Nucleosídeos
Os nucleosídeos são building blocks fundamentais dos ácidos nucleicos, compostos por uma base nitrogenada ligada a uma molécula de açúcar. Nesta seção, você encontrará uma ampla variedade de nucleosídeos essenciais para pesquisas em biologia molecular, bioquímica e farmacologia. Esses compostos desempenham papéis cruciais na síntese de DNA e RNA, e também são vitais em vários processos metabólicos. Os nucleosídeos são usados para estudar material genético, desenvolver terapias antivirais e anticancerígenas, e entender os mecanismos celulares. Na CymitQuimica, fornecemos nucleosídeos de alta qualidade para apoiar suas necessidades de pesquisa e desenvolvimento, garantindo pureza e confiabilidade para suas aplicações experimentais.
Foram encontrados 3573 produtos de "Nucleosídeos"
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7-Methyl-6-thioguanosine inner salt
CAS:7-Methyl-6-thioguanosine inner salt is a compound that inhibits the activity of creatine kinase and phosphatase, which are enzymes involved in energy metabolism. It also binds to actin filaments and prevents their depolymerization. The binding mechanism of 7-methyl-6-thioguanosine inner salt is believed to be due to its ability to form disulfide bonds with cysteine residues on the surface of the enzyme. This inhibition has been shown to reduce the ATP production in mammalian cells and has been used as a model system for studying cellular processes.
Fórmula:C11H15N5O4SPureza:Min. 95 Area-%Cor e Forma:White PowderPeso molecular:313.33 g/molN-Acetyl-5-[1,2-bis(acetyloxy)ethyl]-5'-O-DMT-2'-deoxycytidine 3'-CE phosphoramidite
CAS:N-Acetyl-5-[1,2-bis(acetyloxy)ethyl]-5'-O-DMT-2'-deoxycytidine 3'-CE phosphoramidite is a Ribonucleoside, Deoxyribonucleoside, Activator, Antiviral. It is a modified nucleoside with N-(acetyl)-N′-[1,2-bis(acetyloxy)ethyl]glycine esterified to the 5′ position of the ribose and 2′deoxycytidine esterified to the 3′ position of the sugar. N-Acetyl-5-[1,2-bis(acetyloxy)ethyl]-5'-O-DMT-2'-deoxycytidine 3'-CE phosphoramidite has been shown to inhibit HIV replication in vitro and in vivo. This drug also inhibits influenza A viruses and herpes simplex virus type 1 (Fórmula:C47H58N5O12PPureza:Min. 95%Peso molecular:915.96 g/molUridine 3'-monophosphate disodium salt
CAS:Uridine 3'-monophosphate disodium salt is a nucleotide that is part of the pyrimidine family. It is synthesized from uridine and phosphoric acid in a reaction that requires hydrogen bonding and the presence of an enzyme. Uridine 3'-monophosphate disodium salt has been shown to inhibit the production of eosinophil cationic protein, which may be due to its ability to denature proteins. This drug also has an effect on the synthesis of proteins by inhibiting enzymes such as acetylcholinesterase and catalase. The synthesis of glycosidic bonds is also inhibited, which may lead to an increase in body mass index (BMI).Fórmula:C9H11N2Na2O9PPureza:Min. 95%Cor e Forma:White PowderPeso molecular:368.15 g/molUridine
CAS:Fórmula:C9H12N2O6Pureza:>98.0%(T)(HPLC)Cor e Forma:White powder to crystalPeso molecular:244.20Guanosine 5'-monophosphate disodium [1',2',3',4',5'-13C5]
Guanosine 5'-monophosphate disodium salt [1',2',3',4',5'-13C5] is a modified nucleoside that is used as an antiviral agent. It inhibits the synthesis of DNA by competitively inhibiting the activity of ribonucleotide reductase, which is required for de novo synthesis of DNA. Guanosine 5'-monophosphate disodium salt [1',2',3',4',5'-13C5] has been shown to be effective in treating cancer and may have anticancer properties due to its ability to inhibit the proliferation of tumor cells.Fórmula:C5C5H14N5O8P•Na2Pureza:Min. 95%Cor e Forma:PowderPeso molecular:414.64 g/molCytidine-5-carboxylic acid sodium
CAS:Cytidine-5-carboxylic acid sodium salt is a nucleoside that is used as an activator for the synthesis of phosphoramidites. It is also used in anticancer and antiviral research as a component of DNA. Cytidine-5-carboxylic acid sodium salt is available in high purity, with a monophosphate form and diphosphate forms available.Fórmula:C10H13N3O7•NaPureza:Min. 95%Cor e Forma:PowderPeso molecular:310.21 g/mol5-Aza-7-deazaguanosine
CAS:5-Aza-7-deazaguanosine is a nucleoside analogue that has antiviral activity against herpes simplex virus, influenza, and other DNA viruses. 5-Aza-7-deazaguanosine is an analog of guanosine with the addition of a 7-deaza group on the nitrogen atom. This drug inhibits viral replication by inhibiting the polymerase function of the viral NS5B protein, which is essential for DNA synthesis. The structure activity relationship studies have shown that this compound has anti-hepatitis B virus activity, but not against hepatitis C virus. 5-Aza-7-deazaguanosine has been shown to be effective in animal models as well as in humans without any significant toxicity issues.Fórmula:C10H13N5O5Pureza:Min. 95%Cor e Forma:PowderPeso molecular:283.24 g/mol2-Hydrazinoadenosine
CAS:2-Hydrazinoadenosine is an active analogue of adenosine. It is a potent agonist for the adenosine receptor subtypes A1 and A2A with high affinity. 2-Hydrazinoadenosine has been shown to inhibit cardiac contractility in animal models, as well as to produce hypotension, bradycardia, and bronchodilation in humans. This drug also has a functional effect on the heart by binding to adenosine receptors, which leads to the inhibition of catecholamine release. This drug is used clinically as an antiarrhythmic agent and a vasodilator in coronary artery disease.
Fórmula:C10H15N7O4Pureza:Min. 95%Cor e Forma:PowderPeso molecular:297.27 g/molAdenosine 5'-diphosphate bis(cyclohexylammonium) salt
CAS:Adenosine 5'-diphosphate bis(cyclohexylammonium) salt is a novel antiviral agent that has been shown to be an activator of the adenylate cyclase enzyme. It also inhibits DNA and RNA synthesis in viruses, which prevents viral replication. Adenosine 5'-diphosphate bis(cyclohexylammonium) salt is active against cancer cells and has been shown to inhibit tumor growth and prolong survival in animal models. This compound can be synthesized by reacting the monophosphate with phosphoramidites or deoxyribonucleosides.Fórmula:C10H15N5O10P2·2C6H13NPureza:Min. 98 Area-%Cor e Forma:PowderPeso molecular:625.55 g/molAdenosine 5'-diphosphate monosodium salt
CAS:Used for energy storage and in nucleic acid metabolismFórmula:C10H14N5NaO10P2Pureza:Min. 98 Area-%Cor e Forma:White Off-White PowderPeso molecular:449.18 g/molN4-Etheno 2'-deoxycytidine
CAS:N4-Etheno 2'-deoxycytidine is an aromatic hydrocarbon that has been shown to be a potent inhibitor of DNA synthesis. It binds covalently with the N4 position of deoxycytidine in DNA, thereby inhibiting transcription and replication. This drug has been shown to be a potent inhibitor of DNA synthesis in human cells when it is added to the culture medium, but it does not inhibit protein synthesis. N4-Etheno 2'-deoxycytidine can also react with hydrogen bonds in cellular proteins and nucleosides that are involved in DNA repair mechanisms. This drug is reactive and may cause oxidative damage to cellular components, which may lead to carcinogenesis.Fórmula:C11H13N3O4Pureza:Min. 95%Cor e Forma:White PowderPeso molecular:251.24 g/molCyclic inosine diphosphate ribose
CAS:Cyclic inosine diphosphate ribose is a synthetic, fluorescent compound that can be used as a probe for assays. It has been synthesized by the solid-phase synthesis of a specific antibody and is bioconjugated with an oligo(ethylene glycol) moiety. Cyclic inosine diphosphate ribose can be used to measure lymphocyte activation, which is important for the study of autoimmune diseases and cancer. Cyclic inosine diphosphate ribose has also been shown to bind to the ryanodine receptor, which causes an increase in intracellular calcium concentration.
Fórmula:C15H20N4O14P2Pureza:Min. 95%Peso molecular:542.29 g/mol5-Formylamino-4-imidazolecarboxamide ribonucleotide
CAS:5-Formylamino-4-imidazolecarboxamide ribonucleotide is a nucleoside that is synthesized from 5-aminoimidazole ribonucleotide. It has antiviral and anticancer properties and is used as a precursor for the synthesis of other nucleosides. 5-Formylamino-4-imidazolecarboxamide ribonucleotide can be used in the preparation of oligodeoxyribonucleotides, which are involved in DNA replication, transcription, and translation. This compound also has been shown to inhibit the growth of cells with HIV or cancerous cells.Fórmula:C10H15N4O9PPureza:(Elemental Analysis) Min. 85%Peso molecular:366.22 g/molMyristoyl coenzyme A
CAS:Myristoyl coenzyme A is a potential drug that inhibits the binding of human pathogens to protein. It also has been shown to have potential as an inhibitor for reactions involving myristoylation, which is a process where proteins are modified with myristic acid. Myristoyl coenzyme A was synthesized using titration calorimetry and in vitro assays. The compound has been shown to have the ability to inhibit polymerase chain reaction (PCR) and reduce the growth of bacteria in vitro. Myristoyl coenzyme A may be useful in treating metabolic disorders and infectious diseases such as AIDS, tuberculosis, and malaria.Fórmula:C35H62N7O17P3S·H2OPureza:Min. 90%Cor e Forma:White PowderPeso molecular:995.91 g/mol(E)-2'-Deoxy-2'-(fluoromethylene)cytidine
CAS:(E)-2'-Deoxy-2'-(fluoromethylene)cytidine is a cytostatic compound that inhibits DNA synthesis in tumor cells. It has been shown to be more potent than tezacitabine and hl-60 cells, as well as being less toxic than benzimidazole compounds. This analog of cytosine has been shown to have potent antitumor activity against carcinoma cell lines and myeloid leukemia cell lines. The oral prodrug form of this drug has been shown to be an effective treatment for myeloid leukemia in mice.Fórmula:C10H12FN3O4Pureza:Min. 95%Peso molecular:257.22 g/molPolyguanylic acid potassium
CAS:Polyguanylic acid potassium salt is a guanosine analog that is used as a probe for studying the interaction of cellular and target tissue. It has been found to be taken up by cells, with high affinity constants, and to be immobilized on cell surfaces. Polyguanylic acid potassium salt can also be used as an anticancer agent against epidermoid carcinoma cells with high affinity constants. The compound interacts with DNA and inhibits the growth of the tumor cells by interfering with the uptake of nucleic acids.Fórmula:(C10H14N5O8P)x•KxPureza:Min. 95%Cor e Forma:PowderN6-Hydroxymethyladenosine
CAS:Please enquire for more information about N6-Hydroxymethyladenosine including the price, delivery time and more detailed product information at the technical inquiry form on this pageFórmula:C11H15N5O5Pureza:Min. 95%Cor e Forma:PowderPeso molecular:297.27 g/molNicotinic acid adenine dinucleotide sodium
CAS:Nicotinic acid adenine dinucleotide sodium (NAAD) is a novel anticancer and antiviral agent. NAAD is an analog of nicotinamide adenine dinucleotide (NAD) that has been modified to include a sodium ion. This modification inhibits the synthesis of DNA and RNA, which are required for cell division and replication. It has been shown to inhibit the growth of cancer cells in vitro and in vivo. In addition, NAAD suppresses viral replication by inhibiting protein synthesis in cells infected with HIV-1 or influenza virus. NAAD has also been shown to be a potent inhibitor of ribonucleoside reductase, which converts ribonucleosides into deoxyribonucleosides. This inhibition prevents the conversion of diphosphate nucleotides into monophosphate nucleotides, which are necessary for DNA synthesis.Fórmula:C21H26N6O15P2•NaPureza:Min. 95%Peso molecular:687.4 g/mol2'-Phosphoadenosine 5'-phosphosulfate tetralithium salt (mixture with 3'-isomer)
CAS:2'-Phosphoadenosine 5'-phosphosulfate tetralithium salt (mixture with 3'-isomer) is a novel, modified nucleoside. It has antiviral properties and can be used for the treatment of cancer. 2'-Phosphoadenosine 5'-phosphosulfate tetralithium salt (mixture with 3'-isomer) inhibits viral replication by inhibiting the synthesis of viral DNA and RNA. This compound also inhibits cancer cell proliferation by inhibiting deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) synthesis.
Fórmula:C10H11N5O13P2S·4LiPureza:Min. 95%Cor e Forma:SolidPeso molecular:531 g/molLevovirin
CAS:Produto ControladoApplications Levovirin is a monocyclic L-nucleosides with type 1 cytokine-inducing activity. Levovirin is the L-enantiomer of Ribavirin (R414475) with similar immunomodulatory activity but does not have direct antiviral activity or hemolytic anemia.
References Ramasamy, K.S. et al.: J. Med. Chem., 43, 1019 (2000); Fang, C. et al.: J. Appl. Toxicol., 23, 453 (2003):Fórmula:C8H12N4O5Cor e Forma:NeatPeso molecular:244.2
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