R)-(-)-α-Methoxyphenylacetic Acid is a useful synthetic intermediate. It is used as a reactant in the synthesis of dopamine receptor agonists. It can also be used to prepare hydroxytriamides as potent γ-secretase inhibitors.<br>References Biswas, S., et al.: J. Med. Chem., 51, 101 (2008); Prasad, C., et al.: Bioorg. Med. Chem. Lett., 14, 1917 (2004)<br></p>

<p>Applications Trichostatin A is a known inhibitor of fibrosis in vitro and in vivo, and is used as an anticancer agent. Potent differentiation inducer of friend leukemic cells.<br>References Mori, K. et al.: Tetra., 44, 6013 (1988); Meng, F. et al.: Brit. J. Canc., 108, 579 (2013); Yang, L. et al.: Mol. Pharm., 83, 671 (2013);<br></p>

<p>Applications 2,4-Dichloro-5-trifluoromethylpyrimidine is a reactant in the preparation of pyrimidine derivatives as inhibitors of gene ALK protein Kinase phosphorylating kinase and as cell proliferation inhibitors.<br>References Yang, E.H., et. al.: Bull. Korean Chem. Soc., 34, 3129 (2013)<br></p>

<p>Applications [4,​4'-​Bis(tert-butyl)​-​2,​2'-​bipyridine]​bis[3,​5-​difluoro-​2-​[5-​(trifluoromethyl)​-​2-​pyridinyl]​phenyl]​iridium(III) hexafluorophosphate is commonly used as a catalyst in the synthesis of various compounds such as saturated N-​heterocycles from aldehydes, fosmidomycin analogue, and many more.<br>References Jindakun, C., et al.: Org. Lett. 20, 2071-75 (2018); Guo, T., et al.: Adv. Synth. Catal., 360, 1352-57 (2018); Abbas, S.Y., et al.: Org. Lett., 20, 868-71 (2018)<br></p>

<p>Applications [1,3-Bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene] Dichloro(o-isopropoxyphenylmethylene)ruthenium is a cross-metathesis catalyst used for installation of S-allylcysteine in proteins for enabling olefin metathesis on proteins.<br>References Lin, Y.A., et al.: J. Am. Chem. Soc., 132, 16805 (2010); Chalker, J.M., et al.: Chem. Comm., no vol., 3714 (2009)<br></p>

<p>Applications (R)-1-(Benzyloxy)propan-2-ol is the R-isomer of 1-Benzyloxy-2-propanol (B287760), a compound used in the synthetic preparation of glucokinase activators for the treatment of diabetes.<br>References You, L., et al.: J. Am. Chem. Soc., 134, 7117 (2012); Henze, O., et al.: J. Am. Chem. Soc., 128, 5923 (2006); Hoff, B.H., et al.: Tetrahedron. Asym., 7, 3181 (1996); Sugawara, F., et al.: Agr. Biol. Chem., 50, 2261 (1986);<br></p>

<p>Applications An optically active resolving agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Helv. Chim. Acta, 61, 2773 (1978)<br></p>

<p>Applications 5-Iodovanillin is used in laccase catalyzed synthesis of iodinated phenolic compounds with antifungal activity. Molecular modeling studies of interaction between plasmid DNA (pBR322) and dendritic antioxidants.<br>References Ihssen, J., et al.: PLoS One, 9, e89924 (2014); Chhetri, P., et al.: J. Cancer Sci.Ther., 3, 220 (2011)<br></p>

<p>Applications (S)-(+)-α-Methoxyphenylacetic Acid (cas# 26164-26-1) is a compound useful in organic synthesis.<br></p>

<p>Stability Hygroscopic<br>Applications R-(-)-3-Quinuclidinol Hydrochloride is shown to have weak in vitro acetylcholinesterase inhibitory activity.<br>References Bosak, A., et al.: Croat. Chem. Acta, 78, 121 (2005); Pyttel, R., et al.: J. Pharm. Sci., 62, 684 (1973)<br></p>

<p>Stability Unstable in solution. Small amounts of precipitate should have no effect on use.<br>Applications 1-Chloro-N,N-2-trimethylpropenylamine acts as a reagent in the synthesis and antitumor activity of (-)-bassianolide in human cancer cells through cell cycle arrest. Enantioselective total synthesis of nannocystins A and A0 as elongation factor 1 inhibitors. Total synthesis of (-)-caprazamycin A with antibacterial activity against Mycobacterium tuberculosis (TB) via diastereoselective aldol reaction.<br>References Mun, B., et al.: Bioorg. Chem., 69, 64 (2016); Huang, J., et al.: Org. Lett., 18, 4702 (2016); Nakamura, H., et al.: Angew. Chem., Int. Ed., 54, 3136 (2015)<br></p>

<p>Applications α,α,α-Trifluorotoluene, is used as a specialty solvent in organic synthesis and an intermediate in the production of pesticides and pharmaceuticals.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Skelly, P. D., et al.: Handbook for Critical Cleaning, 1, 191 (2011);<br></p>

<p>Applications ZJ 43 is a glutamate carboxypeptidase II (GCPII) and N-acetylaspartylglutamate (NAAG) inhibitor that reduces the deleterious effects of excessive extracellular glutamate.<br>References Feng, J. et al.: Brain Res., 1469, 144 (2012); Zuo, D. et al.: J. Biol. Chem., 287, 21773 (2012); Feng, J. et al.: Brain Res., 1395, 62 (2011)<br></p>

<p>Applications N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid, referred to as Pemetrexed, is used in the treatment of malignant pleural mesothelioma (MPM).<br>References Pasello, G. et al.: Anticanc. Res., 32, 5393 (2012);<br></p>

<p>Applications 6-Bromo-2H-1,4-benzoxazin-3(4H)-one is used in the synthesis of substituted benzoxazinones; selective 5-HT6 antagonists used for treating central nervous system diseases and gastrointestinal tract disorders.<br></p>

<p>Applications (+)-Biotinyl 3,6,9-Trioxaundecanediamine is a biotin derivative and is used as a reagent in the synthesis of a potent, covalent BTK inhibitor for B-cell lymphoma.<br>References Wu, H., et al.: ACS Chem. Biol., 9, 1086 (2014)<br></p>

<p>Applications (Ethoxycarbonylmethyl)triphenylphosphonium-13C2 bromide is an intermediate in the synthesis of 3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone-13C5, which is an isotope labelled Mutagen X (MX) is a chlorinated furanone that accounts for more of the mutagenic activity of drinking water than any other disinfection byproduct. DNA damages provoked by the six mutagens (furylframide, MX, 4-nitroquinoline N-oxide, sodium azide, 1-nitropyrene, and captan) used in the present study have been known to subject to the nucleotide excision repair system.<br>References Hakulinen, P., et al.: Toxicol. Lett., 151, 439 (2004), Richardson, S., et al.: Mutat. Res., 636, 178 (2007), Kim, J., et al.: Environ. Toxicol., 23, 319 (2008),<br></p>

<p>Applications (S)​-​(+)​-​Pantolactone is a versatile cyclic ester reactant used in the preparation of tunable ligands carbohydrate-derived diarylphosphinites for asymetric catalysis hydrovinylation of styrene derivatives.<br>References Park, H., RajanBabu, T.: J. Am. Chem. Soc., 124, 734 (2002);<br></p>

<p>Applications Oprozomib is the second class of proteasome inhibitors with higher specificities and reduced toxicities, against head and neck squamous cell carcinoma.<br>References Zang, Y., et al.: Autophagy., 8, 1837 (2012); Zang, Y., et al.: Clin. Cancer. Res., 18, 5639 (2012); Mato, A.R., et al.: Oncologist., 17, 694 (2012); Zhou, H.J., et al.: J. Med. Chem., 52, 3028 (2009);<br></p>

<p>Applications 4-Dimethylaminobenzylamine is used in the preparation of N-benzyl and N-aryl furylpurines as inhibitors of mycobacteria for potential use as antituberculosis agents.<br>References Bakkestuen, A., et al.: Bioorg. Med. Chem. Lett., 10, 1207 (2000), Gundersen, L., et al.: Med. Chem., 45, 1383 (2002),<br></p>

<p>Applications 4-(Trifluoromethyl)benzonitrile is used in the synthesis of quinazolines for amidines. Also used in the synthesis of s-transferase p1-1 and cancer cell proliferation.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lv, Y. et al.: Chem. Comm., 49, 6349 (2013); Yang, X. et al.: J. Med. Chem., 53, 1015 (2010);<br></p>

<p>Applications Triphenylsilylamine is used as a reagent to produce 2-Amino-3-hydroxy-indoles with potent in vivo antimalarial activity. Triphenylsilylamine is also used to modify Mo/HZSM-5 catalysts and is predicted to have effects on selectivity in the methane-to-benzene (MTB) reaction.<br>References Kikuchi, S., et al.: J. Catal., 242, 349 (2006); Urgaonkar, S., et al.: Org. Lett., 12, 3998 (2010);<br></p>

<p>Applications BL 918 is a potent small-molecule activator of UNC-51-like kinase 1 (ULK1), a serine-threonine kinase involved in autophagy. Promotes cytoprotective autophagy in MPP+-treated SH-SY5Y cells, via the ULK complex. Improves motor dysfunction and reduces loss of dopaminergic neurons, mediated by MPTP, in in vivo models of Parkinson’s disease.<br>References Ouyang, Liang., et al.: J. Med. Chem., 61, 2776 (2018),<br></p>

<p>Applications 12-CROWN-4 (cas# 294-93-9) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Pentadecanoic acid is a saturated fatty acid. Pentadecanoic acid was utilized as a biomarker to examine for the intake of milk fat in relation to its metabolic risk factors. Pentadecanoic Acid that is also produced by certain plant species and acts as an toxic essential oil, which is known to exhibits potential anxiolytic, antinociceptive and antimicrobial properties.<br>References Smedman, A.EM., et al.: Am. J. Clin. Nutr., 69, 22 (1999); Radulovic, N.S., et al.: Food. Chem. Toxiol., 50, 2016 (2012);<br></p>

<p>Applications A macrolide isolated from Penicillium brefeldianum. It affects the vesticular transport of the Golgi apparatus and induces DNA fragmentation which leads to apoptosis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Misumi, Y., et al.: J. Biol. Chem., 261 (1986), Mordente, J.A., et al.: J. Urol., 159, 275 (1998), Erokhina, M.V., et al.: Membr. Cell Biol., 12, 871 (1999), Nojiri, H., et al.: FEBS Letters, 453, 140 (1999),<br></p>

<p>Applications 4-Carboxymethylphenylboronic acid<br></p>

<p>Applications DI-MU-HYDROXO-BIS[(N,N,N',N'-TETRAMETHYLETHYLENEDIAMINE)COPPER(II)] CHLORIDE (cas# 30698-64-7) is a useful research chemical.<br>Chemical Name: DI-MU-HYDROXO-BIS[(N,N,N',N'-TETRAMETHYLETHYLENEDIAMINE)COPPER(II)] CHLORIDE (cas# 30698-64-7) is a useful research chemical.<br></p>

<p>Applications Inhibits the intestinal absorption of Phenylalanine, making it a prospective treatment for phenylketonuria.<br>References Shimomura, K., et al.: J. Biochem., 78, 269 (1975), Ambler, J., et al.: Bioorg. Med. Chem. Lett., 9, 737 (1999),<br></p>

<p>Applications Iron(II) Chloride is used in preparation of a variety of organically templated iron phosphates. It also serves as a reducing flocculating agent in wastewater treatment. It is the precursor to hydrated iron(III) oxides that are magnetic pigments.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lii, K., et al.: Chem. Mater., 10, 2599 (1998); Wildermuth, E., et al.: Ullmann’s Encyclopedia of Industrial Chemistry Wiley-VCH, Wienheim (2005)<br></p>

<p>Applications Semisynthetic camptothecin which inhibits DNA topoisomerase I. Prodrug of 9-aminocamptothecin. Antineoplastic.<br>References Stehlin, J.S., et al.: Int. J. Oncol., 14, 821 (1999), Verschraegen, C.F., et al.: Curr. Opin. Oncol. Endocr. Metab. Invest. Drugs, 1, 184 (1999),<br></p>

<p>Applications Labelled Carbovir (C177740). A nucleoside/nucleotide reverse transcriptase inhibitor (NRTI) caused mitochondrial toxicity in human hepatoma carcinoma cell.<br>References Suo, Z., et al.: J. Biol. Chem., 273, 27250 (1998), Ray, A., et al.: Antimicrob. Agents Chemother., 48, 1089 (2004), Lynx, M., et al.: Biochem. Pharmacol., 71, 1342 (2006),<br></p>

<p>Applications SR 59230A Hydrochloride is a potent and selective β3 adrenergic receptor antagonist.<br>References Nisoli, E., et al.: Mol. Pharmacol., 49, 7 (1996);<br></p>

<p>Applications 1-Bromo-2-(bromomethyl)-4,5-dimethoxybenzene is used in the synthesis of novel histone deacetylase 1 inhibitors (HDAC 1). Also used in the synthesis of antibacterial gemifloxacin derivatives.<br>References Sun, Q. et al.L: Bioorg. Med. Chem. Lett., 23, 3295 (2013); Feng, L. et al. Eur. J. Med. Chem., 55, 125 (2012);<br></p>

<p>Applications Sodium Perborate Tetrahydrate acts as a bleaching agent using oxygen causing less degradation to dyes and textiles.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Murray, L. et al.: J. Am. Oil Chem. Soc., 45, 493 (1968);<br></p>

<p>Applications A useful wittig reagent.<br></p>

<p>Stability Moisture, Temperature Sensitive<br>Applications An inhibitor of yeast a-glucosidase. Used in the synthesis of 1-deoxynojirimycin (DNJ), an important glycosidase inhibitor.<br>References Legler, G., et al.: Carbohydr. Res., 155, 119 (1986), Mitrakou, A., et al.: Diabetic Med., 15, 657 (1998), Fan, J., et al.: Nat. Med., 5, 112 (1999), Cox, T., et al.: Lancet, 355, 1481 (2000),<br></p>

<p>Applications 1-Bromopentadecane is a building block that has been used in the preparation of 1-alkyl-4-(1-alkyl-4-oxo-1,4-dihydroquinolin-2-yl)pyridinium bromide as antibacterial and antioxidant agents.<br>References Kahriman, N., et. al.: Eur. J. Med. Chem., 69, 348 (2013)<br></p>

<p>Stability Air Sensitive (Oxidize)<br>Applications 3,3-Dimethylbutyraldehyde is an intermediate used to prepare spiro-oxindoles as potent, specific small-molecule Inhibitors of the MDM2-p53 Interaction.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ding, K., et al.: J. Med. Chem., 49, 3432 (2006); Yu, S., et al.: J. Med. Chem., 52, 7970 (2009)<br></p>

<p>Applications Intermediate in the preparation of Histamine antagonists and Omeprazole metabolites<br>References Nishikawa, Y., et al.: J. Med. Chem., 32, 583 (1989),<br></p>

<p>Applications Bretylium tosylate has a biphasic response, initially inducing norepinephrine release followed by sympathetic ganglionic blockade. Bretylium tosylate is a class III antiarrhythmic agent and a competitive inhibitor of acetylcholinesterase.<br>References Kuntzman, R., et al.: Clin. Pharmacol. Ther., 11, 829 (1970), Goldenthal, E.I., et al.: Toxicol. Appl. Pharmacol., 18, 185 (1971), Carter, J.E., et al.: Anal. Profiles Drug Subs., 9, 71 (1980),<br></p>

<p>Applications 9-Methyldecanol is used in the synthesis of apolipoprotein E secretion stimulator N 4909.<br>References Yamada, N., et al.: J. Clin. Invest., 89, 706 (1992), Hiramoto, S., et al.: J. Antibiotics, 49, 949 (1996),<br></p>

<p>Applications Phenidone is a dual LO (lipoxygenase) and Cox (cyclooxygenase) inhibitor.<br>References Pilar, G. et al.: J. Phycol., 52, 1085 (2016);<br></p>

<p>Applications A reagent used in the synthesis of Pitavastatin.<br>References Mukaiyama, H., et al.: Chem. Pharm. Bull., 55, 881 (2007), Paruch, K., et al.: Bioorg. Med. Chem. Lett., 17, 6220 (2007),<br></p>

<p>Applications GBR 12935 dihydrochloride is a DAT and SLC6A2 inhibitor.<br></p>

<p>Stability Moisture Sensitive<br>Applications 2-Chloro-4H-1,2,3-benzodioxaphosphorin-4-one is a highly reactive cyclic phosphitylating reagent which provides fast coupling rates, and hydrolytic cleavage occurs more readily than with acyclic analogs.<br> E0<br>References Bannwarth,W. &amp; Kung, E.: Tetrahedron Lett., 30, 4219 (1989)<br></p>

<p>Applications 1,1-(Ethylenedioxy)-3-bromopropane is used in the synthesis of EGFR inhibitors. Also used in the synthesis of orally active agents of cancer and cell proliferation with quinoline substructures.<br>References Zhang, X. et al.: Arch. Pharm., 346, 44 (2013); Lee, Y. et al.: J. Med. Chem., 55, 10363 (2012);<br></p>

<p>Applications: An orally active, synthetic nonpeptide renin inhibitor. Antihypertensive.<br>References Lefevre, G., et al.: J. Immunoassay, 21, 65 (2000), Allikments, K., et al.: Curr. Opin. Invest. Drugs, 3, 1479 (2002), Wood, J.M., et al.: Biochem. Biophys. Res. Commun., 308, 698 (2003), Grandman, A.H., et al.: Circulation, 111, 1012 (2005),<br></p>