Peptídeos

Applications N-Formyl-Met-Leu-Phe is an inducer of superoxide release and agonist for FPR1.

Applications M-PEG4-THIOL (cas# 52190-55-3) is a useful research chemical.

Applications Boc-Glu(OBzl)-OH, is an amino acid building block used in peptide synthesis. With a growing peptide drug market the fast, reliable synthesis of peptides is of great importance.

Applications Phenylalanine derivative used in enantioselective hydrolysis of amino acid esters. Acts as an inhibitor of gastric acid secretion.
References Tomisaka, K. et al.: Chem. Comm., 1, 133 (2001); Magours, R., et al.: Biochim. Biophys. Acta, Mol. Cell Res., 858, 158 (1985)

Applications Z-VAL-MET-OH (cas# 108543-82-4) is a useful research chemical.

Applications Fmoc-d-asn(trt)-oh, is an amino acid building block used in peptide synthesis. With a growing peptide drug market the fast, reliable synthesis of peptides is of great importance.

Stability Hygroscopic
Applications Poly(ethylene Glycol) molecules of an average molecular mass of 20000. Poly(ethylene Glycol) is used in various applications from industrial chemistry to biological chemistry. Recent research has shown PEG maintains the ability to aid the spinal cord injury recovery process, helping the nerve impulse conduction process in animals. In rats, it has been shown to aid in the repair of severed sciatic axons, helping with nerve damage recovery. It is industrially produced as a lubricating substance for various surfaces to reduce friction. PEG is also used in the preparation of vesicle transport systems in with application towards diagnostic procedures or drug delivery methods.
References Borgens, R. et al.: J. Neurosci. Res., 66, 1179 (2001); Stavisky, R. et al.: Neurosci. Lett., 376, 98 (2005); Nalam, P. et al.: Tribiol. Lett., 37, 541 (2010); Steinmetz, N. et al.: J. Am. Chem. Soc., 131, 17093 (2009); Li, X. et al.: J. Am. Chem. Soc., 133, 11147 (2011); Li, L. et al.: Int. J. Pharm., 447, 192 (2013);

Applications N-CBZ-Glycyl-L-proline 7-Amido-4-methylcoumarin is a fluorogenic substrate used for post-proline cleaving enzyme prolyl endopeptidase.
References J. Momand, S. Clarke Biochemistry 26, 7798, (1987)

Applications N-Fmoc-L-isoleucine is a N-Fmoc-protected form of L-Isoleucine (I820175). L-Isoleucine is classified as an essential amino acid, and is also a tumour promoter of bladder cancer in rats.
References Hatch, T., et al.: Infect. Immun., 12, 211 (1975); Nishio, Y., et al.: Science, 231, 843 (1986)

Stability Unstable in alkaline solution
Applications Met-enkephalin is an endogenous opioid peptide that increases expression levels of δ, μ and κ-opioid receptors, inhibits growth, apoptosis and proliferation in human melanoma A375 cells. Antitumor effect via regulating dendritic cells. Regulation of the immune system, therapy effects of antitumor, autoimmune diseases, AIDS, and other immune-related diseases.
References Wang, D., et al.: Mol. Med. Rep., 14, 5521 (2016); Feng, P., et al.: Weishengwuxue Zazhi, 35, 100 (2015); Meng, Y., et al.: Int. Immunopharmacol., 44, 61 (2017)

Applications N-4-Tosyl-L-arginine Methyl Ester Hydrochloride acts as a synthetic substrate of serine proteases and thus is used to determine serine proteases from diverse organic sources.
References Hummel, B. et al.: Can. J. Biochem. Physiol., 37, 1393 (1959); Matsuda, Y. et al.: J. Biochem. 80, 671 (1976);

Applications L-Proline-N-Fmoc is N-Fmoc protected L-Proline (P755995) which is an amino acid and precursor (with vitamin C) for collagen, the building block of the structure of tendons, ligaments, arteries, veins and muscles. It is important in wound healing.
References Bondarenko, L.B., et al.: Int. J. Peptides., 2, 1687 (2012); Rimer, T., et al.: Biomacromolecules, 13, 2110 (2012);

Applications Caspase-1 Inhibitor II is an inhibitor of caspase-1, caspase-4, and caspase-5.

Applications Boc-​β-​Ala-​OH is a reagent used in the synthesis of quinazolines as platelet aggregation inhibitors and ligands of integrin.
References Krysko, A. et al.: Bioorg. Med. Chem. Lett., 26, 1839 (2016);

Applications Fmoc-Aph(Hor)-OH (CAS# 1253282-31-3) is an intermediate of degarelix, a pharmeceutical hormone used in the treatment of prostate cancer. Fmoc-Aph(Hor)-OH has been used as a building block in peptide elongation reactions.
References Guryanov, I.; et al.: WO 2017103275 (2017); Takahashi, D.; et al.: Angew. Chem. Int. Ed., 56, 7803 (2017).

Stability Hygroscopic
Applications This compound is an impurity in the synthesis of Antazoline (A678405) which acts as a histamine H1 receptor blocker, functioning as an antihistamine pharmaceutical.
References Constanti, A. et al.: Brit. J. Pharmacol. 58, 583 (1976);

Applications N-Acetyl-L-arginine Methyl Ester is used in the synthetic route to biologically important L-arginine peptides.
References Levison, P.R., et al.: Synthetic Communic., 13, 167 (1983),

Applications 1-Boc-amino-3,6,9-trioxaundecanyl-11-ol (cas# 106984-09-2) is a compound useful in organic synthesis.

Applications 1-Amino-3,6,9-trioxaundecanyl-11-ol (cas# 86770-74-3) is a compound useful in organic synthesis.

Applications N-Boc-ethylenediamine is used in the synthesis of Thyronamine derivatives and analogs.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Anon., et al.: J. Pharmacol., 58, 53 (1936), Boissier, J., et al.: Eur. J. Pharmacol., 22, 141 (1973), Nillne, E., et al.: J. Biol. Chem., 277, 48587 (2002),

Applications N-tert-Boc-D-alanine is an N-Boc-protected form of D-Alanine (A480995). D-Alanine is an amino acid that is commonly found in bacteria, such as Streptococcus faecalis. It is essential for the biosynthesis of peptidoglycan crosslinking sub-units that are used for bacterial cell walls. D-Alanine is also known to cause cytotoxic oxidative stress in brain tumour cells.
References Ellsworth, B., et al.: Chem. Biol., 3, 37 (1996); Ferrari, E. et al.: Nat. Biotech., 3, 1003 (1985); Stegman, L., et al.: Human Gene Ther., 9, 185 (1998); Wood, W. & Gunsalus, I.: J. Biol. Chem., 190, 403 (1951)

Applications Poly(ethylene Glycol) molecules of an average molecular mass of 200. Poly(ethylene Glycol) is used in various applications from industrial chemistry to biological chemistry. Recent research has shown PEG maintains the ability to aid the spinal cord injury recovery process, helping the nerve impulse conduction process in animals. In rats, it has been shown to aid in the repair of severed sciatic axons, helping with nerve damage recovery. It is industrially produced as a lubricating substance for various surfaces to reduce friction. PEG is also used in the preparation of vesicle transport systems in with application towards diagnostic procedures or drug delivery methods.
References Borgens, R. et al.: J. Neurosci. Res., 66, 1179 (2001); Stavisky, R. et al.: Neurosci. Lett., 376, 98 (2005); Nalam, P. et al.: Tribiol. Lett., 37, 541 (2010); Steinmetz, N. et al.: J. Am. Chem. Soc., 131, 17093 (2009); Li, X. et al.: J. Am. Chem. Soc., 133, 11147 (2011); Li, L. et al.: Int. J. Pharm., 447, 192 (2013);

Applications Nα-Fmoc-Nε-biotinyl-L-lysine is used in the synthesis of site-specific biotinylated probes.
References Macielag, M., et al.: Int. J. Pep. Protein Res., 44, 582 (1994)

Applications 2-NBDG is a fluorescent glucose uptake indicator, used in real-time confocal, high-resolution, or wide-field fluorescence microscopy as well as in flow cytometry.
References Zou, Chenhui., et al.: J Biochem Biophys Methods., 64, 207 (2005); Yamada, Katsuya., et al.: J. Biol. Chem., 275, 22278 (2000)

Applications Elastatinal is an elastase inhibitor.

Applications N-[1-(Cyano-2-ethoxy-2-oxoethylideneaminooxy)dimethylamino(morpholino)uronium Hexafluorophosphate is used as an efficient coupling agent in phosphonamidation reactions; used as coupling reagent in the synthesis of solid phase peptide
References Fredriksen, K., et al.: Eur. J. Org. Chem., 3, 474 (2016); Achyuthan, K., et al.: J. Pept. Sci., 21, 751 (2015);

Applications A Wittig reagent.
References Laine, D., et al.: J. Med. Chem., 52, 5241 (2009), Nakao, A., et al.: Bioorg. Med. Chem. Lett., 19, 4607 (2009), Arakawa, Y., et al.: Chem. Pharm. Bull., 57, 167 (2009),

Applications L-Tryptophyl-L-arginyl-L-glutaminyl-L-alanyl-L-alanyl-L-phenylalanyl-L-valyl-L-α-aspartyl-L-seryl-L-tyrosine is a connexin mimetic peptide that inhibits pannexin-1 gap junctions.
References Wang, J., et al.: Am J Physiol 293, C1112 (2007); Pinheiro, A. R., et al.: Cell Commun Signal. 18, 11 (2013)

Applications Boc-D-Phenylalanine is used in the synthesis of benzo[de][1,7]napthyridinones as PARP1 inhibitors. Also it is an important reagent in the preparation of proline-containing, β-turn mimetic cycle tetrapeptides.
References Ye, Na. et al.: J. Med. Chem., 56, 2885 (2013); Chouhan, G. et al.: Org. Lett., 15, 1206 (2013);

Applications (Fmoc-amino)-PEG6-carboxylic acid (CAS# 882847-34-9) is a useful building block used in the preparation of cyclic megamolecules, and in L- and D-oligopeptides with circularly polarized luminescence.
References Modica, J. A.; et al.: J. Am. Chem. Soc., 140, 6391 (2018); Nishikawa, T.; et al.: Org. Biomol. Chem., 13, 11426 (2015).

Applications Nα-Boc-D-tryptophan is an N-Boc-protected form of D-Tryptophan (T947205). D-Tryptophan is an unnatural isomer of L-Tryptophan (T947210) and is classified as an essential amino acid. D-Tryptophan has been synthesized as part of some potent Oxytocin (Acetate: O878500) antagonists that treat preterm labour.
References Chan, Y. & Huang, K.: Am. J. Physiol., 224, 140 (1973); Evans, B., et al.: Proc. Nat. Acad. Sci., 83, 4918 (1986); Romero, R., et al.: Am. J. Obstet. Gynecol., 182, 1173 (2000)