Peptídeos e Proteínas
Os peptídeos são cadeias curtas de aminoácidos ligadas por ligações peptídicas, enquanto as proteínas são cadeias mais longas e complexas de aminoácidos que podem adotar estruturas tridimensionais funcionais. Ambos os tipos de compostos são essenciais para diversas funções biológicas, como a catálise de reações (enzimas), a defesa imunológica (anticorpos) e a sinalização celular. As proteínas possuem uma estrutura hierárquica que inclui a sequência de aminoácidos, bem como as estruturas secundária, terciária e quaternária. Os peptídeos são utilizados em terapias farmacológicas e cosméticas devido às suas propriedades biológicas específicas, como no tratamento de doenças metabólicas ou na melhoria da regeneração celular. As proteínas, por sua vez, possuem aplicações em biotecnologia, nutrição e medicina regenerativa.
Na CymitQuimica, oferecemos peptídeos e proteínas de alta pureza para pesquisa em biotecnologia e aplicações terapêuticas.
Foram encontrados 3117 produtos de "Peptídeos e Proteínas"
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FK962
CAS:<p>FK962 is an somatostatin release enhancer , exerts cognitive-enhancing actions.</p>Fórmula:C14H17FN2O2Pureza:99.89%Cor e Forma:SolidPeso molecular:264.3THAL-SNS-032
CAS:<p>THAL-SNS-032 is a selective CDK9 degrader PROTAC.</p>Fórmula:C40H52N8O10S2Pureza:99.68%Cor e Forma:SolidPeso molecular:869.02L-Proline
CAS:<p>L-Proline, a nonessential amino acid crucial for collagen synthesis, supports joint, tendon, and heart muscle health.</p>Fórmula:C5H9NO2Pureza:98% - 98.05%Cor e Forma:Flat Needles From Alcohol + Ether; Prisms From Water SolidPeso molecular:115.13dBET1
CAS:<p>dBET1 fuses (+)-JQ1 with thalidomide, degrades BET proteins via cereblon (EC50: 430 nM), and triggers apoptosis.</p>Fórmula:C38H37ClN8O7SPureza:98.02% - 99.3%Cor e Forma:SolidPeso molecular:785.27Bis(maltolato)oxovanadium(IV)
CAS:<p>BMOV: oral pan-PTP inhibitor, mimics insulin, anti-diabetic, improves heart function in diabetes, IC50s: 126-201 nM.</p>Fórmula:C12H10O7VPureza:99.65% - 99.918%Cor e Forma:SolidPeso molecular:317.15Glecaprevir
CAS:<p>Glecaprevir (ABT-493) is an HCV NS3/4A protease inhibitor, (IC50s: 3.5-11.3 nM).</p>Fórmula:C38H46F4N6O9SPureza:99.16% - 99.69%Cor e Forma:SolidPeso molecular:838.87Atosiban acetate
CAS:<p>Atosiban acetate (RW22164) is an inhibitor of the hormones oxytocin and vasopressin.</p>Fórmula:C45H71N11O14S2Pureza:99.84% - 99.92%Cor e Forma:SolidPeso molecular:1054.24BI-6015
CAS:<p>BI 6015 is an antagonist of HNF4α. HNF4α is a nuclear receptor that regulates gene expression in the intestine cells, liver cells, and pancreas-β cells.</p>Fórmula:C15H13N3O4SPureza:99.81%Cor e Forma:SolidPeso molecular:331.35Daptomycin
CAS:<p>Daptomycin (LY146032) is a cyclic lipopeptide antibiotic that inhibits GRAM-POSITIVE BACTERIA.</p>Fórmula:C72H101N17O26Pureza:99.61% - >99.99%Cor e Forma:White PowderPeso molecular:1620.67Urolithin C
CAS:<p>Urolithin C is a gut metabolite of ellagic acid. Urolithin C induces apoptosis in PC12 cells through a mitochondria-mediated pathway.</p>Fórmula:C13H8O5Pureza:98.01% - 99.53%Cor e Forma:SolidPeso molecular:244.2DC260126
CAS:<p>DC260126 is a small-molecule antagonist of FFA1 (GPR40)</p>Fórmula:C16H18FNO2SPureza:99.77%Cor e Forma:SolidPeso molecular:307.38Deruxtecan
CAS:<p>Deruxtecan is an ADC drug-linker conjugate composed of a derivative of DX-8951 (DXd) and a maleimide-GGFG peptide linker used in the synthesis of DS-8201 and U3-1402.Cost-effective and quality-assured.</p>Fórmula:C52H56FN9O13Pureza:98.15% - 98.20%Cor e Forma:SolidPeso molecular:1034.05Lanreotide Impurity 18 Ditrifluoroacetate (Kyn (For) 4)
Fórmula:C54H69N11O12S2·2C2HF3O2Peso molecular:1128.33 2* 114.02Lanreotide Impurity 16 Ditrifluoroacetate (L-Nal 1)
Fórmula:C54H69N11O10S2·2C2HF3O2Peso molecular:1096.33 2* 114.02Lanreotide Impurity 19 Ditrifluoroacetate (Kyn 4)
Fórmula:C53H69N11O11S2·2C2HF3O2Peso molecular:1100.32 2* 114.02Lanreotide Impurity 20 Ditrifluoroacetate (Dha 7)
Fórmula:C54H69N11O10S·2C2HF3O2Peso molecular:1064.27 2* 114.02Lanreotide Impurity 15 Ditrifluoroacetate (D-Tyr 3)
Fórmula:C54H69N11O10S2·2C2HF3O2Peso molecular:1096.33 2* 114.02Lanreotide Impurity 17 Ditrifluoroacetate (D-Cys 7)
Fórmula:C54H69N11O10S2·2C2HF3O2Peso molecular:1096.33 2* 114.02Lanreotide Impurity 21 Ditrifluoroacetate
Fórmula:C54H69N11O10S·2C2HF3O2Peso molecular:1064.27 2* 114.0Lopinavir-d8
CAS:Produto Controlado<p>Applications A labelled selective HIV protease inhibitor. An analogue of Ritonavir. Antiviral. It is a COVID19-related research product.<br>References Sham, H.L., et al.: Antimicrob. Ag. Chemother., 42, 3218 (1998), Kumar, G.N., et al.: Drug Metab. Dispos., 27, 86 (1999), Murphy, R.L., et al.: Antiviral Ther., 4, Suppl. 3, 85 (1999)<br></p>Fórmula:C37D8H40N4O5Cor e Forma:Light YellowPeso molecular:636.85Glecaprevir
CAS:Produto Controlado<p>Applications Glecaprevir is an antiviral drug used in the treatment of patients with hepatitis C virus (HCV) genotype 1-6, of special interest for the treatment of patients with chronic kidney disease also suffering from HCV.<br>References Kwo, P., et. al.: J. Hepatol, 67, 263 (2017)Gane, E., et. al.: N. Engl. J. Med, 377, 1448 (2017)<br></p>Fórmula:C38H46F4N6O9SCor e Forma:NeatPeso molecular:838.864-Methylbenzenesulfonic Acid Monohydrate
CAS:Produto Controlado<p>Impurity Lisinopril EP Impurity B/ Anastrozole EP Impurity F<br>Applications 4-Methylbenzenesulfonic Acid Monohydrate (Lisinopril EP Impurity B) is used in the synthesis of resveratrol. Also used in the synthesis of oxane derivatives as antimalarial agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Davis, M. et al.: Org. Prep. Proc. Int., 45, 304 (2013); Wang, X. et al.: J. Med. Chem., 56, 2547 (2013);<br></p>Fórmula:C7H8O3S·H2OCor e Forma:WhitePeso molecular:190.223,3',5'-Triiodo-L-thyronine
CAS:Fórmula:C15H12I3NO4Cor e Forma:Light Beige To GreyPeso molecular:650.97(S)-2-((S)-4-Methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenylpropanoic Acid
CAS:Produto Controlado<p>Applications (S)-2-((S)-4-Methyl-2-((S)-2-(2-morpholinoacetamido)-4-phenylbutanamido)pentanamido)-3-phenylpropanoic Acid is an intermediate for Carfilzomib (C183460), which is a second-generation proteasome inhibitor that is used as a treatment in relapsed and refractory multiple myeloma.<br>References Fostier, K., et al.: Oncotargets. Therap., 5, 237 (2012); Geurink, P.P., et al.: J. Med. Chem., 56, 1262 (2013); McCormack, P.L., et al.: Drugs., 72, 2023 (2012);<br></p>Fórmula:C31H42N4O6Cor e Forma:NeatPeso molecular:566.69Dihydro Cyclosporin A
CAS:Produto Controlado<p>Applications A Cyclosporin A (C988900) analog, an immunosuppressant.<br>References Emmer, G., et al.: J. Med. Chem., 37, 1918 (1994), High, K., et al.: J. Biol. Chem., 269, 9105 (1994),<br></p>Fórmula:C62H113N11O12Cor e Forma:WhitePeso molecular:1204.63N-Acetyl-L-carnosine
CAS:Produto Controlado<p>Applications Used in the treatment of cataracts and in the treatment of UV-induced immunosuppression. May act with with lipoic acid (L468725) to reverse age-related metabolic decline and also the indicies of oxidative stress.<br>References Babizhayev, M., et al.: J. Pharmacol. Toxicol., 1, 201 (2006), Min, J., et al.: J. Neurosci. Res., 86, 2984 (2008), Babizhayev, M., et al.: J. Drug Target., 17, 36 (2009); Hagen et. al, PNAS 99: 1870 (2002); Liu et. al, PNAS 99, 2356 (2002)<br></p>Fórmula:C11H16N4O4Cor e Forma:Off-WhitePeso molecular:268.276-Perdeoxy-6-perchloro-γ-cyclodextrin, >90%
CAS:Fórmula:C48H72Cl8O32Pureza:>90%Cor e Forma:NeatPeso molecular:1444.69(R)-3-Carboxy-2-hydroxy-N,N,N-trimethylpropan-1-aminium Chloride
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications (R)-3-Carboxy-2-hydroxy-N,N,N-trimethylpropan-1-aminium chloride is an important co-factor of mammalian mitochondrial energy metabolism. It is also a good active ingredient for dry-skin.<br>References Geier, David A., et al.: Neurochem. Res., 38(11), 2336-2341 (2013);Tanno, Osamu, et al.: Fragrance J., 33(8), 82-85 (2005);<br></p>Fórmula:C7H16NO3·ClCor e Forma:White To Off-WhitePeso molecular:197.660N-[(1S)-2-Amino-2-oxo-1-(phenylmethyl)ethyl]-2-pyrazinecarboxamide
CAS:<p>Impurity Bortezomib USP Impurity B<br>Applications N-[(1S)-2-Amino-2-oxo-1-(phenylmethyl)ethyl]-2-pyrazinecarboxamide is a metabolite of Bortezomib (B675700), a proteasome inhibitor for the treatment of multiple myeloma and is known to also target the ubiquitin-proteasome pathway.<br>References Pekol, T., et al.: Drug. Meta. Disp., 33, 771 (2005); Hsieh, F.Y., et al.: J. Pharma. Biomed. Anal., 49, 115 (2009);<br></p>Fórmula:C14H14N4O2Cor e Forma:NeatPeso molecular:270.29Tabimorelin
CAS:Produto Controlado<p>Applications NN703 (Tabimorelin) is an orally active growth hormone (GH) secretagogue intended for use as an alternative to daily injections of GH. In vitro studies in human liver microsomes have indicated that NN703 is a mechanism-based inhibitor of CYP3A4.<br>References Fabre, G., et al.: Biochem. Pharmacol., 37, 4389 (1988), Thummel, K., et al.: Clin. Pharmacol. Ther., 59, 491 (1996), Yu, D., et al.: J. Clin. Pharmacol., 39, 1203 (1999),<br></p>Fórmula:C32H40N4O3Cor e Forma:NeatPeso molecular:528.68Bivalirudin Trifluoroacetic Acid Salt
CAS:<p>Applications Bivalirudin Trifluoroacetic Acid Salt is an anticoagulant drug that is a direct thrombin inhibitor. It is used for treatment of acute coronary syndromes, and is a safer alternative to heparin due to lower rates of bleeding as an adverse effect of anticoagulant in patients.<br>References Stone, G., et al.: N. Engl. J. Med, 355, 2203 (2006); Stone, G., et al.: N Engl J Med, 358, 2218 (2008);<br></p>Fórmula:C98H138N24O33·(C2HF3O2)xCor e Forma:NeatPeso molecular:2180.2911402N,N-Dimethyl-4-hydroxymethoxy Clomiphene (~90%, contains ~10% Z-isomer)
CAS:Produto ControladoFórmula:C25H26ClNO3Cor e Forma:NeatPeso molecular:423.93Perfluorophenol
CAS:Produto Controlado<p>Applications Perfluorophenol is used in the synthesis of PGA-films as biodegradable polymers. It also participates in the synthesis of tripod macrocyclic Gd(III) chelates for cancer molecular MRI.<br>References Lee, K. et al.: Langmuir., 20, 2531 (2004); Zhou, Z. et al.: Biomater., 34, 7683 (2013);<br></p>Fórmula:C6HF5OCor e Forma:NeatPeso molecular:184.06Bestatin
CAS:<p>Bestatin (Ubenimex) competitively inhibits many aminopeptidases. Bestatin is a microbial metabolite and dipeptide with immunomodulatory and antitumor effects.</p>Fórmula:C16H24N2O4Pureza:98% - 99.63%Cor e Forma:White Crystalline PowderPeso molecular:308.37L-Carnitine-L-tartrate
CAS:Produto Controlado<p>Applications L-Carnitine-L-tartrate (cas# 36687-82-8) is a useful research chemical.<br></p>Fórmula:C7H16NO3·C4H4O6Cor e Forma:White To Off-WhitePeso molecular:472.48(R)-Hydroxy Des(boric Acid) Bortezomib
CAS:Produto Controlado<p>Impurity Bortezomib USP Impurity I<br>Applications (R)-Hydroxy Des(boric acid) Bortezomib is an impurity in the synthesis of Bortezomib (B675700), the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer. A reversible inhibitor of the 26S proteasome-a barrel-shaped multiprotein particle found in the nucleus and cytosol of all eukaryotic cells. Targets the ubiquitin-proteasome pathway.<br>References Nawrocki, S.T., et al: Cancer Research, 65, 11510 (2005); Drahl C. et al.: Chem. and Eng. News, 87, 41 (2009)<br></p>Fórmula:C19H24N4O3Cor e Forma:NeatPeso molecular:356.42Bortezomib
CAS:Produto Controlado<p>Stability Hygroscopic and Moisture Sensitive<br>Applications Bortezomib is the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer. A reversible inhibitor of the 26S proteasome-a barrel-shaped multiprotein particle found in the nucleus and cytosol of all eukaryotic cells. Targets the ubiquitin-proteasome pathway.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Nawrocki, S.T., et al: Cancer Research, 65, 11510 (2005); Drahl C.: Chem. and Eng. News, 87, 41 (2009);<br></p>Fórmula:C19H25BN4O4Cor e Forma:White To Off-WhitePeso molecular:384.24Voclosporin-d4
CAS:Produto Controlado<p>Applications Labelled Voclosporin (V678500). A new agent for the treatment of noninfectious uveitis. Uveitis is an inflammatory, putative Th1-mediated autoimmune disease that affects various parts of the eye and is a leading cause of visual loss. Voclosporin, a rationally designed novel calcineurin inhibitor, exhibits a favorable safety profile, a strong correlation between pharmacokinetic and pharmacodynamic response, and a wide therapeutic window. Immunosuppressant.<br>References Aspeslet, L., et al.: Transplant Proc., 33, 1048 (2001), Cho, M., et al.: Arthritis Rheum., 46, 1202 (2002), Staatz, C., et al.: Clin. Pharmacokinet., 43, 623 (2004),<br></p>Fórmula:C63H107D4N11O12Cor e Forma:NeatPeso molecular:1218.65(2S,4S)-Sacubitril
CAS:<p>Stability Moisture Sensitive<br>Applications (2S,4S)-Sacubitril is an impurity of Sacubitril (S080895) which is an antihypertensive drug used in combination with valsartan.<br>References McMurray, J., et al.: N. Eng. J. Med., 371 (2014);<br></p>Fórmula:C24H29NO5Cor e Forma:NeatPeso molecular:411.49N-Formyl Thyroxine
CAS:Produto Controlado<p>Impurity Levothyroxine N-Formyl Impurity; N-Formyl-T4 (USP)<br>Applications N-Formyl Thyroxine (Levothyroxine N-Formyl Impurity; N-Formyl-T4 (USP)) is a thyroxine derivative which showed less thyroid activity than Thyroxine Sodium (T425601).<br>References Basil, B., et al.: Br. J. Pharmacol. Chemother., 5, 315 (1950),<br></p>Fórmula:C16H11I4NO5Cor e Forma:NeatPeso molecular:804.88Teduglutide-d8 TFA salt x hydrate (Leu-methyl-d3+Phe-d5)
CAS:Produto Controlado<p>Applications Teduglutide-d8 TFA salt x hydrate (Leu-methyl-d3+Phe-d5) is an isotopically labelled form of Teduglutide (T013795), which is glucagon-like peptide-2 (GLP-2) analogue that is used for the treatment of short bowel syndrome.<br>References Jeppesen, P., et al.: Gut, 54, 1224 (2005)<br>Chemical Name: Jeppesen, P., et al.: Gut, 54, 1224 (2005)<br></p>Fórmula:C164H244D8N44O55S•C2HF3O2•x(H2O)Cor e Forma:NeatPeso molecular:3760.081140218Cyclosporin B
CAS:<p>Applications An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection.A group of nonpolar cyclic oligopeptides with immunosupppressant activity.<br>References van Wartburg, A., et al.: Prog. Med. Chem., 25, 1 (1988), Jorgensen, K.A., et al.: Scand. J. Imunol., 57, 93 (2003), Vollenbroeker, et al.: Transplant. Proc., 37, 1741 (2005),<br></p>Fórmula:C61H109N11O12Pureza:>80%Cor e Forma:NeatPeso molecular:1188.58N-Acetyl-L-methionine
CAS:Produto Controlado<p>Applications N-Acetyl-L-methionine (CAS# 65-82-7) has been useful in the study of metabolic phenotypes of standard and cold-stored platelets.<br>References D’Alessandro, A., et al.: Transfusion (Malden, MA, US), 60, S96 (2020)<br></p>Fórmula:C7H13NO3SCor e Forma:NeatPeso molecular:191.00L-Prolinamide
CAS:<p>Applications Proline based organocatalyst.<br>References Alberg, D., et al.: Bioorg. Med. Chem. Lett., 19, 3888 (2009), Huang, X., et al.: J. Phys. Chem., 114, 1068 (2010),<br></p>Fórmula:C5H10N2OCor e Forma:White SolidPeso molecular:114.146(4R)-1-Methyl-4-propyl-L-proline Hydrochloride
CAS:Produto Controlado<p>Applications Proline derivative, and an intermediate in the production of biosynthetic antibiotics.<br></p>Fórmula:C9H17NO2·ClHCor e Forma:NeatPeso molecular:207.70N-Acetyl-DL-methionine
CAS:Produto Controlado<p>Applications C7H13NO3S (cas# 1115-47-5) is a useful research chemical.<br></p>Fórmula:C7H13NO3SCor e Forma:NeatPeso molecular:191.25TD-165
CAS:<p>TD-165, a PROTAC-based cereblon (CRBN) degrader, consists of a cereblon (CRBN) ligand-binding group, a linker, and a von Hippel-Landau (VHL) binding group[1].</p>Fórmula:C46H59N7O8SPureza:99.24%Cor e Forma:SolidPeso molecular:870.07MK 677
CAS:<p>Applications MK-677 is a potent, non-peptide ghrelin receptor agonist.<br>References Kirstie, A., et al.: Mol. Pharmacol., 76, 802 (2009); Birgitte, H. et al.: Mol. Pharmacol., 75, 44 (2009)<br></p>Fórmula:C27H36N4O5S·CH4SO3Cor e Forma:NeatPeso molecular:624.80Cyclosporin H
CAS:<p>Applications Cyclosporin is an immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection.A group of nonpolar cyclic oligopeptides with immunosupppressant activity.<br>References van Wartburg, A., et al.: Prog. Med. Chem., 25, 1 (1988), Jorgensen, K.A., et al.: Scand. J. Imunol., 57, 93 (2003), Vollenbroeker, et al.: Transplant. Proc., 37, 1741 (2005),<br></p>Fórmula:C62H111N11O12Cor e Forma:NeatPeso molecular:1202.61Boceprevir (>90%)
CAS:Produto ControladoFórmula:C27H45N5O5Pureza:>90%Cor e Forma:NeatPeso molecular:519.684-(Phenylamino]-1-benzyl-4-piperidinecarboxylic Acid Methyl Ester
CAS:Produto Controlado<p>Applications Remifentanil derivative.<br>References James, M.K., et al.: J. Pharmacol. Exp. Ther., 259, 712 (1991), Hoffman, W.E., et al.: Anesthesiology, 79, 107 (1993), Selinger, K., et al.: J. Pharm. Biomed. Anal., 12, 243 (1994), Richardson, T.D., et al.: Expert Opin. Drug Saf., 4, 643 (2005),<br></p>Fórmula:C20H24N2O2Cor e Forma:NeatPeso molecular:324.4168Carfilzomib (2R,4S)-Diol
CAS:Produto Controlado<p>Applications Carfilzomib (2R,4S)-Diol is a derivative of Carflizomib (C183460), a second-generation proteasome inhibitor that is used as a treatment in relapsed and refractory multiple myeloma.<br>References Fostier, K., et al.: Oncotargets. Therap., 5, 237 (2012); Geurink, P.P., et al.: J. Med. Chem., 56, 1262 (2013); McCormack, P.L., et al.: Drugs., 72, 2023 (2012);<br></p>Fórmula:C40H59N5O8Cor e Forma:NeatPeso molecular:737.93L-Valine-13C5,15N
CAS:Produto Controlado<p>Applications Labelled analogue of L-Vailne. L-Valine is an essential amino acid and one of 20 proteinogenic amino acids. L-Valine cannot be manufactured by the body and must be acquired through diet or supplementation. L-valine is found in grains, dairy products, mushrooms, meats, peanuts and soy proteins. L-Valine has been used in studies to attenuate arrhythmias and induce hypotensive effects.<br>References Choi, C.W. et al.: Anim. Feed Sci. Technol., 102, 15 (2002); Kolarski, D. et al.: Krmiva, 30, 155 (1988); Oba, M. et al.: J. Dairy Sci., 93, 2044 (2010); Mitrega, K. et al.: Pharmacol. Res., 64, 218 (2011);<br></p>Fórmula:C5H1115NO2Cor e Forma:NeatPeso molecular:123.1N-Nitroso-D-proline
CAS:Produto Controlado<p>Applications A nitrosoamino acid with oncogenic activity. The LD50 of a single ip dose given to Swiss-Webster mice is 203 +/- 22 mg / kg.<br>References Nagasawa, H.T., et al.: J. Med. Chem., 16 (5), 583-585 (1973)<br></p>Fórmula:C5H8N2O3Cor e Forma:NeatPeso molecular:144.13Cyclosporin C
CAS:Produto Controlado<p>Applications A group of nonpolar cyclic oligopeptides with immunosupppressant activity.<br>References van Wartburg, A., et al.: Prog. Med. Chem., 25, 1 (1988), Jorgensen, K.A., et al.: Scand. J. Imunol., 57, 93 (2003), Vollenbroeker, et al.: Transplant. Proc., 37, 1741 (2005),<br></p>Fórmula:C62H111N11O13Pureza:>80%Cor e Forma:NeatPeso molecular:1218.61Bortezomib Trimer
CAS:Produto Controlado<p>Applications Bortezomib Trimer is derived from Bortezomib (B675700), which is the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer. A reversible inhibitor of the 26S proteasome-a barrel-shaped multiprotein particle found in the nucleus and cytosol of all eukaryotic cells. Targets the ubiquitin-proteasome pathway.<br>References Nawrocki, S.T., et al: Cancer Research, 65, 11510 (2005); Drahl C.: Chem. and Eng. News, 87, 41 (2009)<br></p>Fórmula:C57H69B3N12O9Cor e Forma:NeatPeso molecular:1098.666Methyltetrazine-Amine
CAS:<p>Methyltetrazine-Amine is a methyl-substituted tetrazine amine used in the synthesis of PROTAC molecules.</p>Fórmula:C10H11N5Pureza:97.59%Cor e Forma:Pink SolidPeso molecular:201.23Sacubitril-d4
CAS:Produto Controlado<p>Applications Isotope labelled Sacubitril is an antihypertensive drug used in combination with Valsartan (V095750). The combination drug, valsartan/sacubitril, known during trials as LCZ696 and marketed under the brand name, Entresto, is a treatment for heart failure.<br>References McMurray, J., et al.: N. Eng. J. Med., 371 (2014);<br></p>Fórmula:C242H4H25NO5Cor e Forma:Light YellowPeso molecular:415.521,2-Bismethylphenidate (Mixture of Diastereomers)
Produto Controlado<p>Applications 1,2-Bismethylphenidate is an impurity of methylphenidate (M325880), an CNS stimulant.<br>References Greenblatt, E.N., et al.: J. Pharmacol. Exp. Ther., 131, 115 (1961), Padmanabhan, G.R., Anal. Profiles Drug Subs., 10, 473 (1981), Srinivas, N.R., et al.: Pharm. Res., 10, 14 (1993),<br></p>Fórmula:C23H27NO4Cor e Forma:NeatPeso molecular:381.46(2S,4R)-Sacubitril
CAS:Produto Controlado<p>Stability Temperature Sensitive<br>Applications (2S,4R)-Sacubitril is the enantiomer and an impurity of Sacubitril (S080895) which is an antihypertensive drug used in combination with valsartan.<br>References McMurray, J., et al.: N. Eng. J. Med., 371 (2014);<br></p>Fórmula:C24H29NO5Cor e Forma:Colourless To Off-WhitePeso molecular:411.49Cyclosporin AM 1 (>80%)
CAS:Produto Controlado<p>Applications A cyclosporine metabolite specifically inhibits growth of renal cells in culture.<br>References Schultz, J.C.; et al.: Biochem. Pharma., 42, 1403 (1991), Johnson, B., et al.: Drug Metab. Dispos., 34, 556 (2006), Westley, I.S., Drug Metab. Dispos., 36, 46 (2008).<br></p>Fórmula:C62H111N11O13Pureza:>80%Cor e Forma:NeatPeso molecular:1218.615-Oxo-DL-proline-d5
CAS:Produto Controlado<p>Applications 5-Oxo-DL-proline-d5 is a labelled cyclized derivative of L-Glutamic Acid (G596960). The pyroglutamate core has potential application for synthesis of novel anti-bacterials.<br>References Mischo A. et al.: ChemBioChem., 13, 1421 (2012); Angelov P. et al.: Org. Biomol. Chem.: 10, 3472 (2012);<br></p>Fórmula:C52H5H2NO3Cor e Forma:NeatPeso molecular:134.143,3’,5-Triiodo-L-thyronine
CAS:Produto ControladoFórmula:C15H12I3NO4Cor e Forma:White To Off-WhitePeso molecular:650.973,5,3',5'-Tetraiodo Thyroacetamide
CAS:Produto Controlado<p>Impurity Levothyroxine Acetamide Impurity<br>Applications 3,5,3',5'-Tetraiodo Thyroacetamide is a thyroid hormone analogue, a Thyroxine (T425600) impurity.<br>References Andre, M., et al.: J. Chromatogr., 741, 146 (1996),<br></p>Fórmula:C14H9I4NO3Cor e Forma:Light Orange Colour To Light BrownPeso molecular:746.84N2-(S)-1-Carboxy-3-phenylpropyl-L-lysine
CAS:Produto Controlado<p>Stability Hygroscopic<br>Applications Lisinopryl impurity.<br>References Goa, K.L., et al.: Drugs, 52, 564 (1996), Cao, X.J., et al.: J. Pharm. Biomed. Anal., 39, 39 (2005),<br></p>Fórmula:C16H24N2O4Cor e Forma:White To Light BeigePeso molecular:308.37Methionine
CAS:<p>Methionine (D-Methionine) (MRX-1024; D-Methionine) is an effective chemoprotective agent which can also inhibit the neuronal activity through GABAA receptor</p>Fórmula:C5H11NO2SPureza:99.13% - 99.62%Cor e Forma:SolidPeso molecular:149.21L-Methionine [R,S]-Sulfoximine
CAS:Produto Controlado<p>Applications Methionine sulfoximine inhibits both glutamine synthetase and g-glutamylcysteine synthetase. Working concentrations for inhibition of g-glutamylcysteine synthetase are 0.2-2.0 mM (52% inhibition occured at 100 mM).Methionine sulfoximine is also a toxic byproduct of nitrogen trichloride, a compound that was used to bleach unprocessed wheat flour prior to 1968. The compound has been investigated as a potential neurotoxin linked to diseases such as amyotrophic lateral sclerosis (ALS) and Parkinson’s disease.<br>References Griffith, O.W., and Meister, A.: J. Biol. Chem. 254, 7558 (1979), Willard-Mack, C.L., et al: Neuroscience, 71, 2, 589 (1996)<br></p>Fórmula:C5H12N2O3SCor e Forma:NeatPeso molecular:180.23N-Pyrazinylcarbonyl-L-phenylalanine
CAS:Produto Controlado<p>Applications Used for the synthesis of Bortezomib (B675700) from L-phenylalanine via dipeptidyl boronic acid ester intermediates.<br>References Zhu, Y., et al.: J. Med. Chem., 52, 4192 (2009),<br></p>Fórmula:C14H13N3O3Cor e Forma:WhitePeso molecular:271.27[Des-Thr-ol8]-[D-Cys7]-Octreotide TFA
CAS:Produto ControladoFórmula:C45H57N9O9S2•x(C2HF3O2)Cor e Forma:NeatPeso molecular:932.12114023,3’,5-Triiodo-D-thyronine
CAS:Produto Controlado<p>Applications 3,3’,5-Triiodo-D-thyronine is a structural analogue o the thyroid homonef Thyroxine (T425600). 3,3’,5-Triiodo-D-thyronine has been shown to reduce cholesterol in blood serum.<br>References Mintz, D.O., et. al.: New Engl. J. Med., 266, 808 (1962)<br></p>Fórmula:C15H12I3NO4Cor e Forma:Off-White To Light BrownPeso molecular:650.97(S)-Lisinopril Dimer
CAS:Produto Controlado<p>Applications (S)-Lisinopril (L468985) impurity. Lisinopril Impurity G (Dimer Impurity)<br></p>Fórmula:C42H60N6O9Cor e Forma:WhitePeso molecular:792.96L-Threonine
CAS:Produto Controlado<p>Applications L-enantiomer of Threonine. An essential amino acid for human development; last of the common amino acids to be discovered. Identified in oat protein.<br>References LeMaster, D.M., et al.: J. Biol. Chem., 257, 1224 (1982), Ballevre, O., et al.: Anal. Biochem., 193, 212 (1991), Roufs, J.B., et al.: Med. Hypotheses, 34, 20 (1991), Blin, O., et al.: J. Neurol., 239, 79 (1992),<br></p>Fórmula:C4H9NO3Cor e Forma:NeatPeso molecular:119.12Dl-valine
CAS:Produto Controlado<p>Applications Dl-valine<br></p>Fórmula:C5H11NO2Cor e Forma:NeatPeso molecular:117.15Methyl Benzenesulfonate
CAS:Produto Controlado<p>Applications A sulfonate ester as potential genotoxic impurity in drug substances. It may exert genotoxic effects in bacterial and mammalian cell systems.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Eder, E., et al.: Xenobiotica, 12, 831 (1982), Li, W., et al.: J. Chromatogr., 1046, 297 (2004), Glowienke, S., et al.: Mutat. Res., 581, 23 (2005), Colon, I., et al.: J. Pharm. Biomed. Anal., 39, 477 (2005),<br></p>Fórmula:C7H8O3SCor e Forma:ColourlessPeso molecular:172.2Daptomycin
CAS:<p>Applications Daptomycin is a Cyclic lipopeptide antibiotic derived from a fermentation product of Streptomyces roseosporus; disrupts plasma membrane function in gram-positive bacteria. Antibacterial.<br>References Allen, N.E., et al.: Antimicrob. Agents Chemother., 31, 1093 (1987), Tully, F.P., et al.: Expert Opin. Invest. Drugs, 8, 1223 (1999),<br></p>Fórmula:C72H101N17O26Cor e Forma:Light YellowPeso molecular:1620.67Vasopressin Acetic Acid Salt
CAS:Produto Controlado<p>Applications Vasopressin Acetic Acid Salt is an acidic salt of Vasopressin (V991530), an antidiurectic hormone.<br>References Tokushige, S., et al.: Internal Medicine, 55, 1199 (2016)<br></p>Fórmula:C46H65N15O12S2•(C2H4O2)Cor e Forma:NeatPeso molecular:1084.236005trans-4-Hydroxy-L-proline
CAS:Produto Controlado<p>Applications A natural constituent of animal structural proteins such as collagen and elastin. Several microorganisms producing proline trans-4- and cis-3-hydroxylase were discovered and these enzymes were applied to the industrial production of trans-4- and cis-3-hydroxy-L-proline.<br>References Langmaier, F. et al.: Int. J. Cosm. Sci., 24, 273 (2002); Lawrence, C., et al.: Biochem. J., 313, 185 (1996); Mori, H., et al.: J. Bacteriol.; 179, 5677 (1997); Clifton, I., et al.: Eur. J. Biochem., 268, 6625 (2001);<br></p>Fórmula:C5H9NO3Cor e Forma:NeatPeso molecular:131.13Carbetocin
CAS:<p>Applications An obstetric drug used to control postpartum hemorrhaging.<br>References Sanz-Nebot, V., et al.: Anal. Bioanal. Chem., 377, 306 (2003), Gimpl, G., et al.: Eur. J. Pharmacol., 510, 9 (2005), Handler, J., et al.: Theriogenol., 66, 1397 (2006), Klenerova, V., et al.: J. Physiol. Pharmacol., 60, 57 (2009),<br></p>Fórmula:C45H69N11O12SCor e Forma:NeatPeso molecular:988.16(±)-Methionine
CAS:<p>Applications (±)-Methionine is an essential amino acid involved in various biochemical processes in humans and mammals. Also in poultry meal as a source of nutrition.<br>References Martin-Venegas, R. et al.: Food Chem., 141, 1702 (2013); Austic, R. et al.: J. Agri. Food Chem., 61, 7341 (2013); Yan, L. et al.: J. Anim. Phys Anim Nutr., 97, 457 (2013);<br></p>Fórmula:C5H11NO2SCor e Forma:WhitePeso molecular:149.21N-des-succinyl-Sacubitril hydrochloride
CAS:Produto Controlado<p>Applications (2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic Acid Ethyl Ester Hydrochloride is used as a reagent in the synthesis of LCZ696, an angiotensin II receptor and neprilysin receptor dual inhibitor. (2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic Acid Ethyl Ester Hydrochloride is also used as a reagent in the preparation of novel NEP inhibitor prodrugs for the treatment of hypertension and cardiovascular diseases.<br>References Liu, M., et al.: Faming Zhuanli Shenqing. CN 105168205 A 20151223. Dec 23, 2015; Wang, Z.: PCT Int. Appl. WO 2015154673 A1 20151015. Oct 15, 2015<br></p>Fórmula:C20H25NO2·HClCor e Forma:NeatPeso molecular:384.34Eptifibatide
CAS:Produto Controlado<p>Applications An arginine-glycine-aspartate-mimetic, reversibly binds to platelets to reduce the risk of cardiac ischemic events.<br>References Pathak, A., et al.: Cardiovas. Diabetol., 7 (2008), Hantgan, R., et al.: Biochem., 48, 8355 (2009), Giugliano, R., et al.: New Eng. J. Med., 360, 2176 (2009),<br></p>Fórmula:C35H49N11O9S2Cor e Forma:Off White SolidPeso molecular:831.96Carfilzomib (2R,4R)-Diol
Produto Controlado<p>Applications Carfilzomib (2R,4R)-Diol is a derivative of Carflizomib (C183460), a second-generation proteasome inhibitor that is used as a treatment in relapsed and refractory multiple myeloma.<br>References Fostier, K., et al.: Oncotargets. Therap., 5, 237 (2012); Geurink, P.P., et al.: J. Med. Chem., 56, 1262 (2013); McCormack, P.L., et al.: Drugs., 72, 2023 (2012);<br></p>Fórmula:C40H59N5O8Cor e Forma:NeatPeso molecular:737.93Carfilzomib
CAS:Produto Controlado<p>Applications Carfilzomib is a second-generation proteasome inhibitor that is used as a treatment in relapsed and refractory multiple myeloma.<br>References Fostier, K., et al.: Oncotargets. Therap., 5, 237 (2012); Geurink, P.P., et al.: J. Med. Chem., 56, 1262 (2013); McCormack, P.L., et al.: Drugs., 72, 2023 (2012);<br></p>Fórmula:C40H57N5O7Cor e Forma:White To Off-WhitePeso molecular:719.91Oxytocin-d5 Trifluoroacetate
CAS:Produto Controlado<p>Applications Labelled Oxytocin. The principal uterus-contracting and lactation-stimulating hormone of the posterior pituitary gland.<br>References Pierce, et al.: J. Biol. Chem., 199, 929 (1952), Tuppy, et al.: Biochem. Biophys. Acta, 11, 449 (1953), Cash, et al.: J. Med. Pharm. Chem., 5, 413 (1962), Nachtmann, F., et al.: Anal. Profiles Drug Subs., 10, 563 (1981),<br></p>Fórmula:C45H62D5F3N12O14S2Cor e Forma:White To Off-WhitePeso molecular:1126.24
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