Nucleotídeos
Os nucleotídeos são compostos orgânicos que servem como building blocks dos ácidos nucleicos, essenciais para a formação de DNA e RNA. Cada nucleotídeo é composto por uma base nitrogenada, uma molécula de açúcar e um ou mais grupos fosfato. Esses nucleotídeos se unem para formar longas cadeias, criando o material genético que carrega e transmite informações genéticas em todos os organismos vivos. Nesta seção, você encontrará uma ampla variedade de nucleotídeos cruciais para pesquisas em genética, biologia molecular e bioquímica. Eles são fundamentais para estudar processos genéticos, sintetizar ácidos nucleicos e desenvolver ferramentas diagnósticas e terapêuticas. Na CymitQuimica, oferecemos nucleotídeos de alta qualidade para apoiar suas pesquisas científicas e aplicações, garantindo precisão e confiabilidade em seus experimentos.
Subcategorias de "Nucleotídeos"
Foram encontrados 2636 produtos de "Nucleotídeos"
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Adenosine 5'-Diphosphate Disodium Salt
CAS:Fórmula:C10H13N5Na2O10P2Pureza:>93.0%(HPLC)Cor e Forma:White to Light yellow powder to crystalPeso molecular:471.176-Methyl-5-nitrouracil
CAS:Fórmula:C5H5N3O4Pureza:>95.0%(T)(HPLC)Cor e Forma:Light orange to Yellow to Green powder to crystalPeso molecular:171.114-Bromo-3,5-dichloropyridine
CAS:4-Bromo-3,5-dichloropyridine is a reactive intermediate that is used as a reagent in organic synthesis. It has low basicity and reacts with lithium to form the lithium salt. The salt can be deprotonated to form the bromide anion, which is more reactive than the chloride anion. 4-Bromo-3,5-dichloropyridine can also be used for the selective isomerization of ketones and related compounds. Bromine is added to prevent side reactions with oxygen. The intermediates are generated at the site of reaction by using an excess of diisopropylamide over bromination agent.
Fórmula:C5H2BrCl2NPureza:Min. 95%Peso molecular:226.89 g/molUridine
CAS:Fórmula:C9H12N2O6Pureza:>98.0%(T)(HPLC)Cor e Forma:White powder to crystalPeso molecular:244.20Polycytidylic acid
CAS:Polycytidylic acid is a single stranded RNA analog which is combined with Polyinosinic acid to form a stable duplex structure known as Polyinosinic acid-polycytidylic acid (Poly I:C). PolyI:C stimulates the secretion of pro-inflammatory cytokines and type I interferon through its interaction with endosomal Toll-like receptor 3 (TLR-3) and the cytoplasmic receptors melanoma differentiation-associated gene 5 (MDA-5) and retinoic acid-inducible gene I (RIG-I). This immunostimulant activity makes Poly I:C a useful vaccine adjuvant and is used in vaccine formulations. Poly I:C and its stabilized analogs (e.g., poly-ICLC) are also being actively researched for their dual role in oncology: directly targeting tumors and acting as immune potentiators. For example Poly I:C can induce apoptosis in tumor cells and stimulate immunogenic cell death and is therefore being explored alongside chemotherapy, radiotherapy, and checkpoint inhibitors, helping to overcome resistance mechanisms and strengthen treatment outcomes. We can supply PolyI:C to all stages of your project - from R&D and preclinical phases right up to GMP commercial manufacture. Contact our team for custom Poly I:C products.
For more on poly I:C read out blog 'Poly I:C: A Vaccine Adjuvant With Oncological Potential.'Pureza:Min. 95%Cytidine 5'-triphosphate disodium dihydrate
CAS:Cytidine 5'-triphosphate (CTP) disodium dihydrate prevents the action of aspartate carbamoyltransferase, an enzyme involved in pyrimidine biosynthesis. CTP serves as a molecule of high energy and acts as a coenzyme in glycerophospholipid biosynthesis and protein glycosylation.Fórmula:C9H16N3O14P3•(H2O)2•Na2Pureza:Min. 95%Cor e Forma:PowderPeso molecular:565.17 g/molN3-Methylthymidine
CAS:N3-Methylthymidine is a metalloprotease inhibitor that has been shown to inhibit the activity of epidermal growth factor (EGF). N3-Methylthymidine is also an effective inhibitor of HIV infection. The inhibitory effect on HIV infection is due to the competitive inhibition of viral protease and subsequent degradation of viral proteins. N3-Methylthymidine inhibits the synthesis and release of infectious herpes simplex virus particles. This drug also inhibits the growth of human tumor cells in culture by inhibiting cell proliferation, most likely due to its ability to inhibit EGF. An analytical method for determining the concentration of this drug in plasma using chemical ligation has been developed.Fórmula:C11H16N2O5Pureza:Min. 95%Cor e Forma:White PowderPeso molecular:256.26 g/mol2'-Deoxy-N2-phenoxyacetylguanosine
CAS:2'-deoxy-N2-phenoxyacetylguanosine is a synthetic nucleoside that is used as a substrate in experiments to study the properties of guanine. The compound can be synthesized by the reaction of 2'-deoxy-N2-phenoxyacetaldehyde with guanine. The synthesis starts with the condensation of 2'-deoxyribose and N2-phenoxyacetaldehyde, followed by the oxidation of the resulting anhydride to give aldehyde, which reacts with guanine to form a Schiff base. This then undergoes hydrolysis to yield 2'-deoxy-N2-phenoxyacetylguanosine.Fórmula:C18H19N5O6Pureza:Min. 95%Peso molecular:401.38 g/mol2'-Deoxycytidine-5'-diphosphate trisodium salt hydrate
CAS:2'-Deoxycytidine-5'-diphosphate trisodium salt hydrate is a nucleoside that is used as an antiviral agent in the treatment of herpes zoster and varicella zoster. This drug also has anticancer properties, which may be due to its ability to inhibit DNA synthesis. 2'-Deoxycytidine-5'-diphosphate trisodium salt hydrate is a novel nucleotide analogue that has been modified to improve its stability, solubility and bioavailability. It can be used as a starting material for the synthesis of phosphoramidites by reacting with phosphorous pentoxide at elevated temperatures and pH. CAS No. 151151-32-5Fórmula:C9H12N3O10P2·Na3Pureza:Min. 95%Cor e Forma:White Off-White PowderPeso molecular:453.12 g/moldNTP pre-mixes, 10 mM aqueous solution
CAS:dATP, dTTP, dCTP and dGTP pre-mixed in a single vialFórmula:C10H16N5O12P3Pureza:Min. 95%Cor e Forma:Clear LiquidPeso molecular:491.18 g/mol2-Hydrazinoadenosine
CAS:2-Hydrazinoadenosine is an active analogue of adenosine. It is a potent agonist for the adenosine receptor subtypes A1 and A2A with high affinity. 2-Hydrazinoadenosine has been shown to inhibit cardiac contractility in animal models, as well as to produce hypotension, bradycardia, and bronchodilation in humans. This drug also has a functional effect on the heart by binding to adenosine receptors, which leads to the inhibition of catecholamine release. This drug is used clinically as an antiarrhythmic agent and a vasodilator in coronary artery disease.
Fórmula:C10H15N7O4Pureza:Min. 95%Cor e Forma:PowderPeso molecular:297.27 g/mol9-(2'-Deoxy-2'-fluoro-β-D-arabinofuranosyl)guanine
CAS:9-(2'-Deoxy-2'-fluoro-b-D-arabinofuranosyl)guanine is a nucleoside phosphorylase inhibitor that is used to treat inflammatory bowel disease. It has been shown to be effective in treating women with inflammatory bowel disease, and has no significant side effects. 9-(2'-Deoxy-2'-fluoro-b-D-arabinofuranosyl)guanine inhibits the bacterial enzyme nucleoside phosphorylase, which is responsible for the conversion of guanosine triphosphate (GTP) to guanosine diphosphate (GDP). This inhibition prevents the synthesis of DNA and RNA by blocking the conversion of GTP and GDP into AMP and GMP. The drug binds to the active site of nucleoside phosphorylase, which is located in the bacterial cytoplasmic membrane. 9-(2'-Deoxy-2'-fluoroFórmula:C10H12FN5O4Pureza:Min. 97 Area-%Cor e Forma:PowderPeso molecular:285.24 g/molN2,7-Dimethylguanosine
CAS:N2,7-Dimethylguanosine is a modified nucleotide that is an intermediate in the biosynthesis of guanine. This modification is catalyzed by an enzyme called methyltransferase, which transfers a methyl group from S-adenosylmethionine to the guanine base. N2,7-dimethylguanosine has been shown to be involved in epigenetic regulation and translation regulation as well as having a biological function as an acceptor for aminoacylation. N2,7-dimethylguanosine can be detected with mass spectrometry and can also be immobilized onto solid supports for use in biochemical pathways. br> N2,7-dimethylguanosine is synthesized from S-adenosylmethionine (SAM) and 5'-methylthioadenosine (MTA) by a series of reactions involving methyltetrahydrofolate reductase and methyFórmula:C12H18N5O5Pureza:Min. 95%Cor e Forma:White PowderPeso molecular:312.3 g/mol2'-Deoxy-4-thiouridine
CAS:2'-Deoxy-4-thiouridine is a pyrimidine nucleoside for a range of applications
Fórmula:C9H12N2O4SPureza:Min. 98 Area-%Cor e Forma:PowderPeso molecular:244.27 g/mol2'-Deoxyadenosine 5'-O-thiophosphate sodium salt
CAS:2'-Deoxyadenosine 5'-O-thiophosphate sodium salt is a synthetic nucleotide that has antiviral, anticancer and antitumor properties. It is a modified deoxyribonucleoside and it activates the synthesis of DNA by acting as an activator. This drug is not found in nature and it has shown to inhibit the growth of human breast cancer cells in cell culture.Fórmula:C10H14N5O5PSPureza:Min. 95%Peso molecular:347.29 g/mol2-Chloroadenosine hemihydrate
CAS:2-Chloroadenosine hemihydrate is a synthetic purine nucleoside analog, closely related to adenosine, with a chlorine atom substituted at the 2-position on the adenine ring. This molecule has potential application in research.Fórmula:C10H12ClN5O4H2OPureza:Min. 95%Cor e Forma:PowderPeso molecular:310.69 g/mol4-Amino-2,6-dihydroxy-5-nitrosopyrimidine
CAS:4-Amino-2,6-dihydroxy-5-nitrosopyrimidine is a molecule that has been shown to be an effective inhibitor of the enzyme tyrosinase in the oxidation of tyrosine to DOPA, which is a precursor of melanin. It is believed that vibrational and structural changes during these reactions are responsible for the inhibitory effects. 4-Amino-2,6-dihydroxy-5-nitrosopyrimidine has also been shown to have anti cancer effects on glioma cells. This molecule binds to copper ions, forming a chelate ring that can stabilize reactive intermediates and terminate free radicals. The chlorine atom on this molecule may be responsible for its cytotoxic effects by reacting with nucleophilic sites on proteins. The functional groups on this molecule react with acid catalysts, such as protonation or dehydration reactions.Fórmula:C4H4N4O3Pureza:Min. 98 Area-%Cor e Forma:PowderPeso molecular:156.1 g/molQueuosine
CAS:Queuosine is a modified nucleoside found in the tRNA of both eukaryotic and prokaryotic organisms. It is primarily sourced from the gut microbiota and obtained through dietary intake, as humans lack the biosynthetic machinery to produce it endogenously. Queuosine plays a crucial role in cellular processes by contributing to the accuracy of protein synthesis, impacting cellular growth and maintenance. Its importance extends to understanding the molecular mechanisms underpinning various physiological processes and the potential for dysregulation in diseases. Ongoing research is exploring queuosine's implications in cellular metabolism, including its role in cancer biology and neurobiology. Understanding the pathways and effects of queuosine incorporation into tRNA may provide insights into novel therapeutic avenues for targeting metabolic disorders and diseases associated with translational fidelity.Fórmula:C17H23N5O7Pureza:Min. 95 Area-%Cor e Forma:PowderPeso molecular:409.39 g/mol2'-Amino-2'-deoxyadenosine-5'-triphosphate sodium salt - aqueous solution
CAS:2'-Amino-2'-deoxyadenosine-5'-triphosphate sodium salt - aqueous solution is a modified ATP analog, where the ribose has a 2'-amino substitution. This compound has potential research applicationsFórmula:C10H17N6O12P3·xNaPureza:Min. 95 Area-%Cor e Forma:PowderPeso molecular:506.2 g/mol8-Amino[1''-(N''-dansyl)-4''-aminobutyl]-5'-(1-aziridinyl)-5'-deoxy adenosine
CAS:8-Amino-[1''-(N''-dansyl)-4''-aminobutyl]-5'-(1-aziridinyl)-5'-deoxyadenosine is a novel nucleoside phosphoramidite that has antiviral and anticancer activity. It is currently under development as a potential treatment for Hepatitis C, HIV and cancer. 8-Amino-[1''-(N''-dansyl)-4''-aminobutyl]-5'-(1-aziridinyl)-5'-deoxyadenosine is an activator of the enzyme ribonucleotide reductase, which converts ribonucleotides to deoxyribonucleotides. It also inhibits the synthesis of DNA and RNA by inhibiting the enzyme DNA gyrase and topoisomerase IV. 8-Amino-[1''-(N''-dansyl)-4''-aminobutylFórmula:C28H37N9O5SPureza:Min. 95%Cor e Forma:PowderPeso molecular:611.72 g/mol
![8-Amino[1''-(N''-dansyl)-4''-aminobutyl]-5'-(1-aziridinyl)-5'-deoxy adenosine](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F3D%2Fthumb-webp%2FNA16503.webp&w=3840&q=75)