Canabinóides
Os canabinoides são uma classe de compostos químicos diversos derivados de ácidos graxos ou poliquetídeos que atuam sobre os receptores canabinoides nas células, alterando a liberação de neurotransmissores no cérebro. Encontrados principalmente em plantas de cannabis, canabinoides como THC e CBD são amplamente estudados por seus efeitos terapêuticos, incluindo alívio da dor, propriedades anti-inflamatórias e uso potencial em doenças neurodegenerativas. Na CymitQuimica, você encontrará uma ampla variedade de canabinoides para pesquisa em farmacologia, neurobiologia e química medicinal.
Foram encontrados 562 produtos para "Canabinóides".
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(±)5(6)-EET Ethanolamide
(±)5(6)-EET Ethanolamide is a metabolite derived from Anandamide through oxidation by cytochrome P450 enzymes. It acts as a selective cannabinoid receptor 2 (CB2) agonist. The Ki values for (±)5(6)-EET Ethanolamide against human CB1 and CB2 are 11.4 μM and 8.9 nM, respectively. This compound can be used in studies related to immunoregulation and neuroinflammation.NESS 0327
CAS:NESS 0327 is a high selectivity antagonist of the cannabinoid CB1 receptor. NESS 0327 is more than 60,000-fold selective for the CB1 receptor.Fórmula:C24H23Cl3N4OPureza:99.78%Cor e Forma:SolidPeso molecular:489.825GPR55 agonist 4
GPR55 agonist 4 (Compound 28), with an EC50 of 131 nM for hGPR55 and 1.41 nM for rGPR55, effectively induces β-arrestin recruitment to human GPR55 [1].Fórmula:C19H16FN5O2Cor e Forma:SolidPeso molecular:365.36TRPM8 antagonist 4 prodrug
TRPM8 antagonist 4 prodrug (Compound 8b) is an orally active CB2R agonist (EC50: 51.2 nM) and a weak TRPM8 antagonist. It acts as a prodrug of TRPM8 antagonist 4, exhibiting anti-inflammatory and analgesic properties. TRPM8 antagonist 4 prodrug is applicable in studies of inflammation-related pain disorders.Cannabicitran
CAS:Cannabicitran is a cannabinoid that can decrease rabbits intraocular pressure [1] [2].Fórmula:C21H30O2Cor e Forma:SolidPeso molecular:314.46N-(1-(3,4-Dihydroxyphenyl)propan-2-yl)oleamide
CAS:N-(1-(3,4-Dihydroxyphenyl)propan-2-yl)oleamide: binds CB1 (Ki=365 nM), activates PPARα (EC50=698 nM), reduces rat food intake, no FAAH inhibition.Fórmula:C27H45NO3Cor e Forma:SolidPeso molecular:431.661(R)-Zevaquenabant
(R)-Zevaquenabant ((R)-MRI-1867) is the enantiomer of Zevaquenabant. Zevaquenabant ((S)-MRI-1867) is a peripherally restricted, orally bioavailable dual antagonist of the cannabinoid CB1 receptor and inducible nitric oxide synthase (iNOS). It is beneficial in improving chronic kidney disease (CKD) caused by obesity.Cor e Forma:Odour SolidHemopressin(human, mouse) TFA
CAS:Hemopressin TFA: nonapeptide from hemoglobin, oral CB1 inverse agonist, eases inflammatory pain.Fórmula:C52H80F3N13O14Pureza:98%Cor e Forma:SolidPeso molecular:1168.27Hemopressin(rat)
CAS:Peptide inhibitor for ep24.15, neurolysin & ACE with Ki 27.76, 3.43, 1.87 μM. Lowers blood pressure, modulates CB1 receptor, reduces pain & food intake.Fórmula:C53H77N13O12Pureza:98%Cor e Forma:SolidPeso molecular:1088.27Docosahexaenoyl glycerol
CAS:Docosahexaenoyl glycerol, an analog of endocannabinoid, stimulates glucose uptake and exhibits anti-inflammatory efficacy [1] [2].Fórmula:C25H38O4Cor e Forma:SolidPeso molecular:402.57SCOTfluor-89
CAS:SCOTfluor-89 is a small, conjugatable, orthogonal, and multicolor fluorescent group designed for in vivo imaging of cell metabolism.Fórmula:C12H14N4O7SeCor e Forma:SolidPeso molecular:405.22Nervonoyl ethanolamide
CAS:Nervonoyl ethanolamide (NEA), an endogenous cannabinoid, functions as both a presynaptic and postsynaptic neuromodulator. Additionally, it is utilized in inflammation research [1].Fórmula:C26H51NO2Cor e Forma:SolidPeso molecular:409.69TRPV1/CB2 agonist 1
TRPV1/CB2 agonist 1 (compound 41) is a dual agonist targeting hTRPV1 and CB2 receptors, with an EC50 value of 26.8 μM for hTRPV1. It is applicable in research related to the nervous system.Cor e Forma:Odour SolidUVI3502
UVI3502 is a cannabinoid receptor 1 (CB1) antagonist with an IC50 value of 4641 nM for CB1 and approximately 16200 nM for CB2. It can inhibit Gi/o protein coupling induced by the agonist CP55,940. UVI3502 shows potential for research into diseases related to the endocannabinoid system in the central nervous system, such as cognitive impairments and neurodegenerative disorders.CB2R probe 1
CAS:CB2R Probe 1, a cannabinoid 2 receptor (CB2R) fluorescent probe, exhibits both safety and environmental friendliness, boasting a dissociation constant (K i) ofFórmula:C36H42N4O4Cor e Forma:SolidPeso molecular:594.74Hemopressin (human, mouse)
CAS:Endogenous peptide, inhibits ep24.15/24.16/ACE with Ki of 27.76/3.43/1.87 μM. Lowers blood pressure, CB1 inverse agonist, reduces pain in vivo.Fórmula:C50H79N13O12Pureza:98%Cor e Forma:SolidPeso molecular:1054.26RVD-Hpα
CAS:N-terminally extended form of human hemopressin that acts as a selective CB1 receptor agonist.Fórmula:C65H105N19O17Pureza:98%Cor e Forma:SolidPeso molecular:1424.66Zevaquenabant
CAS:Zevaquenabant (S-MRI-1867): oral CB1/iNOS antagonist combatting obesity-induced CKD.Fórmula:C25H21ClF3N5O2SCor e Forma:SolidPeso molecular:547.98Tocrifluor T1117
CAS:Fluorescent form of AM 251, CB1 receptor antagonistFórmula:C56H53Cl2N7O5Pureza:98%Cor e Forma:SolidPeso molecular:974.97CB1R antagonist 2
CB1R antagonist 2 (Compound 11g) functions as an antagonist of the cannabinoid receptor 1 (CB1R), inhibiting the MAPK/NF-κB signaling pathway and exhibiting anti-inflammatory properties. In RAW264.7 cells, it suppresses LPS-induced expression of IL-6, IL-1β, and TNF-α. In murine models, it improves OVA-induced allergic rhinitis.Fórmula:C24H26N4OCor e Forma:SolidPeso molecular:386.49
