Moduladores enzimáticos
Moduladores de enzimas são compostos que podem aumentar ou inibir a atividade de enzimas, regulando assim a taxa de reações bioquímicas. Esses moduladores desempenham um papel crucial no controle de vias metabólicas, sinalização celular e vários processos fisiológicos. Os moduladores de enzimas são amplamente utilizados em pesquisa e desenvolvimento de medicamentos para estudar as funções enzimáticas e desenvolver agentes terapêuticos. Na CymitQuimica, oferecemos uma ampla gama de moduladores de enzimas de alta qualidade para apoiar sua pesquisa em regulação enzimática e descoberta de medicamentos.
Subcategorias de "Moduladores enzimáticos"
Foram encontrados 693 produtos de "Moduladores enzimáticos"
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MK 1775
CAS:Wee1 inhibitor with an IC50 of 5.2 nMFórmula:C27H32N8O2Pureza:Min. 95%Cor e Forma:PowderPeso molecular:500.6 g/molPeiminine
CAS:Inhibitor of TGF-α, CTGF, ERK1/2, NF-κB and FasL; anti-inflammatoryFórmula:C27H43NO3Pureza:Min. 98 Area-%Peso molecular:429.64 g/molSGC AAK1 1
CAS:Dual inhibitor of the adaptor protein 2-associated kinase 1 (AAK1) and BMP2-inducible kinase (BMP2K) with IC50 values of 270 nM and 1 μM, respectively. In a recent study, SGC AAK1 1 stabilised β-catenin, inhibited phosphorylation of the AP2 complex subunit mu protein (AP2M1) and activated Wnt signalling in in vitro experiments._x000D_Fórmula:C21H25N5O3SPureza:Min. 95%Cor e Forma:SolidPeso molecular:427.52 g/molSNS 314 mesylate
CAS:Inhibitor of Aurora kinases A, B and CFórmula:C18H15ClN6OS2•CH4O3SPureza:Min. 95%Cor e Forma:PowderPeso molecular:527.04 g/molHistone deacetylase inhibitor VIII
CAS:Potent and selective inhibitor of histone deacetylase 6 (HDAC6) with IC50 of 2.4 nM. Its anti-inflammatory activity was examined in a mouse model for acute colitis. The compound protected from intestinal inflammation by prevention of infiltration of CD19+ B-cells into the lamina propria of colonic epithelium and attenuated neutrophil activation. Its broad anti-inflammatory response involved decrease in 24 inflammatory chemokines and cytokines. Also, it is a potent inhibitor of cell proliferation in pancreatic cancer cell lines.
Fórmula:C22H30N4O6Pureza:Min. 95%Cor e Forma:White To Off-White SolidPeso molecular:446.21653Hydroxychloroquine sulfate - Bio-X ™
CAS:Hydroxychloroquine is a drug that is used to treat multiple types of autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus and discoid lupus. It is a prodrug, which is activated in the liver to hydroxychloroquine. It inhibits the production of inflammatory cytokines and nitric oxide by binding to the toll-like receptor 4 (TLR4) and inhibiting signaling pathways downstream of TLR4 activation. Additionally, Hydroxychloroquine is used to prevent and treat malaria caused by parasitic protozoan from the Plasmodium genus. Furthermore, recent studies revealed that hydroxychloroquine has beneficial effects on COVID-19 patients, as the current evidence shows that hydroxychloroquine inhibits SARS CoV-2 entry in host cells by interfering with endocytosis and affecting the glycoprofile on the spike glycoprotein.Fórmula:C18H28ClN3O5SPureza:Min. 95%Cor e Forma:PowderPeso molecular:433.95 g/molEN 6
CAS:Autophagy activator that acts through targeting the ATP6V1A subunit of vATPaseFórmula:C19H14F2N4O2Pureza:Min. 95%Cor e Forma:White To Yellow To Beige SolidPeso molecular:368.34 g/molNilotinib HCl monohydrate - Bio-X ™
CAS:Nilotinib is a kinase inhibitor that is used for the treatment of Chronic Myeloid Leukemia (CML). This drug is also used for the treatment of CML that is resistant to imatinib. Nilotinib inhibits the tyrosine kinase activity of the BCR-ABL protein. It also inhibits PDGFR and c-kit.
Fórmula:C28H22F3N7O•HCl•H2OPureza:Min. 95%Cor e Forma:PowderPeso molecular:583.99 g/molCobicistat
CAS:Cobicistat is an inhibitor of human cytochrome P450 3A enzymes (CYP) with no antiviral activity. Cobicistat is used in the treatment of HIV-1 infection, as an alternative to ritonavir, to increase the half-life of antiviral medications (von Hentig, 2016). Cobicistat acts as a booster by selectively inhibiting the hepatic degradation of the drugs, for example, in the pharmacological regime against HIV-1, which often includes protease inhibitors, such as, darunavir, atazanavir, and lopinavir, or the integrase inhibitor elvitegravir (Deeks, 2014).Fórmula:C40H53N7O5S2Pureza:Min. 95%Cor e Forma:PowderPeso molecular:776.03 g/molO151
CAS:Selective and potent inhibitor of 8-oxoguanine DNA glycosylase OGG1 with IC50 of 0.6 μM. OGG1 is a key enzyme in DNA repair mechanism called base excision repair (BER). The compound inhibits the hydrolysis of glycosidic bond required for the excision of 8-oxoguanine from double stranded DNA, which leads to accumulation of mutations. It has been proposed as monotherapy for certain types of cancers as well as adjuvant for cancer therapy with DNA damaging agents. It has potential to sensitize tumours for chemotherapy and inhibit development of drug resistance mechanisms.Fórmula:C13H15BrN2OPureza:Min. 95%Cor e Forma:PowderPeso molecular:295.18 g/molZileuton- Bio-X ™
CAS:Zileuton is an inhibitor of the 5-lipoxygenase enzyme, thus preventing the leukotrienes LTE4, LDT4, LTB4 and LTC4 from being formed. This in turn reduces inflammation, bronchoconstriction and mucus secretion in the airways. As a result, Zileuton can be used in the treatment and management of asthma and allergic rhinitis. Studies have shown that Zileuton has the potential to reverse dementia-related brain damage.Fórmula:C11H12N2O2SPureza:(%) Min. 95%Cor e Forma:PowderPeso molecular:236.29 g/mol4-Deoxyuridine
CAS:A cytidine analogue and inhibitor of DNA methyl transferases (DNMTs) with anti-cancer activity. This stable, hydrophilic compound forms covalent complexes between DNMT and zebularine-substrate DNA. It causes DNA lesions that block replication and cause replication fork collapse, leading to the formation of DNA double-strand breaks. It was also shown that zebularine-induced DNA methylation decrease in the IL-1β promoter region and disrupts molecular mechanisms of neuroinflammation. Moreover, this molecule down-regulates the DNA-methylation profile in the pluripotency genes’ promoters, which leads to improved development of somatic cell nuclear transfer (SCNT) embryos.Fórmula:C9H12N2O5Pureza:Min. 95%Cor e Forma:PowderPeso molecular:228.21 g/molPelitinib
CAS:EGFR tyrosine kinase inhibitor; pro-apoptotic; antiproliferative in cancer cellsFórmula:C24H23ClFN5O2Pureza:Min. 95%Cor e Forma:PowderPeso molecular:467.92 g/molApremilast - Bio-X ™
CAS:Apremilast is the commercial name of a phosphodiesterase-4 (PDE4) inhibitor developed to treat chronic inflammatory disorders. Similarly to thalidomide, the apremilast molecule carries a phthalimide ring, but it lacks however the glutarimide ring needed to bind to cereblon, specifically targeted by thalidomide. As a drug, apremilast is indicated for the treatment of psoriasis and psoriatic arthritis.Fórmula:C22H24N2O7SPureza:Min. 99 Area-%Cor e Forma:White/Off-White SolidPeso molecular:460.5 g/molKenpaullone
CAS:Inhibitor of glycogen synthase 3 (GSK-3) and cyclin-dependent kinases CDK1, CDK2 and CDK5. Kenpaullone can substitute transcription factor Klf4 in reprogramming of fibroblast to induced pluripotent stem cells when using the method of ectopic expression of transcriptional factors. In an in vitro model for Alzheimer’s disease, kenpaullone decreased production of amyloid beta peptides Aβ40 and Aβ42.
Fórmula:C16H11BrN2OPureza:Min. 95%Cor e Forma:Yellow To Dark Yellow SolidPeso molecular:326.00548U 0126 monoethanolate
CAS:Inhibitor of MEK1 and MEK2 kinasesFórmula:C18H16N6S2•C2H6OPureza:Min. 95%Cor e Forma:White To Beige SolidPeso molecular:426.56 g/molNolatrexed dihydrochloride
CAS:Thymidylate synthase inhibitorFórmula:C14H14Cl2N4OSPureza:Min. 95%Cor e Forma:White To Light (Or Pale) Yellow SolidPeso molecular:357.26 g/molGSK 2606414
CAS:Inhibitor of EIF2AK3/PERK kinasesFórmula:C24H20F3N5OPureza:Min. 95%Cor e Forma:PowderPeso molecular:451.44 g/molMeloxicam - Bio-X ™
CAS:Meloxicam is a non-steroidal anti-inflammatory drug (NSAID) which is used to treat various types of pain and inflammation caused by arthritis. It is also a COX-2 inhibitor which reduces gastrointestinal effects of this drug. Inhibiting these enzymes, allow for a decrease in inflammatory symptoms.Fórmula:C14H13N3O4S2Pureza:Min. 95%Cor e Forma:PowderPeso molecular:351.4 g/molPimecrolimus
CAS:Immune suppressant; prevents pro-inflammatory cytokine releaseFórmula:C43H68ClNO11Pureza:Min. 95%Cor e Forma:PowderPeso molecular:810.45 g/molMK 886 sodium salt
CAS:Inhibitor of 5-lipoxygenase activating protein_x000D_
Fórmula:C27H33ClNNaO2SPureza:Min. 95%Cor e Forma:PowderPeso molecular:494.06 g/molGefitinib - Bio-X ™
CAS:Gefitinib is an inhibitor of the epidermal growth factor receptor (EGFR) protein. This inhibition is on the EGFR tyrosine kinase domain, where Gefitinib bindings to the ATP-binding site. As a a tyrosine kinase inhibitor, Gefitinib blocks tumor growth and has led to its use in slowing the progression of non-small cell lung cancer. Gefitinib also inhibits invasion and metastasis through inhibition of macrophage receptor interacting protein kinase 2 (RIPK2), rather than EGFR.Fórmula:C22H24ClFN4O3Pureza:Min. 98 Area-%Cor e Forma:PowderPeso molecular:446.9 g/molLenalidomide - Bio-X ™
CAS:Produto ControladoLenalidomide is a thalidomide derivative that is used to treat multiple myeloma and anemia. This drug exerts immunomodulatory effects by altering cytokine production. Lenalidomide also directly inhibits the cullin ring E3 ubiquitin ligase complex.Fórmula:C13H13N3O3Pureza:Min. 95%Cor e Forma:PowderPeso molecular:259.26 g/molA 939572 - Bio-X ™
CAS:A 939572 is an inhibitor of stearoyl-CoA desaturase 1 (SCD1). It exhibits anticancer activity as it inhibits cell growth and promotes cell death in human non-small cell lung carcinoma cells.Fórmula:C20H22ClN3O3Pureza:Min. 95%Cor e Forma:PowderPeso molecular:387.86 g/molAtorvastatin sodium salt - Bio-X ™
CAS:Atorvastatin is an HMG-CoA reductase inhibitor which is used to lower lipid levels and to reduce the risk of cardiovascular disease. This drug belongs to the class of medicines called statins. It lowers abnormal levels of cholesterol and lipids to reduce the risk of cardiovascular disease by inhibiting the enzyme HMG-CoA.Fórmula:C33H35FN2O5•NaPureza:(%) Min. 95%Cor e Forma:PowderPeso molecular:581.63 g/molDMAT
CAS:Inhibitor of protein kinase CK2
Fórmula:C9H7Br4N3Pureza:Min. 95%Cor e Forma:White PowderPeso molecular:476.79 g/molDeracoxib
CAS:Inhibitor of COX-2 and PDE4 enzymes; NSAID of coxib classFórmula:C17H14F3N3O3SPureza:Min. 95%Cor e Forma:White To Off-White To Brown SolidPeso molecular:397.37 g/mol6-Thioguanine - Bio-X ™
CAS:6-Thioguanine is a purine analog used in the therapy for leukemia and for remission consolidation in patients with acute nonlymphocytic anemia. This drug also has antimetabolite action. It replaces guanine during DNA replication. This substitution disrupts the accurate pairing of DNA bases, leading to errors in DNA replication and hinders cell division.Fórmula:C5H5N5SPureza:Min. 95%Cor e Forma:PowderPeso molecular:167.19 g/molSC 560
CAS:Inhibitor of COX1 cyclooxygenaseFórmula:C17H12ClF3N2OPureza:Min. 95%Peso molecular:352.74 g/molPolmacoxib
CAS:Polmacoxib is a non-steroidal anti-inflammatory drug (NSAID), which is derived through synthetic chemical processes. It functions as a selective cyclooxygenase-2 (COX-2) inhibitor. By selectively inhibiting the COX-2 enzyme, polmacoxib reduces the conversion of arachidonic acid to prostaglandins that mediate inflammation and pain, while sparing the COX-1 enzyme that protects gastric mucosa and maintains platelet function.
Fórmula:C18H16FNO4SPureza:Min. 95%Cor e Forma:Light (Or Pale) Yellow To Yellow SolidPeso molecular:361.07841Erdafitinib
CAS:Fibroblast growth factor receptor inhibitorFórmula:C25H30N6O2Pureza:Min. 95%Cor e Forma:White PowderPeso molecular:446.54 g/mol(+/-)-Thalidomide - Bio-X ™
CAS:Produto ControladoThalidomide is a piperidinyl isoindole drug that is used to treat various cancers such as myeloma and erythema nodosum leprosum. This drug is immunosuppressive and has anti-angiogenic activity. Thalidomide’s mechanism of action is not fully understood however it is thought to block the activity of tumor necrosis factor-alpha (TNF-α).Fórmula:C13H10N2O4Pureza:Min. 95%Cor e Forma:PowderPeso molecular:258.23 g/molVH 298
CAS:A selective VHL inhibitor that stabilizes the hydroxylated form of HIF-α, resulting in upregulation of downstream target genes and proteins. Provides a tool for studying hypoxic signaling pathway.Fórmula:C27H33N5O4SPureza:Min. 95%Cor e Forma:PowderPeso molecular:523.65 g/molBRD 6989
CAS:A small molecule inhibitor with high selectivity for CDK8 over CDK19. Increases IL-10 production in stimulated human and murine macrophages and dendritic cells. Modulatory action on inflammatory responses has therapeutic potential.Fórmula:C16H16N4Pureza:Min. 95%Cor e Forma:SolidPeso molecular:264.33 g/molIndomethacin - Bio-X ™
CAS:Indomethacin is a nonsteroidal anti-inflammatory drug that inhibits the production of prostaglandin PGE2. It is used to treat pain, fever, and inflammation. Indomethacin's mechanism of action is not well understood, but it may be due to interference with the ability of PMNs to bind to the surface of bacteria or to release reactive oxygen species. The drug has been shown to reduce mitochondrial membrane potential in mammalian cells, leading to apoptosis. This effect on mitochondria may also contribute to Indomethacin's anti-inflammatory effects. Indomethacin is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Fórmula:C19H16ClNO4Pureza:(%) Min. 95%Cor e Forma:PowderPeso molecular:357.79 g/molA 769662
CAS:Allosteric activator of AMP-activated protein kinase (AMPK) acting on the AMPK-β subunit with therapeutic potential in metabolic disorders such as diabetes, obesity, etc. A769662 also blocks the differentiation of mouse embryonic stem cells (mESCs) and maintains the mESCs in naïve state even in the absence of leukemia inhibitory factor (2i/L).Fórmula:C20H12N2O3SPureza:Min. 95%Cor e Forma:SolidPeso molecular:360.39 g/molToceranib phosphate - Bio-X ™
CAS:Produto ControladoToceranib phosphate is a receptor tyrosine kinase inhibitor. Toceranib phosphate has been shown to be effective in the treatment of skin cancer and other types of cancer, including lung cancer and breast cancer. It is approved in the US as a treatment for canine mastocytoma (mast cell tumours).Fórmula:C22H25FN4O2·H3O4PPureza:Min. 95%Cor e Forma:PowderPeso molecular:494.45 g/molDutasteride - Bio-X ™
CAS:Dutasteride is an androgenic compound and a 5α-reductase inhibitor that is used to treat benign prostatic hyperplasia (BPH) and male pattern baldness. Dutasteride reduces prostate volume and improves symptoms of BPH by inhibiting the enzyme 5α-reductase, which converts testosterone to dihydrotestosterone.Fórmula:C27H30F6N2O2Pureza:(%) Min. 99%Cor e Forma:PowderPeso molecular:528.53 g/molDiclofenac sodium salt - Bio-X ™
CAS:Diclofenac is a non-steroidal anti-inflammatory drug that is used to treat the signs and symptoms of arthritis and osteoarthritis. This drug inhibits COX-1 and COX-2 enzymes. As a result, it reduces pain and inflammation in joints. Diclofenac is usually used as a first line therapy for acute and chronic pain.Fórmula:C14H11NO2Cl2•NaPureza:Min. 95%Cor e Forma:PowderPeso molecular:319.14 g/molRosuvastatin lactone
CAS:HMG-CoA reductase inhibitorFórmula:C22H26FN3O5SPureza:Min. 98%Cor e Forma:PowderPeso molecular:463.52 g/molAZD 9291
CAS:A potent inhibitor of EGFR with sensitizing and T790M resistance mutations, selective over the wild-type form of the receptor. Causes tumour regression in EGFR mutant T790M transgenic and xenograft models in vivo.Fórmula:C28H33N7O2Pureza:Min. 97%Cor e Forma:SolidPeso molecular:499.61 g/molRamipril - Bio-X ™
CAS:Ramipril is an angiotensin-converting enzyme (ACE) inhibitor. It is used in the treatment of high blood pressure, congestive heart failure and other cardiovascular diseases. Ramipril inhibits the conversion of angiotensin I to angiotensin II by blocking ACE, which lowers blood pressure and reduces fluid retention.This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Fórmula:C23H32N2O5Pureza:Min. 95%Cor e Forma:PowderPeso molecular:416.51 g/molPAC 1
CAS:PAC 1 is a small-molecule apoptosis inducer, derived from synthetic sources, with a unique mode of action targeting the apoptotic pathways in cancer cells. PAC 1 functions by selectively activating procaspase-3, an inactive precursor of the caspase enzymes, which play a crucial role in the execution phase of cell apoptosis. By facilitating the conversion of procaspase-3 to its active form, PAC 1 enhances the apoptotic response in cancer cells, promoting cell death and offering potential therapeutic advantages.Fórmula:C23H28N4O2Pureza:Min. 98 Area-%Cor e Forma:White PowderPeso molecular:392.49 g/molR-Rolipram
CAS:Inhibitor of PDE4 enzyme; anti-inflammatory
Fórmula:C16H21NO3Pureza:Min. 95%Cor e Forma:PowderPeso molecular:275.34 g/molNGI1
CAS:A cell permeable inhibitor of oligosaccharyltransferase that interferes with the transfer of mature glycan precursors to recipient proteins. Causes reduced proliferation, G1 arrest and senescence in EGFR- and FGFR-dependent non-small-cell lung carcinoma (NSCLC) cells.Fórmula:C17H22N4O3S2Pureza:Min. 99 Area-%Peso molecular:394.51 g/molVolitinib
CAS:Inhibitor of c-Met kinaseFórmula:C17H15N9Pureza:Min. 95%Cor e Forma:White PowderPeso molecular:345.36 g/molPamidronic acid disodium hydrate - Bio-X ™
CAS:Pamidronic acid is a bisphosphate used in the treatment of Paget’s disease, osteolytic bone lesions and in the treatment of hypercalcemia of malignancy. This drug inhibits farnesyl diphosphate and induces apoptosis of hematopoietic tumor cells.Fórmula:C3H9NNa2O7P2·4H2OPureza:Min. 95%Cor e Forma:PowderPeso molecular:351.11 g/molAZD 9291 mesylate
CAS:Inhibitor of EGFR transmembrane receptorFórmula:C28H33N7O2·CH4O3SPureza:Min. 98 Area-%Cor e Forma:White To Yellow To Brown SolidAmlexanox - Bio-X ™
CAS:Amlexanox is an antiallergic and anti-inflammatory drug that has been shown to be effective in treating rhinitis and allergic asthma in clinical studies. It prevents the slow-reacting substance of anaphylaxis (SRS-A) from being released chemically as a mediator and may have antagonistic effects on interleukin-3.Fórmula:C16H14N2O4Pureza:(%) Min. 99%Cor e Forma:PowderPeso molecular:298.29 g/mol
